The DOI matches its Crossref record; 188 of the 203 references it cites were found in a registry or an index.
The role of 17 beta-hydroxysteroid dehydrogenases
Abstract
The biological activity of steroid hormones is regulated at the pre-receptor level by several enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta -HSD). The latter are present in many microorganisms, invertebrates and vertebrates. Dysfunctions in human 17 beta-hydroxysteroid dehydrogenases result in disorders of biology of reproduction and neuronal diseases, the enzymes are also involved in the pathogenesis of various cancers. 17 beta-hydroxysteroid dehydrogenases reveal a remarkable multifunctionality being able to modulate concentrations not only of steroids but as well of fatty and bile acids. Current knowledge on genetics, biochemistry and medical implications is presented in this review.
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“To date, 14 human enzymes with 17β-HSD/oxoreductase activities have been identified [105,106,113].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [105]
Citations
Cites
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van der Geize, R., Yam, K. C., Heuser, T., Wilbrink, M. H., Hara, H., Anderton, M. C., Sim, E., Dijkhuizen, L., DAVIES, J. E., Mohn, W. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605728104 · Cited by 552
A supergene determines highly divergent male reproductive morphs in the ruff
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The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
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Cinnamic Acid Derivatives as Anticancer Agents-A Review
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Metadata
- Authors
- Mindnich, R., Möller, G., & Adamski, J.
- Affiliations
- Helmholtz Munich (DE)
- Corresponding author
- Adamski, J
- ORCID
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 218
- Issue
- 1-2
- Pages
- 7-20
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2083859759
- Cited by
- 354
- References
- 203
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 8 · 2012: 10
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- 17β-hydroxysteroid dehydrogenase, steroid hormone metabolism, steroidogenesis, reproductive disorders, neuronal diseases, carcinogenesis, fatty acid metabolism, bile acid metabolism, enzyme genetics, enzyme biochemistry
- MeSH terms
- Androgens, Animals, Estrogens, Humans, 17-Hydroxysteroid Dehydrogenases, Molecular Structure
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