Cited by 342Osteoarthritis Treatment and MechanismsHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite

Open access
Sharma, Blanka, Fermanian, Sara, Gibson, Matthew, Unterman, Shimon, Herzka, Daniel A., Cascio, Brett, Coburn, Jeannine, Hui, Alexander Y. +3 more·2013·Science Translational Medicine

Abstract

A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients.

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Integrity signals

Registry

Crossref · 10.1126/scitranslmed.3004838

Cites

37 of 37 references verified0 citation errors · 0 not checkable

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  • The superficial and deep cartilage layers interact to maintain homeostasis and increase new tissue production when needed.

    “the superficial and deep cartilage layers interact to maintain homeostasis and increase new tissue production when needed25”

    From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [25]

    The Results section (‘Cartilage growth in hydrogels in vitro’; page unavailable) reports that chondrocytes cultured adjacent to mesenchymal stem cells increased cartilage-matrix production. But those were cell populations in a bilayered hydrogel, not the superficial and deep cartilage layers; the paper does not establish that those layers interact to maintain homeostasis or increase tissue production when needed. (LLM, conf=0.79)

    Experimental — accuracy not yet measured

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Authors
Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., & Elisseeff, J. H.
Affiliations
  • Johns Hopkins University (US)
  • Department of Orthopedics, Lake Charles Memorial Hospital, Lake Charles, LA 70601, USA.
  • Private Practice Orthopedic Surgery, Springfield, VA 22151, USA.
  • Stanford Medicine (US)
Corresponding author
  • Gold, Garry E.
  • Elisseeff, Jennifer H.
Venue
Science Translational Medicine
Published
2013-01-09
Volume
5
Issue
167
Pages
167ra6-167ra6
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2106782312
Cited by
342
References
37
Citations by year
2026: 11 · 2025: 26 · 2024: 25 · 2023: 20 · 2022: 32 · 2021: 32 · 2020: 34 · 2019: 27 · 2018: 23 · 2017: 27 · 2016: 28 · 2015: 18 · 2014: 30 · 2013: 8 · 2012: 1
FWCI
22.97
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service (1P01159992-01)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054005, K24AR062068)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB005517, R01EB002524)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
cartilage repair, articular cartilage defects, composite hydrogels, poly(ethylene glycol) diacrylate hydrogel, mesenchymal stem cells, extracellular matrix deposition, knee osteoarthritis, cartilage resurfacing, IKDC score
MeSH terms
Animals, Biocompatible Materials, Cartilage, Goats, Humans, Magnetic Resonance Imaging, Tissue Adhesives, Hydrogels, Tissue Engineering

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