Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature
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BACKGROUND: ) infection, and has also shown potentials in the treatment of inflammatory bowel disease, irritable bowel syndrome, and non-alcohol fatty liver disease. CASE SUMMARY: An 86-year-old man, with a history of sigmoid colon carcinoma, suffered from recurrent abdominal pain and distension, and diarrhea for six months, with inappetence. At admission, he was also diagnosed with depression. Upon physical examination, the patient presented with a 1.5 cm × 2.0 cm alopecia areata on his right occiput. Due to the negative results of laboratory testing, capsule endoscopy, and colonoscopy, the patient was diagnosed with noninfectious diarrhea, depressive disorder, and patchy alopecia areata. Considering that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis, he was given six rounds of FMT. His diarrhea improved remarkably one month after FMT, with improved appetite and disappearance of abdominal pain, distension, and depressive symptoms. Surprisingly, he reported new hair growth on the affected region of his scalp, with some of his white hair gradually turning to black, without taking any other therapies for alopecia areata before and after FMT. CONCLUSION: FMT might act as a potential therapy for patients who suffer from alopecia areata. Large and well-designed studies are required to confirm the role of FMT in alopecia areata.
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Xie et al. found a persistent decrease in depression symptoms lasting up to 17 months after the final round of FMT.
“Xie et al., however, found a persistent decrease in depression symptoms lasting up to 17 months after the final round of FMT [47].”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as [47]
The majority of studies found symptom alleviation to be transient.
“but the majority found this to be transient (Xie et al. 2019 [45]; H. L. Huang et al. 2019 [46]; Mazzawi et al. 2018 [44]; Mizuno et al. 2017 [47]).”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as Xie et al. 2019 [45]
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Cites
Unique Biosynthesis by Kidney of a Biologically Active Vitamin D Metabolite
Fraser, D. R., & Kodicek, E. H. (1970) · Nature · doi:10.1038/228764a0 · Cited by 1,284 · see citing works
Diet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works
European consensus conference on faecal microbiota transplantation in clinical practice
Cammarota, G., Ianiro, G., Tilg, H., Rajilić-Stojanović, M., Kump, P., Satokari, R., Sokol, H., Arkkila, P., Pintus, C., Hart, A., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313017 · Cited by 1,207 · see citing works
Mechanisms of Disease: Inflammatory Bowel Diseases
Ramos, G. P., & Papadakis, K. A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.09.013 · Cited by 1,045 · see citing works
Scher, J. U., Úbeda, C., Artacho, A., Attur, M. G., Isaac, S., Reddy, S. M., Marmon, S., Neimann, A. L., Brusca, S. B., Patel, T., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38892 · Cited by 820 · see citing works
Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works
Pratt, C. H., King, L. E., Messenger, A. G., Christiano, A. M., & Sundberg, J. P. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.11 · Cited by 791 · see citing works
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., Kheradman, R., Heuman, D. M., Wang, J., Gurry, T., et al. (2017) · Hepatology · doi:10.1002/hep.29306 · Cited by 637 · see citing works
Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works
Bech, P., Kastrup, M., & Rafaelsen, O. J. (1986) · PubMed · Cited by 466 · see citing works
Johnsen, P. H., Hilpüsch, F., Cavanagh, J. P., Leikanger, I. S., Kolstad, C., Valle, P. C., & Goll, R. (2018) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(17)30338-2 · Cited by 437 · see citing works
The role of the intestinal microbiota in the development of atopic disorders
Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 435 · see citing works
Song, H., Yoo, Y., Hwang, J., Na, Y.-C., & Kim, H. S. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.021 · Cited by 416 · see citing works
Hvas, C. L., Dahl Jørgensen, S. M., Jørgensen, S. P., Storgaard, M., Lemming, L., Hansen, M. M., Erikstrup, C., & Dahlerup, J. F. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.019 · Cited by 390 · see citing works
Halkjær, S. I., Christensen, A. H., Lo, B. Z. S., Browne, P. D., Günther, S., Hansen, L. H., & Petersen, A. M. (2018) · Gut · doi:10.1136/gutjnl-2018-316434 · Cited by 340 · see citing works
Clinical Application and Potential of Fecal Microbiota Transplantation
Ooijevaar, R. E., Terveer, E. M., Verspaget, H. W., Kuijper, E. J., & Keller, J. J. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-111717-122956 · Cited by 337 · see citing works
Fecal microbiota transplantation in cancer management: Current status and perspectives
Chen, D., Wu, J., Jin, D., Wang, B., & Cao, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.32003 · Cited by 330 · see citing works
Gerassy-Vainberg, S., Blatt, A., Danin‐Poleg, Y., Gershovich, K., Sabo, E., Nevelsky, A., Daniel, S., Dahan, A., Ziv, O., Dheer, R., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-313789 · Cited by 321 · see citing works
Alopecia areata: A multifactorial autoimmune condition
Simakou, T., Butcher, J. P., Reid, S., & Henriquez, F. L. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.12.001 · Cited by 311 · see citing works
Cui, B., Feng, Q., Wang, H., Wang, M., Peng, Z., Li, P., Huang, G., Liu, Z., Wu, P., Fan, Z., et al. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12727 · Cited by 298 · see citing works
Vitamin status in patients with inflammatory bowel disease.
Fernández‐Bañares, F., Abad-Lacruz, A., Xiol, X., Gine, J. J., Dolz, C., Cabré, E., Esteve, M., Gónzalez‐Huix, F., & Gassull, M. A. (1989) · PubMed · Cited by 201 · see citing works
Stress in patients with alopecia areata and vitiligo
Manolache, L., & Benea, V. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.02106.x · Cited by 201 · see citing works
Biotin and biotinidase deficiency
Zempleni, J., Hassan, Y. I., & Wijeratne, S. S. K. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.6.715 · Cited by 201 · see citing works
Xie, Z., Kömüves, L. G., Yu, Q., Elalieh, H. Z., Ng, D. C., Leary, C., Chang, S., Crumrine, D. A., Bikle, D. D., Yoshizawa, T., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01644.x · Cited by 200 · see citing works
Alopecia Areata: a Comprehensive Review of Pathogenesis and Management
Trüeb, R. M., & Dias, M. F. R. G. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8620-9 · Cited by 192 · see citing works
Battaglioli, E. J., Hale, V. L., Chen, J., Jeraldo, P., Ruiz-Mojica, C. A., Schmidt, B. A., Rekdal, V. M., Till, L. M., Huq, L., Smits, S. A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7019 · Cited by 173 · see citing works
Diet and microbiota in inflammatory bowel disease: The gut in disharmony
Rapozo, D. C. M., Bernardazzi, C., & de Souza, H. S. P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i12.2124 · Cited by 160 · see citing works
Cui, B., Li, P., Xu, L., Zhao, Y., Wang, H., Peng, Z., Xu, H., Xiang, J., He, Z., Zhang, T., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0646-2 · Cited by 148 · see citing works
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris
Visser, M. J. E., Kell, D. B., & Pretorius, E. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00007 · Cited by 141 · see citing works
Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.057 · Cited by 133 · see citing works
Appleyard, C. B., Cruz, M. L., Isidro, A., Arthur, J. C., Jobin, C., & Simone, C. D. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00167.2011 · Cited by 131 · see citing works
Moayyedi, P., Yuan, Y., Baharith, H., & Ford, A. C. (2017) · The Medical Journal of Australia · doi:10.5694/mja17.00295 · Cited by 127 · see citing works
Psychosomatic Factors in First-Onset Alopecia Areata
Picardi, A., Pasquini, P., Cattaruzza, M. S., Gaetano, P., Baliva, G., Melchi, C. F., Papi, M., Camaioni, D., Tiago, A., Gobello, T., et al. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.5.374 · Cited by 126 · see citing works
The Role of Micronutrients in Alopecia Areata: A Review
Thompson, J. M., Mirza, M. A., Park, M. K., Qureshi, A. A., & Cho, E. (2017) · American Journal of Clinical Dermatology · doi:10.1007/s40257-017-0285-x · Cited by 123 · see citing works
Chen, C. H., Sakai, Y., & Demay, M. B. (2001) · Endocrinology · doi:10.1210/endo.142.12.8650 · Cited by 116 · see citing works
Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant
Rebello, D., Wang, E. J., Yen, E. F., Lio, P., & Kelly, C. R. (2017) · ACG Case Reports Journal · doi:10.14309/crj.2017.107 · Cited by 113 · see citing works
Gut microbiota dysbiosis and diarrhea in kidney transplant recipients
Lee, J. R., Magruder, M. L., Zhang, L., Westblade, L. F., Satlin, M. J., Robertson, A., Edusei, E., Crawford, C. V., Ling, L., Taur, Y., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14974 · Cited by 109 · see citing works
Pandhi, D., & Khanna, D. (2013) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.116733 · Cited by 101 · see citing works
Pulse Corticosteroid Therapy for Alopecia Areata: Study of 139 Patients
Nakajima, T., Inui, S., & Itami, S. (2007) · Dermatology · doi:10.1159/000107626 · Cited by 97 · see citing works
Vitamin D signaling in osteocytes: Effects on bone and mineral homeostasis
