Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents

Gurjar, Anagha Ashok; Kushwaha, Sapana; Chattopadhyay, Sourav; Das, Nabanita; Pal, Subhashis; China, Shyamsundar Pal; Kumar, Harish; Trivedi, Arun Kumar; Guha, Rajdeep; Chattopadhyay, Naibedya; Sanyal, Sabyasachi

doi:10.1016/j.metabol.2019.154044

Cited by 79Muscle Physiology and DisordersNutrition and Health in AgingAdipose Tissue and Metabolism

Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents

Gurjar, Anagha Ashok, Kushwaha, Sapana, Chattopadhyay, Sourav, Das, Nabanita, Pal, Subhashis, China, Shyamsundar Pal, Kumar, Harish, Trivedi, Arun Kumar +3 more·2020·Metabolism

DOI 10.1016/j.metabol.2019.154044

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Abstract

Background Skeletal muscle atrophy is characterized by muscle wasting with partial or complete functional loss. Skeletal muscle atrophy severely affects the quality of life and currently, there is no available therapy except for spinal muscular atrophy.Objective Drug repositioning is a promising strategy that reduces cost and time due to prior availability of safety and toxicity details. Here we investigated myogenic and anti-atrophy effects of glucagon-like peptide-1 (GLP-1) analog liraglutide.Methods We used several in vitro atrophy models in C2C12 cells and in vivo models in Sprague Dawley rats to study Liraglutide's efficacy. Western blotting was used to assess cAMP-dependent signaling pathways specifically activated by liraglutide. Therapeutic efficacy of liraglutide was investigated by histological analysis of transverse muscle sections followed by morphometry. Myogenic capacity was investigated by immunoblotting for myogenic factors.Results Liraglutide induced myogenesis in C2C12 myoblasts through GLP-1 receptor via a cAMP-dependent complex network of signaling events involving protein kinase A, phosphoinositide 3-kinase/protein kinase B, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. Liraglutide imparted protection against freeze injury, denervation, and dexamethasone -induced skeletal muscle atrophy and improved muscular function in all these models. In a therapeutic model, liraglutide restored myofibrillar architecture in ovariectomy-induced atrophy. Anti-atrophy actions of liraglutide involved suppression of atrogene expression and enhancement in expression of myogenic factors.Conclusion Liraglutide imparted protection and restored myofibrillar architecture in diverse models of muscle atrophy. Given its potent anti-atrophy, and recently reported osteoanabolic effects, we propose liraglutide's clinical evaluation in skeletal muscle atrophy and musculoskeletal disorders associated with diverse pathologies.

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Another rodent study showed that GLP1 directly induces myogenesis via a cAMP-dependent signalling network in skeletal muscle.
“Another study in rodents showed that GLP1 directly induces myogenesis via a complex cAMP-dependent signalling network in skeletal muscle209.”
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Authors: Gurjar, A. A., Kushwaha, S., Chattopadhyay, S., Das, N., Pal, S., China, S. P., Kumar, H., Trivedi, A. K., Guha, R., Chattopadhyay, N., & Sanyal, S.
Affiliations: Central Drug Research Institute (IN)
Corresponding author: Sanyal, Sabyasachi
ORCID: Kushwaha, Sapana
Chattopadhyay, Sourav
Das, Nabanita
Pal, Subhashis
China, Shyamsundar Pal
Kumar, Harish
Trivedi, Arun Kumar
Guha, Rajdeep
Chattopadhyay, Naibedya
Sanyal, Sabyasachi
Venue: Metabolism
Publisher: Elsevier BV
Published: 2020-02
Volume: 103
Pages: 154044
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2019.154044
OpenAlex: W2992978377
Cited by: 79
References: 58
Citations by year: 2026: 15 · 2025: 25 · 2024: 21 · 2023: 10 · 2022: 7 · 2021: 1
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: University Grants Commission
Council of Scientific and Industrial Research, India
Department of Biotechnology, Ministry of Science and Technology, India
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: liraglutide, skeletal muscle atrophy, GLP-1 receptor, drug repurposing, myogenesis, cAMP signaling, protein kinase A, PI3K/Akt signaling, MAPK signaling, denervation-induced atrophy, dexamethasone-induced atrophy, frost damage, ovariectomy, atrogenes, myogenic factors
MeSH terms: Liraglutide, Animals, Cells, Cultured, Delayed-Action Preparations, Male, Muscular Atrophy, Rodentia, Rats, Sprague-Dawley, Muscle, Skeletal, Muscle Development, Myoblasts, Rats, Glucagon-Like Peptide 1

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Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents

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