Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

Rickard, Brittany P.; Rizvi, Imran; Fenton, Suzanne E.

doi:10.1016/j.tox.2021.153031

Cited by 334Per- and polyfluoroalkyl substances researchEffects and risks of endocrine disrupting chemicalsFluorine in Organic Chemistry

Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

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Rickard, Brittany P., Rizvi, Imran, Fenton, Suzanne E.·2022·Toxicology

DOI 10.1016/j.tox.2021.153031PMC PMC8743032

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Abstract

Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women's health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data - the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women.

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Studies that provided an estimate of half-life solely based on renal clearance were excluded, because PFAS are also excreted through other routes.
“Additionally, we excluded all studies that provided an estimate of half-life solely based on renal clearance, since PFAS are also excreted through blood loss, maternal transfer to the foetus, breastfeeding, menstruation (Rickard et al., 2022), as well as through bile and faeces (Roberts et al., 2013; Chambers et al., 2021; Fletcher et al., 2022).”
From Estimation of per- and polyfluoroalkyl substances (PFAS) half-lives in human studies: a systematic review and meta-analysis (2024) · cites this paper as Rickard et al., 2022

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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
(2013) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/103.1437-1588 · Cited by 11,769 · see citing works
Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641 · see citing works
A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects
Sunderland, E. M., Hu, X. C., Dassuncao, C., Tokranov, A. K., Wagner, C. C., & Allen, J. G. (2019) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0094-1 · Cited by 2,786 · see citing works
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research
Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445 · see citing works
Self-citation
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407 · see citing works
Self-citation
Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment
Escobar-Morreale, H. F. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.24 · Cited by 2,083 · see citing works
Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
Male reproductive health and environmental xenoestrogens.
Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., et al. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s4741 · Cited by 1,414 · see citing works
Fluorinated Surfactants and Repellents
(2001) · Textile Research Journal · doi:10.1177/004051750107100823 · Cited by 1,376 · see citing works
Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants
Hu, X. C., Andrews, D. Q., Lindstrom, A. B., Bruton, T. A., Schaider, L. A., Grandjean, P., Lohmann, R., Carignan, C. C., Blum, A., Balan, S. A., et al. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00260 · Cited by 1,333 · see citing works
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
Williams, A. J., Grulke, C., Edwards, J., McEachran, A. D., Mansouri, K., Baker, N., Patlewicz, G. Y., Shah, I., Wambaugh, J. F., Judson, R., et al. (2017) · Journal of Cheminformatics · doi:10.1186/s13321-017-0247-6 · Cited by 1,164 · see citing works
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056 · see citing works
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989 · see citing works
Perfluorinated compounds – Exposure assessment for the general population in western countries
Fromme, H., Tittlemier, S. A., Völkel, W., Wilhelm, M., & Twardella, D. (2008) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2008.04.007 · Cited by 963 · see citing works
Premature menopause or early menopause: Long-term health consequences
Shuster, L. T., Rhodes, D. J., Gostout, B. S., Grossardt, B. R., & Rocca, W. A. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.08.003 · Cited by 808 · see citing works
Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant
Barry, V., Winquist, A. G., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306615 · Cited by 781 · see citing works
Accumulation of perfluoroalkyl substances in human tissues
Pérez, F., Nadal, M., Navarro-Ortega, A., Fàbrega, F., Domingo, J. L., Barceló, D., & Farré, M. (2013) · Environment International · doi:10.1016/j.envint.2013.06.004 · Cited by 730 · see citing works
The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global who guidance
Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works
Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina
Sun, M., Arevalo, E., Strynar, M., Lindstrom, A., Richardson, M., Kearns, B., Pickett, A., Smith, C., & Knappe, D. R. U. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00398 · Cited by 688 · see citing works
Hormonal Regulation of Mammary Differentiation and Milk Secretion
Neville, M. C., McFadden, T. B., & Forsyth, I. A. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1015770423167 · Cited by 628 · see citing works
Exposure to Perfluorooctane Sulfonate during Pregnancy in Rat and Mouse. II: Postnatal Evaluation
Lau, C., Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Stanton, M. E., Butenhoff, J. L., & Stevenson, L. A. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg122 · Cited by 549 · see citing works
Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
Lau, C., Thibodeaux, J. R., Hanson, R., Narotsky, M., Rogers, J. M., Lindstrom, A., & Strynar, M. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj105 · Cited by 547 · see citing works
Early Life Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Latent Health Outcomes: A Review Including the Placenta as a Target Tissue and Possible Driver of Peri- and Postnatal Effects
Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499 · see citing works
Self-citation
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.067 · Cited by 465 · see citing works
Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases
Fröhlich, E., & Wahl, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00521 · Cited by 464 · see citing works
The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth
Johnson, P. I., Sutton, P., Atchley, D. S., Koustas, E., Lam, J., Sen, S., Robinson, K. A., Axelrad, D. A., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307893 · Cited by 449 · see citing works
Exposure to Perfluorooctane Sulfonate during Pregnancy in Rat and Mouse. I: Maternal and Prenatal Evaluations
Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Barbee, B. D., Richards, J. H., Butenhoff, J. L., Stevenson, L. A., & Lau, C. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg121 · Cited by 445 · see citing works
Presence of Emerging Per- and Polyfluoroalkyl Substances (PFASs) in River and Drinking Water near a Fluorochemical Production Plant in the Netherlands
Gebbink, W. A., van Asseldonk, L., & van Leeuwen, S. P. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02488 · Cited by 438 · see citing works
Binding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins
Han, X., Snow, T. A., Kemper, R. A., & Jepson, G. W. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034005w · Cited by 411 · see citing works
Non-Monotonic Dose Responses in Studies of Endocrine Disrupting Chemicals: Bisphenol a as a Case Study
Vandenberg, L. N. (2013) · Dose-Response · doi:10.2203/dose-response.13-020.vandenberg · Cited by 406 · see citing works
Occurrence of select perfluoroalkyl substances at U.S. Air Force aqueous film-forming foam release sites other than fire-training areas: Field-validation of critical fate and transport properties
Anderson, R. H., Long, G. C., Porter, R. C., & Anderson, J. K. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.01.014 · Cited by 394 · see citing works
Maternal levels of perfluorinated chemicals and subfecundity
Fei, C., McLaughlin, J. K., Lipworth, L., & Olsen, J. (2009) · Human Reproduction · doi:10.1093/humrep/den490 · Cited by 385 · see citing works
The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding
Fraser, I., Critchley, H., Broder, M., & Munro, M. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1287662 · Cited by 384 · see citing works
Epidemiology of Menstruation and Its Relevance to Women's Health
Harlow, S. D., & Ephross, S. A. (1995) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036193 · Cited by 372 · see citing works
Competitive Binding of Poly- and Perfluorinated Compounds to the Thyroid Hormone Transport Protein Transthyretin
Weiss, J. M., Andersson, P. L., Lamoree, M. H., Leonards, P. E. G., van Leeuwen, S. P. J., & Hamers, T. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp055 · Cited by 363 · see citing works
Alternative and Legacy Perfluoroalkyl Substances: Differences between European and Chinese River/Estuary Systems
Heydebreck, F., Tang, J., Xie, Z., & Ebinghaus, R. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01648 · Cited by 360 · see citing works
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
(2015) · Molecular and Integrative Toxicology · doi:10.1007/978-3-319-15518-0 · Cited by 360 · see citing works
Perfluorooctanoic Acid Exposure and Cancer Outcomes in a Contaminated Community: A Geographic Analysis
Vieira, V. M., Hoffman, K., Shin, H., Weinberg, J., Webster, T. F., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205829 · Cited by 355 · see citing works
A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans
Olsen, G. W., Chang, S.-C., Noker, P. E., Gorman, G. S., Ehresman, D. J., Lieder, P. H., & Butenhoff, J. L. (2009) · Toxicology · doi:10.1016/j.tox.2008.11.008 · Cited by 355 · see citing works
First Report on the Occurrence and Bioaccumulation of Hexafluoropropylene Oxide Trimer Acid: An Emerging Concern
Pan, Y., Zhang, H., Cui, Q., Sheng, N., Yeung, L. W. Y., Guo, Y., Sun, Y., & Dai, J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02259 · Cited by 355 · see citing works
The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth
Koustas, E., Lam, J., Sutton, P., Johnson, P. I., Atchley, D. S., Sen, S., Robinson, K. A., Axelrad, D. A., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307177 · Cited by 349 · see citing works
Neuroendocrine Effects of Perfluorooctane Sulfonate in Rats
Austin, M. E., Kasturi, B. S., Barber, M., Kannan, K., MohanKumar, P. S., & MohanKumar, S. M. J. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6128 · Cited by 347 · see citing works
Perfluorinated compounds affect the function of sex hormone receptors
Kjeldsen, L. S., & Bonefeld‐Jørgensen, E. C. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1753-3 · Cited by 345 · see citing works
Thyroid Disrupting Effects of Old and New Generation PFAS
Coperchini, F., Croce, L., Ricci, G., Magri, F., Rotondi, M., Imbriani, M., & Chiovato, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.612320 · Cited by 340 · see citing works
Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies
Mamsen, L. S., Björvang, R. D., Mucs, D., Vinnars, M.-T., Papadogiannakis, N., Lindh, C. H., Andersen, C. Y., & Damdimopoulou, P. (2019) · Environment International · doi:10.1016/j.envint.2019.01.010 · Cited by 338 · see citing works
Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)
Fromme, H., Mosch, C., Morovitz, M., Alba‐Alejandre, I., Boehmer, S., Kiranoglu, M., Faber, F. L., Hannibal, I., Genzel‐Boroviczény, O., Koletzko, B. V., et al. (2010) · Environmental Science & Technology · doi:10.1021/es101184f · Cited by 332 · see citing works
Worldwide drinking water occurrence and levels of newly-identified perfluoroalkyl and polyfluoroalkyl substances
Kaboré, H. A., Vo Duy, S., Munoz, G., Méité, L., Desrosiers, M., Liu, J., Sory, T. K., & Sauvé, S. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.210 · Cited by 329 · see citing works
Perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy, and child development: a potential mechanistic role for placental peroxisome proliferator-activated receptors (PPARs)
Szilagyi, J. T., Avula, V., & Fry, R. C. (2020) · Current Environmental Health Reports · doi:10.1007/s40572-020-00279-0 · Cited by 328 · see citing works
A review of sources, multimedia distribution and health risks of novel fluorinated alternatives
Wang, Y., Chang, W., Wang, L., Zhang, Y., Zhang, Y., Wang, M., Wang, Y., & Li, P. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109402 · Cited by 319 · see citing works
Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague–Dawley rats: Dose–response, and biochemical and pharamacokinetic parameters
Luebker, D. J., York, R. G., Hansen, K. J., Moore, J. A., & Butenhoff, J. L. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.019 · Cited by 314 · see citing works
Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives.
Olsen, G., Butenhoff, J., & Zobel, L. R. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.001 · Cited by 296 · see citing works
Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanoic Acid (PFOA) in Female CD-1 Mice: Low Doses Induce Elevated Serum Leptin and Insulin, and Overweight in Mid-life☆☆
Hines, E. P., White, S. S., Stanko, J. P., Gibbs-Flournoy, E. A., Lau, C., & Fenton, S. E. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.02.021 · Cited by 282 · see citing works
Two-generation reproduction and cross-foster studies of perfluorooctanesulfonate (PFOS) in rats
Luebker, D. J., Case, M. T., York, R. G., Moore, J. A., Hansen, K. J., & Butenhoff, J. L. (2005) · Toxicology · doi:10.1016/j.tox.2005.07.018 · Cited by 274 · see citing works
Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
Forsthuber, M., Kaiser, A. M., Granitzer, S., Hassl, I., Hengstschläger, M., Stangl, H., & Gundacker, C. (2020) · Environment International · doi:10.1016/j.envint.2019.105324 · Cited by 274 · see citing works
Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community
Worley, R. R., Moore, S. M., Tierney, B. C., Ye, X., Calafat, A. M., Campbell, S., Woudneh, M. B., & Fisher, J. (2017) · Environment International · doi:10.1016/j.envint.2017.06.007 · Cited by 272 · see citing works
Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with Age of Puberty among Children Living near a Chemical Plant
Lopez-Espinosa, M.-J., Fletcher, T., Armstrong, B., Genser, B., Dhatariya, K., Mondal, D., Ducatman, A., & Leonardi, G. (2011) · Environmental Science & Technology · doi:10.1021/es1038694 · Cited by 262 · see citing works
Serum Levels of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and Pregnancy Outcome
Stein, C. R., Savitz, D. A., & Dougan, M. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp212 · Cited by 262 · see citing works
Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012
Lewis, R. C., Johns, L. E., & Meeker, J. D. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120606098 · Cited by 254 · see citing works
Synergy between Asbestos and Smoking on Lung
Erren, T. C., Jacobsen, M. H., & Piekarski, C. (1999) · Epidemiology · doi:10.1097/00001648-199907000-00011 · Cited by 247 · see citing works
Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: Paired serum-urine data from the 2013–2014 National Health and Nutrition Examination Survey
Calafat, A. M., Kato, K., Hubbard, K., Jia, T., Botelho, J. C., & Wong, L.-Y. (2019) · Environment International · doi:10.1016/j.envint.2019.105048 · Cited by 245 · see citing works
Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: a systematic review of epidemiologic studies
Ballesteros, V., Costa, O., Iñiguez, C., Fletcher, T., Ballester, F., & Lopez-Espinosa, M.-J. (2017) · Environment International · doi:10.1016/j.envint.2016.10.015 · Cited by 242 · see citing works
Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco
Eick, S., Thepaksorn, E. K. H., Izano, M., Cushing, L., Wang, Y.-Z., Smith, S., Gao, S., Park, J.-S., Padula, A., DeMicco, E., et al. (2020) · Environmental Health · doi:10.1186/s12940-020-00654-2 · Cited by 238 · see citing works
Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort
Blake, B. E., Pinney, S. M., Hines, E. P., Fenton, S. E., & Ferguson, K. K. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.042 · Cited by 236 · see citing works
Self-citation
National Report on Human Exposure to Environmental Chemicals
(2023) · doi:10.15620/cdc:133100 · Cited by 232 · see citing works
Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.
