Cited by 415Estrogen and related hormone effectsGenomics and Chromatin DynamicsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 172 of the 174 references it cites were found in a registry or an index.

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

Ratman, Dariusz, Vanden Berghe, Wim, Dejager, Lien, Libert, Claude, Tavernier, Jan, Beck, Ilse M., De Bosscher, Karolien·2013·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2012.12.014

Open this paper in CoChat — free account

Abstract

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response elements in regulatory regions of particular target genes, GR can also inhibit gene expression via transrepression, a mechanism largely based on protein:protein interactions. Hereby GR can influence the activity of other transcription factors, without contacting DNA itself. GR is known to inhibit the activity of a growing list of immune-regulating transcription factors. Hence, GCs still rule the clinic for treatments of inflammatory disorders, notwithstanding concomitant deleterious side effects. Although patience is a virtue when it comes to deciphering the many mechanisms GR uses to influence various signaling pathways, the current review is testimony of the fact that groundbreaking mechanistic work has been accumulating over the past years and steadily continues to grow.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2012.12.014

Cites

172 of 172 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor
Yamagata, K., Fujiyama, S., Ito, S., Ueda, T., Murata, T., Naitou, M., Takeyama, K., Minami, Y., O’Malley, B. W., & Kato, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.017 · Cited by 197
Retracted
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847
Molecular and Cellular Endocrinology
Rainey, W. E., & Rodgers, R. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.007 · Cited by 1,340
Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor
Kovacs, J. J., Murphy, P. J. M., Gaillard, S., Zhao, X., Wu, J.-T., Nicchitta, C. V., Yoshida, M., Toft, D. O., Pratt, W. B., & Yao, T.-P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.021 · Cited by 1,153
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,138
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089
DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068

