The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cartilage diseases
Open accessAbstract
Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth. The structure and organization of cartilage’s extracellular matrix (ECM) are the primary determinants of normal function. Most diseases involving cartilage lead to dramatic changes in the ECM which can govern disease progression (e.g., in osteoarthritis), cause the main symptoms of the disease (e.g., dwarfism caused by genetically inherited mutations) or occur as collateral damage in pathological processes occurring in other nearby tissues (e.g., osteochondritis dissecans and inflammatory arthropathies). Challenges associated with cartilage diseases include poor understanding of the etiology and pathogenesis, delayed diagnoses due to the aneural nature of the tissue and drug delivery challenges due to the avascular nature of adult cartilages. This narrative review provides an overview of the clinical and pathological features as well as current treatment options available for various cartilage diseases. Late breaking advances are also described in the quest for development and delivery of effective disease modifying drugs for cartilage diseases including osteoarthritis, the most common form of arthritis that affects hundreds of millions of people worldwide.
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Cited by
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
The extracellular matrix as a multitasking player in disease
Theocharis, A. D., Manou, D., & Karamanos, N. K. (2019) · The FEBS Journal · doi:10.1111/febs.14818 · Cited by 511
Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications
Teixeira, M. A., Amorim, M. T. P., & Felgueiras, H. P. (2019) · Polymers · doi:10.3390/polym12010007 · Cited by 287
Li, Q., Xu, S., Feng, Q., Dai, Q., Yao, L., Zhang, Y., Gao, H., Dong, H., Chen, D., & Cao, X. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.013 · Cited by 231
Wang, Z., Sun, F., Lu, Y., Zhang, B., Zhang, G., & Shi, H. (2021) · ACS Omega · doi:10.1021/acsomega.0c06247 · Cited by 25
Metadata
- Authors
- Krishnan, Y., & Grodzinsky, A. J.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 71-72
- Pages
- 51-69
- ISSN
- 0945-053X (ISSN-L)
- OpenAlex
- W4210995681
- Cited by
- 443
- References
- 10
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
