Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

Ngo, Sherry; Barry, Janelle B.; Nisbet, Janelle C.; Prins, Johannes B.; Whitehead, Jonathan P.

doi:10.1016/j.mce.2008.10.020

Cited by 17Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

Ngo, Sherry, Barry, Janelle B., Nisbet, Janelle C., Prins, Johannes B., Whitehead, Jonathan P.·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.020

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Abstract

Excess glucocorticoids induce insulin resistance and reduce glucose uptake although the underlying mechanisms are unclear. Here we demonstrate that Dex (1 microM for 24h) inhibits basal and insulin (1 nM) stimulated glucose uptake in human and murine adipocytes by 50% with a concomitant reduction in the levels of GLUT1/4 at the plasma membrane but no change in total GLUT1/4 levels. Expression and phosphorylation of proximal insulin signalling molecules (IRS1, PI3K, AKT) was unaffected by Dex as was phosphorylation of mTOR and FOXO1. In contrast, phosphorylation of AKT substrate 160kDa (AS160) at T642, which is essential for 14-3-3 recruitment and GLUT4 translocation, was reduced by 50% in basal and insulin-stimulated cells and this was mirrored by decreased 14-3-3 association. Co-treatment with the glucocorticoid receptor antagonist RU486 (10 microM) abrogated the Dex effect on AS160-T642 phosphorylation and restored glucose uptake by 80%. These data suggest Dex inhibits glucose uptake in adipocytes, at least in part, by reducing AS160 phosphorylation and interaction with 14-3-3.