Show all 174 references

Sorted by citations

Immune regulation by glucocorticoids
Cain, D. W., & Cidlowski, J. A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.1 · Cited by 1,846
Therapeutic Mechanisms of Glucocorticoids
Vandewalle, J., Luypaert, A., Bosscher, K. D., & Libert, C. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.010 · Cited by 569
Self-citation
Molecular regulations of circadian rhythm and implications for physiology and diseases
Fagiani, F., Marino, D. D., Romagnoli, A., Travelli, C., Voltan, D., Mannelli, L. D. C., Racchi, M., Govoni, S. M., & Lanni, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00899-y · Cited by 518
Interleukin-1 Beta—A Friend or Foe in Malignancies?
Bent, R., Moll, L., Grabbe, S., & Bros, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082155 · Cited by 475
A users guide to HPA axis research
Spencer, R. L., & Deak, T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.014 · Cited by 454
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308
Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297
60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253
Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes
Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0373 · Cited by 216
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
Franco, L. M., Gadkari, M., Howe, K. N., Sun, J., Kardava, L., Kumar, P., Kumari, S., Hu, Z., Fraser, I. D. C., Moir, S. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20180595 · Cited by 201
Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development
Argentieri, M. A., Nagarajan, S., Seddighzadeh, B., Baccarelli, A., & Shields, A. E. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.044 · Cited by 199
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Steininger, A., & ARZT, E. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00235 · Cited by 190
Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome
Vockley, C. M., D’Ippolito, A. M., McDowell, I. C., Majoros, W. H., Safi, A., Song, L., Crawford, G. E., & Reddy, T. E. (2016) · Cell · doi:10.1016/j.cell.2016.07.049 · Cited by 182
Retinoic Acid Actions through Mammalian Nuclear Receptors
Huang, P., Chandra, V., & Rastinejad, F. (2013) · Chemical Reviews · doi:10.1021/cr400161b · Cited by 173
Adrenal function and dysfunction in critically ill patients
Téblick, A., Peeters, B., Langouche, L., & den Berghe, G. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0185-7 · Cited by 158
New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor
Scheschowitsch, K., Leite, J. A., & Assreuy, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00016 · Cited by 164
Glucocorticoid Signaling: An Update from a Genomic Perspective
Sacta, M. A., Chinenov, Y. V., & Rogatsky, I. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105323 · Cited by 155
Mechanisms of cortisol action in fish hepatocytes
Faught, E. L., & Vijayan, M. M. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.06.012 · Cited by 149
DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation
Roy, B., Shelton, R. C., & Dwivedi, Y. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.02.005 · Cited by 139
Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review
BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 144
The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity
Lockett, J., Inder, W. J., & Clifton, V. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae008 · Cited by 135
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Voisin, M., de Médina, P., Mallinger, A., Dalenc, F., Huc‐Claustre, E., Leignadier, J., Serhan, N., Soulès, R., Segala, G., Mougel, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707965114 · Cited by 135
Glucocorticoids, genes and brain function
Juszczak, G. R., & Stankiewicz, A. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.020 · Cited by 138
Stress and the dynamic genome: Steroids, epigenetics, and the transposome
Hunter, R. G., Gagnidze, K., McEwen, B. S., & Pfaff, D. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411260111 · Cited by 137
Hypothalamic-pituitary – adrenal axis-feedback control
Keller‐Wood, M. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140065 · Cited by 131
Progress and challenges of selective Farnesoid X Receptor modulation
Massafra, V., Pellicciari, R., Gioiello, A., & van Mil, S. W. C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.009 · Cited by 133
Genome reading by the NF-κB transcription factors
Mulero, M. C., Wang, V. Y., Huxford, T., & Ghosh, G. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz739 · Cited by 130
Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges
Johnson, F. K., & Kaffman, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.008 · Cited by 127
Glucocorticoids in Sepsis: To Be or Not to Be
Vandewalle, J., & Libert, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01318 · Cited by 125
Self-citation
Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
Alam, M. M., Okazaki, K., Nguyen, L. T. T., Ota, N., Kitamura, H., Murakami, S., Shima, H., Igarashi, K., Sekine, H., & Motohashi, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.773960 · Cited by 122
