Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy
Abstract
Normal menopause is associated with vascular endothelial dysfunction, an early stage of atherosclerosis. The effect of premature ovarian failure (or premature menopause) on endothelial function in young women is unknown. Endothelial function was assessed in 18 women with premature ovarian failure before and after 6 months of hormone therapy and was compared with the endothelial function of 20 age- and body mass index-matched premenopausal women. Brachial artery diameter was measured both during hyperemia (an index of endothelium-dependent vasodilation) and in response to glyceryl trinitrate (an index of endothelium-independent vaso-dilation). Flow-mediated dilation was significantly lower in women with premature ovarian failure at baseline (increase in brachial artery diameter during hyperemia by 3.06 +/- 4.33%) than in control women (increase by 8.84 +/- 2.15%; P < 0.0005). Glyceryl trinitrate-induced vasodilation did not differ between the groups. After hormone therapy for 6 months, flow-mediated dilation was improved in women with premature ovarian failure, increasing by more than 2-fold (7.41 +/- 3.86%; P < 0.005 compared with pretreatment) and reaching normal values (P not significant compared with control women). Glyceryl trinitrate-induced vasodilation did not change after treatment in women with premature ovarian failure. Young women with premature ovarian failure have significant vascular endothelial dysfunction. Early onset of endothelial dysfunction associated with sex steroid deficiency may contribute to the increased risk of cardiovascular disease and mortality in young women with premature ovarian failure. Hormone therapy restores endothelial function within 6 months of treatment.
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Endothelial dysfunction, which has been found in women with premature menopause and in those with adverse pregnancy outcomes, might trigger pregnancy complications and remain beyond these complications to predispose women to future cardiovascular disease.
“Endothelial dysfunction, which has been found in women with premature menopause and in those with adverse pregnancy outcomes, might trigger pregnancy complications and remain beyond these complications to predispose women to future cardiovascular disease”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [147]
Cites
1 retracted
Changes in energy balance and body composition at menopause: a controlled longitudinal study.
Poehlman, E. T., Toth, M. J., & Gardner, A. W. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-9-199511010-00005 · Cited by 520 · see citing works
RetractedFriedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Hulley, S. (1998) · JAMA · doi:10.1001/jama.280.7.605 · Cited by 6,216 · see citing works
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,584 · see citing works
Estrogen plus Progestin and the Risk of Coronary Heart Disease
Manson, J. E., Hsia, J., Johnson, K. C., Rossouw, J. E., Assaf, A. R., Lasser, N. L., Trevisan, M., Black, H. R., Heckbert, S. R., Detrano, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030808 · Cited by 2,065 · see citing works
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · see citing works
Postmenopausal Estrogen and Progestin Use and the Risk of Cardiovascular Disease
Grodstein, F., Stampfer, M. J., Manson, J. E., Colditz, G. A., Willett, W. C., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608153350701 · Cited by 1,294 · see citing works
Menopause and the Risk of Coronary Heart Disease in Women
Colditz, G. A., Willett, W. C., Stampfer, M. J., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704303161801 · Cited by 1,153 · see citing works
Walsh, B. W., Schiff, I., Rosner, B., Greenberg, L., Ravnikar, V., & Sacks, F. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110243251702 · Cited by 1,152 · see citing works
Incidence of Premature Ovarian Failure
Coulam, C. B., Adamson, S. C., & Annegers, J. F. (1987) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198703000-00020 · Cited by 1,024 · see citing works
Goswami, D., & Conway, G. S. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi012 · Cited by 713 · see citing works
Estrogen in the Prevention of Atherosclerosis
Hodis, H. N., Mack, W. J., Lobo, R. A., Shoupe, D., Sevanian, A., Mahrer, P. R., Selzer, R. H., Liu, C., Ci-hua, L., & Azen, S. P. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-11-200112040-00005 · Cited by 688 · see citing works
Age at menopause as a risk factor for cardiovascular mortality
van der Schouw, Y. T., van der Graaf, Y., Steyerberg, E. W., Eijkemans, M. J. C., & Banga, J. D. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90075-6 · Cited by 616 · see citing works
Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women
Sack, M. N., Rader, D. J., & Cannon, R. O. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91117-7 · Cited by 525 · see citing works
Post, W. S. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00153-4 · Cited by 480 · see citing works
Age at Natural Menopause and Risk of Cardiovascular Disease
Hu, F. B., Grodstein, F., Hennekens, C. H., Colditz, G. A., Johnson, M., Manson, J. E., ROSNER, B. A., & Stampfer, M. J. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.10.1061 · Cited by 414 · see citing works
Hormone Therapy and the Progression of Coronary-Artery Atherosclerosis in Postmenopausal Women
Hodis, H. N., Mack, W. J., Azen, S. P., Lobo, R. A., Shoupe, D., Mahrer, P. R., Faxon, D. P., Cashin-Hemphill, L., Sanmarco, M. E., French, W. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030830 · Cited by 386 · see citing works
Is early natural menopause a biologic marker of health and aging?
