Enhancement of diabetic wound healing using a core-shell nanofiber platform with sequential antibacterial, angiogenic, and collagen deposition activities
Open accessAbstract
Infected diabetic wound (DW) healing entails a series of temporally and spatially regulated stages including antibacterial responses, revascularization, and collagen deposition, underscoring the need for the controlled sequential delivery of appropriate compounds when treating these wounds. Here, we designed a multifunctional core–shell [email protected]/[email protected] nanofiber loaded with three bioactive agents, including chitosan (CTS), copper (Cu), and decellularized Wharton’s jelly matrix (DWJM). We used this platform to facilitate regulated antibacterial, angiogenic, and collagen deposition activity in the context of DW healing. These [email protected]/[email protected] nanofibers exhibited satisfactory mechanical properties, excellent absorption, acceptable biodegradability, a high level of biocompatibility, elevated adhesive rates, and the ability to sequentially mediate controlled sequential CTS and Cu release. Further in vitro analyses revealed that the initial release of the CTS shell was sufficient to exert antibacterial activity, after which the sustained release of the Cu core promoted cellular migration, neovascularization, and enhanced angiogenesis-related gene expression. In vivo, DWJM further accelerated the deposition of collagen. Together, the sequential antibacterial, angiogenic, and collagen deposition activities synergistically enhanced DW healing. We thus posit that the core–shell [email protected]/[email protected] nanofiber holds great promise for use as a dressing material capable of promoting the appropriate stages of DW healing in a regulated, sequential manner.
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PLCL has become an important biomaterial in biomedical engineering due to its excellent biocompatibility, tunable biodegradability, and multifunctional mechanical properties.
“Poly (L-lactide-co-ε-caprolactone) (PLCL) has become an important biomaterial in biomedical engineering due to its excellent biocompatibility, tunable biodegradability, and multifunctional mechanical properties [1–4].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [2]
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- Authors
- Zhan, A., Chen, L., Sun, W., Tang, Y., Chen, J., Yu, D., & Zhang, W.
- Affiliations
- Weifang Medical University (CN)
- China National Nuclear Corporation (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Chen, Jie
- Yu, Daojiang
- Zhang, Wei
- Venue
- Materials & Design
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 218
- Pages
- 110660
- ISSN
- 0264-1275 (ISSN-L)
- OpenAlex
- W4223945175
- Cited by
- 41
- References
- 41
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 13 · 2023: 9 · 2022: 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials & Design (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81970014, 2017YFC1103900, 81701843, 2020YJ0194, 81301647, 32071238)
- National Key Research and Development Program of China (2017YFC1103900)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- diabetic wound healing, wound infection, core-shell nanofibers, chitosan, copper nanoparticles, controlled drug release, antibacterial activity, angiogenesis, collagen deposition, wound dressings, sustained drug release
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