Hormonal control of T-cell development in health and disease
Savino, W., Mendes‐da‐Cruz, D. A., Lepletier, A., & Dardenne, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.168 · Cited by 121
Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
Shimba, A., & Ikuta, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02143 · Cited by 121
A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females
Ren, B., & Zhu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052708 · Cited by 123
Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119
ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factorsPreprint
Starick, S. R., Ibn-Salem, J., Jurk, M., Hernandez, C., Love, M. I., Chung, H., Vingron, M., Thomas‐Chollier, M., & Meijsing, S. H. (2015) · Genome Research · doi:10.1101/gr.185157.114 · Cited by 120
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice
Rodrigues, M. E. D. S., Bekhbat, M., Houser, M. C., Chang, J., Walker, D. I., Jones, D. P., do Nascimento, C. M. P. O., Barnum, C. J., & Tansey, M. G. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.021 · Cited by 122
Endothelial Response to Glucocorticoids in Inflammatory Diseases
Zielińska, K. A., Moortel, L. V., Opdenakker, G., Bosscher, K. D., & den Steen, P. E. V. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00592 · Cited by 120
The Pro-inflammatory Effects of Glucocorticoids in the Brain
Duque, É. D. A., & Munhoz, C. D. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00078 · Cited by 118
Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 125
Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration
Xie, Y., Tolmeijer, S. H., Oskam, J. M., Tonkens, T., Meijer, A. H., & Schaaf, M. J. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037887 · Cited by 114
More similar than you think: Frog metamorphosis as a model of human perinatal endocrinology
Buchholz, D. R. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.018 · Cited by 105
Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging
DuPont, J. J., McCurley, A., Davel, A. P., McCarthy, J., Bender, S. B., Hong, K., Yang, Y., Yoo, J., Aronovitz, M. J., Baur, W. E., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88942 · Cited by 107
Defining the role of glucocorticoids in inflammation
Ronchetti, S., Migliorati, G., Bruscoli, S., & Riccardi, C. (2018) · Clinical Science · doi:10.1042/cs20171505 · Cited by 104
Steroids and endocrine disruptors—History, recent state of art and open questions
Hampl, R., Kubátová, J., & Stárka, L. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.04.013 · Cited by 97
Neuroendocrine-immune interaction: Evolutionarily conserved mechanisms that maintain allostasis in an ever-changing environment
Kemenade, B. M. L. V.-V., Cohen, N., & Chadzińska, M. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.05.015 · Cited by 98
Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation
Voutsadakis, I. A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5010011 · Cited by 94
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Heier, C. R., Yu, Q., Fiorillo, A. A., Tully, C., Tucker, A., Mázala, D. A. G., Uaesoontrachoon, K., Srinivassane, S., Damsker, J. M., Hoffman, E. P., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201800186 · Cited by 95
Glucocorticoid Receptor and Adipocyte Biology
Lee, R. A., Harris, C. A., & Wang, J.-C. (2018) · Nuclear Receptor Research · doi:10.32527/2018/101373 · Cited by 97
Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations
Morris, G., Berk, M., Maes, M. H. J., Carvalho, A. F., & Puri, B. K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1498-1 · Cited by 91
Glucocorticoid resistance as a major drive in sepsis pathology
Dendoncker, K., & Libert, C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.002 · Cited by 85
Self-citation
Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex
Hua, G., Ganti, K. P., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522826113 · Cited by 84
GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression
Hua, G., Paulen, L., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522821113 · Cited by 84
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells
Billan, F. L., Khan, J. A., Lamribet, K., Viengchareun, S., Bouligand, J., Fagart, J., & Lombès, M. (2015) · The FASEB Journal · doi:10.1096/fj.15-274266 · Cited by 82
Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 84
Oxysterols and nuclear receptors
Ma, L., & Nelson, E. R. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.01.016 · Cited by 87
Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety
Pan-Vazquez, A., Rye, N., Ameri, M., McSparron, B., Smallwood, G., Bickerdyke, J., Rathbone, A., Dajas‐Bailador, F., & Toledo‐Rodriguez, M. (2015) · Molecular Brain · doi:10.1186/s13041-015-0128-8 · Cited by 80
New insights into the novel anti-inflammatory mode of action of glucocorticoids
Ingawale, D. K., & Mandlik, S. K. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1728765 · Cited by 78
Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health
Harris, B. N. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113355 · Cited by 79
Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals
Thambirajah, A. A., Wade, M. G., Jonathan Verreault, A., Buisine, N., Alves, V. A., Langlois, V. S., & Helbing, C. C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111906 · Cited by 76
Regulation of TRH neurons and energy homeostasis-related signals under stress
Joseph‐Bravo, P., Jaimes-Hoy, L., & Charli, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0593 · Cited by 78
Sex and stress steroids in adolescence: Gonadal regulation of the hypothalamic–pituitary–adrenal axis in the rat
Green, M. R., & McCormick, C. M. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.02.004 · Cited by 84
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
Weikum, E. R., de Vera, I. M. S., Nwachukwu, J. C., Hudson, W. H., Nettles, K. W., Kojetin, D. J., & Ortlund, E. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx509 · Cited by 76
The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells
Prenek, L., Boldizsár, F., Kugyelka, R., Ugor, E., Berta, G., Németh, P., & Berki, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1320-8 · Cited by 79
Maternal stress and fish reproduction: The role of cortisol revisited
Faught, E. L., & Vijayan, M. M. (2018) · Fish and Fisheries · doi:10.1111/faf.12309 · Cited by 73
Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology
Sevilla, L. M., & Pérez, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071906 · Cited by 77
Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways
Sevilla, L. M., Jiménez‐Panizo, A., Alegre‐Martí, A., Estébanez‐Perpiñá, E., Caelles, C., & Pérez, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810049 · Cited by 78
Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity
Lesovaya, E. A., Yemelyanov, A. Y., Swart, A. C., Swart, P., Haegeman, G., & Budunova, I. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5078 · Cited by 73
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
Ratman, D., Mylka, V., Bougarne, N., Pawlak, M., Caron, S., Hennuyer, N., Paumelle, R., Cauwer, L. D., Thommis, J., Rider, M. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw742 · Cited by 73
Self-citation
A Body Shape Index (ABSI), hip index, and risk of cancer in the UK Biobank cohort
Christakoudi, S., Tsilidis, K. K., Εvangelou, Ε., & Ríboli, E. (2021) · Cancer Medicine · doi:10.1002/cam4.4097 · Cited by 72
Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 73
Role of microRNAs in Immune Regulation with Translational and Clinical Applications
Gaál, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031942 · Cited by 73
Comparing the rules of engagement of androgen and glucocorticoid receptors
Claessens, F., Joniau, S., & Helsen, C. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2467-3 · Cited by 69
Glucocorticoid receptor function in health and disease
Caratti, G., Matthews, L. C., Poolman, T. M., Kershaw, S., Baxter, M. D., & Ray, D. W. (2015) · Clinical Endocrinology · doi:10.1111/cen.12728 · Cited by 68
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Achuthan, A. A., Aslam, A. S. M., Nguyen, Q., Lam, P. Y., Fleetwood, A. J., Frye, A. T., Louis, C., Lee, M.-C., Smith, J. E., Cook, A. D., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0332-4 · Cited by 67
Genetics of Guillain‐Barré syndrome ( GBS ) and chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP ): current knowledge and future directions
Blum, S., & McCombe, P. (2014) · Journal of the Peripheral Nervous System · doi:10.1111/jns5.12074 · Cited by 71
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcomePreprint
Paakinaho, V., Johnson, T. A., Presman, D. M., & Hager, G. L. (2019) · Genome Research · doi:10.1101/gr.244814.118 · Cited by 70
Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept
Bosscher, K. D., Beck, I. M. E., Ratman, D., Berghe, W. V., & Libert, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.09.002 · Cited by 65
Self-citation
Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain–gut axis
Wiley, J. W., Higgins, G. A., & Athey, B. D. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12706 · Cited by 66
Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress
Shimba, A., Ejima, A., & Ikuta, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706951 · Cited by 64
REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids
Baida, G. E., Bhalla, P., Игоревич, К. К., Lesovaya, E. A., Геннадиевна, Я. М., Yuen, K., Guo, S., Lavker, R. M., Readhead, B., Dudley, J. T., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404601 · Cited by 66
Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD
Klepsch, V., Moschen, A. R., Tilg, H., Baier, G., & Hermann‐Kleiter, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01070 · Cited by 63
Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?
Mayayo-Peralta, I., Zwart, W., & Preković, S. (2021) · Endocrine-Related Cancer · doi:10.1530/erc-20-0489 · Cited by 53
