Complex assembly on the human CYP17 promoter

Sewer, Marion B.; Jagarlapudi, Srinath

doi:10.1016/j.mce.2008.10.006

Cited by 31Estrogen and related hormone effectsAdrenal Hormones and DisordersGenomics and Chromatin Dynamics

Complex assembly on the human CYP17 promoter

Open access

Sewer, Marion B., Jagarlapudi, Srinath·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.006PMC PMC2754694

Open this paper in CoChat — free account

Abstract

Optimal steroid hormone biosynthesis occurs via the integration of multiple regulatory processes, one of which entails a coordinate increase in the transcription of all genes required for steroidogenesis. In the human adrenal cortex adrenocorticotropin (ACTH) activates a signaling cascade that promotes the dynamic assembly of protein complexes on the promoters of steroidogenic genes. For CYP17, multiple transcription factors, including steroidogenic factor-1 (SF-1), GATA-6, and sterol regulatory binding protein 1 (SREBP1), are recruited to the promoter during activated transcription. The ability of these factors to increase CYP17 mRNA expression requires the formation of higher order coregulatory complexes, many of which contain enzymatic activities that post-translationally modify both the transcription factors and histones. We discuss the mechanisms by which transcription factors and coregulatory proteins regulate CYP17 transcription and summarize the role of kinases, phosphatases, acetyltransferases, and histone deacetylases in controlling CYP17 mRNA expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2008.10.006