White, S., Calafat, A., Kuklenyik, Z., Villanueva, L. R., Zehr, R. D., Helfant, L., Strynar, M., Lindstrom, A., Thibodeaux, J. R., Wood, C., et al. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl177 · Cited by 229 · see citing works
Self-citation
Enhanced Elimination of Perfluorooctane Sulfonic Acid by Menstruating Women: Evidence from Population-Based Pharmacokinetic Modeling
Wong, F., MacLeod, M., Mueller, J. F., & Cousins, I. T. (2014) · Environmental Science & Technology · doi:10.1021/es500796y · Cited by 220 · see citing works
Elevated levels of PFOS and PFHxS in firefighters exposed to aqueous film forming foam (AFFF)
Rotander, A., Toms, L.-M. L., Aylward, L. L., Kay, M. P., & Mueller, J. F. (2015) · Environment International · doi:10.1016/j.envint.2015.05.005 · Cited by 218 · see citing works
Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
Bonefeld‐Jørgensen, E. C., Long, M., Bossi, R., Ayotte, P., Asmund, G., Krüger, T., Ghisari, M., Mulvad, G., Kern, P., Nzulumiki, P., et al. (2011) · Environmental Health · doi:10.1186/1476-069x-10-88 · Cited by 216 · see citing works
Fecundability in Relation to Body Mass and Menstrual Cycle Patterns
Jensen, T. K., Scheike, T., Keiding, N., Schaumburg, I., & Grandjean, P. (1999) · Epidemiology · doi:10.1097/00001648-199907000-00014 · Cited by 216 · see citing works
Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
Chang, S., Thibodeaux, J. R., Eastvold, M. L., Ehresman, D. J., Bjork, J. A., Froehlich, J. W., Lau, C. S., Singh, R. J., Wallace, K. B., & Butenhoff, J. L. (2007) · Toxicology · doi:10.1016/j.tox.2007.10.014 · Cited by 209 · see citing works
Serum Levels of Perfluoroalkyl Substances (PFAS) in Adolescents and Young Adults Exposed to Contaminated Drinking Water in the Veneto Region, Italy: A Cross-Sectional Study Based on a Health Surveillance Program
Pitter, G., Re, F. D., Canova, C., Barbieri, G., Jeddi, M. Z., Daprà, F., Manea, F., Zolin, R., Bettega, A. M., Stopazzolo, G., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5337 · Cited by 204 · see citing works
Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo
Du, G., Hu, J., Huang, H., Qin, Y., Han, X., Wu, D., Song, L., Xia, Y., & Wang, X. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2034 · Cited by 201 · see citing works
Endogenous Estrogen Exposure and Cardiovascular Mortality Risk in Postmenopausal Women
de Kleijn, M. J. J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.4.339 · Cited by 201 · see citing works
Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)
Blake, B., Cope, H. A., Hall, S. M., Keys, R. D., Mahler, B., McCord, J. P., Scott, B. E., Stapleton, H., Strynar, M., Elmore, S., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6233 · Cited by 201 · see citing works
Self-citation
Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
Hunt, P. A., Sathyanarayana, S., Fowler, P., & Trasande, L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2873 · Cited by 199 · see citing works
Implications of Early Menopause in Women Exposed to Perfluorocarbons
Knox, S. S., Jackson, T., Javins, B., Frisbee, S. J., Shankar, A., & DUCATMAN, A. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2401 · Cited by 195 · see citing works
Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women
Brantsæter, A. L., Whitworth, K. W., Ydersbond, T. A., Haug, L. S., Haugen, M. A., Knutsen, H. K., Thomsen, C., Meltzer, H. M., Becher, G., Sabaredzovic, A., et al. (2013) · Environment International · doi:10.1016/j.envint.2012.12.014 · Cited by 193 · see citing works
Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism
Yu, W., Liu, W., & Jin, Y. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-345.1 · Cited by 192 · see citing works
Impact of endocrine disruptor chemicals in gynaecology
Caserta, D., Maranghi, L., Mantovani, A., Marci, R., Maranghi, F., & Moscarini, M. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm025 · Cited by 191 · see citing works
Breastfeeding as an exposure pathway for perfluorinated alkylates
Mogensen, U. B., Grandjean, P., Nielsen, F., Weihe, P., & Budtz-Jørgensen, E. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b02237 · Cited by 190 · see citing works
Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study
Vélez, M. P., Arbuckle, T. E., & Fraser, W. D. (2015) · Human Reproduction · doi:10.1093/humrep/deu350 · Cited by 187 · see citing works
Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China
Fu, J., Gao, Y., Cui, L., Wang, T., Liang, Y., Qu, G., Yuan, B., Wang, Y., Zhang, A., & Jiang, G. (2016) · Scientific Reports · doi:10.1038/srep38039 · Cited by 184 · see citing works
Distribution, source identification and health risk assessment of PFASs and two PFOS alternatives in groundwater from non-industrial areas
Wei, C., Wang, Q., Song, X., Chen, X., Fan, R., Ding, D., & Liu, Y. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.01.039 · Cited by 183 · see citing works
Changes in Serum Concentrations of Maternal Poly- and Perfluoroalkyl Substances over the Course of Pregnancy and Predictors of Exposure in a Multiethnic Cohort of Cincinnati, Ohio Pregnant Women during 2003–2006
Kato, K., Wong, L.-Y., Chen, A., Dunbar, C. A., Webster, G. M., Lanphear, B. P., & Calafat, A. M. (2014) · Environmental Science & Technology · doi:10.1021/es501811k · Cited by 182 · see citing works
Determinants of per- and polyfluoroalkyl substances (PFAS) in midlife women: Evidence of racial/ethnic and geographic differences in PFAS exposure
Park, S. K., Peng, Q., Ding, N., Mukherjee, B., & Harlow, S. D. (2019) · Environmental Research · doi:10.1016/j.envres.2019.05.028 · Cited by 179 · see citing works
