Mitochondria in skin health, aging, and disease
Open accessAbstract
The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron transport chain (ETC) that is located on the inner membrane of the mitochondria. However, reactive oxygen species (ROS) like superoxide, singlet oxygen, peroxides are inevitably produced during respiration and disrupt macromolecular and cellular structures if not quenched by the antioxidant system. The oxidative damage caused by mitochondrial ROS production has been established as the molecular basis of multiple pathophysiological conditions, including aging and cancer. Not surprisingly, the mitochondria are the primary organelle affected during chronological and UV-induced skin aging, the phenotypic manifestations of which are the direct consequence of mitochondrial dysfunction. Also, deletions and other aberrations in the mitochondrial DNA (mtDNA) are frequent in photo-aged skin and skin cancer lesions. Recent studies have revealed a more innate role of the mitochondria in maintaining skin homeostasis and pigmentation, which are affected when the essential mitochondrial functions are impaired. Some common and rare skin disorders have a mitochondrial involvement and include dermal manifestations of primary mitochondrial diseases as well as congenital skin diseases caused by damaged mitochondria. With studies increasingly supporting the close association between mitochondria and skin health, its therapeutic targeting in the skin-either via an ATP production boost or free radical scavenging-has gained attention from clinicians and aestheticians alike. Numerous bioactive compounds have been identified that improve mitochondrial functions and have proved effective against aged and diseased skin. In this review, we discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.
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Mitochondrion is the main organelle involved in skin photoaging.
“Mitochondrion is the main organelle involved in skin photoaging [67].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [67]
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Flagged first, then by citations
Research works printed but not linked: 1
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Boosting the Photoaged Skin: The Potential Role of Dietary Components
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- Authors
- Sreedhar, A., Aguilera-Aguirre, L., & Singh, K. K.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Singh, Keshav K.
- Venue
- Cell Death & Disease
- Published
- 2020-06-09
- Volume
- 11
- Issue
- 6
- Pages
- 444-444
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC7283348
- OpenAlex
- W3033656382
- Cited by
- 339
- References
- 151
- Citations by year
- 2026: 59 · 2025: 80 · 2024: 66 · 2023: 49 · 2022: 50 · 2021: 31 · 2020: 4
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- mitochondria, skin aging, photoaging, mitochondrial dysfunction, reactive oxygen species, electron transport chain, mitochondrial respiration, mitochondrial DNA deletions, skin cancer, skin pigmentation, skin homeostasis, primary mitochondrial disease, congenital skin disorders, bioactive compounds, antioxidant therapy
- MeSH terms
- Animals, Homeostasis, Humans, Mitochondria, Regeneration, Skin, Skin Diseases, Skin Aging
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