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The Ras superfamily at a glance
Wennerberg, K., Rossman, K. L., & Der, C. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01660 · Cited by 1,549 · see citing works
Regulated transport of the glucose transporter GLUT4
Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183 · see citing works
Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity
Rask, E., Olsson, T., Söderberg, S., Andrew, R., Livingstone, D. E. W., Johnson, O., & Walker, B. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7453 · Cited by 657 · see citing works
FoxO proteins in insulin action and metabolism
Barthel, A., Schmoll, D., & Unterman, T. G. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.03.010 · Cited by 599 · see citing works
Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking
Wieman, H. L., Wofford, J. A., & Rathmell, J. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0593 · Cited by 593 · see citing works
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
Wabitsch, M., Brenner, R., Melzner, I., Braun, M., Möller, P., Heinze, E., Debatin, K., & Hauner, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801520 · Cited by 563 · see citing works
Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes.
Frost, S. C., & Lane, M. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89409-1 · Cited by 513 · see citing works
Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family
Olson, A. L., & Pessin, J. E. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001315 · Cited by 456 · see citing works
Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking
Larance, M., Ramm, G., Stöckli, J., van Dam, E. M., Winata, S. C., Wasinger, V. C., Simpson, F., Graham, M. W., Junutula, J. R., Guilhaus, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503897200 · Cited by 385 · see citing works
Rab10, a Target of the AS160 Rab GAP, Is Required for Insulin-Stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane
Sano, H., Eguez, L., Teruel, M. N., Fukuda, M., Chuang, T. D., Chavez, J. A., Lienhard, G. E., & McGraw, T. E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.001 · Cited by 374 · see citing works
Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family
Olson, A. L. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.16.1.235 · Cited by 372 · see citing works
Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats1
Livingstone, D. E. W., Jones, G. C., Smith, K., Jamieson, P. M., Andrew, R., Kenyon, C. J., & Walker, B. R. (2000) · Endocrinology · doi:10.1210/endo.141.2.7297 · Cited by 348 · see citing works
Pivotal role of the mineralocorticoid receptor in corticosteroid‐induced adipogenesis
Caprio, M., Fève, B., Claës, A., Viengchareun, S., Lombès, M., & Zennaro, M.-C. (2007) · The FASEB Journal · doi:10.1096/fj.06-7970com · Cited by 337 · see citing works
Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor
Stayrook, K. R., Bramlett, K. S., Savkur, R. S., FICORILLI, J. V., Cook, T. G., Christe, M. E., Michael, L. F., & Burris, T. P. (2004) · Endocrinology · doi:10.1210/en.2004-0965 · Cited by 288 · see citing works
Insulin action on glucose transporters through molecular switches, tracks and tethers
Zaid, H., Antonescu, C. N., Randhawa, V. K., & Klip, A. (2008) · Biochemical Journal · doi:10.1042/bj20080723 · Cited by 286 · see citing works
Differential sorting of two glucose transporters expressed in insulin-sensitive cells
Piper, R. C., Hess, L., & James, D. E. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.3.c570 · Cited by 259 · see citing works
The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating GLUT4 Traffic
Thong, F. S. L., Bilan, P. J., & Klip, A. (2007) · Diabetes · doi:10.2337/db06-0900 · Cited by 242 · see citing works
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Sakoda, H., Ogihara, T., Anai, M., Funaki, M., Inukai, K., Katagiri, H., Fukushima, Y., Onishi, Y., Ono, H., Fujishiro, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1700 · Cited by 241 · see citing works
Glucose transporter 4: cycling, compartments and controversies
Dugani, S. B., & Klip, A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400584 · Cited by 229 · see citing works
Bridging the GAP between insulin signaling and GLUT4 translocation
Watson, R. T., & Pessin, J. E. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.02.007 · Cited by 219 · see citing works
The Origin and Functions of Multiple Human Glucocorticoid Receptor Isoforms
Lu, N. Z., & Cidlowski, J. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.008 · Cited by 215 · see citing works
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes.
Ng, Y., Ramm, G., Lopez, J., & James, D. E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.008 · Cited by 204 · see citing works
A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160
Ramm, G., Larance, M., Guilhaus, M., & James, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603274200 · Cited by 200 · see citing works
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1
Roach, W. G., Chavez, J. A., Mı̂inea, C. P., & Lienhard, G. E. (2007) · Biochemical Journal · doi:10.1042/bj20061798 · Cited by 192 · see citing works
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G., & MacKintosh, C. (2007) · Biochemical Journal · doi:10.1042/bj20070649 · Cited by 181 · see citing works
Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans.
Dinneen, S., Alzaid, A., Miles, J., & Rizza, R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116832 · Cited by 175 · see citing works
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
Nasrin, N., Ogg, S., Cahill, C. M., Biggs, W., Nui, S., Dore, J., Calvo, D., Shi, Y., Ruvkun, G., & Alexander-Bridges, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190326997 · Cited by 165 · see citing works
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Burén, J., Liu, H., Jensen, J., & Eriksson, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460419 · Cited by 160 · see citing works
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