Sociodemographic and Perinatal Predictors of Early Pregnancy Per- and Polyfluoroalkyl Substance (PFAS) Concentrations
Sagiv, S. K., Rifas‐Shiman, S. L., Webster, T. F., Mora, A. M., Harris, M. H., Calafat, A. M., Ye, X., Gillman, M. W., & Oken, E. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b02489 · Cited by 178 · see citing works
Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009–2010
Khalil, N., Chen, A., Lee, M., Czerwinski, S. A., Ebert, J. R., DeWitt, J. C., & Kannan, K. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1307909 · Cited by 170 · see citing works
Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case–control study
Vagi, S. J., Azziz‐Baumgartner, E., Sjödin, A., Calafat, A. M., Dumesic, D. A., Gonzalez, L., Kato, K., Silva, M. J., Ye, X., & Azziz, R. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-86 · Cited by 169 · see citing works
Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease
Macon, M. B., & Fenton, S. E. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9275-7 · Cited by 169 · see citing works
Self-citation
An Epidemiologic Investigation of Reproductive Hormones in Men with Occupational Exposure to Perfluorooctanoic Acid
Olsen, G. W., Gilliland, F. D., Burlew, M., Burris, J. M., Mandel, J. S., & Mandel, J. H. (1998) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199807000-00006 · Cited by 169 · see citing works
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Maternal and Neonatal Thyroid Function in the Project Viva Cohort: A Mixtures Approach
Preston, E. V., Webster, T. F., Claus Henn, B., McClean, M. D., Gennings, C., Oken, E., Rifas-Shiman, S. L., Pearce, E. N., Calafat, A. M., Fleisch, A. F., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105728 · Cited by 169 · see citing works
Chlorinated Polyfluoroalkyl Ether Sulfonic Acids in Matched Maternal, Cord, and Placenta Samples: A Study of Transplacental Transfer
Chen, F., Yin, S., Kelly, B. C., & Liu, W. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06049 · Cited by 168 · see citing works
Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study
Wang, Y., Rogan, W. J., Chen, P.-C., Lien, G.-W., Chen, H.-Y., Tseng, Y.-C., Longnecker, M. P., & Wang, S.-L. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306925 · Cited by 162 · see citing works
Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)
Palioura, E., & Diamanti-Kandarakis, E. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9326-7 · Cited by 161 · see citing works
Comparison of in vitro cytotoxicity, estrogenicity and anti‐estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid
Henry, N. D., & Fair, P. A. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1736 · Cited by 160 · see citing works
The influence of a low-dose combined oral contraceptive on menstrual blood loss and iron status
Larsson, G., Milsom, L., Lindstedt, G., & Rybo, G. (1992) · Contraception · doi:10.1016/0010-7824(92)90095-b · Cited by 160 · see citing works
Effect of diethylstilbestrol on reproductive function
Goldberg, J. M., & Falcone, T. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00153-3 · Cited by 159 · see citing works
Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women
Zhou, W., Zhang, L., Tong, C., Fang, F., Zhao, S., Tian, Y., Tao, Y., Zhang, J., & Study, F. T. S. B. C. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1203 · Cited by 159 · see citing works
Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: A pilot study
Ericson, I., Gómez, M., Nadal, M., van Bavel, B., Lindström, G., & Domingo, J. L. (2007) · Environment International · doi:10.1016/j.envint.2007.01.003 · Cited by 158 · see citing works
Breastfeeding: A Potential Excretion Route for Mothers and Implications for Infant Exposure to Perfluoroalkyl Acids
Mondal, D., Weldon, R. H., Armstrong, B., Gibson, L. J., López-Espinosa, M.-J., Shin, H., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306613 · Cited by 153 · see citing works
Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction
Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., & Toft, G. (2013) · Human Reproduction · doi:10.1093/humrep/det382 · Cited by 151 · see citing works
Association between prenatal exposure to PFAS and fetal sex hormones: Are the short-chain PFAS safer?
Nian, M., Luo, K., Luo, F., Aimuzi, R., Huo, X., Chen, Q., Tian, Y., & Zhang, J. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c02444 · Cited by 148 · see citing works
Perfluorinated Compounds and Subfecundity in Pregnant Women
Whitworth, K. W., Haug, L. S., Baird, D. D., Becher, G., Hoppin, J. A., Skjærven, R., Thomsen, C., Eggesbø, M. Å., Travlos, G. S., Wilson, R., et al. (2011) · Epidemiology · doi:10.1097/ede.0b013e31823b5031 · Cited by 146 · see citing works
Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study
Webster, G. M., Venners, S. A., Mattman, A., & Martin, J. W. (2014) · Environmental Research · doi:10.1016/j.envres.2014.06.012 · Cited by 145 · see citing works
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy
Huang, R., Chen, Q., Zhang, L., Luo, K., Chen, L., Zhao, S., Feng, L., & Zhang, J. (2019) · Environmental Health · doi:10.1186/s12940-018-0445-3 · Cited by 143 · see citing works
A Time Trend Study of Significantly Elevated Perfluorocarboxylate Levels in Humans after Using Fluorinated Ski Wax
Nilsson, H., Kärrman, A., Westberg, H., Rotander, A., van Bavel, B., & Lindström, G. (2010) · Environmental Science & Technology · doi:10.1021/es9034733 · Cited by 142 · see citing works
Endocrine disrupting chemicals: impacts on human fertility and fecundity during the peri-conception period.
