The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Mechanisms of Disease: Inflammatory Bowel Diseases
Open accessAbstract
Inflammatory Bowel Diseases (IBD), represented by Crohn’s Disease (CD) and Ulcerative Colitis (UC), are associated with significant morbidity in western countries and with increasing incidence in the developing world. While analysis of the genome of IBD patients, especially through genome-wide association studies, has unraveled multiple pathways involved in IBD pathogenesis only part of IBD heritability has been explained by genetic studies. This has demonstrated that environmental factors also play a significant role in promoting intestinal inflammation, mostly through their effects in the composition of the microbiome. However, in order for microbial dysbiosis to result in uncontrolled intestinal inflammation, the intestinal barrier formed by intestinal epithelial cells and the innate immune system should also be compromised. Finally, activation of the immune system depends on the working balance between effector and regulatory cells present in the intestinal mucosa, which have also been shown to be dysregulated in this patient population. Therefore, IBD pathogenesis is a result of the interplay of genetic susceptibility, environmental impact on the microbiome that through a weakened intestinal barrier will lead to inappropriate intestinal immune activation. In this review, we will approach the mechanisms proposed to cause IBD from the genetic, environmental, intestinal barrier and the immunologic perspectives.
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Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124
Xie, W.-R., Yang, X.-Y., Xia, H. H.-X., Wu, L.-H., & He, X.-X. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i19.3074 · Cited by 67
Metadata
- Authors
- Ramos, G. P., & Papadakis, K. A.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 94
- Issue
- 1
- Pages
- 155-165
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2906727442
- Cited by
- 1,021
- References
- 118
- FWCI
- 51.74
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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