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Cited by 808

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Premature menopause or early menopause: Long-term health consequences

Open access
Shuster, Lynne T., Rhodes, Deborah J., Gostout, Bobbie S., Grossardt, Brandon R., Rocca, Walter A.·2010·Maturitas

Abstract

Objective To review and summarize current evidence on the health consequences of premature menopause and early menopause. Methods We reviewed existing literature and combined graphically some results from the Mayo Clinic Cohort Study of Oophorectomy and Aging. Results Premature menopause or early menopause may be either spontaneous or induced. Women who experience premature menopause (before age 40 years) or early menopause (between ages 40 and 45 years) experience an increased risk of overall mortality, cardiovascular diseases, neurological diseases, psychiatric diseases, osteoporosis, and other sequelae. The risk of adverse outcomes increases with earlier age at the time of menopause. Some of the adverse outcomes may be prevented by estrogen treatment initiated after the onset of menopause. However, estrogen alone does not prevent all long-term consequences and other hormonal mechanisms are likely involved. Conclusions Regardless of the cause, women who experience hormonal menopause and estrogen deficiency before reaching the median age of natural menopause are at increased risk for morbidity and mortality. Estrogen treatment should be considered for these women, but may not eliminate all of the adverse outcomes.

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Metadata

Authors
Shuster, L. T., Rhodes, D. J., Gostout, B. S., Grossardt, B. R., & Rocca, W. A.
Venue
Maturitas
Publisher
Elsevier BV
Published
2010-02
Volume
65
Issue
2
Pages
161-166
ISSN
0378-5122 (ISSN-L)
OpenAlex
W2161226706
Cited by
808
References
8
FWCI
19.79
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Premature menopause or early menopause: Long-term health consequences. https://app.cochat.ai/papers/10.1016/j.maturitas.2009.08.003
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Shuster, L. T., Rhodes, D. J., Gostout, B. S., Grossardt, B. R., & Rocca, W. A. (2010). Premature menopause or early menopause: Long-term health consequences. Maturitas. https://doi.org/10.1016/j.maturitas.2009.08.003

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