Green, M. P., Harvey, A., Finger, B., & Tarulli, G. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110694 · Cited by 142 · see citing works
Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats
Butenhoff, J. L., Chang, S., Ehresman, D. J., & York, R. G. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.01.004 · Cited by 139 · see citing works
Gestational and Chronic Low-Dose PFOA Exposures and Mammary Gland Growth and Differentiation in Three Generations of CD-1 Mice
White, S., Stanko, J., Kato, K., Calafat, A., Hines, E., & Fenton, S. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002741 · Cited by 138 · see citing works
Self-citation
Polyfluoroalkyl Chemicals and Menopause among Women 20–65 Years of Age (NHANES)
Taylor, K. W., Hoffman, K., Thayer, K. A., & Daniels, J. L. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306707 · Cited by 137 · see citing works
Serum concentrations of PFASs and exposure-related behaviors in African American and non-Hispanic white women
Boronow, K. E., Brody, J. G., Schaider, L. A., Peaslee, G. F., Havas, L., & Cohn, B. A. (2018) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-018-0109-y · Cited by 136 · see citing works
Fertility and abortion rates in the United States, 1960–2002
Hamilton, B. E., & Ventura, S. J. (2006) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00638.x · Cited by 134 · see citing works
Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults
Tsai, M., Lin, C., Lin, C., Chen, M., Hsu, S. H.-J., Chien, K., Sung, F., Chen, P., & Su, T. (2015) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2015.03.008 · Cited by 134 · see citing works
Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues
Pan, Y., Wang, J., Yeung, L. W. Y., Wei, S., & Dai, J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.04.013 · Cited by 133 · see citing works
Early ovarian ageing
Nikolaou, D. S., & Templeton, A. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.09.024 · Cited by 131 · see citing works
Emissions of Per- and Polyfluoroalkyl Substances in a Textile Manufacturing Plant in China and Their Relevance for Workers’ Exposure
Heydebreck, F., Tang, J., Xie, Z., & Ebinghaus, R. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03213 · Cited by 131 · see citing works
Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Premature Ovarian Insufficiency in Chinese Women
Zhang, S., Tan, R., Pan, R., Xiong, J., Tian, Y., Wu, J., & Chen, L. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02783 · Cited by 129 · see citing works
Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro
Behr, A., Lichtenstein, D., Braeuning, A., Lampen, A., & Buhrke, T. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.029 · Cited by 127 · see citing works
Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma.
Mamsen, L., Jönsson, B., Lindh, C. H., Olesen, R. H., Larsen, A., Ernst, E., Kelsey, T., & Andersen, C. (2017) · Science of the Total Environment · doi:10.1016/j.scitotenv.2017.04.058 · Cited by 123 · see citing works
Perfluorinated alkylated substances serum concentration and breast cancer risk: Evidence from a nested case‐control study in the French E3N cohort
Mancini, F. R., Cano-Sancho, G., Gambaretti, J., Marchand, P., Boutron‐Ruault, M., Severi, G., Arveux, P., Antignac, J., & Kvaskoff, M. (2019) · International Journal of Cancer · doi:10.1002/ijc.32357 · Cited by 123 · see citing works
Per- and polyfluoroalkyl substances in sera from children 3 to 11 years of age participating in the National Health and Nutrition Examination Survey 2013–2014
Ye, X., Kato, K., Wong, L.-Y., Jia, T., Kalathil, A. A., Latremouille, J., & Calafat, A. M. (2017) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2017.09.011 · Cited by 118 · see citing works
Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation
Feng, X., Wang, X., Cao, X., Xia, Y., Zhou, R., & Chen, L. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv197 · Cited by 117 · see citing works
Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey
Gannon, S. A., Fasano, W. J., Mawn, M. P., Nabb, D. L., Buck, R. C., Buxton, L. W., Jepson, G. W., & Frame, S. R. (2015) · Toxicology · doi:10.1016/j.tox.2015.12.006 · Cited by 115 · see citing works
Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population
Midasch, O., Schettgen, T., & Angerer, J. (2006) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2006.06.002 · Cited by 112 · see citing works
Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women
Barrett, E. S., Chen, C., Thurston, S. W., Haug, L. S., Sabaredzovic, A., Fjeldheim, F., Frydenberg, H., Lipson, S. F., Ellison, P. T., & Thune, I. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.001 · Cited by 111 · see citing works
Cross-Sectional Associations of Serum Perfluoroalkyl Acids and Thyroid Hormones in U.S. Adults: Variation According to TPOAb and Iodine Status (NHANES 2007–2008)
Webster, G. M., Rauch, S., Marie, N., Mattman, A., Lanphear, B., & Venners, S. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409589 · Cited by 111 · see citing works
Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low-Dose Developmental Effects and Internal Dosimetry
Macon, M. B., Villanueva, L. R., Tatum-Gibbs, K. R., ZEHR, R. D. J., Strynar, M. J., Stanko, J. P., White, S. S., Helfant, L., & Fenton, S. E. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr076 · Cited by 110 · see citing works
Self-citation
Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters
Heffernan, A. L., Cunningham, T. K., Drage, D. S., Aylward, L. L., Thompson, K., Vijayasarathy, S., Mueller, J. F., Atkin, S. L., & Sathyapalan, T. (2018) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2018.07.009 · Cited by 110 · see citing works
Nontargeted identification of per- and polyfluoroalkyl substances in human follicular fluid and their blood-follicle transfer
Kang, Q., Gao, F., Zhang, X., Wang, L., Liu, J., Fu, M., Zhang, S., Wan, Y., Shen, H., & Hu, J. (2020) · Environment International · doi:10.1016/j.envint.2020.105686 · Cited by 110 · see citing works
Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach
Berg, V., Nøst, T. H., Hansen, S., Elverland, A., Veyhe, A. S., Jorde, R., Odland, J. Ø., & Sandanger, T. M. (2015) · Environment International · doi:10.1016/j.envint.2015.01.007 · Cited by 109 · see citing works
Metastin/Kisspeptin and control of estrous cycle in rats
