Unlocking Longevity with GLP-1: A Key to Turn Back the Clock?

The Physiology of Glucagon-like Peptide 1

Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works

Glucagon-like peptide 1 (GLP-1)

Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868 · see citing works

Senescence in Health and Disease

He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works

The World Health Organization (WHO) approach to healthy ageing

Rudnicka, E., Napierała, P., Podfigurna, A., Męczekalski, B., Smolarczyk, R., & Grymowicz, M. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.05.018 · Cited by 1,750 · see citing works

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

Meier, J. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.140 · Cited by 1,311 · see citing works

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 891 · see citing works

GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects

Zhao, X., Wang, M., Wen, Z., Lu, Z., Cui, L., Fu, C., Xue, H., Liu, Y., & Zhang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.721135 · Cited by 463 · see citing works

Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes

Hinnen, D. (2017) · Diabetes Spectrum · doi:10.2337/ds16-0026 · Cited by 394 · see citing works

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

McClean, P. L., & Hölscher, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.005 · Cited by 359 · see citing works

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Robbins, P. D., Jurk, D., Khosla, S., Kirkland, J. L., LeBrasseur, N. K., Miller, J. D., Passos, J. F., Pignolo, R. J., Tchkonia, T., & Niedernhofer, L. J. (2021) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-050120-105018 · Cited by 339 · see citing works

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

Ma, X., Liu, Z., Ilyas, I., Little, P. J., Kamato, D., Sahebka, A., Chen, Z., Luo, S., Zheng, X., Weng, J., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59965 · Cited by 299 · see citing works

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

Abbas, T. F., Faivre, É., & Hölscher, C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.035 · Cited by 282 · see citing works

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

Sharma, S., Mells, J. E., Fu, P. P., Saxena, N. K., & Anania, F. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025269 · Cited by 272 · see citing works

Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing

Kamal, A., Biessels, G. J., Duis, S., & Gispen, W. H. (2000) · Diabetologia · doi:10.1007/s001250051335 · Cited by 223 · see citing works

Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases

Grieco, M., Giorgi, A., Gentile, M. C., d’Erme, M., Morano, S., Maras, B., & Filardi, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01112 · Cited by 218 · see citing works

Tirzepatide, a new era of dual-targeted treatment for diabetes and obesity: A mini-review

Chavda, V. P., Ajabiya, J., Teli, D., Bojarska, J., & Apostolopoulos, V. (2022) · Molecules · doi:10.3390/molecules27134315 · Cited by 208 · see citing works

Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer’s and Parkinson’s disease therapeutics

Salameh, T. S., Rhea, E. M., Talbot, K., & Banks, W. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114187 · Cited by 188 · see citing works

Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model.

Hirata, K., Kume, S., Araki, S., Sakaguchi, M., Chin-Kanasaki, M., Isshiki, K., Sugimoto, T., Nishiyama, A., Koya, D., Haneda, M., et al. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2009.01.003 · Cited by 160 · see citing works

Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis

Meurot, C., Martin, C., Sudre, L., Breton, J., Bougault, C., Rattenbach, R., Bismuth, K., Jacques, C., & Berenbaum, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-05323-7 · Cited by 160 · see citing works

Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats

Zhang, W.-J., Tan, Y., Yue, J. T. Y., Vranić, M., & Wojtowicz, J. M. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00928.x · Cited by 150 · see citing works

Enhancing the GLP‐1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells

Li, Y., Tweedie, D., Mattson, M. P., Holloway, H. W., & Greig, N. H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06731.x · Cited by 149 · see citing works

GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes

Olmo-García, M. I. D., & Merino-Torres, J. F. (2018) · Journal of Diabetes Research · doi:10.1155/2018/4020492 · Cited by 144 · see citing works

CAPABLE trial: A randomized controlled trial of nurse, occupational therapist and handyman to reduce disability among older adults: Rationale and design

Szanton, S. L., Wolff, J. W., Leff, B., Thorpe, R. J., Tanner, E. K., Boyd, C., Xue, Q., Guralnik, J., Bishai, D., & Gitlin, L. N. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.03.005 · Cited by 138 · see citing works

Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes

Luna-Marco, C., de Marañon, A. M., Hermo-Argibay, A., Rodriguez-Hernandez, Y., Hermenejildo, J., Fernández-Reyes, M., Apostolova, N., Vila, J. M., Solá, E., Morillas, C., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102849 · Cited by 130 · see citing works

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

Kimura, R., Okouchi, M., Fujioka, H., Ichiyanagi, A., Ryuge, F., Mizuno, T., Imaeda, K., Okayama, N., Kamiya, Y., Asai, K., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.025 · Cited by 129 · see citing works

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

McClean, P. L., Jalewa, J., & Hölscher, C. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.024 · Cited by 125 · see citing works

GLP-1 receptor agonist-associated tumor adverse events: A real-world study from 2004 to 2021 based on FAERS

Yang, Z., Lv, Y., Yu, M., Mei, M., Xiang, L., Zhao, S., & Li, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.925377 · Cited by 120 · see citing works

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

Parthsarathy, V., & Hölscher, C. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.12.012 · Cited by 119 · see citing works

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

Miao, X., Gu, Z., Liu, P., Hu, Y., Li, L., Gong, Y., Shu, H., Liu, Y., & Li, C. (2012) · Peptides · doi:10.1016/j.peptides.2012.10.006 · Cited by 103 · see citing works

GLP-1a: Going beyond Traditional Use

Laurindo, L. F., Barbalho, S. M., Guiguer, E. L., da Silva Soares de Souza, M., de Souza, G. A., Fidalgo, T. M., Araújo, A. C., de Souza Gonzaga, H. F., de Bortoli Teixeira, D., de Oliveira Silva Ullmann, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020739 · Cited by 102 · see citing works

GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R/AMPK pathway

Wu, L., Zhou, M., Li, T., Dong, N., Yi, L., Zhang, Q., & Mi, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119300 · Cited by 101 · see citing works

Glucagon-like Peptide 1 Receptor Agonists, Diabetic Retinopathy and Angiogenesis: The AngioSafe Type 2 Diabetes Study

Gaborit, B., Julla, J.-B., Besbes, S., Proust, M., Vincentelli, C., Alos, B., Ancel, P., Alzaid, F., Garcia, R., Mailly, P., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz069 · Cited by 95 · see citing works

Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?

Meurot, C., Jacques, C., Martin, C., Sudre, L., Breton, J., Rattenbach, R., Bismuth, K., & Berenbaum, F. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.02.001 · Cited by 94 · see citing works

GLP-1 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress

Jiang, Y., Wang, Z., Ma, B., Fan, L., Yi, N., Lu, B., Wang, Q., & Liu, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01168 · Cited by 88 · see citing works

GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer’s disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway

Xie, Y., Zheng, J., Li, S., Li, H., Zhou, Y., Zheng, W., Zhang, M., Liu, L., & Chen, Z. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114578 · Cited by 87 · see citing works

The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases

Cheng, D., Yang, S., Zhao, X., & Wang, G. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s348055 · Cited by 84 · see citing works

Effect of metformin versus metformin plus liraglutide on gonadal and metabolic profiles in overweight patients with polycystic ovary syndrome

Xing, C., Zhao, H., Zhang, J., & He, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.945609 · Cited by 82 · see citing works

Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer’s disease

An, J., Zhou, Y., Zhang, M., Xie, Y., Ke, S., Liu, L., Pan, X., & Zhou, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111932 · Cited by 79 · see citing works

Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents

Gurjar, A. A., Kushwaha, S., Chattopadhyay, S., Das, N., Pal, S., China, S. P., Kumar, H., Trivedi, A. K., Guha, R., Chattopadhyay, N., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2019.154044 · Cited by 79 · see citing works

Activation of glucagon-like peptide-1 receptor ameliorates cognitive decline in type 2 diabetes mellitus through a metabolism-independent pathway

Li, Q., Jia, M., Yan, Z., Li, Q., Sun, F., He, C., Li, Y., Zhou, X., Zhang, H., Liu, X., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020734 · Cited by 77 · see citing works

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

Porter, W. D., Flatt, P. R., Hölscher, C., & Gault, V. A. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.91 · Cited by 76 · see citing works

Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1

Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K., & Gotoh, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808400106 · Cited by 75 · see citing works

Differential Risk of Cancer Associated with Glucagon-like Peptide-1 Receptor Agonists: Analysis of Real-world Databases

Wang, J., & Kim, C. H. (2022) · Endocrine Research · doi:10.1080/07435800.2021.1955255 · Cited by 74 · see citing works

Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1

Yang, J., Chen, W., Chen, Y.-P., Kuo, C.-Y., & Chen, S. (2016) · Theranostics · doi:10.7150/thno.15993 · Cited by 73 · see citing works

GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction

Zhang, L., Tian, J., Diao, S., Zhang, G., Xiao, M., & Chang, D. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109252 · Cited by 73 · see citing works

Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases

Peng, W., Zhou, R., Sun, Z., Long, J.-W., & Gong, Y.-Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.0928 · Cited by 73 · see citing works

Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells

Kang, M. Y., Oh, T. J., & Cho, Y. M. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.2.216 · Cited by 70 · see citing works

Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways

Wu, Y., Wang, W., Lee, S., Kuo, Y., Wang, Y., Yen, S., Lee, M., & Yeh, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143435 · Cited by 70 · see citing works

GLP-1 receptor agonists for Parkinson's disease

Mulvaney, C. A., Duarte, G. S., Handley, J. D., Evans, D. J., Menon, S., Wyse, R. K. H., & Emsley, H. C. A. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012990.pub2 · Cited by 69 · see citing works

GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling

Wang, Y., Chen, S., Zheng, X., Chen, S., Yao, W., & Gao, X. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.048 · Cited by 67 · see citing works

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression

Zeng, Y. Z., Yang, K., Wang, F., Zhou, L., Hu, Y. H., Tang, M., Zhang, S., Jin, S., Zhang, J., Wang, J., et al. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.05.002 · Cited by 65 · see citing works

Aging and stress induced β cell senescence and its implication in diabetes development

Li, N., Liu, F., Yang, P. C., Xiong, F., Yu, Q., Li, J., Zhou, Z., Zhang, S., & Wang, C. (2019) · Aging · doi:10.18632/aging.102432 · Cited by 62 · see citing works

Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice

Åhrén, B., & Pacini, G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e996 · Cited by 59 · see citing works

Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway

Yang, S., Lin, C., Zhuo, X., Wang, J., Rao, S., Xu, W., Cheng, Y., & Yang, L. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2019 · Cited by 57 · see citing works

Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors

Bonds, J. A., Shetti, A., Bheri, A., Chen, Z., Disouky, A., Tai, L. M., Mao, M., Head, B. P., Bonini, M. G., Haus, J. M., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-19.2019 · Cited by 56 · see citing works

GLP-1 and Underlying Beneficial Actions in Alzheimer’s Disease, Hypertension, and NASH

Li, Q.-X., Gao, H., Guo, Y.-X., Wang, B.-Y., Hua, R.-X., Gao, L., Shang, H.-W., Lu, X., & Xu, J.-D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.721198 · Cited by 56 · see citing works

Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer’s Disease and Type 2 Diabetes

Carranza-Naval, M. J., del Marco, À., Hierro‐Bujalance, C., Alves-Martínez, P., Infante‐Garcia, C., Vargas-Soria, M., Herrera, M., Barba-Cordoba, B., Atienza‐Navarro, I., Lubián‐López, S. P., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.741923 · Cited by 54 · see citing works

GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome

Seppa, K., Toots, M., Reimets, R., Jagomäe, T., Koppel, T., Pallase, M., Hasselholt, S., Krogsbaek, M., Nyengaard, J. R., Vasar, E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52295-2 · Cited by 53 · see citing works

A Phase II, Randomized, Double-Blinded, Placebo-Controlled Trial of Liraglutide in Parkinson's Disease

Hogg, E., Wu, T., Bresee, C., Wertheimer, J., Malatt, C., Tan, E., Pomeroy, H., Nuno, M., Wyse, R., & Tagliati, M. (2022) · doi:10.2139/ssrn.4212371 · Cited by 52 · see citing works

Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice

Lennox, R., Flatt, P. R., & Gault, V. A. (2014) · Peptides · doi:10.1016/j.peptides.2014.08.014 · Cited by 47 · see citing works

Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model

Luciani, P., Deledda, C., Benvenuti, S., Cellai, I., Squecco, R., Monici, M., Cialdai, F., Luciani, G., Danza, G., Stefano, C. D., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0398-3 · Cited by 47 · see citing works

Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress

Ramos, H., Bogdanov, P. M., Sampedro, J., Huerta, J., Simó, R., & Hernández, C. (2020) · Antioxidants · doi:10.3390/antiox9090846 · Cited by 47 · see citing works

Brain Insulin Administration Triggers Distinct Cognitive and Neurotrophic Responses in Young and Aged Rats

Haas, C. B., Kalinine, E., Zimmer, E. R., Hansel, G., Brochier, A., Oses, J. P., Portela, L. V., & Muller, A. P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9494-6 · Cited by 46 · see citing works

Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex

Ohtake, N., Saito, M., Eto, M., & Seki, K. (2014) · Regulatory Peptides · doi:10.1016/j.regpep.2014.04.003 · Cited by 45 · see citing works

Activation of GLP-1 receptor enhances the chemosensitivity of pancreatic cancer cells

Zhao, H.-J., Jiang, X., Hu, L., Yang, L., Deng, L.-D., Wang, Y.-P., & Ren, Z. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0186 · Cited by 45 · see citing works

Anti-Inflammatory Effects of GLP-1R Activation in the Retina

Puddu, A., & Maggi, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012428 · Cited by 42 · see citing works

Liraglutide, a glucagon-like peptide-1 analog, induce autophagy and senescence in HepG2 cells

Krause, G. C., Lima, K. G., Dias, H. B., da Silva, E. F. G., Haute, G. V., Basso, B. D. S., Gassen, R. B., Marczak, E. S., Nunes, R. S. B., & de Oliveira, J. R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.015 · Cited by 41 · see citing works

Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis

Wang, T., Yang, L., Liang, Z., Wang, L., Su, F., Wang, X., You, X., & He, C. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00528-0 · Cited by 40 · see citing works

Combination Therapy With Exenatide Plus Pioglitazone Versus Basal/Bolus Insulin in Patients With Poorly Controlled Type 2 Diabetes on Sulfonylurea Plus Metformin: The Qatar Study

Abdul‐Ghani, M. A., Migahid, O., Megahed, A., Adams, J. M., Triplitt, C. L., DeFronzo, R. A., Zirie, M. A., & Jayyousi, A. (2017) · Diabetes Care · doi:10.2337/dc16-1738 · Cited by 39 · see citing works

Nutrient control of neural stem cells

Spéder, P., Liu, J., & Brand, A. H. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.08.004 · Cited by 35 · see citing works

Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon‐like peptide‐1 on glomeruli and tubules in diabetic rats

Yin, W., Jiang, Y., Xu, S., Wang, Z., Peng, L., Fang, Q., Deng, T., Zhao, W., Zhang, W., & Lou, J. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12956 · Cited by 33 · see citing works

Effect of combined therapy of mesenchymal stem cells with GLP-1 receptor agonist, exenatide, on early-onset nephropathy induced in diabetic rats

Habib, H. A., Heeba, G. H., & Khalifa, M. M. A. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173721 · Cited by 33 · see citing works

The Effect of Exenatide Once Weekly on Carotid Atherosclerosis in Individuals With Type 2 Diabetes: An 18-Month Randomized Placebo-Controlled Study

Koška, J., Migrino, R. Q., Chan, K. C., Cooper-Cox, K., & Reaven, P. D. (2021) · Diabetes Care · doi:10.2337/dc20-2014 · Cited by 32 · see citing works

Contribution of Mitochondria to Insulin Secretion by Various Secretagogues

Ježek, P., Holendová, B., Jabůrek, M., Dlasková, A., & Plecitá‐Hlavatá, L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0113 · Cited by 32 · see citing works

Efficacy and Safety of GPR119 Agonist DS-8500a in Japanese Patients with Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Controlled, 12-Week Study