Lieben, L., & Carmeliet, G. (2012) · Bone · doi:10.1016/j.bone.2012.10.007 · Cited by 95 · see citing works
Zhu, W., Yan, J., Zhi, C., Zhou, Q., & Yuan, X. (2019) · Gut Pathogens · doi:10.1186/s13099-019-0291-z · Cited by 90 · see citing works
Reversing Bacteria‐induced Vitamin D Receptor Dysfunction Is Key to Autoimmune Disease
Waterhouse, J. C., Perez, T. H., & Albert, P. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04637.x · Cited by 74 · see citing works
Treatment of Slow Transit Constipation With Fecal Microbiota Transplantation: A Pilot Study
Tian, H., Ding, C., Gong, J., Ge, X., Mcfarland, L. V., Gu, L.-L., Wei, Y., Chen, Q.-Y., Zhu, W.-M., Li, J.-S., et al. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000472 · Cited by 69 · see citing works
Lee, S., Kim, B. J., Lee, C. H., & Lee, W. S. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14987 · Cited by 66 · see citing works
Alopecia areata and the gut—the link opens up for novel therapeutic interventions
Borde, A., & Åstrand, A. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1481504 · Cited by 58 · see citing works
HIV and diarrhoea: what is new?
Logan, C., Beadsworth, M., & Beeching, N. J. (2016) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000305 · Cited by 56 · see citing works
Singh, P., Kumar, M., & Khodor, S. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01042 · Cited by 54 · see citing works
Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia
Fawzi, M. M., Mahmoud, S. B., Ahmed, S. F., & Shaker, O. G. (2016) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12224 · Cited by 47 · see citing works
Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead
Borody, T. J., Fischer, M., Mitchell, S., & Campbell, J. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1086267 · Cited by 44 · see citing works
Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives
Groen, R. N., de Clercq, N. C., Nieuwdorp, M., Hoenders, R. H. J., & Groen, A. K. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1463507 · Cited by 43 · see citing works
Vitamin D deficiency in patients with alopecia areata: A systematic review and meta-analysis
Tsai, T., & Huang, Y. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.07.051 · Cited by 34 · see citing works
Fecal Microbiota Transplantation: Beyond Clostridium difficile
Millan, B., Laffin, M., & Madsen, K. L. (2017) · Current Infectious Disease Reports · doi:10.1007/s11908-017-0586-5 · Cited by 31 · see citing works
Psychological and psychopathological factors in alopecia areata
Kuty-Pachecka, M. (2015) · Psychiatria Polska · doi:10.12740/pp/39064 · Cited by 29 · see citing works
Yang, C., Lee, C.-T., Hsu, C., Lee, Y.-P., Wong, T., Chao, S., Lee, J. Y., Sheu, H., & Chen, W. (2013) · Annals of Dermatology · doi:10.5021/ad.2013.25.4.471 · Cited by 26 · see citing works
Persistent diarrhea: a persistent infection with enteropathogens or a gut commensal dysbiosis?
Sarker, S. A., Ahmed, T., & Brüssow, H. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13873 · Cited by 26 · see citing works
Alopecia areata and relationship with stressful events in children
Manolache, L., Petrescu‐Seceleanu, D., & Benea, V. (2008) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.02748.x · Cited by 25 · see citing works
Ulcerative colitis and total alopecia in a mother and her son
Treem, W. R., Ln, V., Rotter, J. I., Targan, S. R., & Hyams, J. S. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90291-j · Cited by 24 · see citing works
Hair Loss in Patients with Inflammatory Bowel Disease
Patel, K., FARRANT, P. B. J., Sanderson, J. D., & Irving, P. M. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828132de · Cited by 23 · see citing works
Alopecia areata in patients with inflammatory bowel disease: an overview.
Sobolewska-Włodarczyk, A., Włodarczyk, M., Fichna, J., & Wiśniewska‐Jarosińska, M. (2016) · PubMed · Cited by 17 · see citing works
Mechanisms of tolerance and potential therapeutic interventions in Alopecia Areata
Skogberg, G., Jackson, S. G., & Åstrand, A. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.008 · Cited by 17 · see citing works
[Clinical case of a combination of ulcerative colitis and alopecia areata].
Дамировна, С. Д., Abdulkhakov, R. A., Abdulkhakov, Odintsova, A. K., & Александровна, Ч. Н. (2013) · PubMed · Cited by 10 · see citing works
Xie, W.-R., Yang, X., Xia, H. H., & He, X. (2018) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2018.00017 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817 · see citing works
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 498 · see citing works
Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review
Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254 · see citing works
Role of gut microbiota in infectious and inflammatory diseases
Maciel-Fiuza, M. F., Müller, G. C., Campos, D. M. S., Costa, P. D. S. S., Peruzzo, J., Bonamigo, R. R., Veit, T. D., & Vianna, F. S. L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1098386 · Cited by 253 · see citing works
The Human Skin Microbiome in Selected Cutaneous Diseases
Carmona-Cruz, S., Orozco-Covarrubias, L., & Sáez-de-Ocariz, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.834135 · Cited by 170 · see citing works
Exploring the human hair follicle microbiome*
Lousada, M. B., Lachnit, T., Edelkamp, J., Rouillé, T., Ajdić, D., Uchida, Y., Nardo, A. D., Bosch, T. C. G., & Paus, R. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19461 · Cited by 127 · see citing works
Green, J. E., Berk, M., Mohebbi, M., Loughman, A., McGuinness, A. J., Castle, D. J., Chatterton, M. L., Perez, J., Strandwitz, P., Athan, E., et al. (2023) · The Canadian Journal of Psychiatry · doi:10.1177/07067437221150508 · Cited by 87 · see citing works
How Our Microbiome Influences the Pathogenesis of Alopecia Areata
Sánchez-Pellicer, P., Navarro-Moratalla, L., Núñez-Delegido, E., Agüera-Santos, J., & Navarro‐López, V. (2022) · Genes · doi:10.3390/genes13101860 · Cited by 57 · see citing works
Xie, W.-R., Yang, X., Deng, Z., Zheng, Y.-M., Zhang, R., Wu, L., Cai, J., Kong, L.-P., Xia, H. H., & He, X. (2021) · Digestive Diseases · doi:10.1159/000521273 · Cited by 48 · see citing works
Self-citationColonic transendoscopic tube-delivered enteral therapy (with video): a prospective study
Zhang, T., Long, C., Cui, B., Buch, H., Wen, Q., Li, Q., Ding, X., Ji, G., & Zhang, F. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01285-0 · Cited by 37 · see citing works
Gut Microbiota and Autoimmune Diseases: A Charming Real World Together with Probiotics
Piccioni, A., Cicchinelli, S., Valletta, F., Luca, G. D., Longhitano, Y., Candelli, M., Ojetti, V., Sardeo, F., Navarra, S. M., Covino, M., et al. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210922161913 · Cited by 36 · see citing works
Ross, F. C., Mayer, D. E., Gupta, A., Gill, C. I. R., Rio, D. D., Cryan, J. F., Lavelle, A., Ross, R. P., Stanton, C., & Mayer, E. A. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.018 · Cited by 35 · see citing works
Colucci, R., & Moretti, S. (2021) · Dermatology and Therapy · doi:10.1007/s13555-021-00485-0 · Cited by 28 · see citing works
Kronsten, V. T., & Shawcross, D. L. (2022) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114437 · Cited by 27 · see citing works
The cutaneous and intestinal microbiome in psoriatic disease
Le, S. T., Toussi, A. M., Maverakis, N., Marusina, A. I., Barton, V. R., Merleev, A. A., Luxardi, G., Raychaudhuri, S. P., & Maverakis, E. M. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108537 · Cited by 26 · see citing works
The role of faecal microbiota transplantation: looking beyond Clostridioides difficile infection
Goldenberg, S. D., & Merrick, B. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/2049936120981526 · Cited by 26 · see citing works
