Cited by 96Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchBone Tumor Diagnosis and Treatments

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation

Melrose, James, Shu, Cindy, Whitelock, John M., Lord, Megan S.·2016·Matrix Biology

Abstract

The cartilage growth plate is a specialized developmental tissue containing characteristic zonal arrangements of chondrocytes. The proliferative and differentiative states of chondrocytes are tightly regulated at all stages including the initial limb bud and rudiment cartilage stages of development, the establishment of the primary and secondary ossification centers, development of the growth plates and laying down of bone. A multitude of spatio-temporal signals, including transcription factors, growth factors, morphogens and hormones, control chondrocyte maturation and terminal chondrocyte differentiation/hypertrophy, cell death/differentiation, calcification and vascular invasion of the growth plate and bone formation during morphogenetic transition of the growth plate. This involves hierarchical, integrated signaling from growth and factors, transcription factors, mechanosensory cues and proteases in the extracellular matrix to regulate these developmental processes to facilitate progressive changes in the growth plate culminating in bone formation and endochondral ossification. This review provides an overview of selected components which have particularly important roles in growth plate biology including collagens, proteoglycans, glycosaminoglycans, growth factors, proteases and enzymes.

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Registry

Crossref · 10.1016/j.matbio.2016.01.008

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288 of 288 references verified0 citation errors · 0 not checkable

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  • Cartilage acts as a template for primary and secondary ossification centers, development of the growth plates and the end of long bones, and the laying down of bone.

    “Cartilage also acts as a template for primary and secondary ossi fi cation centers, development of the growth plates and the end of long bones, and the laying down of bone (578).”

    From Biological roles of glycans (2017) · cites this paper as [578]

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Authors
Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S.
Affiliations
  • The University of Sydney (AU)
  • Northern Sydney Local Health District (AU)
Corresponding author
Lord, Megan S.
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2016-05
Volume
52-54
Pages
363-383
ISSN
0945-053X (ISSN-L)
OpenAlex
W2252208090
Cited by
96
References
288
Citations by year
2026: 7 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 6
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Locations
  • Matrix Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
Keywords
growth plate, cartilage matrix, chondrocyte maturation, endochondral ossification, chondrocyte hypertrophy, chondrogenic differentiation, collagen, proteoglycans, glycosaminoglycans, growth factors, proteolytic enzymes, mechanosensing, vascular invasion, bone formation, ossification centers
MeSH terms
Animals, Calcification, Physiologic, Cartilage, Cell Differentiation, Extracellular Matrix, Growth Plate, Humans, Signal Transduction, Extracellular Matrix Proteins, Chondrocytes, Chondrogenesis, Mice

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