Snowdon, D. A., Kane, R. L., Beeson, W. L., Burke, G. L., Sprafka, J. M., Potter, J. D., Iso, H., Jacobs, D. R., & Phillips, R. L. (1989) · American Journal of Public Health · doi:10.2105/ajph.79.6.709 · Cited by 342 · see citing works
Understanding the Divergent Data on Postmenopausal Hormone Therapy
Grodstein, F., Clarkson, T. B., & Manson, J. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmsb022365 · Cited by 328 · see citing works
Merz, C. N. B., Johnson, B. D., Sharaf, B. L., Bittner, V., Berga, S. L., Braunstein, G. D., Hodgson, T. K., Matthews, K. A., Pepine, C. J., Reís, S. E., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02763-8 · Cited by 287 · see citing works
Age at Natural Menopause and Mortality
Cooper, G. S., & Sandler, D. P. (1998) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00207-x · Cited by 278 · see citing works
Age at Natural Menopause and Total Mortality and Mortality from Ischemic Heart Disease
Jacobsen, B. K., Knutsen, S. F., & Fraser, G. E. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00170-x · Cited by 251 · see citing works
Kalantaridou, S., Davis, S. R., & Nelson, L. M. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70051-7 · Cited by 205 · see citing works
Self-citationEndogenous Estrogen Exposure and Cardiovascular Mortality Risk in Postmenopausal Women
de Kleijn, M. J. J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.4.339 · Cited by 201 · see citing works
Virdis, A., Ghiadoni, L., Pinto, S., Lombardo, M., Petraglia, F., Gennazzani, A., Buralli, S., Taddei, S., & Salvetti, A. (2000) · Circulation · doi:10.1161/01.cir.101.19.2258 · Cited by 173 · see citing works
Nelson, L. M., Anasti, J. N., Kimzey, L. M., Defensor, R., Lipetz, K. J., White, B. J., Shawker, T. H., & Merino, M. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962345 · Cited by 172 · see citing works
Bone Loss in Young Women With Karyotypically Normal Spontaneous Premature Ovarian Failure
Anasti, J. N. (1998) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00583-8 · Cited by 147 · see citing works
Koh, K. K., Jin, D., Yang, S. H., Lee, S.-K., Hwang, H. Y., Kang, M. H., Kim, W. S., Kim, D. S., Choi, I. S., & Shin, E. K. (2001) · Circulation · doi:10.1161/01.cir.103.15.1961 · Cited by 142 · see citing works
Estrogen Replacement and Brachial Artery Flow-Mediated Vasodilation in Older Women
Herrington, D. M., Espeland, M. A., Crouse, J. R., Robertson, J., Riley, W. A., McBurnie, M. A., & Burke, G. L. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100241 · Cited by 140 · see citing works
Estrogen Replacement Reverses Endothelial Dysfunction in Postmenopausal Women
Bush, D. E., Jones, C. E., Bass, K. M., Walters, G. K., Bruza, J. M., & Ouyang, P. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00117-x · Cited by 122 · see citing works
Kim, T. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00077-x · Cited by 121 · see citing works
Endogenous Estrogen and Acetylcholine-Induced Vasodilation in Normotensive Women
Pinto, S., Virdis, A., Ghiadoni, L., Bernini, G., Lombardo, M., Petraglia, F., Genazzani, A. R., Taddei, S., & Salvetti, A. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.268 · Cited by 106 · see citing works
Kaplan, J. R., Adams, M. R., Anthony, M. S., Morgan, T. M., Manuck, S. B., & Clarkson, T. B. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2094 · Cited by 76 · see citing works
Hormone replacement therapy and endothelial function
de Kleijn, M. J. J., Wilmink, H. W., Bots, M. L., Bak, A. A. A., van der Schouw, Y. T., Planellas, J., Engelen, S., Banga, J.-D., & Grobbee, D. E. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00507-x · Cited by 65 · see citing works
Ohta, H., Sugimoto, I., Masuda, A., Komukai, S., Suda, Y., Makita, K., Takamatsu, K., Horiguchi, F., & Nozawa, S. (1996) · Bone · doi:10.1016/8756-3282(95)00480-7 · Cited by 64 · see citing works
Hormone replacement therapy and coronary artery atherosclerosis: the monkey model.
