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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

Open access
Iozzo, Renato V., Schaefer, Liliana·2015·Matrix Biology

Abstract

We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.

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Metadata

Authors
Iozzo, R. V., & Schaefer, L.
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2015-03
Volume
42
Pages
11-55
ISSN
0945-053X (ISSN-L)
OpenAlex
W2058229406
Cited by
1,263
References
14
FWCI
45.47
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. https://app.cochat.ai/papers/10.1016/j.matbio.2015.02.003
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Iozzo, R. V., & Schaefer, L. (2015). Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biology. https://doi.org/10.1016/j.matbio.2015.02.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.