Nuclear receptor coactivators: structural and functional biochemistry

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

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A signature motif in transcriptional co-activators mediates binding to nuclear receptors

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InterPro: the integrative protein signature database

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A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,251 · see citing works

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

Wang, Y., Wysocka, J., Sayegh, J., Lee, Y., Perlin, J. R., Leonelli, L., Sonbuchner, L. S., McDonald, C. H., Cook, R. G., Dou, Y., et al. (2004) · Science · doi:10.1126/science.1101400 · Cited by 1,013 · see citing works

Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination

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Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

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Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density.

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PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation

Hornbeck, P. V., Chabra, I., Kornhauser, J. M., Skrzypek, E., & Zhang, B. (2004) · PROTEOMICS · doi:10.1002/pmic.200300772 · Cited by 590 · see citing works

Decoding signalling networks by mass spectrometry-based proteomics

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A Corepressor/Coactivator Exchange Complex Required for Transcriptional Activation by Nuclear Receptors and Other Regulated Transcription Factors

Perissi, V., Aggarwal, A. K., Glass, C. K., Rose, D. W., & Rosenfeld, M. G. (2004) · Cell · doi:10.1016/s0092-8674(04)00133-3 · Cited by 566 · see citing works

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.022 · Cited by 561 · see citing works

PML Nuclear BodiesPreprint

Lallemand-Breitenbach, V., & de Thé, H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000661 · Cited by 561 · see citing works

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

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Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II

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Steroid hormone receptors compete for factors that mediate their enhancer function.

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Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation

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Mir-17-5pRegulates Breast Cancer Cell Proliferation by Inhibiting Translation ofAIB1mRNA

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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator

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Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)

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The Protein Information Resource

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CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

Dentin, R., Liu, Y., Koo, S., Hedrick, S. A., Vargas, T., Heredia, J., Yates, J. R., & Montminy, M. (2007) · Nature · doi:10.1038/nature06128 · Cited by 400 · see citing works

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

Gronroos, E. C., Hellman, U., Heldin, C., & Ericsson, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00639-1 · Cited by 383 · see citing works

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

Zhao, Y., Lang, G., Ito, S., Bonnet, J., Metzger, E., Sawatsubashi, S., Suzuki, E., Le Guezennec, X., Stunnenberg, H. G., Krasnov, A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.011 · Cited by 382 · see citing works

A Highly Conserved Enhancer in the Dlx5/Dlx6 Intergenic Region is the Site of Cross-Regulatory Interactions between Dlx Genes in the Embryonic Forebrain

Zerucha, T., Stühmer, T., Hatch, G., Park, B. K., Long, Q., Yu, G. K., Gambarotta, A., Schultz, J. R., Rubenstein, J. L. R., & Ekker, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00709.2000 · Cited by 360 · see citing works

Coordinate Regulation of Transcription and Splicing by Steroid Receptor Coregulators

Auboeuf, D., Hönig, A., Berget, S. M., & O’Malley, B. W. (2002) · Science · doi:10.1126/science.1073734 · Cited by 357 · see citing works

Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells

Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works

The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60

Patel, J. H., Du, Y., Ard, P. G., Phillips, C., Carella, B. A., Chen, C., Rakowski, C., Chatterjee, C., Lieberman, P. M., Lane, W. S., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10826-10834.2004 · Cited by 354 · see citing works

Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs

Taverna, S. D., Ilin, S., Rogers, R. S., Tanny, J. C., Lavender, H. F., Li, H., Baker, L. A., Boyle, J., Blair, L. P., Chait, B. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.10.026 · Cited by 332 · see citing works

The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response

Castellano, L., Giamas, G., Jacob, J., Coombes, R. C., Lucchesi, W., Thiruchelvam, P. T. R., Barton, G. R., Jiao, L. R., Wait, R., Waxman, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906947106 · Cited by 329 · see citing works

Interaction of the Glucocorticoid Receptor with the Chromatin Landscape

John, S., Sabo, P. J., Johnson, T. A., Sung, M., Biddie, S. C., Lightman, S. L., Voss, T. C., Davis, S. R., Meltzer, P. S., Stamatoyannopoulos, J. A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.010 · Cited by 311 · see citing works

Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor

Gaughan, L., Logan, I. R., Cook, S., Neal, D. E., & Robson, C. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203423200 · Cited by 310 · see citing works

Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Reponses to Multiple Cellular Signaling Pathways

Wu, R., Qin, J., Yi, P., Wong, J., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.019 · Cited by 297 · see citing works

The SRC-3/AIB1 Coactivator Is Degraded in a Ubiquitin- and ATP-Independent Manner by the REGγ Proteasome

Li, X., Lonard, D. M., Jung, S. Y., Malovannaya, A., Feng, Q. F., Qin, J., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (2006) · Cell · doi:10.1016/j.cell.2005.11.037 · Cited by 274 · see citing works

Control of protein synthesis and mRNA degradation by microRNAs

Liu, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.006 · Cited by 264 · see citing works

Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modificationsPreprint

Huang, S., Litt, M. D., & Felsenfeld, G. (2005) · Genes & Development · doi:10.1101/gad.1333905 · Cited by 262 · see citing works

Activation of nuclear receptor coactivator PGC-1α by arginine methylationPreprint

Teyssier, C., Ma, H., Emter, R., Kralli, A., & Stallcup, M. R. (2005) · Genes & Development · doi:10.1101/gad.1295005 · Cited by 260 · see citing works

The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and exportPreprint

Yoh, S. M., Cho, H. K., Pickle, L., Evans, R. M., & Jones, K. A. (2007) · Genes & Development · doi:10.1101/gad.1503107 · Cited by 257 · see citing works

Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity

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SRC-3 Is Required for Prostate Cancer Cell Proliferation and Survival

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8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

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Targeting of SWI/SNF chromatin remodelling complexes to estrogen‐responsive genes

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BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone Acetylation

DiRenzo, J., Shang, Y., Phelan, M. L., Sif, S., Myers, M., Kingston, R. E., & Brown, M. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7541-7549.2000 · Cited by 231 · see citing works

Activating Signal Cointegrator 2 Belongs to a Novel Steady-State Complex That Contains a Subset of Trithorax Group Proteins

Goo, Y., Sohn, Y. C., Kim, D., Kim, S., Kang, M., Jung, D.-J., Kwak, E., Barlev, N. A., Berger, S. L., Chow, V. T. K., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.140-149.2003 · Cited by 231 · see citing works

The multi-tasking P-TEFb complex

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Cloning and Characterization of Human Prostate Coactivator ARA54, a Novel Protein That Associates with the Androgen Receptor

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Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors

Giandomenico, V., Simonsson, M., Grünroos, E., & Ericsson, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2587-2599.2003 · Cited by 229 · see citing works

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock

Wu, R., Feng, Q. F., Lonard, D. M., & O’Malley, B. W. (2007) · Cell · doi:10.1016/j.cell.2007.04.039 · Cited by 223 · see citing works

Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat GenomePreprint

Zhang, Z., Burch, P. E., Cooney, A. J., Lanz, R. B., Pereira, F. A., Wu, J., Gibbs, R. A., Weinstock, G. M., & Wheeler, D. A. (2004) · Genome Research · doi:10.1101/gr.2160004 · Cited by 221 · see citing works

A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo

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The microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity

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Splicing and transcription-associated proteins PSF and p54nrb/NonO bind to the RNA polymerase II CTD

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Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2

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Functional Inhibitory Cross-talk between Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 in Hepatic Lipid/Glucose Metabolism Is Mediated by Competition for Binding to the DR1 Motif and to the Common Coactivators, GRIP-1 and PGC-1α

Miao, J., Fang, S., Bae, Y., & Kemper, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510713200 · Cited by 197 · see citing works

Steroid Hormone Receptor Coactivation and Alternative RNA Splicing by U2AF65-Related Proteins CAPERα and CAPERβ

Dowhan, D. H., Hong, E. P., Auboeuf, D., Dennis, A. P., Wilson, M. M., Berget, S. M., & O'Malley, B. W. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.025 · Cited by 193 · see citing works