Implicating the Role of GILZ in Glucocorticoid Modulation of T-Cell Activation
Cannarile, L., Delfino, D. V., Adorisio, S., Riccardi, C., & Ayroldi, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01823 · Cited by 65
Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels
Giulbudagian, M., Hönzke, S., Bergueiro, J., Işık, D., Schumacher, F., Saeidpour, S., Lohan, S. B., Meinke, M. C., Teutloff, C., Schäfer‐Korting, M., et al. (2017) · Nanoscale · doi:10.1039/c7nr04480a · Cited by 61
G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone
Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60
Glucocorticoid hormone treatment enhances the cytokine production of regulatory T cells by upregulation of Foxp3 expression
Ugor, E., Prenek, L., Pap, R., Berta, G., Ernszt, D., Najbauer, J., Németh, P., Boldizsár, F., & Berki, T. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.010 · Cited by 58
The glucocorticoid receptor in inflammatory processes: transrepression is not enough
Hübner, S., Dejager, L., Libert, C., & Tuckermann, J. P. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0106 · Cited by 57
Self-citation
Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages
Jubb, A. W., Young, R. S., Hume, D. A., & Bickmore, W. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1502009 · Cited by 61
Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway
Hu, S., Xia, L., Luo, H., Xu, Y., Yu, H., Xu, D., & Wang, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.02.008 · Cited by 55
Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients
Dulek, D. E., Fuhlbrigge, R. C., Tribble, A. C., Connelly, J. A., Loi, M. M., Chebib, H. E., Chandrakasan, S., Otto, W. R., Diorio, C. J., Keim, G. P., et al. (2020) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaa098 · Cited by 56
The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies
Harding, T., Baughn, L. B., Kumar, S. K., & Ness, B. V. (2019) · Leukemia · doi:10.1038/s41375-018-0362-z · Cited by 56
Mechanisms of Glucocorticoid-Regulated Gene Transcription
Meijsing, S. H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_3 · Cited by 56
Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway
Zhang, Y., Shi, G., Zhang, H.-T., Xiong, Q., Cheng, F.-Y., Wang, H.-L., Luo, J.-Y., Zhang, Y., Shi, P., Xu, J., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01944-w · Cited by 48
Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae
He, M., Halima, M., Xie, Y., Schaaf, M. J. M., Meijer, A. H., & Wang, M. (2020) · Cells · doi:10.3390/cells9051107 · Cited by 53
Regulation of the Immune System Development by Glucocorticoids and Sex Hormones
Quatrini, L., Ricci, B., Ciancaglini, C., Tumino, N., & Moretta, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672853 · Cited by 51
The Acute Stress Response in the Multiomic Era
Floriou-Servou, A., von Ziegler, L., Waag, R., Schläppi, C., Germain, P.-L., & Bohacek, J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.031 · Cited by 51
Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress
Dowell, J., Elser, B. A., Schroeder, R. E., & Stevens, H. E. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134368 · Cited by 51
Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs
Ballester, M., Ramayo‐Caldas, Y., Revilla, M., Corominas, J., Castelló, A., Estellé, J., Fernández, A. I., & Folch, J. M. (2017) · Scientific Reports · doi:10.1038/srep46539 · Cited by 53
Genome-wide fetalization of enhancer architecture in heart disease
Spurrell, C. H., Barozzi, I., Kosicki, M., Mannion, B. J., Blow, M. J., Fukuda-Yuzawa, Y., Slaven, N., Afzal, S. Y., Akiyama, J. A., Afzal, V., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111400 · Cited by 48
Glucocorticoid-targeted therapies for the treatment of rheumatoid arthritis
Strehl, C., van der Goes, M. C., Bijlsma, J. W. J., Jacobs, J. W. G., & Buttgereit, F. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1276562 · Cited by 46

Authors: Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K.
Affiliations: Ghent University (BE)
Ghent University Hospital (BE)
ORCID: Libert, Claude
Tavernier, Jan
Beck, Ilse M.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 380
Issue: 1-2
Pages: 41-54
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2012.12.014
OpenAlex: W2067181732
Cited by: 411
References: 174
Citations by year: 2026: 17 · 2025: 16 · 2024: 17 · 2023: 25 · 2022: 34 · 2021: 30 · 2020: 30 · 2019: 51 · 2018: 46 · 2017: 45 · 2016: 36 · 2015: 35 · 2014: 22 · 2013: 7
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Vlaamse regering
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoid receptor, transrepression, transcription factor regulation, protein-protein interaction, glucocorticoid response element, glucocorticoid signaling, inflammatory diseases, glucocorticoid adverse effects, nuclear receptors
MeSH terms: Animals, Chromatin, Humans, Protein Kinases, Protein Processing, Post-Translational, Receptors, Glucocorticoid, Transcription Factors, Transcriptional Activation, Response Elements, Epigenetic Repression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks