Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite
Open accessAbstract
A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The superficial and deep cartilage layers interact to maintain homeostasis and increase new tissue production when needed.
“the superficial and deep cartilage layers interact to maintain homeostasis and increase new tissue production when needed25”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [25]
The Results section (‘Cartilage growth in hydrogels in vitro’; page unavailable) reports that chondrocytes cultured adjacent to mesenchymal stem cells increased cartilage-matrix production. But those were cell populations in a bilayered hydrogel, not the superficial and deep cartilage layers; the paper does not establish that those layers interact to maintain homeostasis or increase tissue production when needed. (LLM, conf=0.79)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oliver, W. C., & Pharr, G. M. (1992) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/jmr.1992.1564 · Cited by 26,941 · see citing works
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992 · see citing works
Hunziker, E. B. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2002.0801 · Cited by 1,983 · see citing works
Outcomes of microfracture for traumatic chondral defects of the knee: Average 11‐year follow‐up
Steadman, J. R., Briggs, K. K., Rodrigo, J. J., Kocher, M. S., Gill, T. J., & Rodkey, W. G. (2003) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1053/jars.2003.50112 · Cited by 1,212 · see citing works
Clinical Efficacy of the Microfracture Technique for Articular Cartilage Repair in the Knee
Mithoefer, K., McAdams, T. R., Williams, R. J., Kreuz, P., & Mandelbaum, B. R. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546508328414 · Cited by 1,013 · see citing works
A Randomized Trial Comparing Autologous Chondrocyte Implantation with Microfracture
Knutsen, G., Isaksen, V., Johansen, O., Drogset, J. O., Grøntvedt, T., Engebretsen, L., Ludvigsen, T. C., Sally, R., Solheim, E., & Strand, T. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.g.00003 · Cited by 887 · see citing works
Multifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
Wang, D., Varghese, S., Sharma, B., Strehin, I. A., Fermanian, S., Gorham, J. M., Fairbrother, D. H., Cascio, B. M., & Elisseeff, J. H. (2007) · Nature Materials · doi:10.1038/nmat1890 · Cited by 695 · see citing works
Self-citationTHE MICROFRACTURE TECHNIQUE FOR THE TREATMENT OF ARTICULAR CARTILAGE LESIONS IN THE KNEE
Mithoefer, K., Williams, R. J., Warren, R. F., Potter, H. G., Spock, C. R., Jones, E. C., Wickiewicz, T. L., & Marx, R. G. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02846 · Cited by 679 · see citing works
Yang, F., Williams, C. G., Wang, D., Lee, H., Manson, P. N., & Elisseeff, J. H. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.03.018 · Cited by 458 · see citing works
Self-citationWilliams, C. G., Kim, T. K., Taboas, A., Malik, A. N., Manson, P. N., & Elisseeff, J. H. (2003) · Tissue Engineering · doi:10.1089/107632703768247377 · Cited by 395 · see citing works
Self-citationChondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells
Varghese, S., Hwang, N. S.-Y., Canver, A. C., Theprungsirikul, P., Lin, D. W., & Elisseeff, J. H. (2007) · Matrix Biology · doi:10.1016/j.matbio.2007.07.002 · Cited by 380 · see citing works
Self-citationMechanics and contraction dynamics of single platelets and implications for clot stiffening
Lam, W. A., Chaudhuri, O., Crow, A., Webster, K. D., Li, T., Kita, A., Huang, J. N., & Fletcher, D. A. (2010) · Nature Materials · doi:10.1038/nmat2903 · Cited by 350 · see citing works
Hoemann, C. D., Hurtig, M., Rossomacha, E., Sun, J., Chevrier, A., Shive, M. S., & Buschmann, M. D. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02536 · Cited by 305 · see citing works
Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes
Gersh, K. C., Nagaswami, C., & Weisel, J. W. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-03-0199 · Cited by 295 · see citing works
Strategies for Articular Cartilage Lesion Repair and Functional Restoration
Ahmed, T. A., & Hincke, M. T. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0590 · Cited by 270 · see citing works
MR Imaging and T2 Mapping of Femoral Cartilage
Mosher, T. J., Smith, H. E., Dardzinski, B. J., Schmithorst, V. J., & Smith, M. B. H. (2001) · American Journal of Roentgenology · doi:10.2214/ajr.177.3.1770665 · Cited by 235 · see citing works
Benoit, D. S. W., & Anseth, K. S. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.03.002 · Cited by 231 · see citing works
Hoemann, C. D., Sun, J., McKee, M. D., Chevrier, A., Rossomacha, E., Rivard, G., Hurtig, M., & Buschmann, M. D. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.06.015 · Cited by 224 · see citing works
Mosher, T. J., Liu, Y., & Torok, C. M. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.11.011 · Cited by 202 · see citing works
Change in Knee Cartilage T2 at MR Imaging after Running: A Feasibility Study
Mosher, T. J., Smith, H. E., Collins, C. M., Liu, Y., Hancy, J., Dardzinski, B. J., & Smith, M. B. H. (2005) · Radiology · doi:10.1148/radiol.2341040041 · Cited by 201 · see citing works
Magnetic Resonance Imaging Appearance of Cartilage Repair in the Knee
Brown, W. E., Potter, H. G., Marx, R. G., Wickiewicz, T. L., & Warren, R. F. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000129162.36302.4f · Cited by 185 · see citing works
Benthien, J. P., & Behrens, P. (2011) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-010-1356-1 · Cited by 176 · see citing works
Dhollander, A. A. M., Neve, F. D., Almqvist, K., Verdonk, R. E., Lambrecht, S., Elewaut, D. S., Verbruggen, G., & VERDONK, P. C. M. (2010) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-010-1337-4 · Cited by 167 · see citing works
Shinzato, S., Kobayashi, M., Mousa, W. F., Kamimura, M., Neo, M., Kitamura, Y., Kokubo, T., & Nakamura, T. (2000) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(200008)51:2 · Cited by 165 · see citing works
Self-citationAssche, D. V., Staes, F. F. G. M., Caspel, D. V., Vanlauwe, J., Bellemans, J., Saris, D. B. F., & Luyten, F. P. (2009) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-009-0955-1 · Cited by 148 · see citing works
Designing Zonal Organization into Tissue-Engineered Cartilage
Sharma, B., Williams, C. G., Kim, T. K., Sun, D., Malik, A. N., KHAN, M. A., Leong, K. W., & Elisseeff, J. H. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0068 · Cited by 142 · see citing works
Self-citationHambly, K., & Griva, K. (2008) · The American Journal of Sports Medicine · doi:10.1177/0363546508317718 · Cited by 126 · see citing works
One‐step osteochondral repair with cartilage fragments in a composite scaffold
Marmotti, A., Bruzzone, M., Bonasia, D. E., Castoldi, F., Rossi, R., Piras, L. A., Maiello, A., Realmuto, C., & Peretti, G. M. (2012) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-012-1920-y · Cited by 104 · see citing works
Articular cartilage regeneration with microfracture and hyaluronic acid
Kang, S., Bada, L. P., Kang, C.-S., Lee, J. S., Kim, C., Park, J. H., & Kim, B. (2007) · Biotechnology Letters · doi:10.1007/s10529-007-9576-2 · Cited by 97 · see citing works
The Survey on Cellular and Engineered Tissue Therapies in Europe in 2011
Martín, I., Baldomero, H., Bocelli‐Tyndall, C., Emmert, M. Y., Hoerstrup, S. P., Ireland, H., Passweg, J. R., & Tyndall, A. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0372 · Cited by 95 · see citing works
Musumeci, G., Loreto, C., Carnazza, M. L., Strehin, I. A., & Elisseeff, J. H. (2011) · PubMed · doi:10.14670/hh-26.1265 · Cited by 72 · see citing works
Self-citationCusters, R. J. H., Saris, D. B. F., Dhert, W. J. A., Verbout, A. J., van Rijen, M., Mastbergen, S. C., Lafeber, F. P. J. G., & Creemers, L. B. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00668 · Cited by 58 · see citing works
Schmidt, O., Mizrahi, J., Elisseeff, J. H., & Seliktar, D. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21072 · Cited by 57 · see citing works
Self-citationThe Survey on Cellular and Engineered Tissue Therapies in Europe in 2010
Martín, I., Baldomero, H., Bocelli‐Tyndall, C., Passweg, J. R., Saris, D. B. F., & Tyndall, A. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0169 · Cited by 35 · see citing works
Science and Animal Models of Marrow Stimulation for Cartilage Repair
Fortier, L. A., Cole, B. J., & McIlwraith, C. W. (2012) · The Journal of Knee Surgery · doi:10.1055/s-0032-1310389 · Cited by 32 · see citing works
Biomechanical properties of mixtures of blood and synovial fluid
McCarty, W. J., Luan, A., Siddiqui, M., Hansen, B. C., Masuda, K., & Sah, R. L. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21209 · Cited by 23 · see citing works
Mesenchymal Stem Cell Stimulation of Tissue Growth Depends on Differentiation State
Rothenberg, A. R., Ouyang, L., & Elisseeff, J. H. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0097 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Tough adhesives for diverse wet surfaces
Li, J., Celiz, A. D., Yang, J., Yang, Q., Wamala, I., Whyte, W., Seo, B. R., Vasilyev, N. V., Vlassak, J. J., Suo, Z., et al. (2017) · Science · doi:10.1126/science.aah6362 · Cited by 1,610 · see citing works
Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works
Self-citationHydrogel Adhesion: A Supramolecular Synergy of Chemistry, Topology, and Mechanics
Yang, J., Bai, R., Chen, B., & Suo, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901693 · Cited by 1,037 · see citing works
3D printing of hydrogels: Rational design strategies and emerging biomedical applications
Li, J., Wu, C., Chu, P. K.-H., & Gelinsky, M. (2020) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2020.100543 · Cited by 867 · see citing works
Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation
Liu, Y., Liu, J., Chen, S., Lei, T., Kim, Y., Niu, S., Wang, H., Wang, X., Foudeh, A. M., Tok, J. B.-H., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0335-6 · Cited by 811 · see citing works
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764 · see citing works
A Review of 3D Printing Technology for Medical Applications
Yan, Q., Dong, H., Su, J. D., Han, J., Song, B., Wei, Q., & Shi, Y. (2018) · Engineering · doi:10.1016/j.eng.2018.07.021 · Cited by 732 · see citing works
Hydrogel interfaces for merging humans and machines
Yuk, H., Wu, J., & Zhao, X. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00483-4 · Cited by 683 · see citing works
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652 · see citing works
Biomaterials for articular cartilage tissue engineering: Learning from biology
Armiento, A. R., Stoddart, M. J., Alini, M., & Eglin, D. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.021 · Cited by 579 · see citing works
Photoresponsive biomaterials for targeted drug delivery and 4D cell culture
Ruskowitz, E. R., & DeForest, C. A. (2018) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.87 · Cited by 399 · see citing works
Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo
Choi, M., Choi, J. W., Kim, S., Nizamoğlu, S., Hahn, S. K., & Yun, S. H. (2013) · Nature Photonics · doi:10.1038/nphoton.2013.278 · Cited by 379 · see citing works
Askari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M. (2021) · Biomaterials Science · doi:10.1039/d0bm00973c · Cited by 369 · see citing works
Advanced hydrogels for the repair of cartilage defects and regeneration
Wei, W., Ma, Y., Yao, X., Zhou, W., Wang, X., Li, C., Lin, J., He, Q., Leptihn, S., & Ouyang, H. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.030 · Cited by 358 · see citing works
Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue
Yuk, H., Wu, J., Sarrafian, T. L., Mao, X., Varela, C. E., Roche, E. T., Griffiths, L. G., Nabzdyk, C. S., & Zhao, X. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00769-y · Cited by 348 · see citing works
Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges
Wei, W., & Dai, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.011 · Cited by 328 · see citing works
Design, clinical translation and immunological response of biomaterials in regenerative medicine
Sadtler, K., Singh, A., Wolf, M. T., Wang, X.-K., Pardoll, D., & Elisseeff, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.40 · Cited by 294 · see citing works
Self-citationHan, L., Wang, M., Li, P., Gan, D., Yan, L., Xu, J., Wang, K., Fang, L., Chan, C. W., Zhang, H., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b05314 · Cited by 312 · see citing works
<i>In situ</i>handheld three‐dimensional bioprinting for cartilage regeneration
Di Bella, C., Duchi, S., O'Connell, C. D., Blanchard, R., Augustine, C., Yue, Z., Thompson, F., Richards, C., Beirne, S., Onofrillo, C., et al. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2476 · Cited by 313 · see citing works
Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction
Bovone, G., Dudaryeva, O. Y., Marco‐Dufort, B., & Tibbitt, M. W. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01677 · Cited by 307 · see citing works
Tailoring Gelation Mechanisms for Advanced Hydrogel Applications
Nele, V., Wojciechowski, J. P., Armstrong, J. P. K., & Stevens, M. M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002759 · Cited by 299 · see citing works
Gao, Y., Peng, K., & Mitragotri, S. (2021) · Advanced Materials · doi:10.1002/adma.202006362 · Cited by 304 · see citing works
3D-printing of transparent bio-microfluidic devices in PEG-DA
Urrios, A., Parra‐Cabrera, C., Bhattacharjee, N., Gonzalez‐Suarez, A. M., Rigat-Brugarolas, L. G., Nallapatti, U., Samitier, J., DeForest, C. A., Posas, F., Garcia-Cordero, J. L., et al. (2016) · Lab on a Chip · doi:10.1039/c6lc00153j · Cited by 275 · see citing works
In situ bioprinting – Bioprinting from benchside to bedside?
Singh, S., Choudhury, D., Yu, F., Mironov, V. A., & Naing, M. W. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.045 · Cited by 275 · see citing works
O’Connell, C. D., Bella, C. D., Thompson, F., Augustine, C., Beirne, S., Cornock, R., Richards, C. J., Chung, J. H.-Y., Gambhir, S., Yue, Z., et al. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/015019 · Cited by 277 · see citing works
Multifaceted Design and Emerging Applications of Tissue Adhesives
Ma, Z., Bao, G., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202007663 · Cited by 271 · see citing works
Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction
Yang, Y., Zhang, J., Liu, Z., Lin, Q., Liu, X., Bao, C., Wang, Y., & Zhu, L. (2016) · Advanced Materials · doi:10.1002/adma.201505336 · Cited by 267 · see citing works
Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering
Ren, K., He, C., Xiao, C., Li, G., & Chen, X. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.026 · Cited by 266 · see citing works
Qi, C., Liu, J., Jin, Y., Xu, L., Wang, G., Wang, Z., & Wang, L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.016 · Cited by 247 · see citing works
A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering
Webber, M. J., Khan, O. F., Sydlik, S. A., Tang, B. C., & Langer, R. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-014-1104-7 · Cited by 243 · see citing works
Singh, A., Corvelli, M., Unterman, S. A., Wepasnick, K. A., McDonnell, P. J., & Elisseeff, J. H. (2014) · Nature Materials · doi:10.1038/nmat4048 · Cited by 237 · see citing works
Self-citationChen, J., Yang, J., Wang, L., Zhang, X., Heng, B. C., Wang, D., & Ge, Z. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.020 · Cited by 238 · see citing works
An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects
Wu, J., Yuk, H., Sarrafian, T. L., Guo, C. F., Griffiths, L. G., Nabzdyk, C. S., & Zhao, X. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abh2857 · Cited by 234 · see citing works
Engineered hydrogels for mechanobiology
Blache, U., Ford, E. M., Ha, B. H., Rijns, L., Chaudhuri, O., Dankers, P. Y. W., Kloxin, A. M., Snedeker, J. G., & Gentleman, E. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00179-7 · Cited by 236 · see citing works
Biomechanics and mechanobiology in functional tissue engineering
Guilak, F., Butler, D. L., Goldstein, S. A., & Baaijens, F. F. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.04.019 · Cited by 230 · see citing works
Hydrogel: Diversity of Structures and Applications in Food Science
Li, J., Jia, X. T., & Yin, L. (2021) · Food Reviews International · doi:10.1080/87559129.2020.1858313 · Cited by 211 · see citing works
Biomaterials for tissue repair
Christman, K. L. (2019) · Science · doi:10.1126/science.aar2955 · Cited by 197 · see citing works
Organocobalt Complexes as Sources of Carbon-Centered Radicals for Organic and Polymer Chemistries
Demarteau, J., Debuigne, A., & Detrembleur, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00715 · Cited by 194 · see citing works
Hua, Y., Xia, H., Jia, L., Zhao, J., Zhao, D., Yan, X., Zhang, Y., Tang, S., Zhou, G., Zhu, L., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg0628 · Cited by 191 · see citing works
Glycosaminoglycans in Tissue Engineering: A Review
Sodhi, H., & Panitch, A. (2020) · Biomolecules · doi:10.3390/biom11010029 · Cited by 188 · see citing works
Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light
Guo, Y., Wang, Y., Zhao, X., Li, X., Wang, Q., Zhong, W., Mequanint, K., Zhan, R., Xing, M. M. Q., & Luo, G. (2021) · Science Advances · doi:10.1126/sciadv.abf9635 · Cited by 187 · see citing works
Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion‐Adhesion Balance
Song, R., Wang, X., Johnson, M., Milne, C., Lesniak‐Podsiadlo, A., Li, Y., Lyu, J., Li, Z., Zhao, C., Yang, L., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202313322 · Cited by 187 · see citing works
Mredha, M. T. I., & Jeon, I. (2021) · Progress in Materials Science · doi:10.1016/j.pmatsci.2021.100870 · Cited by 188 · see citing works
Chen, K., Lin, Q., Wang, L., Zhuang, Z., Zhang, Y., Huang, D., & Wang, H. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00637 · Cited by 183 · see citing works
Strong and Rapidly Self‐Healing Hydrogels: Potential Hemostatic Materials
Huang, W., Wang, Y., Chen, Y., Zhao, Y., Zhang, Q., Zheng, X., Chen, L., & Zhang, L. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600720 · Cited by 181 · see citing works
Polymers for medical and tissue engineering applications
Ozdil, D., & Aydın, H. M. (2014) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4505 · Cited by 179 · see citing works
Advanced cell therapies for articular cartilage regeneration
Madeira, C. G., Santhagunam, A., Salgueiro, J. B., & Cabral, J. M. S. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.11.003 · Cited by 178 · see citing works
Advances of injectable hydrogel-based scaffolds for cartilage regeneration
Li, J., Chen, G., Xu, X., Abdou, P., Jiang, Q. Y., Shi, D., & Gu, Z. (2019) · Regenerative Biomaterials · doi:10.1093/rb/rbz022 · Cited by 175 · see citing works
In situ repair of bone and cartilage defects using 3D scanning and 3D printing
Li, L., Yu, F., Shi, J., Shen, S., Teng, H., Yang, J., Wang, X., & Jiang, Q. Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-10060-3 · Cited by 172 · see citing works
Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair
Han, L., Xu, J., Lu, X., Gan, D., Wang, Z., Wang, K., Zhang, H., Yuan, H., & Weng, J. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02348g · Cited by 169 · see citing works
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Sharifi, R., Islam, M. M., Sharifi, H., Islam, R., Koza, D. J., Reyes‐Ortega, F., Alba-Molina, D., Nilsson, P. H., Dohlman, C. H., Mollnes, T. E., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.042 · Cited by 167 · see citing works
Hyaluronic Acid Enhances the Mechanical Properties of Tissue-Engineered Cartilage Constructs
Levett, P. A., Hutmacher, D. W., Malda, J., & Klein, T. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113216 · Cited by 160 · see citing works
Wu, D., Yu, Y., Tan, J., Huang, L., Luo, B., Lu, L., & Zhou, C. (2018) · Materials & Design · doi:10.1016/j.matdes.2018.09.040 · Cited by 159 · see citing works
3D bioprinting via an in situ crosslinking technique towards engineering cartilage tissue
Galarraga, J. H., Kwon, M. Y., & Burdick, J. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-56117-3 · Cited by 155 · see citing works
Tolabi, H., Davari, N., Khajehmohammadi, M., Malektaj, H., Nazemi, K., Vahedi, S., Ghalandari, B., Reis, R. L., Ghorbani, F., & Oliveira, J. M. (2023) · Advanced Materials · doi:10.1002/adma.202208852 · Cited by 153 · see citing works
Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine
Foyt, D. A., Norman, M. D. A., Yu, T. T. L., & Gentleman, E. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700939 · Cited by 150 · see citing works
Bioconjugated Hydrogels for Tissue Engineering and Regenerative Medicine
Ahadian, S., Sadeghian, R. B., Salehi, S., Ostrovidov, S., Bae, H., Ramalingam, M., & Khademhosseini, A. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00360 · Cited by 149 · see citing works
Autologous liquid platelet rich fibrin: A novel drug delivery system
Miron, R. J., & Zhang, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.05.021 · Cited by 153 · see citing works
Lin, H., Cheng, A. W. M., Alexander, P. G., Beck, A. M., & Tuan, R. S. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0642 · Cited by 149 · see citing works
Exquisite design of injectable Hydrogels in Cartilage Repair
Wu, J., Chen, Q., Deng, C., Xu, B., Zhang, Z., Yang, Y., & Lu, T. (2020) · Theranostics · doi:10.7150/thno.46450 · Cited by 146 · see citing works
Meng, X., Xiao, X., Jeon, S., Kim, D., Park, B., Kim, Y., Rubab, N., Kim, S., & Kim, S. (2022) · Advanced Materials · doi:10.1002/adma.202209054 · Cited by 146 · see citing works
Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies
Burdick, J. A., Mauck, R. L., Gorman, J. H., & Gorman, R. C. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3003997 · Cited by 139 · see citing works
Feng, Q., Li, Q., Wen, H., Chen, J., Liang, M., Huang, H., Lan, D., Dong, H., & Cao, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906690 · Cited by 138 · see citing works
Tough polyacrylamide-tannic acid-kaolin adhesive hydrogels for quick hemostatic application
Fan, X., Wang, S., Fang, Y., Li, P., Zhou, W., Wang, Z., Chen, M., & Liu, H. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110649 · Cited by 136 · see citing works
Mussel-inspired hydrogel tissue adhesives for wound closure
Rahimnejad, M., & Zhong, W. (2017) · RSC Adv. · doi:10.1039/c7ra06743g · Cited by 135 · see citing works
Tissue Engineering and Regenerative Medicine: A Year in Review
Harrison, R. H., St‐Pierre, J., & Stevens, M. M. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0668 · Cited by 134 · see citing works
A functional biphasic biomaterial homing mesenchymal stem cells for in vivo cartilage regeneration
Huang, H., Zhang, X., Hu, X., Shao, Z., Zhu, J., Dai, L., Man, Z., Yuan, L., Chen, H., Zhou, C., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.020 · Cited by 134 · see citing works
Hydrogel based cartilaginous tissue regeneration: recent insights and technologies
Chuah, Y. J., Peck, Y., Lau, J. E. J., Hee, H. T., & Wang, D. (2017) · Biomaterials Science · doi:10.1039/c6bm00863a · Cited by 130 · see citing works
Emerging Soft Conductors for Bioelectronic Interfaces
Gao, D., Parida, K., & Lee, P. S. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201907184 · Cited by 129 · see citing works
Sani, E. S., Lara, R. P., Spencer, A., Yu, W., Geilich, B., Noshadi, I., Webster, T. J., & Annabi, N. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00408 · Cited by 128 · see citing works
Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration
Leach, J. K., & Whitehead, J. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00741 · Cited by 126 · see citing works
Cohesion mechanisms for bioadhesives
Bu, Y., & Pandit, A. S. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.11.008 · Cited by 126 · see citing works
Jeon, O., Samorezov, J. E., & Alsberg, E. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.09.004 · Cited by 124 · see citing works
Constitutive behaviors of tough physical hydrogels with dynamic metal-coordinated bonds
Lin, J., Zheng, S. Y., Xiao, R., Yin, J., Wu, Z. L., Zheng, Q., & Qian, J. W. (2020) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2020.103935 · Cited by 112 · see citing works
Flégeau, K., Pace, R., Gautier, H., Réthoré, G., Guicheux, J., Visage, C. L., & Weiss, P. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.07.012 · Cited by 110 · see citing works
Digital Manufacturing for Microfluidics
Naderi, A., Bhattacharjee, N., & Folch, A. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092618-020341 · Cited by 107 · see citing works
Chen, K., Feng, Y., Zhang, Y., Lei, Y., Hao, X., Shao, F., Dou, Z., An, C., Zhuang, Z., Luo, Y., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b14348 · Cited by 106 · see citing works
Harnessing the secreted extracellular matrix to engineer tissues
Blache, U., Stevens, M. M., & Gentleman, E. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0500-6 · Cited by 103 · see citing works
Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration
Atwal, A., Dale, T. P., Snow, M., Forsyth, N. R., & Davoodi, P. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.103030 · Cited by 104 · see citing works
Bio-inspired 3D microenvironments: a new dimension in tissue engineering
Magin, C. M., Alge, D. L., & Anseth, K. S. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/2/022001 · Cited by 100 · see citing works
Design Molecular Topology for Wet–Dry Adhesion
Yang, J., Bai, R., Li, J., Yang, C., Yao, X., Liu, Q., Vlassak, J. J., Mooney, D. J., & Suo, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b07522 · Cited by 98 · see citing works
Advances in Regenerative Orthopedics
Evans, C. H. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.04.027 · Cited by 97 · see citing works
Hydrogels for Cartilage Regeneration, from Polysaccharides to Hybrids
Sánchez-Téllez, D. A., Téllez-Jurado, L., & Rodríguez-Lorenzo, L. M. (2017) · Polymers · doi:10.3390/polym9120671 · Cited by 95 · see citing works
Wang, L., Li, B., Xu, F., Xu, Z., Wei, D., Feng, Y., Wang, Y., Jia, D., & Zhou, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.013 · Cited by 95 · see citing works
Management of knee osteoarthritis. Current status and future trends
Ondrésik, M., Maia, F. R., Morais, A. D. S., Gertrudes, A. C., Bacelar, A. H. D., Correia, C. O., Gonçalves, C., Radhouani, H., Sousa, R. A., Oliveira, J. M., et al. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26182 · Cited by 91 · see citing works
Wang, X., Li, Z., Shi, T. C., Zhao, P., An, K., Lin, C., & Liu, H. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.12.053 · Cited by 90 · see citing works
Sun, X., Yin, H., Wang, Y., Lü, J., Shen, X., Lu, C., Tang, H., Meng, H., Yang, S., Yu, W. L., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b11687 · Cited by 89 · see citing works
Sridhar, B. V., Doyle, N. R., Randolph, M. A., & Anseth, K. S. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35115 · Cited by 89 · see citing works
