The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Melatonin membrane receptors in peripheral tissues: Distribution and functions
Open accessAbstract
Many of melatonin’s actions are mediated through interaction with the G-protein coupled membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or, indirectly with nuclear orphan receptors from the RORα/RZR family. Melatonin also binds to the quinone reductase II enzyme, previously defined the MT3 receptor. Melatonin receptors are widely distributed in the body; herein we summarize their expression and actions in non-neural tissues. Several controversies still exist regarding, for example, whether melatonin binds the RORα/RZR family. Studies of the peripheral distribution of melatonin receptors are important since they are attractive targets for immunomodulation, regulation of endocrine, reproductive and cardiovascular functions, modulation of skin pigmentation, hair growth, cancerogenesis, and aging. Melatonin receptor agonists and antagonists have an exciting future since they could define multiple mechanisms by which melatonin modulates the complexity of such a wide variety of physiological and pathological processes.
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Cites
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Self-citationMelanin pigmentation in mammalian skin and its hormonal regulation
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Self-citationRegulation of antioxidant enzymes: a significant role for melatonin
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Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., & Reiter, R. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00249 · Cited by 689
Self-citationCircadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 521
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400
Self-citationMelatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371
Self-citationMitochondria in skin health, aging, and disease
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Metadata
- Authors
- Slominski, R. M., Reiter, R. J., Schlabritz-Loutsevitch, N., Ostrom, R. S., & Slominski, A. T.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 351
- Issue
- 2
- Pages
- 152-166
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2043774516
- Cited by
- 675
- References
- 228
- FWCI
- 17.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Slominski, R. M., Reiter, R. J., Schlabritz-Loutsevitch, N., Ostrom, R. S., & Slominski, A. T. (2012). Melatonin membrane receptors in peripheral tissues: Distribution and functions. Molecular and Cellular Endocrinology. https://doi.org/10.1016/j.mce.2012.01.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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