Clarkson, T. B., Ms, A., & Kp, K. (1996) · PubMed · Cited by 59 · see citing works
Influence of the menstrual cycle on the timing of acute coronary events in premenopausal women
Hamelin, B. A., Méthot, J., Arsenault, M., Pilote, S., Poirier, P., Planté, S., & Bogaty, P. M. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00051-2 · Cited by 54 · see citing works
Hormone Replacement Therapy and Endothelial Function
Vita, J. A., & Keaney, J. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.21.12.1867 · Cited by 44 · see citing works
Hormone Replacement Following Early Menopause
Cooper, G. S. (2002) · JAMA · doi:10.1001/jama.288.22.2824-jlt1211-2-1 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
ESHRE Guideline: management of women with premature ovarian insufficiency
The ESHRE Guideline Group on POI, Webber, L. J., Davies, M. C., Anderson, R. A., Bartlett, J., Braat, D. D. M., Cartwright, B., Cífková, R., Keizer‐Schrama, S. D. M., Hogervorst, E., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew027 · Cited by 1,578 · see citing works
Premature menopause or early menopause: Long-term health consequences
Shuster, L. T., Rhodes, D. J., Gostout, B. S., Grossardt, B. R., & Rocca, W. A. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.08.003 · Cited by 808 · see citing works
Long-term health consequences of premature or early menopause and considerations for management
Faubion, S. S., Kuhle, C. L., Shuster, L. T., & Rocca, W. A. (2015) · Climacteric · doi:10.3109/13697137.2015.1020484 · Cited by 553 · see citing works
Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause
Sullivan, S. D., Sarrel, P. M., & Nelson, L. M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.09.046 · Cited by 515 · see citing works
Okoth, K., Chandan, J. S., Marshall, T., Thangaratinam, S., Thomas, G. N., Nirantharakumar, K., & Adderley, N. J. (2020) · BMJ · doi:10.1136/bmj.m3502 · Cited by 416 · see citing works
Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women
Moreau, K. L., Hildreth, K. L., Meditz, A. L., Deane, K. D., & Kohrt, W. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2244 · Cited by 353 · see citing works
Maas, A. H. E. M., Rosano, G. M. C., Cífková, R., Chieffo, A., van Dijken, D., Hamoda, H., Kunadian, V., Laan, E. T. M., Lambrinoudaki, I. V., Maclaran, K., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1044 · Cited by 361 · see citing works
Hot Flashes and Subclinical Cardiovascular Disease
Thurston, R. C., Sutton-Tyrrell, K., Everson‐Rose, S. A., Hess, R., & Matthews, K. A. (2008) · Circulation · doi:10.1161/circulationaha.108.776823 · Cited by 323 · see citing works
Premature ovarian insufficiency: an international menopause society white paper
Panay, N., Anderson, R. A., Nappi, R. E., Vincent, A. J., Vujovic, S., Webber, L., & Wolfman, W. (2020) · Climacteric · doi:10.1080/13697137.2020.1804547 · Cited by 297 · see citing works
Turgeon, J. L., Carr, M. C., Maki, P. M., Mendelsohn, M. E., & Wise, P. M. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0020 · Cited by 263 · see citing works
Ishizuka, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.626924 · Cited by 269 · see citing works
Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science
McSweeney, J., Rosenfeld, A., Abel, W. M., Braun, L., Burke, L. E., Daugherty, S., Fletcher, G., Gulati, M., Mehta, L. S., Pettey, C. M., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000381 · Cited by 235 · see citing works
Hypertension in Postmenopausal Women
Lima, R., Wofford, M. R., & Reckelhoff, J. F. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0260-0 · Cited by 256 · see citing works
Premature ovarian insufficiency: the context of long-term effects
Podfigurna-Stopa, A., Czyzyk, A., Grymowicz, M., Smolarczyk, R., Katulski, K., Czajkowski, K., & Męczekalski, B. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0467-z · Cited by 230 · see citing works
Body composition and cardiometabolic health across the menopause transition
Marlatt, K. L., Pitynski, D., Gavin, K. M., Moreau, K. L., Melanson, E. L., Santoro, N. F., & Kohrt, W. M. (2021) · Obesity · doi:10.1002/oby.23289 · Cited by 246 · see citing works
Premature Ovarian Insufficiency - an update on recent advances in understanding and management
Torrealday, S., Kodaman, P. H., & Pal, L. (2017) · F1000Research · doi:10.12688/f1000research.11948.1 · Cited by 224 · see citing works
The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk
Agarwala, A., Michos, E. D., Samad, Z. Z., Ballantyne, C. M., & Virani, S. S. (2020) · Circulation · doi:10.1161/circulationaha.119.043429 · Cited by 220 · see citing works
Metabolic Syndrome and Menopause
Stefańska, A., Bergmann, K., & Sypniewska, G. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.07.001 · Cited by 219 · see citing works
Gender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences
Pérez-López, F. R., Larrad-Mur, L., Kallen, A. N., Chedraui, P. A., & Taylor, H. S. (2010) · Reproductive Sciences · doi:10.1177/1933719110367829 · Cited by 202 · see citing works
Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome
Kravariti, M., Naka, K. Κ., Kalantaridou, S., Kazakos, N., Katsouras, C. S., Makrigiannakis, A., Paraskevaidis, E. A., Chrousos, G. P., Tsatsoulis, A. A., & Michalis, L. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0151 · Cited by 188 · see citing works
Self-citationAromatase: Contributions to Physiology and Disease in Women and Men
Blakemore, J. K., & Naftolin, F. N. (2016) · Physiology · doi:10.1152/physiol.00054.2015 · Cited by 188 · see citing works
Yanes, L. L., & Reckelhoff, J. F. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.71 · Cited by 187 · see citing works
Shi, Y., Zhu, X.-T., Su-na, Z., Ma, Y., Han, Y., Yue, J., & Zhang, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1172481 · Cited by 179 · see citing works
Estrogen and memory in women: how can we reconcile the findings?
Sherwin, B. B. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.12.002 · Cited by 164 · see citing works
Management of premature ovarian failure
Panay, N., & Kalu, E. (2008) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2008.10.008 · Cited by 155 · see citing works
Bechlioulis, A., Kalantaridou, S., Naka, K. Κ., Chatzikyriakidou, A., Calis, K. A., Makrigiannakis, A., Papanikolaou, O., Kaponis, A. I., Katsouras, C. S., Georgiou, I. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2262 · Cited by 146 · see citing works
Self-citationHRT for women with premature ovarian insufficiency: a comprehensive review
Webber, L., Anderson, R. A., Davies, M., Janse, F., & Vermeulen, N. (2017) · Human Reproduction Open · doi:10.1093/hropen/hox007 · Cited by 141 · see citing works
Ovarian function in girls and women with GALT‐deficiency galactosemia
Fridovich‐Keil, J. L., Gubbels, C. S., Spencer, J. B., Sanders, R. D., Land, J. A., & Rubio‐Gozalbo, M. E. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9221-4 · Cited by 141 · see citing works
Current Concepts in Premature Ovarian Insufficiency
Maclaran, K., & Panay, N. (2015) · Women s Health · doi:10.2217/whe.14.82 · Cited by 134 · see citing works
Associated features in females with an FMR1 premutation
Wheeler, A., Bailey, D. B., Berry‐Kravis, E., Greenberg, J. S., Losh, M. C., Seltzer, M. M., Milà, M., Olichney, J., Rodríguez‐Revenga, L., Sherman, S. L., et al. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-30 · Cited by 134 · see citing works
Clinical Effects of Early or Surgical Menopause
Kingsberg, S. A., Larkin, L. C., & LIU, J. H. (2020) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003729 · Cited by 153 · see citing works
Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure
Shareghi-Oskoue, O., Maleki, L. A., & Yousefi, M. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02529-w · Cited by 124 · see citing works
Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency
(2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002044 · Cited by 123 · see citing works
Novel Aspects of Endothelium-Dependent Regulation of Vascular Tone
Villar, I. C., Francis, S., Webb, A., Hobbs, A. J., & Ahluwalia, A. (2006) · Kidney International · doi:10.1038/sj.ki.5001680 · Cited by 112 · see citing works
Premature Ovarian Insufficiency and Long-Term Health Consequences
Tsiligiannis, S., Panay, N., & Stevenson, J. C. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190122101611 · Cited by 113 · see citing works
Kovanci, E., & Schutt, A. K. (2015) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2014.10.004 · Cited by 112 · see citing works
Ostberg, J. E., Storry, C., Donald, A. E., Hosseinzadeh‐Attar, M. J., Halcox, J., & Conway, G. S. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02772.x · Cited by 106 · see citing works
Amenorrhea: evaluation and treatment.
Master-Hunter, T., & Heiman, D. L. (2006) · PubMed · Cited by 106 · see citing works
Maclaran, K., & Panay, N. (2011) · Journal of Family Planning and Reproductive Health Care · doi:10.1136/jfprhc.2010.0015 · Cited by 104 · see citing works
Popat, V., Prodanov, T., Calis, K. A., & Nelson, L. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.040 · Cited by 102 · see citing works
Self-citationLipid profile of women with premature ovarian failure
Knauff, E. A. H., Westerveld, H. E., Goverde, A. J., Eijkemans, M. J. C., Valkenburg, O., van Santbrink, E. J. P., Fauser, B. C. J. M., & van der Schouw, Y. T. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31816b4509 · Cited by 100 · see citing works
Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function
Mueller, K. B., Lu, Q. R., Mohammad, N. N., Luu, V., McCurley, A., Williams, G. H., Adler, G. K., Karas, R. H., & Jaffe, I. Z. (2014) · Endocrinology · doi:10.1210/en.2014-1270 · Cited by 99 · see citing works
Premature ovarian insufficiency
Nash, Z., & Davies, M. C. (2024) · BMJ · doi:10.1136/bmj-2023-077469 · Cited by 105 · see citing works
Sherwood, A., Bower, J. K., McFetridge-Durdle, J., Blumenthal, J. A., Newby, L. K., & Hinderliter, A. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145383 · Cited by 97 · see citing works
Estrogen and the Vascular Endothelium: The Unanswered Questions
SenthilKumar, G., Katunaric, B., Bordas-Murphy, H., Sarvaideo, J. L., & Freed, J. K. (2023) · Endocrinology · doi:10.1210/endocr/bqad079 · Cited by 99 · see citing works
MENOPAUSE, ESTROGENS, AND ENDOTHELIAL DYSFUNCTION: CURRENT CONCEPTS
Maturana, M. A., Irigoyen, M. C., & Spritzer, P. M. (2007) · Clinics · doi:10.1590/s1807-59322007000100012 · Cited by 97 · see citing works
Premature ovarian failure: a review
Nippita, T. A. C., & Baber, R. (2007) · Climacteric · doi:10.1080/13697130601135672 · Cited by 91 · see citing works
Premature ovarian insufficiency, early menopause, and induced menopause
Hamoda, H., & Sharma, A. (2023) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2023.101823 · Cited by 103 · see citing works
Jumbo‐Lucioni, P. P., Garber, K. B., Kiel, J., Barić, I., Berry, G. T., Bosch, A. M., Burlina, A., Chiesa, A. E., Couce, M. L., Estrada, S. C., et al. (2012) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-012-9477-y · Cited by 88 · see citing works
Elder, P., Sharma, G. V., Gulati, M., & Michos, E. D. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100028 · Cited by 88 · see citing works