Ishikura, S., Bilan, P. J., & Klip, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.140 · Cited by 158 · see citing works
Characterization of the Insulin-regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes
Ross, S. A., Scott, H. M., Morris, N. J., Leung, W., Mao, F., Lienhard, G. E., & Keller, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.3328 · Cited by 151 · see citing works
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition
Stone, S., Abkevich, V., Russell, D. L., Riley, R., Timms, K. M., Tran, T., Trem, D. J., Frank, D., Jammulapati, S., Neff, C. D., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl204 · Cited by 150 · see citing works
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice
Shao, J., Yamashita, H., Qiao, L., & Friedman, J. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1670107 · Cited by 148 · see citing works
The Role of Ca2+ in Insulin-stimulated Glucose Transport in 3T3-L1 Cells
Whitehead, J. P., Molero, J. C., Clark, S. F., Martin, S., Meneilly, G. S., & James, D. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011590200 · Cited by 147 · see citing works
Self-citation
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein
Huang, J., Imamura, T., & Olefsky, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241368698 · Cited by 121 · see citing works
Akt Activation Is Required at a Late Stage of Insulin-Induced GLUT4 Translocation to the Plasma Membrane
van Dam, E. M., Govers, R., & James, D. E. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0413 · Cited by 121 · see citing works
Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats
Livingstone, D. E. W. (2000) · Endocrinology · doi:10.1210/en.141.2.560 · Cited by 121 · see citing works
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
Jing, Y. A. N. G., CLARKE, J. F., ESTER, C. J., Young, P. W., Kasuga, M., & Holman, G. D. (1996) · Biochemical Journal · doi:10.1042/bj3130125 · Cited by 96 · see citing works
Development of an intracellular pool of glucose transporters in 3T3-L1 cells.
Yang, J., CLARK, A. E., Kozka, I. J., Cushman, S. W., & Holman, G. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50032-1 · Cited by 88 · see citing works
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Jiang, L., Fan, J., Bai, L., Wang, Y., Chen, Y., Lü, Y., Chen, L., & Xu, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708688200 · Cited by 84 · see citing works
Characterization of the transcriptional and functional effects of fibroblast growth factor‐1 on human preadipocyte differentiation
Newell, F., Su, H., Tornqvist, H. E., Whitehead, J. P., Prins, J. B., & Hutley, L. J. (2006) · The FASEB Journal · doi:10.1096/fj.05-5710fje · Cited by 79 · see citing works
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Gathercole, L. L., Bujalska, I. J., Stewart, P. M., & Tomlinson, J. W. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1399 · Cited by 73 · see citing works
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Kubo, Y. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018817 · Cited by 69 · see citing works
Separation of Insulin Signaling into Distinct GLUT4 Translocation and Activation Steps
Funaki, M., Randhawa, P. K., & Janmey, P. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7567-7577.2004 · Cited by 64 · see citing works
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Konrad, D., Bilan, P. J., Nawaz, Z., Sweeney, G., Niu, W., Liu, Z., Antonescu, C. N., Rudich, A., & Klip, A. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2719 · Cited by 63 · see citing works
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Liao, W., Nguyen, M. T., Imamura, T., Singer, O., Verma, I. M., & Olefsky, J. M. (2006) · Endocrinology · doi:10.1210/en.2005-1638 · Cited by 60 · see citing works
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes
Zhou, Q. L., Jiang, Z. Y., Holik, J., Chawla, A., Hagan, G. N., Leszyk, J., & Czech, M. (2008) · Biochemical Journal · doi:10.1042/bj20071084 · Cited by 55 · see citing works
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Kino, T., Martino, M. U. D., Charmandari, E., Ichijo, T., Outas, T., & Chrousos, G. P. (2005) · Diabetes · doi:10.2337/diabetes.54.1.23 · Cited by 47 · see citing works
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Howlett, K. F., Sakamoto, K., Garnham, A., Cameron-Smith, D., & Hargreaves, M. (2007) · Diabetes · doi:10.2337/db06-1398 · Cited by 37 · see citing works
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to insulin-like growth factor 1, EGF, PMA and AICAR
Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F. M., Toth, R. L., Nick, A., Vandermoere, F., Moorhead, G. B. G., Hardie, D. G., & MacKintosh, C. (2007) · Cited by 6 · see citing works

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Authors: Ngo, S., Barry, J. B., Nisbet, J. C., Prins, J. B., & Whitehead, J. P.
Affiliations: The University of Queensland (AU)
ORCID: Nisbet, Janelle C.
Prins, Johannes B.
Whitehead, Jonathan P.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-04
Volume: 302
Issue: 1
Pages: 33-40
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.020
OpenAlex: W2003401065
Cited by: 17
References: 50
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
FWCI: 0.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion)
Funders: Lions Medical Research Foundation
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: AS160, glucocorticoid resistance, dexamethasone, glucose uptake, adipocytes, insulin signaling, GLUT4 translocation, GLUT1, 14-3-3 proteins, Akt phosphorylation, insulin resistance, glucocorticoid receptor, RU486, mTOR, FOXO1
MeSH terms: Animals, Cells, Cultured, Cricetulus, Gene Expression Regulation, Glucocorticoids, Glucose, Cricetinae, Humans, Insulin, Phosphorylation, Protein Binding, Signal Transduction, CHO Cells, Adipocytes, GTPase-Activating Proteins, 14-3-3 Proteins, Carbohydrate Metabolism, Mice

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Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

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