Kim, H. S., Mandakhbayar, N., Kim, H., Leong, K. W., & Yoo, H. S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120214 · Cited by 88 · see citing works
Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review
Hashemi-Afzal, F., Fallahi, H., Bagheri, F., Collins, M. N., Eslaminejad, M. B., & Seitz, H. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.005 · Cited by 88 · see citing works
Tissue-Adhesive Chondroitin Sulfate Hydrogel for Cartilage Reconstruction
Shin, J., Kang, E. H., Choi, S., Jeon, E. J., Cho, J. H., Kang, D., Lee, H., Yun, I. S., & Cho, S. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01414 · Cited by 87 · see citing works
Li, J., Huang, Y., Song, J., Li, X., Zhang, X., Zhou, Z., Chen, D., Ma, P. X., Peng, W., Wang, W., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.029 · Cited by 86 · see citing works
Fisher, M. B., Belkin, N. S., Milby, A. H., Henning, E. A., Bostrom, M., Kim, M., Pfeifer, C., Meloni, G. R., Dodge, G. R., Burdick, J. A., et al. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0384 · Cited by 85 · see citing works
Nanopharmaceuticals for wound healing – Lost in translation?
Ashtikar, M., & Wacker, M. G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.03.005 · Cited by 84 · see citing works
Yang, F., Li, Y., Wang, L., Che, H., Zhang, X., Jahr, H., Wang, L., Jiang, D., Huang, H., & Wang, J. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.10.014 · Cited by 82 · see citing works
Gionet‐Gonzales, M., & Leach, J. K. (2018) · Biomedical Materials · doi:10.1088/1748-605x/aab0b3 · Cited by 81 · see citing works
Teng, L., Chen, Y., Jia, Y., & Ren, L. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01698h · Cited by 80 · see citing works
Li, X., Xu, Q., Johnson, M., Wang, X., Lyu, J., Li, Y., Mcmahon, S., Greiser, U., A, S., & Wang, W.-X. (2021) · Biomaterials Science · doi:10.1039/d1bm00482d · Cited by 54 · see citing works
Micro- and nanotechnology for neural electrode-tissue interfaces
Liu, S., Zhao, Y., Hao, W., Zhang, X., & Ming, D. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112645 · Cited by 79 · see citing works
Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications
Ouyang, C., Yu, H., Wang, L., Ni, Z., Liu, X., Shen, D., Yang, J., Shi, K., & Wang, H. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.102982 · Cited by 82 · see citing works
- Authors
- Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., & Elisseeff, J. H.
- Affiliations
- Johns Hopkins University (US)
- Department of Orthopedics, Lake Charles Memorial Hospital, Lake Charles, LA 70601, USA.
- Private Practice Orthopedic Surgery, Springfield, VA 22151, USA.
- Stanford Medicine (US)
- Corresponding author
- Gold, Garry E.
- Elisseeff, Jennifer H.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-01-09
- Volume
- 5
- Issue
- 167
- Pages
- 167ra6-167ra6
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3972413
- OpenAlex
- W2106782312
- Cited by
- 342
- References
- 37
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 25 · 2023: 20 · 2022: 32 · 2021: 32 · 2020: 34 · 2019: 27 · 2018: 23 · 2017: 27 · 2016: 28 · 2015: 18 · 2014: 30 · 2013: 8 · 2012: 1
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (1P01159992-01)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054005, K24AR062068)
- National Institute of Biomedical Imaging and Bioengineering (R01EB005517, R01EB002524)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- cartilage repair, articular cartilage defects, composite hydrogels, poly(ethylene glycol) diacrylate hydrogel, mesenchymal stem cells, extracellular matrix deposition, knee osteoarthritis, cartilage resurfacing, IKDC score
- MeSH terms
- Animals, Biocompatible Materials, Cartilage, Goats, Humans, Magnetic Resonance Imaging, Tissue Adhesives, Hydrogels, Tissue Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review