Cited by 415Estrogen and related hormone effectsGenomics and Chromatin DynamicsAdrenal Hormones and Disorders

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How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

Ratman, Dariusz, Vanden Berghe, Wim, Dejager, Lien, Libert, Claude, Tavernier, Jan, Beck, Ilse M., De Bosscher, Karolien·2013·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2012.12.014

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Abstract

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response elements in regulatory regions of particular target genes, GR can also inhibit gene expression via transrepression, a mechanism largely based on protein:protein interactions. Hereby GR can influence the activity of other transcription factors, without contacting DNA itself. GR is known to inhibit the activity of a growing list of immune-regulating transcription factors. Hence, GCs still rule the clinic for treatments of inflammatory disorders, notwithstanding concomitant deleterious side effects. Although patience is a virtue when it comes to deciphering the many mechanisms GR uses to influence various signaling pathways, the current review is testimony of the fact that groundbreaking mechanistic work has been accumulating over the past years and steadily continues to grow.

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Authors: Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K.
Affiliations: Ghent University (BE)
Ghent University Hospital (BE)
ORCID: Libert, Claude
Tavernier, Jan
Beck, Ilse M.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 380
Issue: 1-2
Pages: 41-54
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2012.12.014
OpenAlex: W2067181732
Cited by: 411
References: 174
Citations by year: 2026: 17 · 2025: 16 · 2024: 17 · 2023: 25 · 2022: 34 · 2021: 30 · 2020: 30 · 2019: 51 · 2018: 46 · 2017: 45 · 2016: 36 · 2015: 35 · 2014: 22 · 2013: 7
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Universiteit Antwerpen
Vlaamse regering
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoid receptor, transrepression, transcription factor regulation, protein-protein interaction, glucocorticoid response element, glucocorticoid signaling, inflammatory diseases, glucocorticoid adverse effects, nuclear receptors
MeSH terms: Animals, Chromatin, Humans, Protein Kinases, Protein Processing, Post-Translational, Receptors, Glucocorticoid, Transcription Factors, Transcriptional Activation, Response Elements, Epigenetic Repression

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How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

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