Cited by 104Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

The hinge region in androgen receptor control

Clinckemalie, Liesbeth, Vanderschueren, Dirk, Boonen, Steven, Claessens, Frank·2012·Molecular and Cellular Endocrinology

Abstract

The region between the DNA-binding domain and the ligand-binding domain of nuclear receptors is termed the hinge region. Although this flexible linker is poorly conserved, diverse functions have been ascribed to it. For the androgen receptor (AR), the hinge region and in particular the (629)RKLKKL(634) motif, plays a central role in controlling AR activity, not only because it acts as the main part of the nuclear translocation signal, but also because it regulates the transactivation potential and intranuclear mobility of the receptor. It is also a target site for acetylation, ubiquitylation and methylation. The interplay between these different modifications as well as the phosphorylation at serine 650 will be discussed here. The hinge also has an important function in AR binding to classical versus selective androgen response elements. In addition, the number of coactivators/corepressors that might act via interaction with the hinge region is still growing. The importance of the hinge region is further illustrated by the different somatic mutations described in patients with androgen insensitivity syndrome and prostate cancer. In conclusion, the hinge region serves as an integrator for signals coming from different pathways that provide feedback to the control of AR activity.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2012.02.019

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Clinckemalie, L., Vanderschueren, D., Boonen, S., & Claessens, F.
Affiliations
KU Leuven (BE)
Corresponding author
Claessens, Frank
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2012-07
Volume
358
Issue
1
Pages
1-8
ISSN
0303-7207 (ISSN-L)
OpenAlex
W1983131802
Cited by
104
References
83
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 12 · 2013: 11 · 2012: 6
FWCI
1.70
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fonds Wetenschappelijk Onderzoek
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
androgen receptor, hinge region, nuclear receptors, nuclear translocation, transcriptional activation, post-translational modification, acetylation, ubiquitination, methylation, androgen response element, transcriptional coactivator, corepressors, androgen insensitivity syndrome, prostate cancer, somatic mutations
MeSH terms
Acetylation, Animals, DNA-Binding Proteins, Humans, Methylation, Peptides, Phosphorylation, Receptors, Androgen, Transcriptional Activation, Response Elements, Protein Interaction Domains and Motifs, Ubiquitination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review