PPAR control: it's SIRTainly as easy as PGC

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An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

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Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activityPreprint

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The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription terminationPreprint

Kaneko, S., Rozenblatt–Rosen, O., Meyerson, M. M., & Manley, J. L. (2007) · Genes & Development · doi:10.1101/gad.1565207 · Cited by 181 · see citing works

Distinct steady–state nuclear receptor coregulator complexes exist in vivo

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Signaling within a Coactivator Complex: Methylation of SRC-3/AIB1 Is a Molecular Switch for Complex Disassembly

Feng, Q. F., Yi, P., Wong, J., & O’Malley, B. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00568-06 · Cited by 164 · see citing works

Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486

Liu, Z., Auboeuf, D., Wong, J., Chen, J. D., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225699 · Cited by 159 · see citing works

CoAA, a Nuclear Receptor Coactivator Protein at the Interface of Transcriptional Coactivation and RNA Splicing

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The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways

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Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)

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Interplay between chromatin remodelers and protein arginine methyltransferases

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The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiationPreprint

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The Inhibitory Function in Human Progesterone Receptor N Termini Binds SUMO-1 Protein to Regulate Autoinhibition and Transrepression

Abdel-Hafiz, H. A., Takimoto, G. S., Tung, L. W., & Horwitz, K. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204573200 · Cited by 149 · see citing works

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α

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SUMOrganization of the nucleus

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Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

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Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor α and Is Involved in the Regulation of Receptor Activity

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Identification and Characterization of RRM-containing Coactivator Activator (CoAA) as TRBP-interacting Protein, and Its Splice Variant as a Coactivator Modulator (CoAM)

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Coactivator AIB1 links estrogen receptor transcriptional activity and stability

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SRC-3Δ4 Mediates the Interaction of EGFR with FAK to Promote Cell Migration

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An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response

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A Subset of Nuclear Receptor Coregulators Act as Coupling Proteins during Synthesis and Maturation of RNA Transcripts

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PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

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Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

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MED14 Tethers Mediator to the N-Terminal Domain of Peroxisome Proliferator-Activated Receptor γ and Is Required for Full Transcriptional Activity and Adipogenesis

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Nipped-A, the Tra1/TRRAP Subunit of the Drosophila SAGA and Tip60 Complexes, Has Multiple Roles in Notch Signaling during Wing Development

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Selective Recruitment of p160 Coactivators on Glucocorticoid-Regulated Promoters in Schwann Cells

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Gene Control by Large Noncoding RNAs

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The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor

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Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation

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Ubc9 and protein inhibitor of activated STAT 1 activate chicken ovalbumin upstream promoter-transcription factor I-mediated human CYP11B2 gene transcription

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Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

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PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression

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RXR Agonist Modulates TR: Corepressor Dissociation Upon 9-cis Retinoic Acid Treatment

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Structural Studies with Coactivators for the Estrogen Receptor

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Steroid-receptor coactivator complexes in thyroid hormone-regulation of Xenopus metamorphosis

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EFFICACY OF COSUPPLEMENTATION THERAPY WITH VITAMINS B9, B12, AND D ON ENDOTHELIAL DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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The gene regulatory effects of selective glucocorticoid receptor ligandsPreprint

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Cell cycle activation in thyroid hormone-induced apoptosis and stem cell development during Xenopus intestinal metamorphosis

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Nuclear receptors: a pandora of hope for metabolic syndrome.

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Nuclear Receptors and NR ‐coregulators: Mechanism of Action and Cell Signaling

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Corticosteroid Receptors

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Essential and subtype-dependent function of thyroid hormone receptors during Xenopus metamorphosis

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Nuclear Receptor Coregulators: Cellular and Molecular Biology

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Topic 1.2 Nuclear receptor coregulators*

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Molecular Endocrinology. First published ahead of print February 6, 2007 as doi:10.1210/me.2007-0012 COREGULATORS: FROM WHENCE CAME THESE ‘MASTER GENES’

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