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Adrenal expression of human CYP17A1 requires the transcription factors SF1, SP1, SP3, CTF2, CTF5, GATA4 and GATA6.
“Adrenal expression of human CYP17A1 requires the transcription factors SF1, SP1, SP3, CTF2, CTF5, GATA4 and GATA6 (250 -255).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [255]
Sections 3.1–3.3 describe SF-1, Sp1, Sp3, GATA-4 and GATA-6 as regulators of human CYP17 transcription in the adrenal context. The GATA section says GATA-4 or GATA-6 can form a complex with Sp1, rather than establishing that both are required. The copy does not identify CTF2 or CTF5 as required factors, so it does not support the full list as a requirement for adrenal expression. (LLM, conf=0.87)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128 · see citing works
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
Luo, X., Ikeda, Y., & Parker, K. L. (1994) · Cell · doi:10.1016/0092-8674(94)90211-9 · Cited by 1,631 · see citing works
Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter
Métivier, R., Penot, G., Hübner, M. R., Reid, G., Brand, H., Koš, M., & Gannon, F. (2003) · Cell · doi:10.1016/s0092-8674(03)00934-6 · Cited by 1,431 · see citing works
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Lee, M.-J., Brocklyn, J. R. V., Thangada, S., Liu, C. H., Hand, A. R., Menzeleev, R., Spiegel, S., & Hla, T. (1998) · Science · doi:10.1126/science.279.5356.1552 · Cited by 1,007 · see citing works
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons
Hojo, Y., Hattori, T.-A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.-T., Mukai, H., Morrison, J. H., Janssen, W. G. M., Kominami, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2630225100 · Cited by 644 · see citing works
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
Hu, X., & Lazar, M. A. (1999) · Nature · doi:10.1038/47069 · Cited by 642 · see citing works
Regulation of Corepressor Function by Nuclear NADH
Zhang, Q., Piston, D. W., & Goodman, R. H. (2002) · Science · doi:10.1126/science.1069300 · Cited by 620 · see citing works
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activationPreprint
McInerney, E. M., Rose, D. W., Flynn, S. E., Westin, S. K., Mullen, T.-M., Krones, A., Inostroza, J. A., Torchia, J., Nolte, R. T., Assa‐Munt, N., et al. (1998) · Genes & Development · doi:10.1101/gad.12.21.3357 · Cited by 610 · see citing works
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule
Spiegel, S., & Milstien, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200007200 · Cited by 554 · see citing works
Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer
Auchus, R. J., Lee, T. C., & Miller, W. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3158 · Cited by 541 · see citing works
Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought
Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0532 · Cited by 538 · see citing works
Controlling nuclear receptors: the circular logic of cofactor cycles
Perissi, V., & Rosenfeld, M. G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1680 · Cited by 507 · see citing works
Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival
Brocklyn, J. R. V., Lee, M.-J., Menzeleev, R., Olivera, A., Edsall, L. C., Cuvillier, O., Thomas, D. M., Coopman, P. J. P., Thangada, S., Liu, C. H., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.229 · Cited by 459 · see citing works
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.
Zhang, L. H., Rodriguez, H., Ohno, S., & Miller, W. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10619 · Cited by 455 · see citing works
Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities
Ding, X. F., Anderson, C. M., Ma, H., Hong, H., Uht, R. M., Kushner, P. J., & Stallcup, M. R. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.2.0065 · Cited by 434 · see citing works
Gene regulation by Sp1 and Sp3
Li, L., He, S., Sun, J., & Davie, J. (2004) · Biochemistry and Cell Biology · doi:10.1139/o04-045 · Cited by 418 · see citing works
Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1
Krylova, I. N., Sablin, E. P., Moore, J. M. R., Xu, R. X., Waitt, G. M., MacKay, J. A., JUZUMIENE, D. I., Bynum, J. M., Madauss, K. P., Montana, V. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.024 · Cited by 405 · see citing works
Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.
Schaeper, U., Boyd, J. M., Verma, S., Uhlmann, E. J., Subramanian, T., & Chinnadurai, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10467 · Cited by 379 · see citing works
Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment
Hammer, G. D., Krylova, I., Zhang, Y., Darimont, B. D., Simpson, K., Weigel, N. L., & Ingraham, H. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80480-3 · Cited by 375 · see citing works
Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes
Wierstra, I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.074 · Cited by 337 · see citing works
Minireview: Regulation of Steroidogenesis by Electron Transfer
Miller, W. L. (2005) · Endocrinology · doi:10.1210/en.2005-0096 · Cited by 324 · see citing works
Nuclear Receptor Coregulators and Human Disease
Lonard, D. M., Lanz, R. B., & O’Malley, B. W. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0012 · Cited by 303 · see citing works
Transcription Corepressor CtBP Is an NAD+-Regulated Dehydrogenase
Kumar, V., Carlson, J. E., Ohgi, K. A., Edwards, T. A., Rose, D. W., Escalante, C. R., Rosenfeld, M. G., & Aggarwal, A. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00650-0 · Cited by 299 · see citing works
P54nrb Forms a Heterodimer with PSP1 That Localizes to Paraspeckles in an RNA-dependent Manner
Fox, A. H., Bond, C. S., & Lamond, A. I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0587 · Cited by 236 · see citing works
Sp1: Regulation of gene expression by phosphorylation