Hamoda, H. (2017) · Post Reproductive Health · doi:10.1177/2053369117699358 · Cited by 84 · see citing works
Cardiovascular risk assessment in women – an update
Collins, P. D., Webb, C. M., de Villiers, T. J., Stevenson, J. C., Panay, N., & Baber, R. (2016) · Climacteric · doi:10.1080/13697137.2016.1198574 · Cited by 81 · see citing works
Daan, N. M. P., Muka, T., Koster, M. P. H., van Lennep, J. E. R., Lambalk, C. B., Laven, J. S. E., Fauser, C. G. K. M., Meun, C., de Rijke, Y. B., Boersma, E. H., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1141 · Cited by 82 · see citing works
Premature ovarian insufficiency: A toolkit for the primary care physician
Lambrinoudaki, I. V., Paschou, S. Α., Lumsden, M. A., Faubion, S. S., Makrakis, E., Kalantaridou, S., & Panay, N. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.11.004 · Cited by 80 · see citing works
Self-citationPremature ovarian failure, endothelial dysfunction and estrogen–progestogen replacement
Kalantaridou, S., Naka, K. Κ., Bechlioulis, A., Makrigiannakis, A., Michalis, L. K., & Chrousos, G. P. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.02.003 · Cited by 73 · see citing works
Self-citationTirri, B. F., Häusermann, P., Bertz, H., Greinix, H., Lawitschka, Á., Schwarze, C. P., Wolff, D., Halter, J. P., Dörfler, D., & Moffat, R. (2014) · Bone Marrow Transplantation · doi:10.1038/bmt.2014.242 · Cited by 68 · see citing works
Hormone replacement therapy in women with past history of endometriosis
Soliman, N. F., & Hillard, T. C. (2006) · Climacteric · doi:10.1080/13697130600868711 · Cited by 65 · see citing works
Ateş, S., Yeşil, G., Şevket, O., Molla, T., & Yıldız, Ş. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.07.008 · Cited by 62 · see citing works
Decreased ovarian reserve relates to pre-eclampsia in IVF/ICSI pregnancies
Woldringh, G. H., Frunt, M. H. A., Kremer, J. A. M., & Spaanderman, M. E. A. (2006) · Human Reproduction · doi:10.1093/humrep/del155 · Cited by 62 · see citing works
Sherman, S. L., Curnow, E. C., Easley, C. A., Jin, P., Hukema, R. K., Tejada, M., Willemsen, R., & Usdin, K. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-26 · Cited by 61 · see citing works
Spontaneous premature ovarian failure: Management challenges
Kalu, E., & Panay, N. (2008) · Gynecological Endocrinology · doi:10.1080/09513590801990764 · Cited by 61 · see citing works
Regulation of bone mass by mechanical loading: Microarchitecture and genetics
Suva, L. J., Gaddy, D., Perrien, D. S., Thomas, R. L., & Findlay, D. M. (2005) · Current Osteoporosis Reports · doi:10.1007/s11914-005-0003-0 · Cited by 61 · see citing works
Reproductive and gynecologic care of women with fragile X primary ovarian insufficiency (FXPOI)
Hipp, H. S., Charen, K. H., Spencer, J. B., Allen, E. G., & Sherman, S. L. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000658 · Cited by 60 · see citing works
Update on sex specific risk factors in cardiovascular disease
Nguyen, A. H., Hurwitz, M., Sullivan, S. A., Saad, A. F., Kennedy, J. L., & Sharma, G. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1352675 · Cited by 50 · see citing works
Premature ovarian failure: long-term sequelae
Maclaran, K., Horner, E., & Panay, N. (2010) · Menopause international · doi:10.1258/mi.2010.010014 · Cited by 54 · see citing works
Metabolic Profile of Patients with Premature Ovarian Insufficiency
Podfigurna, A., Stellmach, A., Szeliga, A., Czyzyk, A., & Męczekalski, B. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100374 · Cited by 52 · see citing works
Cardiometabolic health in premature ovarian insufficiency
Stevenson, J. C., Collins, P. D., Hamoda, H., Lambrinoudaki, I. V., Maas, A. H. E. M., Maclaran, K., & Panay, N. (2021) · Climacteric · doi:10.1080/13697137.2021.1910232 · Cited by 54 · see citing works
Janse, F., Tanahatoe, S., Eijkemans, M. J. C., & Fauser, B. C. J. M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms013 · Cited by 51 · see citing works
Cattoni, A., Parissone, F., Porcari, I., Molinari, S., Masera, N., Franchi, M. P., Cesaro, S., Gaudino, R., Passoni, P., & Balduzzi, A. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100730 · Cited by 51 · see citing works
Similar phenotype characteristics comparing familial and sporadic premature ovarian failure
Janse, F., Knauff, E. A. H., Niermeijer, M. F., Eijkemans, M. J. C., Laven, J. S. E., Lambalk, C. B., Fauser, B. C. J. M., & Goverde, A. J. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181cf8521 · Cited by 47 · see citing works
Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)
Janse, F., de With, L. M., Duran, K. J., Kloosterman, W. P., Goverde, A. J., Lambalk, C. B., Laven, J. S. E., Fauser, B. C. J. M., & Giltay, J. C. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.10.032 · Cited by 47 · see citing works
Gaba, F., & Manchanda, R. (2020) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2020.01.006 · Cited by 47 · see citing works
Epidemiology, Genetic Etiology, and Intervention of Premature Ovarian Insufficiency
Guo, T., Liu, H., Xu, B., Qi, Y., Xu, K., Wu, X., He, X., Qin, Y., & Chen, Z. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf011 · Cited by 44 · see citing works
Cui, J., & Wang, Y. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-023-01330-y · Cited by 45 · see citing works
Torrealday, S., & Pal, L. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.004 · Cited by 42 · see citing works
Cai, W.-Y., Luo, X., Wu, W., Song, J., Xie, N.-N., Duan, C., Wu, X., & Xu, J. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01041-w · Cited by 42 · see citing works
Tezini, G. C., Dias, D., & Souza, H. C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.009 · Cited by 38 · see citing works
The cardiovascular effects of premature ovarian failure
Yorgun, H., Tokgözoğlu, L. S., Canpolat, U., Gürses, K. M., Bozdağ, G., Yapıcı, Z., ŞAHINER, L., Kaya, E. B., Kabakçı, G., Oto, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.197 · Cited by 40 · see citing works
Bone and heart health in menopause
Nash, Z., Wattar, B. H. A., & Davies, M. C. (2022) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2022.03.002 · Cited by 42 · see citing works
Ovarian dysfunction and the premenopausal origins of coronary heart disease
Kaplan, J. R., & Manuck, S. B. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31815eb18e · Cited by 38 · see citing works
Saltiki, K., & Alevizaki, M. K. (2007) · PubMed · Cited by 37 · see citing works
Hormone replacement therapy and the adolescent
DiVasta, A. D., & Gordon, C. M. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32833e4a35 · Cited by 37 · see citing works
Cardiometabolic Effects of Endocrine Treatment of Estrogen Receptor–Positive Early Breast Cancer
Cheung, Y.-M. M., Ramchand, S. K., Yeo, B. J., & Grossmann, M. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00096 · Cited by 36 · see citing works
Gasparri, M. L., Taghavi, K., Fiacco, E., Zuber, V., Micco, R. D., Gazzetta, G., Valentini, A., Mueller, M. D., Papadia, A., & Gentilini, O. (2019) · Medicina · doi:10.3390/medicina55080415 · Cited by 36 · see citing works
Machura, P., Grymowicz, M., Rudnicka, E., Pięta, W., Calik-Ksepka, A., Skórska, J., & Smolarczyk, R. (2018) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2018.78559 · Cited by 35 · see citing works
Lipskind, S. T., Lindsey, J. S., Gerami‐Naini, B., Eaton, J. L., O’Connell, D., Kieżun, A., Ho, J. W. K., Ng, N., Parasar, P., Ng, M. C., et al. (2017) · Reproductive Sciences · doi:10.1177/1933719117725814 · Cited by 34 · see citing works
Infertility: a marker of future health risk in women?