Maeda, K., Adachi, S., Inoue, K., Ohkura, S., & Tsukamura, H. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9032-6 · Cited by 106 · see citing works
Relationships of Chemical Concentrations in Maternal and Cord Blood: A Review of Available Data
Aylward, L. L., Hays, S. M., Kirman, C. R., Marchitti, S. A., Kenneke, J. F., English, C. A., Mattison, D. R., & Becker, R. A. (2014) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2014.884956 · Cited by 105 · see citing works
A Simple Pharmacokinetic Model of Prenatal and Postnatal Exposure to Perfluoroalkyl Substances (PFASs)
Verner, M.-A., Ngueta, G., Jensen, E. T., Fromme, H., Völkel, W., Nygaard, U. C., Granum, B. B., & Longnecker, M. P. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b04399 · Cited by 104 · see citing works
Association Between Serum Perfluorinated Chemicals and Thyroid Function in U.S. Adults: The National Health and Nutrition Examination Survey 2007–2010
Wen, L., Lin, L., Su, T., Chen, P., & Lin, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1282 · Cited by 103 · see citing works
A Study of Reverse Causation: Examining the Associations of Perfluorooctanoic Acid Serum Levels with Two Outcomes
Dhingra, R., Winquist, A. G., Darrow, L. A., Klein, M., & Steenland, K. (2016) · Environmental Health Perspectives · doi:10.1289/ehp273 · Cited by 103 · see citing works
A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women
Tsai, M., Chang, S.-H., Kuo, W., Kuo, C., Li, S.-Y., Wang, M.-Y., Chang, D., Lu, Y., Huang, C., Cheng, A., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.105850 · Cited by 103 · see citing works
The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure
Tucker, D. K., Macon, M. B., Strynar, M. J., Dagnino, S., Andersen, E., & Fenton, S. E. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.12.002 · Cited by 101 · see citing works
Self-citation
Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays
Du, G., Huang, H., Hu, J., Qin, Y., Wu, D., Song, L., Xia, Y., & Wang, X. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.01.012 · Cited by 101 · see citing works
Per- and poly-fluoroalkyl substances (PFASs) in follicular fluid from women experiencing infertility in Australia
Kim, Y. R., White, N. M., Bräunig, J., Vijayasarathy, S., Mueller, J. F., Knox, C. L., Harden, F. A., Pacella, R., & Toms, L.-M. L. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109963 · Cited by 101 · see citing works
Transcriptional changes in steroidogenesis by perfluoroalkyl acids (PFOA and PFOS) regulate the synthesis of sex hormones in H295R cells
Kang, J. S., Choi, J.-S., & Park, J. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.04.070 · Cited by 100 · see citing works
Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort
Ernst, A., Brix, N., Lauridsen, L. L. B., Olsen, J., Parner, E. T., Liew, Z., Olsen, L. H., & Ramlau‐Hansen, C. H. (2019) · Environmental Health Perspectives · doi:10.1289/ehp3567 · Cited by 99 · see citing works
Sociodemographic and behavioral determinants of serum concentrations of per- and polyfluoroalkyl substances in a community highly exposed to aqueous film-forming foam contaminants in drinking water
Barton, K. E., Starling, A. P., Higgins, C. P., McDonough, C. A., Calafat, A. M., & Adgate, J. L. (2019) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2019.07.012 · Cited by 99 · see citing works
Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women
Nisio, A. D., Rocca, M. S., Šabović, I., Ponce, M. D. R., Corsini, C., Guidolin, D., Zanon, C., Acquasaliente, L., Carosso, A. R., Toni, L. D., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125208 · Cited by 99 · see citing works
Perfluorinated substances in the Flemish population (Belgium): Levels and determinants of variability in exposure
Colles, A., Bruckers, L. M., Hond, E. D., Govarts, E., Morrens, B., Schettgen, T., Buekers, J., Coertjens, D., Nawrot, T. S., Loots, I., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125250 · Cited by 99 · see citing works
Perfluoroalkyl substances and endometriosis-related infertility in Chinese women
Wang, B., Zhang, R., Jin, F., Lou, H., Mao, Y., Zhu, W., Zhou, W., Zhang, P., & Zhang, J. (2017) · Environment International · doi:10.1016/j.envint.2017.03.003 · Cited by 97 · see citing works
Perfluoroalkyl substances in human milk: A first survey in Italy
Barbarossa, A., Masetti, R., Gazzotti, T., Zama, D., Astolfi, A., Veyrand, B., Pession, A., & Pagliuca, G. (2012) · Environment International · doi:10.1016/j.envint.2012.10.001 · Cited by 96 · see citing works
Early-life exposure to per- and poly-fluorinated alkyl substances and growth, adiposity, and puberty in children: a systematic review
Lee, Y. J., Jung, H. W., Kim, H. Y., Choi, Y.-J., & Lee, Y. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683297 · Cited by 96 · see citing works
Varied thyroid disrupting effects of perfluorooctanoic acid (PFOA) and its novel alternatives hexafluoropropylene-oxide-dimer-acid (GenX) and ammonium 4,8-dioxa-3H-perfluorononanoate (ADONA) in vitro
Zhang, S., Chen, K., Li, W., Chai, Y., Zhu, J., Chu, B., Li, N., Yan, J., Zhang, S., & Yang, Y. (2021) · Environment International · doi:10.1016/j.envint.2021.106745 · Cited by 95 · see citing works
Serum per- and polyfluoroalkyl substance (PFAS) concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia
Chang, C.-J., Ryan, P. B., Smarr, M. M., Kannan, K., Panuwet, P., Dunlop, A. L., Corwin, E. J., & Barr, D. B. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110445 · Cited by 94 · see citing works
Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial
Fraser, I. S., Römer, T., Parke, S., Zeun, S., Mellinger, U., Machlitt, A., & Jensen, J. T. (2011) · Human Reproduction · doi:10.1093/humrep/der224 · Cited by 93 · see citing works
Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility
Rashtian, J., Chavkin, D. E., & Merhi, Z. O. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0448-5 · Cited by 90 · see citing works
Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures
White, S., Kato, K., Jia, L. T., Basden, B. J., Calafat, A., Hines, E., Stanko, J., Wolf, C. J., Abbott, B., & Fenton, S. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.11.054 · Cited by 88 · see citing works
Self-citation
Developmental toxicity of perfluorononanoic acid in mice