Chu, S., & Ferro, T. J. (2005) · Gene · doi:10.1016/j.gene.2005.01.013 · Cited by 231 · see citing works
Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome
Bingham, N. C., Anderson, K. K., Reuter, A. L., Stallings, N. R., & Parker, K. L. (2008) · Endocrinology · doi:10.1210/en.2007-1200 · Cited by 213 · see citing works
StAR Search—What We Know about How the Steroidogenic Acute Regulatory Protein Mediates Mitochondrial Cholesterol Import
Miller, W. L. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0303 · Cited by 209 · see citing works
Splicing and transcription-associated proteins PSF and p54nrb/NonO bind to the RNA polymerase II CTD
Emili, A., Shales, M., McCracken, S. A., Xie, W., Tucker, P. W., Kobayashi, R., Blencowe, B. J., & Ingles, C. J. (2002) · RNA · doi:10.1017/s1355838202025037 · Cited by 206 · see citing works
Crystallographic Identification and Functional Characterization of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1
Li, Y., Choi, M., Cavey, G. S., Daugherty, J., Suino, K., Kovach, A., Bingham, N. C., Kliewer, S. A., & Xu, H. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.002 · Cited by 205 · see citing works
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system
Compagnone, N. A., Bulfone, A., Rubenstein, J. L., & Mellon, S. H. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588260 · Cited by 201 · see citing works
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
Bassett, M. H., Suzuki, T., Sasano, H., White, P. C., & Rainey, W. E. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0005 · Cited by 192 · see citing works
p54nrb associates with the 5′ splice site within large transcription/splicing complexes
Kameoka, S., Duque, P., & Konarska, M. M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600187 · Cited by 186 · see citing works
P450c17 Mutations R347H and R358Q Selectively Disrupt 17,20-Lyase Activity by Disrupting Interactions with P450 Oxidoreductase and Cytochrome b<sub>5</sub>
Geller, D. H., Auchus, R. J., & Miller, W. L. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0219 · Cited by 183 · see citing works
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6
Brocklyn, J. R. V., Gräler, M. H., Bernhardt, G., et al. (2000) · Blood · doi:10.1182/blood.v95.8.2624 · Cited by 177 · see citing works
The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase).
Zhang, P., & Mellon, S. H. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.2.8825555 · Cited by 176 · see citing works
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
Wang, W., Zhang, C., Marimuthu, A., Krupka, H. I., Tabrizizad, M., Shellooe, R., Mehra, U., Eng, K., Nguyen, H. T., Settachatgul, C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409482102 · Cited by 145 · see citing works
Nuclear Receptor-Mediated Transactivation Through Interaction with Sp Proteins
Safe, S. H., & Kim, K. (2004) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(04)77001-4 · Cited by 143 · see citing works
Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene
Bakke, M., & Lund, J. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.3.7776979 · Cited by 138 · see citing works
Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17
Pandey, A. V., Mellon, S. H., & Miller, W. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209527200 · Cited by 137 · see citing works
PSF and p54nrb bind a conserved stem in U5 snRNA
Peng, R., Dye, B. T., REZ, I. P., Barnard, D. C., THOMPSON, A. B., & Patton, J. G. (2002) · RNA · doi:10.1017/s1355838202022070 · Cited by 136 · see citing works
Determinants of CoRNR-Dependent Repression Complex Assembly on Nuclear Hormone Receptors
Hu, X., Li, Y., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1747-1758.2001 · Cited by 130 · see citing works
GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1
Flück, C. E., & Miller, W. L. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0342 · Cited by 127 · see citing works
The Orphan Nuclear Receptor NGFIB Regulates Transcription of 3β-Hydroxysteroid Dehydrogenase
Bassett, M. H., Suzuki, T., Sasano, H., de Vries, C. J. M., Jimenez, P. T., Carr, B. R., & Rainey, W. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405431200 · Cited by 126 · see citing works
Transcriptional Activation of Human CYP17 in H295R Adrenocortical Cells Depends on Complex Formation among p54<sup>nrb</sup>/NonO, Protein-Associated Splicing Factor, and SF-1, a Complex That Also Participates in Repression of Transcription
Sewer, M. B., Nguyen, V. Q., Huang, C.-J., Tucker, P. W., Kagawa, N., & Waterman, M. R. (2002) · Endocrinology · doi:10.1210/endo.143.4.8748 · Cited by 123 · see citing works
Self-citation
Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT
Li, H., Leo, C., Schroen, D. J., & Chen, J. D. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0028 · Cited by 119 · see citing works
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.
Yang, Y. S., Hanke, J. H., Carayannopoulos, L. N., Craft, C. M., Capra, J. D., & Tucker, P. W. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5593 · Cited by 117 · see citing works
A coactivator trap identifies NONO (p54 nrb ) as a component of the cAMP-signaling pathway
Amelio, A. L., Miraglia, L. J., Conkright, J. J., Mercer, B. A., Batalov, S., Cavett, V. J., Orth, A. P., Caldwell-Busby, J., Hogenesch, J. B., & Conkright, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707999105 · Cited by 112 · see citing works
Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9
Komatsu, T., Mizusaki, H., Mukai, T., Ogawa, H., Baba, D., Shirakawa, M., Hatakeyama, S., Nakayama, K. I., Yamamoto, H., Kikuchi, A., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0173 · Cited by 111 · see citing works
GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis
Jimenez, P., Saner, K., Mayhew, B., & Rainey, W. E. (2003) · Endocrinology · doi:10.1210/en.2003-0472 · Cited by 107 · see citing works
SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1)
Chen, W.-Y., Lee, W.-C., Hsu, N.-C., Huang, F., & Chung, B.-C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405006200 · Cited by 104 · see citing works
Novel roles for GATA transcription factors in the regulation of steroidogenesis
Tremblay, J., & Viger, R. S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00211-5 · Cited by 95 · see citing works
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
Urs, A. N., Dammer, E., & Sewer, M. B. (2006) · Endocrinology · doi:10.1210/en.2006-0355 · Cited by 94 · see citing works
Self-citation
Acetylation of Steroidogenic Factor 1 Protein Regulates Its Transcriptional Activity and Recruits the Coactivator GCN5
Jacob, A. L. J., Lund, J., Martı́nez, P., & Hedin, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104427200 · Cited by 90 · see citing works
Cloning of zebrafish ovarian P450c17 (CYP17, 17α-hydroxylase/17, 20-lyase) and characterization of its expression in gonadal and extra-gonadal tissues
Wang, Y., & Ge, W. (2003) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2003.09.015 · Cited by 89 · see citing works
Transcription of the Human Genes for Cytochrome P450scc and P450c17 Is Regulated Differently in Human Adrenal NCI-H295 Cells Than in Mouse Adrenal Y1 Cells1
Rodriguez, H., Hum, D. W., Staels, B., & Miller, W. L. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3721 · Cited by 89 · see citing works
Differential Expression of GATA-4 and GATA-6 in Fetal and Adult Mouse and Human Adrenal Tissue
Kiiveri, S., Liu, J., Westerholm‐Ormio, M., Narita, N., Wilson, D. B., Voutilainen, R., & Heikinheimo, M. (2002) · Endocrinology · doi:10.1210/endo.143.8.8939 · Cited by 82 · see citing works
Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis
Compagnone, N. A., Zhang, P., Vigne, J.-L., & Mellon, S. H. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.6.0469 · Cited by 81 · see citing works
Orphan nuclear receptors adopted by crystallography
Ingraham, H. A., & Redinbo, M. R. (2005) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2005.10.009 · Cited by 80 · see citing works
Central Nervous System-Specific Knockout of Steroidogenic Factor 1 Results in Increased Anxiety-Like Behavior
Zhao, L., Kim, K. W., Ikeda, Y., Anderson, K. K., Beck, L., Chase, S., Tobet, S. A., & Parker, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0034 · Cited by 80 · see citing works
Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene
Shea-Eaton, W. K., Trinidad, M. J., Lopez, D., Nackley, A., & McLean, M. P. (2001) · Endocrinology · doi:10.1210/endo.142.4.8075 · Cited by 80 · see citing works
SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding
Chen, W., Juan, L., & Chung, B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10442-10453.2005 · Cited by 78 · see citing works
Adrenocorticotropin/Cyclic Adenosine 3',5'-Monophosphate-Mediated Transcription of the Human CYP17 Gene in the Adrenal Cortex Is Dependent on Phosphatase Activity
Sewer, M. B., & Waterman, M. R. (2002) · Endocrinology · doi:10.1210/endo.143.5.8820 · Cited by 77 · see citing works
Self-citation
Expression and localization of cytochrome P450 17α-hydroxylase/c17,20-lyase in the avian brain
Matsunaga, M., Ukena, K., & Tsutsui, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02217-x · Cited by 76 · see citing works
Adrenocorticotropic Hormone-Mediated Signaling Cascades Coordinate a Cyclic Pattern of Steroidogenic Factor 1-Dependent Transcriptional Activation
Winnay, J. N., & Hammer, G. D. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0215 · Cited by 74 · see citing works
NF-1C, Sp1, and Sp3 Are Essential for Transcription of the Human Gene for P450c17 (Steroid 17α-hydroxylase/17,20 lyase) in Human Adrenal NCI-H295A Cells
Lin, C. J., Martens, J. W. M., & Miller, W. L. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.8.0679 · Cited by 71 · see citing works
Pituitary-specific knockout of steroidogenic factor 1
Zhao, L., Bakke, M., & Parker, K. L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00621-9 · Cited by 70 · see citing works
Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells
Bird, I. M., Pasquarette, M. M., Rainey, W. E., & Mason, J. I. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964847 · Cited by 70 · see citing works
Transcription of the Human Genes for Cytochrome P450scc and P450c17 Is Regulated Differently in Human Adrenal NCI-H295 Cells Than in Mouse Adrenal Y1 Cells
Rodriguez, H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.365 · Cited by 66 · see citing works
Deletion of the Mouse P450c17 Gene Causes Early Embryonic Lethality
Bair, S. R., & Mellon, S. H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5383-5390.2004 · Cited by 63 · see citing works
Steroid Sulfotransferase 2A1 Gene Transcription Is Regulated by Steroidogenic Factor 1 and GATA-6 in the Human Adrenal
Saner, K. J., Suzuki, T., Sasano, H., Pizzey, J. A., Ho, C. K. M., Strauss, J. F., Carr, B. R., & Rainey, W. E. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0332 · Cited by 61 · see citing works
Gene expression regulation and domain function of hematopoietic GATA factors
Shimizu, R., & Yamamoto, M. P. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.11.001 · Cited by 61 · see citing works
NonO enhances the association of many DNA-binding proteins to their targets
Yang, Y. S., Yang, M. C., Tucker, P. W., & Capra, J. D. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.12.2284 · Cited by 60 · see citing works
Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17
Li, D., Urs, A. N., Allegood, J., Leon, A., Merrill, A. H., & Sewer, M. B. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00355-07 · Cited by 58 · see citing works
Self-citation
Pathways Leading to Phosphorylation of P450c17 and to the Posttranslational Regulation of Androgen Biosynthesis
Tee, M. K., Dong, Q., & Miller, W. L. (2008) · Endocrinology · doi:10.1210/en.2007-1527 · Cited by 55 · see citing works
Transcriptional Regulation of Adrenocortical Steroidogenic Gene Expression
Sewer, M. B., Dammer, E. B., & Jagarlapudi, S. (2007) · Drug Metabolism Reviews · doi:10.1080/03602530701498828 · Cited by 55 · see citing works
Self-citation
Cyclic adenosine 5′-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1
Ozbay, T., Rowan, A., Leon, A., Patel, P., & Sewer, M. B. (2006) · Endocrinology · doi:10.1210/en.2005-1091 · Cited by 55 · see citing works
Self-citation
Coregulator Exchange and Sphingosine-Sensitive Cooperativity of Steroidogenic Factor-1, General Control Nonderepressed 5, p54, and p160 Coactivators Regulate Cyclic Adenosine 3′,5′-Monophosphate-Dependent Cytochrome P450c17 Transcription Rate
Dammer, E. B., Leon, A., & Sewer, M. B. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0361 · Cited by 53 · see citing works
Self-citation
Developmentally Regulated Expression and Activity of 17α-Hydroxylase/C-17,20-Lyase Cytochrome P450 in Rat Liver1
Vianello, S., Waterman, M. R., Valle, L. D., & Colombo, L. (1997) · Endocrinology · doi:10.1210/endo.138.8.5297 · Cited by 52 · see citing works
p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation
Liang, S., & Lutz, C. S. (2005) · RNA · doi:10.1261/rna.2213506 · Cited by 51 · see citing works
The 25th Volume: Role of the GATA Family of Transcription Factors in Andrology
Viger, R. S., Taniguchi, H., Robert, N. M., & Tremblay, J. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb02813.x · Cited by 49 · see citing works
Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17α‐hydroxylase/C17, 20‐lyase (P450C17) in the frog brain and pituitary
do Rego, J. L., Tremblay, Y., Luu‐The, V., Repetto, E., Castel, H., Vallarino, M., Bélanger, A., Pelletier, G., & Vaudry, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04209.x · Cited by 49 · see citing works
Phosphorylation of Steroidogenic Factor 1 Is Mediated by Cyclin-Dependent Kinase 7
Lewis, A. E., Rusten, M., Høivik, E. A., Vikse, E. L., Hansson, M. L., Wallberg, A. E., & Bakke, M. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0478 · Cited by 44 · see citing works
A Role for the NGFI‐B Family in Adrenal Zonation and Adrenocortical Disease
Bassett, M. H., White, P. C., & Rainey, W. E. (2004) · Endocrine Research · doi:10.1081/erc-200043715 · Cited by 44 · see citing works
Occurrence of cytochrome P450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract
Dalla Valle, L., Couët, J., Labrie, Y., Simard, J., Belvedere, P., Simontacchi, C., Labrie, F., & Colombo, L. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03553-j · Cited by 43 · see citing works
Haploinsufficiency of Cytochrome P450 17α-Hydroxylase/17,20 Lyase (CYP17) Causes Infertility in Male Mice
Liu, Y., Yao, Z., Bendavid, C., Borgmeyer, C., Han, Z. J., Cavalli, L. R., Chan, W., Folmer, J. S., Zirkin, B. R., Haddad, B. R., et al. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0418 · Cited by 43 · see citing works
Regulation of the dual-function transcription factor Sp3 by SUMO
Valín, Á., & Gill, G. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351393 · Cited by 42 · see citing works
GATA transcription factors and fat cell formation
Tong, Q., Tsai, J., & Hotamışlıgil, G. S. (2003) · Drug News & Perspectives · doi:10.1358/dnp.2003.16.9.829340 · Cited by 42 · see citing works
Regulation of Cytochrome b5 Gene Transcription by Sp3, GATA-6, and Steroidogenic Factor 1 in Human Adrenal NCI-H295A Cells
Huang, N., Dardis, A., & Miller, W. L. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0411 · Cited by 42 · see citing works
Androgen biosynthesis in the stomach: expression of cytochrome P450 17 alpha-hydroxylase/17,20-lyase messenger ribonucleic acid and protein, and metabolism of pregnenolone and progesterone by parietal cells of the rat gastric mucosa.
Le Goascogne, C., Sananès, N., Eychenne, B., Gouézou, M., Baulieu, E. E., & Robel, P. (1995) · Endocrinology · doi:10.1210/endo.136.4.7895686 · Cited by 42 · see citing works
Steroidogenic Factor 1 Regulates Expression of the Cannabinoid Receptor 1 in the Ventromedial Hypothalamic Nucleus
Kim, K. W., Jo, Y., Zhao, L., Stallings, N. R., Chua, S. C., & Parker, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0127 · Cited by 38 · see citing works
ACTH Regulates Steroidogenic Gene Expression and Cortisol Biosynthesis in the Human Adrenal Cortex via Sphingolipid Metabolism
Ozbay, T., Merrill, A. H., & Sewer, M. B. (2004) · Endocrine Research · doi:10.1081/erc-200044040 · Cited by 35 · see citing works
Self-citation
Transcription Factors GATA‐4 and GATA‐6 in Human Adrenocortical Tumors
Kiiveri, S., Liu, J., Heikkilä, P., Arola, J. T., Lehtonen, E., Voutilainen, R., & Heikinheimo, M. (2004) · Endocrine Research · doi:10.1081/erc-200044149 · Cited by 34 · see citing works
Phosphorylation of CtBP1 by cAMP-dependent Protein Kinase Modulates Induction of CYP17 by Stimulating Partnering of CtBP1 and 2
Dammer, E. B., & Sewer, M. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708432200 · Cited by 31 · see citing works
Self-citation
Hypomorphic phenotype in mice with pituitary‐specific knockout of steroidogenic factor 1
Zhao, L., Bakke, M., Krimkevich, Y., Cushman, L. J., Parlow, A. F., Camper, S. A., & Parker, K. L. (2001) · genesis · doi:10.1002/gene.1034 · Cited by 26 · see citing works
GATA transcription factors in adrenal development and tumors
Parviainen, H., Kiiveri, S., Bielińska, M., Rahman, N. A., Huhtaniemi, I. T., Wilson, D. B., & Heikinheimo, M. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.033 · Cited by 21 · see citing works
A boundary for histone acetylation allows distinct expression patterns of the Ad4BP/SF-1 and GCNF loci in adrenal cortex cells
Ishihara, S., & Morohashi, K.-I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.011 · Cited by 20 · see citing works