Zhong, M., Buch, H., Wen, Q., Long, C., Cui, B., & Zhang, F. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6676962 · Cited by 26 · see citing works
Green, J. E., McGuinness, A. J., Berk, M., Castle, D. J., Athan, E., Hair, C., Strandwitz, P., Loughman, A., Nierenberg, A. A., Cryan, J. F., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01235-z · Cited by 23 · see citing works
Skin Deep: The Role of the Microbiota in Cutaneous Autoimmunity
Pereira, M. S., Redanz, S., & Kriegel, M. A. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.12.005 · Cited by 23 · see citing works
Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis
Borrego-Ruiz, A., & Borrego, J. J. (2024) · Nutrients · doi:10.3390/nu16203559 · Cited by 26 · see citing works
Gut microbiome, metabolome and alopecia areata
Liu, Z., & Liu, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1281660 · Cited by 21 · see citing works
Just a gut feeling: Faecal microbiota transplant for treatment of depression – A mini-review
Chang, M., Chang, K. T., & Chang, F. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241240308 · Cited by 19 · see citing works
Fecal microbiota transplantation for the treatment of chronic inflammatory skin diseases
Wu, M., Chen, X., Lu, Q., & Yao, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37432 · Cited by 17 · see citing works
Liu, N., Liu, H.-Q., Zheng, J., Zhu, M., Wu, L., Pan, H., & He, X. (2023) · The Journal of Microbiology · doi:10.1007/s12275-023-00069-x · Cited by 16 · see citing works
Self-citationProbiotics in Dermatology: An Evidence-based Approach
Gowda, V., Sarkar, R., Verma, D., & Das, A. (2024) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_614_23 · Cited by 19 · see citing works
Shafqat, A., Masters, M. C., Tripathi, U., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102400 · Cited by 15 · see citing works
The Gut and Skin Microbiome in Alopecia: Associations and Interventions.
Carrington, A. E., Maloh, J., Nong, Y., Agbai, O. N., Bodemer, A. A., & Sivamani, R. K. (2023) · PubMed Central · Cited by 14 · see citing works
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Lee, J. H., Shin, J. H., Kim, J. Y., Ju, H. J., & Kim, G. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084256 · Cited by 12 · see citing works
Wu, D., Zhang, C., Liu, Y., Yao, J., Yang, X., Wu, S., Du, J., & Yang, X. (2023) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2023.02.005 · Cited by 12 · see citing works
Self-citationZhong, M., Sun, Y., Wang, H., Marcella, C., Cui, B., Miao, Y., & Zhang, F. (2020) · World Journal of Clinical Cases · doi:10.12998/wjcc.v8.i17.3786 · Cited by 12 · see citing works
Navarro‐Belmonte, M. R., Aguado-García, Á., Sánchez-Pellicer, P., Núñez-Delegido, E., Martínez-Villaescusa, M., Navarro-Moratalla, L., García-Navarro, A., & Navarro‐López, V. (2024) · Cosmetics · doi:10.3390/cosmetics11040119 · Cited by 11 · see citing works
Wen, Q., Liu, K., Cui, B., Li, P., Wu, X., Zhong, M., Lu, W., Tu, H., Yu, Y., Lin, D., et al. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i39.6098 · Cited by 11 · see citing works
Papa, V., Pomi, F. L., Minciullo, P. L., Borgia, F., & Gangemi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010179 · Cited by 10 · see citing works
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Feng, Y. (2023) · Current Research in Translational Medicine · doi:10.1016/j.retram.2023.103408 · Cited by 5 · see citing works
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Severino, A., Porcari, S., Rondinella, D., Capuano, E., Rozera, T., Kaitsas, F., Gasbarrini, A., Cammarota, G., & Ianiro, G. (2025) · Biomedicines · doi:10.3390/biomedicines13061379 · Cited by 5 · see citing works
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Rinaldi, F., Trink, A., Papale, A., Giuliani, G., & Pinto, D. (2022) · Cosmetics · doi:10.3390/cosmetics9030055 · Cited by 5 · see citing works
Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation
Poole, I. C. L. (2021) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12957 · Cited by 5 · see citing works
Kang, Y., Cai, Y., Zhao, Y., & Yang, Y. X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.979876 · Cited by 4 · see citing works
Arif, T. B., Damianos, J., Rahman, A., & Hasnain, N. (2025) · Current Gastroenterology Reports · doi:10.1007/s11894-025-01001-6 · Cited by 2 · see citing works
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Singh, V. B., Hussain, M. S., Das, J., Chellappan, D. K., Chaudhary, P., Sridhar, S. B., Panigrahy, U. P., Ramzan, M., Mondal, M., & Ashique, S. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10918-x · Cited by 2 · see citing works
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Liu, X., & Jia, L. I. U. (2024) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2024-051 · Cited by 2 · see citing works
Li, B., Fu, J., Wang, S., Bi, X., Xu, D., Wang, L., & Qiao, D. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121717 · Cited by 1 · see citing works
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Curbelo-Paz, A., Lee, E. T., Sadur, A., D’Angelo, N., & Choudhary, S. (2026) · Dermato · doi:10.3390/dermato6020020 · Cited by 1 · see citing works
Almarzooqi, S., Yassin, L. K., AlNuaimi, F., Alketbi, S., Skrabulyte-Barbulescu, J., AlAhbabi, N., Alremeithi, D., Almarashda, R., Almazrouei, S., Shehab, S., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04305-x · Cited by 1 · see citing works
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Agarwal, P., Wolfe, S. M., Sanabria, B., Pathak, G. N., Alamgir, M., & Rao, B. K. (2024) · JAAD reviews. · doi:10.1016/j.jdrv.2024.09.002 · Cited by 2 · see citing works
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Orias, D. E. B., Moreno-Arrones, Ó. M., & Vañó-Galván, S. (2021) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2021.03.011 · Cited by 1 · see citing works
Intestinal Flora as Initiatives of Autoimmunity
Alkhatib, A. J. (2022) · Springer eBooks · doi:10.1007/978-981-19-1162-0_6 · Cited by 1 · see citing works
Influência da Disbiose na Patologia do Couro Cabeludo
Morgado, F., & Soares, R. O. (2021) · Journal of the Portuguese Society of Dermatology and Venereology · doi:10.29021/spdv.79.4.1420
Alopecia areata - basic disease characteristics and an overview of current and new treatment options
Štěpánková, E., Boháčová, P., & Arenbergerová, M. (2022) · Dermatologie pro praxi · doi:10.36290/der.2022.001
The role of the skin microbiome in the development of alopecia areata
Brzuszkiewicz, K., Rudziński, G., Pożarowska, K., Grunwald, A., Satora, M., Piwowar, K., & Klas, J. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.11.030
Hairy tongue associated with the use of baricitinib therapy for ophiasis pattern alopecia areata
Gaspari, A. A. (2023) · JEADV Clinical Practice · doi:10.1002/jvc2.348
Functional foods for hair loss and alopecia
Zahedinia, S., Bayar, E., Karimidastjerd, A., & Khan, Z. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-28862-3.00019-4
Lima, I. R., & Silva, F. G. (2025) · Scientia Generalis · doi:10.22289/sg.v6n2a24
Sgarbossa, C., Meyyappan, A. C., Forth, E., Bromley, H., & Milev, R. V. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1663719
庄承杰, & Song, X. (2026) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2026.2697856
Fecal microbiota transplant in dermatology – A narrative review
Alex, M. M., & Criton, V. J. S. (2026) · Journal of Skin and Sexually Transmitted Diseases · doi:10.25259/jsstd_95_2026
- Authors
- Xie, W.-R., Yang, X.-Y., Xia, H. H.-X., Wu, L.-H., & He, X.-X.
- Affiliations
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Venue
- World Journal of Clinical Cases
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2019-10-06
- Volume
- 7
- Issue
- 19
- Pages
- 3074-3081
- ISSN
- 2307-8960 (ISSN-L)
- PMC
- PMC6795734
- OpenAlex
- W2975884975
- Cited by
- 67
- References
- 62
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 6
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Clinical Cases (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Keywords
- fecal microbiota transplantation, alopecia areata, hair regrowth, gut dysbiosis, elderly patients, sigmoid colon cancer, depression
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