Das, K. P., Grey, B. E., Rosen, M. B., Wood, C. R., Tatum-Gibbs, K. R., Zehr, R. D., Strynar, M. J., Lindstrom, A. B., & Lau, C. S. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.12.012 · Cited by 86 · see citing works
PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cells
Pierozan, P., & Karlsson, O. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2077-8 · Cited by 85 · see citing works
Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding
Romano, M. E., Xu, Y. Y., Calafat, A. M., Yolton, K. A., Chen, A., Webster, G. M., Eliot, M., Howard, C. R., Lanphear, B. P., & Braun, J. M. (2016) · Environmental Research · doi:10.1016/j.envres.2016.04.034 · Cited by 84 · see citing works
Per- and Polyfluoroalkyl Substances Differentially Inhibit Placental Trophoblast Migration and Invasion In Vitro
Szilagyi, J. T., Freedman, A. N., Kepper, S. L., Keshava, A. M., Bangma, J. T., & Fry, R. C. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa043 · Cited by 84 · see citing works
Perfluorinated compounds in the vicinity of a fire training area – Human biomonitoring among 10 persons drinking water from contaminated private wells in Cologne, Germany
Weiß, O., Wiesmüller, G. A., Bunte, A., Göen, T., Schmidt, C. K., Wilhelm, M., & Hölzer, J. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.08.016 · Cited by 82 · see citing works
Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort
Christensen, K. L. Y., Maisonet, M., Rubin, C., Holmes, A. K., Calafat, A. M., Kato, K., Flanders, W. D., Heron, J., McGeehin, M. A., & Marcus, M. (2010) · Environment International · doi:10.1016/j.envint.2010.08.007 · Cited by 82 · see citing works
Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study
Hurley, S. E., Goldberg, D. E., Wang, M., Park, J.-S., Petreas, M. X., Bernstein, L., Anton‐Culver, H., Nelson, D. O., & Reynolds, P. (2018) · Environmental Health · doi:10.1186/s12940-018-0426-6 · Cited by 82 · see citing works
Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women
Wikström, S., Lindh, C. H., Shu, H., & Bornehag, C.-G. (2019) · Scientific Reports · doi:10.1038/s41598-019-45483-7 · Cited by 82 · see citing works
Association between thyroid profile and perfluoroalkyl acids: Data from NHNAES 2007–2008
Jain, R. B. (2013) · Environmental Research · doi:10.1016/j.envres.2013.08.006 · Cited by 81 · see citing works
The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults
Lin, C., Wen, L.-L., Lin, L., Wen, T.-W., Lien, G., Hsu, S. H.-J., Chien, K., Liao, C., Sung, F.-C., Chen, P., et al. (2012) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2012.10.049 · Cited by 80 · see citing works
Analysis of PFOA in dosed CD-1 mice. Part 2: Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups
Fenton, S., Reiner, J. L., Nakayama, S., Delinsky, A. D., Stanko, J., Hines, E., White, S., Lindstrom, A., Strynar, M., & Petropoulou, S.-S. E. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.012 · Cited by 80 · see citing works
Self-citation
Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation
Ding, N., Harlow, S. D., Batterman, S., Mukherjee, B., & Park, S. K. (2019) · Environment International · doi:10.1016/j.envint.2019.105381 · Cited by 80 · see citing works
Age at Natural Menopause in Women Exposed to Diethylstilbestrol in Utero
Hatch, E. E., Troisi, R. J., Wise, L. A., Hyer, M., Palmer, J. R., Titus-Ernstoff, L. T., Strohsnitter, W. C., Kaufman, R. H., Adam, E., Noller, K. L., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj257 · Cited by 79 · see citing works
Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility
Crawford, N., Fenton, S. E., Strynar, M. J., Hines, E. P., Pritchard, D. A., & Steiner, A. Z. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.01.006 · Cited by 79 · see citing works
Self-citation
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and birth outcomes: a longitudinal cohort with repeated measurements
Chen, L., Tong, C., Huo, X., Zhang, J., & Tian, Y. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.128899 · Cited by 79 · see citing works
Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy
Aimuzi, R., Luo, K., Huang, R., Huo, X., Nian, M., Ouyang, F., Du, Y., Feng, L., Wang, W., & Zhang, J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114557 · Cited by 78 · see citing works
Identifying Risk Factors for Levels of Per- and Polyfluoroalkyl Substances (PFAS) in the Placenta in a High-Risk Pregnancy Cohort in North Carolina
Bangma, J., Eaves, L. A., Oldenburg, K. S., Reiner, J. L., Manuck, T. A., & Fry, R. C. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b07102 · Cited by 78 · see citing works
Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study
Lyngsø, J., Ramlau‐Hansen, C. H., Høyer, B. B., Støvring, H., Bonde, J. ., Jönsson, B., Lindh, C. H., Pedersen, H. S., Ludwicki, J. K., Zviezdai, V., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det390 · Cited by 77 · see citing works
Perfluoroalkyl Substances During Pregnancy and Validated Preeclampsia Among Nulliparous Women in the Norwegian Mother and Child Cohort Study
Starling, A. P., Engel, S. M., Richardson, D. B., Baird, D. D., Haug, L. S., Stuebe, A. M., Klungsøyr, K., Harmon, Q. E., Becher, G., Thomsen, C., et al. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt432 · Cited by 77 · see citing works
Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring
Feng, X., Cao, X., Zhao, S., Wang, X., Xu, H., Chen, L., & Chen, L. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw219 · Cited by 77 · see citing works
Perfluorohexane Sulfonate (PFHxS) and a Mixture of Endocrine Disrupters Reduce Thyroxine Levels and Cause Antiandrogenic Effects in Rats
Ramhøj, L., Hass, U., Boberg, J., Scholze, M., Christiansen, S., Nielsen, F., & Axelstad, M. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy055 · Cited by 77 · see citing works
Perfluoroalkyl substances exposure and risk of polycystic ovarian syndrome related infertility in Chinese women
Wang, W., Zhou, W., Wu, S., Liang, F., Li, Y., Zhang, J., Cui, L., Feng, Y., & Wang, Y. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.01.039 · Cited by 77 · see citing works
Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study
Lebeaux, R. M., Doherty, B. T., Gallagher, L. G., Zoeller, R. T., Hoofnagle, A. N., Calafat, A. M., Karagas, M. R., Yolton, K. A., Chen, A., Lanphear, B. P., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109395 · Cited by 76 · see citing works
Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants.