Flagged first, then by citations

Sorted by citations

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works

Nuclear Receptor Coregulators and Human Disease
Lonard, D. M., Lanz, R. B., & O’Malley, B. W. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0012 · Cited by 303 · see citing works
Nuclear receptor coactivators: structural and functional biochemistry
Bulynko, Y. A., & O’Malley, B. W. (2011) · Biochemistry · doi:10.1021/bi101762x · Cited by 113 · see citing works
Diverse transcription factors are involved in the quantitative regulation of transcriptional activation of χ promoters
Bemark, M., & Leanderson, T. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270603 · Cited by 13 · see citing works
Effects of the transcription factor Ets-1 on P21WAF1/CIP1 promoter
Zhang, C. (2006) · Zhongguo bingli shengli zazhi
Identification of an upstream region of the mousep53promoter critical for transcriptional expression
Hale, T. K., & Braithwaite, A. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.4.663 · Cited by 29 · see citing works

Authors: Sewer, M. B., & Jagarlapudi, S.
Affiliations: Georgia Institute of Technology (US)
Corresponding author: Sewer, Marion B.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-03
Volume: 300
Issue: 1-2
Pages: 109-114
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.006
PMC: PMC2754694
OpenAlex: W2002260125
Semantic Scholar: e8f92cfed019138ee0393501a86b49dfc78b6afb
Cited by: 31
References: 99
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 0.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R56GM073241, R01GM073241, GM073241)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: CYP17, steroidogenic factor 1, GATA6, SREBP1, steroidogenesis, adrenal cortex, ACTH signaling, histone modifications, histone acetyltransferase, histone deacetylase, transcriptional regulation, steroidogenic gene expression
MeSH terms: Adrenal Glands, Humans, Promoter Regions, Genetic, Steroid 17-alpha-Hydroxylase, Transcription Factors, Gene Expression Regulation, Enzymologic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Complex assembly on the human CYP17 promoter

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks