Assessment of microplastic-sorbed contaminant bioavailability through analysis of biomarker gene expression in larval zebrafish
Open accessAbstract
Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here “co-contaminants”) can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log10Kow = 4.57; and 17α-ethinylestradiol (EE2), log10Kow = 3.67] to MPs; and assess whether co-contaminant bioavailability was increased after MP settlement. Bioavailability was indicated by gene expression in larval zebrafish. Both Phe and EE2 sorbed to MPs, which reduced bioavailability by a maximum of 33% and 48% respectively. Sorption occurred, but was not consistent with predictions based on co-contaminant physicochemistry (Phe having higher log10Kow was expected to have higher sorption). Contaminated MPs settled to the bottom of the exposures did not lead to increased bioavailability of Phe or EE2. Phe was 48% more bioavailable than predicted by a linear sorption model, organism-based measurements therefore contribute unique insight into MP co-contaminant bioavailability.
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They documented genotoxicity, reproductive and behavioural effects in the fish D. rerio.
“They documented genotoxicity, reproductive and behavioural effects in the fish D. rerio.”
From Studies of the Effects of Microplastics on Aquatic Organisms: What Do We Know and Where Should We Focus Our Efforts in the Future? (2018) · cites this paper as Sleight et al., 2017
Chen et al. (2017a) and Sleight et al. (2017) studied the interactions of MPs and the 17α-ethinylestradiol, a synthetic hormone which can function as an EDC.
“Chen et al. (2017a) and Sleight et al. (2017) studied the interactions of MPs and the 17α-ethinylestradiol, a synthetic hormone which can function as an EDC.”
From Studies of the Effects of Microplastics on Aquatic Organisms: What Do We Know and Where Should We Focus Our Efforts in the Future? (2018) · cites this paper as Sleight et al., 2017
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Cites
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“The sorption of Phe to uPVC MPs was previously characterized in our laboratory (Bakir et al., 2012), and the following sorption equation was obtained: y ¼ 0 : 51 x − 0 : 14 (where y =concentration of Pheleft in thepelagic scenario and x = the initial concentration of Phe).”
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Miller, M. M., Wasik, S. P., Huang, G. L., Shiu, W. Y., & Mackay, D. (1985) · Environmental Science & Technology · doi:10.1021/es00136a007 · Cited by 468 · cited 1× · see citing works
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“Over the last decade, investigations have reported the presence of MPs in sediments (Reddy et al., 2006) and in pelagic zones (Collignon et al., 2012); however, the ecological implications of MPs are unknown.”
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BackgroundScales of Spatial Heterogeneity of Plastic Marine Debris in the Northeast Pacific Ocean
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Polychlorinated biphenyls and organochlorine pesticides in plastics ingested by seabirds
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“…that have ingested MPs have been reported to have elevated amounts of polychlorinated biphenyls (PCBs) and other persistent organic contaminants (Colabuono et al., 2010; Tanaka et al., 2013), although whether the increased amounts of these contaminants is a consequence of desorption from…”
BackgroundEstrogen-Induced Vitellogenin mRNA and Protein in Sheepshead Minnow (Cyprinodon variegatus)
Bowman, C., Kroll, K. J., Hemmer, M. J., Folmar, L. C., & Denslow, N. D. (2000) · General and Comparative Endocrinology · doi:10.1006/gcen.2000.7565 · Cited by 118 · cited 1× · see citing works
“The concentration-related induction of vtg with EE2 was consistent with our previous work (Henry et al., 2009; Park et al., 2010; Reinardy et al., 2013), and other reports (Bowman et al., 2000; Solé et al., 2000).”
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Reinardy, H. C., Scarlett, A. G., Henry, T. B., West, C. E., Hewitt, L. M., Frank, R. A., & Rowland, S. J. (2013) · Environmental Science & Technology · doi:10.1021/es304799m · Cited by 91 · cited 4× · see citing works
“1) (Henry et al., 2009; Park et al., 2010; Reinardy et al., 2013).”
MethodResultInfluentialHenry, T. B., McPherson, J. T., Rogers, E. D., Heah, T. P., Hawkins, S. A., Layton, A. C., & Sayler, G. S. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.05.009 · Cited by 71 · cited 9× · see citing works
“After sample homogenization (3–5 s of sonication) and tissue disaggregation (QiaShredder column, Qiagen), total RNA was extracted (RNeasy MiniKit for animal tissue, Qiagen, West Crawley, UK) from zebrafish larvae (35 fish in each sample) as previously described (Henry et al., 2009; Park et al., 2010; Reinardy et al.,…”
BackgroundMethodResultInfluentialRemoval of ethinylestradiol (EE2) from water via adsorption on aliphatic polyamides
Han, J., Qiu, W., Meng, S., & Gao, W. (2012) · Water Research · doi:10.1016/j.watres.2012.08.001 · Cited by 57 · cited 1× · see citing works
“Analytical chemistry was not used to characterize sorption of EE2 to uPVC particles due to dif fi culty in detecting such low concentrations; however, previous studies have demonstrated EE2 has a strong sorption af fi nity to plastic (Han et al., 2012; Walker and Watson, 2010).”
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BackgroundPark, J., Henry, T. B., Ard, S. G., Menn, F., Compton, R. N., & Sayler, G. S. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.525329 · Cited by 42 · cited 1× · see citing works
“…concentration and target gene expression indicated that measurement of the expression of these genes is a useful approach for evaluation of changes in co-contaminant bioavailability during sorption reactions with particles as we have demonstrated previously (Henry et al., 2013; Park et al., 2011).”
MethodPark, J., Henry, T. B., Menn, F., Compton, R. N., & Sayler, G. S. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.09.036 · Cited by 42 · cited 5× · see citing works
“The concentration-related induction of vtg with EE2 was consistent with our previous work (Henry et al., 2009; Park et al., 2010; Reinardy et al., 2013), and other reports (Bowman et al., 2000; Solé et al., 2000).”
MethodResultInfluentialGündel, U., Kalkhof, S., Zitzkat, D., von Bergen�, M., Altenburger, R., & Küster, E. (2011) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2011.10.010 · Cited by 42 · cited 1× · see citing works
“The concentrations of each substance were selected as they are the highest non-lethal concentrations which allowed for high gene expression whilst avoiding mortality (Gündel et al., 2012; Henry et al., 2009).”
BackgroundAdsorption of Estrogens on Laboratory Materials and Filters during Sample Preparation
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“Analytical chemistry was not used to characterize sorption of EE2 to uPVC particles due to dif fi culty in detecting such low concentrations; however, previous studies have demonstrated EE2 has a strong sorption af fi nity to plastic (Han et al., 2012; Walker and Watson, 2010).”
MethodHenry, T. B., Wileman, S. J., Boran, H., & Sutton, P. (2013) · Environmental Science & Technology · doi:10.1021/es4015597 · Cited by 28 · cited 3× · see citing works
“When NPs with sorbed Hg 2+ sedimented to the bottom of beakers, Hg 2+ exposure in fi sh at the bottom of the beaker increased (Henry et al., 2013).”
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“The improvement observed in the number of MPs held in thewater column within thechamber is consistentwith that observed for engineered nanoparticles in a chamber of similar design (Boyle et al., 2015).”
ResultPark, J., Hecker, M., Murphy, M. B., Jones, P. D., Solomon, K. R., Kraak, G. V. D., Carr, J. A., Smith, E. E., Preez, L. D., Kendall, R. J., et al. (2006) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2006.01.003 · Cited by 21 · cited 1× · see citing works
“Relative quanti fi cation of gene expression was by the comparative C T method, in which the change in expression of the gene of interest is normalized to that of an internal housekeeping gene (Park et al., 2006).”
Method
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- Authors
- Sleight, V. A., Bakir, A., Thompson, R. C., & Henry, T. B.
- Affiliations
- British Antarctic Survey (GB)
- University of Portsmouth (GB)
- University of Plymouth (GB)
- Corresponding author
- Sleight, Victoria A.
- Venue
- Marine Pollution Bulletin
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 116
- Issue
- 1-2
- Pages
- 291-297
- ISSN
- 0025-326X (ISSN-L)
- OpenAlex
- W2579412410
- Cited by
- 190
- References
- 49
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 26 · 2022: 34 · 2021: 32 · 2020: 32 · 2019: 21 · 2018: 15 · 2017: 3
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Marine Pollution Bulletin (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NERC Open Research Archive (Natural Environment Research Council) (acceptedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- PEARL (University of Plymouth) (submittedVersion)
- Funders
- Natural Environment Research Council (NE/N006526/1, bas0100036)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- microplastics, co-contaminants, contaminant sorption, bioavailability, phenanthrene, ethinyl estradiol, zebrafish larvae, gene expression biomarkers, octanol-water partition coefficient, marine pollution
- MeSH terms
- Animals, Biological Availability, Ethinyl Estradiol, Larva, Phenanthrenes, Plastics, Water Pollutants, Chemical, Zebrafish, Biomarkers, Gene Expression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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