Arbuckle, T., Kubwabo, C., Walker, M., Davis, K. A., Lalonde, K., Kosarac, I., Wen, S.-W., & Arnold, D. (2013) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2012.03.004 · Cited by 75 · see citing works
Concentration and correlations of perfluoroalkyl substances in whole blood among subjects from three different geographical areas in Korea
Cho, C. R., Lam, N. H., Cho, B. M., Kannan, K., & Cho, H.-S. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.01.070 · Cited by 74 · see citing works
Perfluorinated compounds differentially affect steroidogenesis and viability in the human adrenocortical carcinoma (H295R) in vitro cell assay
Kraugerud, M., Zimmer, K. E., Ropstad, E., & Verhaegen, S. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.230 · Cited by 74 · see citing works
Perfluoroalkyl substances and endometriosis in US women in NHANES 2003–2006
Campbell, S., Raza, M., & Pollack, A. Z. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.08.009 · Cited by 74 · see citing works
The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats
Shi, Z., Zhang, H., Ding, L., Feng, Y., Xu, M., & Dai, J. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.008 · Cited by 73 · see citing works
Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population
Ingelido, A. M., Marra, V., Abballe, A., Valentini, S., Iacovella, N., Barbieri, P., Porpora, M. G., Domenico, A. D., & Felip, E. D. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.06.025 · Cited by 70 · see citing works
Levels of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) in blood samples from different groups of adults living in Greece
Vassiliadou, I., Costopoulou, D., Ferderigou, A., & Leondiadis, L. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.06.014 · Cited by 69 · see citing works
Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991–2012
Herrick, R. L., Buckholz, J. M., Biro, F. M., Calafat, A. M., Ye, X., Xie, C., & Pinney, S. M. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.04.092 · Cited by 69 · see citing works
EPA 's Unprecedented Interim Drinking Water Health Advisories for PFOA and PFOS
Cotruvo, J. A., Goldhaber, S. B., & Cohen, A. J. B. (2023) · Ground Water · doi:10.1111/gwat.13303 · Cited by 67 · see citing works
Parental plasma concentrations of perfluoroalkyl substances and In Vitro fertilization outcomes
Ma, X., Cui, L., Chen, L., Zhang, J., Zhang, X., Kang, Q., Jin, F., & Ye, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116159 · Cited by 65 · see citing works
Toxicological evaluation of sodium perfluorohexanoate
Loveless, S. E., Slezak, B., Serex, T. L., Lewis, J., Mukerji, P., O’Connor, J. C., Donner, E. M., Frame, S. R., Korzeniowski, S. H., & Buck, R. C. (2009) · Toxicology · doi:10.1016/j.tox.2009.07.011 · Cited by 64 · see citing works
Adverse effects of in vitro GenX exposure on rat thyroid cell viability, DNA integrity and thyroid-related genes expression
Coperchini, F., Croce, L., Denegri, M., Pignatti, P., Agozzino, M., Netti, G. S., Imbriani, M., Rotondi, M., & Chiovato, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114778 · Cited by 63 · see citing works
Persistent organic pollutants and couple fecundability: a systematic review
Kahn, L. G., Harley, K. G., Siegel, E., Zhu, Y., Factor-Litvak, P. R., Porucznik, C. A., Klein‐Fedyshin, M., Hipwell, A. E., & Program, P. C. F. E. I. O. C. H. O. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa037 · Cited by 63 · see citing works
Associations of Maternal Stress, Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFAS), and Demographic Risk Factors with Birth Outcomes and Offspring Neurodevelopment: An Overview of the ECHO.CA.IL Prospective Birth Cohorts
Eick, S. M., Enright, E. A., Geiger, S. D., Dzwilewski, K. L. C., DeMicco, E., Smith, S. C., Park, J.-S., Aguiar, A., Woodruff, T. J., Morello-Frosch, R. A., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020742 · Cited by 62 · see citing works
Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice
Gannon, S. A., Johnson, T. L., Nabb, D. L., Serex, T. L., Buck, R. C., & Loveless, S. E. (2011) · Toxicology · doi:10.1016/j.tox.2011.02.004 · Cited by 61 · see citing works
Effect of hypothyroidism on female reproductive hormones
Saran, S., Gupta, B. S., Philip, R., Singh, K. S., Bende, S. A., Agroiya, P., & Agrawal, P. (2015) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.172245 · Cited by 61 · see citing works
Perfluorinated chemicals in blood serum of inhabitants in central Poland in relation to gender and age
Góralczyk, K., Pachocki, K. A., Hernik, A., Struciński, P., Czaja, K., Lindh, C. H., Jönsson, B., Lenters, V. C., Korcz, W., Minorczyk, M., et al. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.06.050 · Cited by 60 · see citing works
Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances
Timmermann, C. A. G., Budtz–Jørgensen, E., Petersen, M. S., Weihe, P., Steuerwald, U., Nielsen, F., Jensen, T. K., & Grandjean, P. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.07.010 · Cited by 60 · see citing works
Reduction of progesterone, estradiol and hCG secretion by perfluorooctane sulfonate via induction of apoptosis in human placental syncytiotrophoblasts
Zhang, N., Wang, W., Li, W. J., Liu, C., Wang, Y., & Sun, K. (2015) · Placenta · doi:10.1016/j.placenta.2015.02.008 · Cited by 59 · see citing works
Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study
Itoh, S., Araki, A., Miyashita, C., Yamazaki, K., Goudarzi, H., Minatoya, M., Bamai, Y. A., Kobayashi, S., Okada, E., Kashino, I., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105139 · Cited by 59 · see citing works
Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort
Inoue, K., Ritz, B. R., Andersen, S. L., Ramlau‐Hansen, C. H., Høyer, B. B., Bech, B. H., Henriksen, T. B., Bonefeld‐Jørgensen, E. C., Olsen, J., & Liew, Z. (2019) · Environmental Health Perspectives · doi:10.1289/ehp5482 · Cited by 59 · see citing works
Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding, N., Harlow, S. D., Randolph, J. F., Calafat, A. M., Mukherjee, B., Batterman, S., Gold, E. B., & Park, S. K. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa303 · Cited by 59 · see citing works
Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice
Chang, S., Butenhoff, J. L., Parker, G. A., Coder, P. S., Zitzow, J. D., Krisko, R. M., Bjork, J. A., Wallace, K. B., & Seed, J. G. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.04.007 · Cited by 58 · see citing works
In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer
Cohn, B. A., Merrill, M. A. L., Krigbaum, N. Y., Wang, M., Park, J.-S., Petreas, M. X., Yeh, G., Hovey, R. C., Zimmermann, L. M., & Cirillo, P. M. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.06.012 · Cited by 58 · see citing works
An assessment of serum‐dependent impacts on intracellular accumulation and genomic response of per‐ and polyfluoroalkyl substances in a placental trophoblast model
Bangma, J., Szilagyi, J. T., Blake, B. E., Plazas, C., Kepper, S. L., Fenton, S. E., & Fry, R. C. (2020) · Environmental Toxicology · doi:10.1002/tox.23004 · Cited by 58 · see citing works
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Authors: Rickard, B. P., Rizvi, I., & Fenton, S. E.
Affiliations: University of North Carolina at Chapel Hill (US)
National Institute of Environmental Health Sciences (US)
Corresponding author: Fenton, Suzanne E.
ORCID: Rickard, Brittany P.
Rizvi, Imran
Fenton, Suzanne E.
Venue: Toxicology
Publisher: Elsevier BV
Published: 2022-01
Volume: 465
Pages: 153031
ISSN: 0300-483X (ISSN-L)
DOI: 10.1016/j.tox.2021.153031
PMC: PMC8743032
OpenAlex: W3214282621
Cited by: 334
References: 237
Citations by year: 2026: 66 · 2025: 102 · 2024: 86 · 2023: 57 · 2022: 21 · 2021: 1
FWCI: 3.02
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Toxicology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (ZIA ES102785-11)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
Keywords: per- and polyfluoroalkyl substances, PFAS, women's reproductive health, endocrine disruption, PFAS mixtures, short-chain PFAS, long-chain PFAS, menstrual cyclicity, female fertility, breast tissue, thyroid function, hypothalamic-pituitary-gonadal axis, drinking water contamination
MeSH terms: Endocrine System Diseases, Environmental Exposure, Environmental Pollutants, Female, Fertility, Humans, Hydrocarbons, Fluorinated, Infertility, Female, Menstrual Cycle, Pregnancy, Pregnancy Complications, Prognosis, Reproduction, Risk Factors, Risk Assessment, Endocrine Disruptors

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Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

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