Senapati, S. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.08.058 · Cited by 33 · see citing works
Endothelial Vascular Function as a Surrogate of Vascular Risk and Aging in Women
Collins, P. D., Maas, A. H. E. M., Prasad, M., Schierbeck, L. L., & Lerman, A. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.07.001 · Cited by 32 · see citing works
Johnson, B. D., Dwyer, K. M., Stanczyk, F. Z., Bittner, V., Berga, S. L., Braunstein, G. D., Azziz, R., Yang, Y., Hale, G. E., & Merz, C. N. B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0126 · Cited by 31 · see citing works
Association between arterial stiffness and variations in oestrogen-related genes
Peter, I., Kelley-Hedgepeth, A., Huggins, G. S., Housman, D. E., Mendelsohn, M. E., Vita, J. A., Vasan, R. S., Levy, D. A., Benjamin, E. J., & Mitchell, G. F. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.1 · Cited by 31 · see citing works
Hypertensive pregnancy complications in poor and normal responders after in vitro fertilization
van Disseldorp, J., Eijkemans, M. J. C., Fauser, B. C. J. M., & Broekmans, F. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.092 · Cited by 30 · see citing works
Antonicelli, R., Olivieri, F., Morichi, V., Urbani, E., & Mais, V. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.03.051 · Cited by 29 · see citing works
Chrysis, D., Spiliotis, B. E., Stene, M. A., CACCIARI, E., & Davenport, M. L. (2006) · Hormone Research in Paediatrics · doi:10.1159/000092516 · Cited by 29 · see citing works
Christin‐Maître, S., Givony, M., Albarel, F., Bachelot, A., Bidet, M., Blanc, J.-V., Bouvattier, C. M., de la Perrière, A. B., Catteau-Jonard, S., Chevalier, N., et al. (2021) · Annales d Endocrinologie · doi:10.1016/j.ando.2021.09.001 · Cited by 28 · see citing works
Hormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis
Gonçalves, C. R., de Vasconcellos, A. S., Rodrigues, T. R., Comin, F. V., & dos Reis, F. M. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.02.006 · Cited by 27 · see citing works
Menopausal hormone treatment cardiovascular disease: another look at an unresolved conundrum
Harman, S. M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.042 · Cited by 27 · see citing works
Verma, A. K., Khan, E., Bhagwat, S. R., & Kumar, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01724-4 · Cited by 27 · see citing works
Thompson, A. K., Przemska-Kosicka, A., Vasilopoulou, D., Newens, K. J., & Williams, C. M. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00094.x · Cited by 27 · see citing works
Rubinow, D. R., & Girdler, S. S. (2011) · Depression and Anxiety · doi:10.1002/da.20833 · Cited by 26 · see citing works
Kiriakova, V., Cooray, S. D., Yeganeh, L., Somarajah, G., Milat, F., & Vincent, A. J. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.07.021 · Cited by 26 · see citing works
- Authors
- Kalantaridou, S. N., Naka, K. K., Papanikolaou, E., Kazakos, N., Kravariti, M., Calis, K. A., Paraskevaidis, E. A., Sideris, D. A., Tsatsoulis, A., Chrousos, G. P., & Michalis, L. K.
- Affiliations
- University of Ioannina (GR)
- University Hospital of Ioannina (GR)
- National Institutes of Health (US)
- Corresponding author
- Kalantaridou, Sophia N.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-08
- Volume
- 89
- Issue
- 8
- Pages
- 3907-3913
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2104874274
- Cited by
- 284
- References
- 45
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 19 · 2023: 19 · 2022: 16 · 2021: 20 · 2020: 20 · 2019: 18 · 2018: 10 · 2017: 17 · 2016: 19 · 2015: 7 · 2014: 11 · 2013: 3 · 2012: 14
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- premature ovarian failure, endothelial dysfunction, hormone therapy, estrogen replacement therapy, flow-mediated dilation, endothelium-dependent vasodilation, nitroglycerin, premature menopause, sex hormone deficiency, cardiovascular risk, young women
- MeSH terms
- Adult, Brachial Artery, Constriction, Endothelium, Vascular, Female, Nitroglycerin, Hand, Humans, Hyperemia, Regional Blood Flow, Ultrasonography, Vasodilation, Vasodilator Agents, Cohort Studies, Estrogen Replacement Therapy, Primary Ovarian Insufficiency
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