Yamada, Y., Terauchi, Y., Watada, H., Nakatsuka, Y., Shiosakai, K., Washio, T., & Taguchi, T. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0668-2 · Cited by 31 · see citing works

Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in�vitro

Shi, J., & Huang, Q. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9085 · Cited by 31 · see citing works

Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway

Ao, N., Ma, Z., Yang, J., Jin, S., Zhang, K., Luo, E., & Du, J. (2020) · Peptides · doi:10.1016/j.peptides.2020.170375 · Cited by 29 · see citing works

Glucagonostatic potency of GLP-1 in patients with type 2 diabetes, patients with type 1 diabetes, and healthy control subjects

Bagger, J. I., Grøndahl, M. F. G., Lund, A., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2021) · Diabetes · doi:10.2337/db20-0998 · Cited by 27 · see citing works

Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model

Navabi, R., Negahdari, B., Hajizadeh‐Saffar, E., Hajinasrollah, M., Jenab, Y., Rabbani, S., Pakzad, M., Hassani, S., Hezavehei, M., Atrabi, M. J., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119374 · Cited by 27 · see citing works

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Wang, M., Yoon, G., Song, J., & Jo, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87809-4 · Cited by 27 · see citing works

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Chavda, V. P., Zajac, K. K., Gunn, J., Balar, P. C., Khadela, A. D., Vaghela, D. A., Soni, S., Ashby, C. R., & Tiwari, A. K. (2023) · Cancer Reports · doi:10.1002/cnr2.1821 · Cited by 26 · see citing works

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Sacai, H., Sasaki‐Hamada, S., Sugiyama, A., Saitoh, A., Mori, K. J., Yamada, M., & Oka, J. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.02.002 · Cited by 25 · see citing works

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Reisi, P., Alaei, H., Babri, S., Sharifi, M. R., Mohaddes, G., & Soleimannejad, E. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.03.003 · Cited by 21 · see citing works

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Peng, Z., Yang, C.-T., Lin, W., Yao, W., Ou, H., & Kuo, S. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01991-5 · Cited by 21 · see citing works

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Ishihara, H., Yamaguchi, S., Nakao, I., & Sakatani, T. (2018) · Diabetes Therapy · doi:10.1007/s13300-018-0455-8 · Cited by 14 · see citing works

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Aslam, B., Zafar, M. D. B., Changez, M. I. K., ABDULLAH, M., Safwan, M., QAMAR, B., SHINWARI, A., & Sanjana, R. A. I. (2023) · Minerva Endocrinology · doi:10.23736/s2724-6507.23.04101-5 · Cited by 14 · see citing works

Exenatide regulates inflammation and the production of reactive oxygen species via inhibition of S1PR2 synthesis

Yang, Y., & Qingyi, Z. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/133483 · Cited by 9 · see citing works

Self-assembled peptide hydrogels for the treatment of diabetes and associated complications.

Chavda, V., Teli, D. M., Balar, P. C., Davidson, M., Bojarska, J., Vaghela, D. A., & Apostolopoulos, V. (2024) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2024.113761 · Cited by 8 · see citing works

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Kikkawa, K., Hoshi, H., Isoda, A., Okada, K., Okada, J., Watanabe, T., Yamada, E., Ohshima, K., & Okada, S. (2021) · Dubai Diabetes and Endocrinology Journal · doi:10.1159/000519008 · Cited by 7 · see citing works

Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome

Jagomäe, T., Gaur, N., Seppa, K., Reimets, R., Pastak, M., Plaas, M., Kaasik, A., Vasar, E., & Plaas, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1234925 · Cited by 5 · see citing works

GLP-1 directs differentiation of human embryonic stem cells

Heath, V. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.285 · Cited by 1 · see citing works

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Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44 · see citing works

Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential

AL-Noshokaty, T. M., Abdelhamid, R., Abdelmaksoud, N. M., Khaled, A., Hossam, M., Ahmed, R., Saber, T., Khaled, S., Elshaer, S. S., & Abulsoud, A. I. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101895 · Cited by 30 · see citing works

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Hawkins, D. (2017)

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Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

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Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

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Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

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Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works