Direct and rapid effects of 3,5-diiodo-L-thyronine (T2)
Abstract
A growing number of researchers are focusing their attention on the possibility that thyroid hormone metabolites, particularly 3,5-diiodothyronine (T2), may actively regulate energy metabolism at the cellular, rather than the nuclear, level. Due to their biochemical features, mitochondria have been the focus of research on the thermogenic effects of thyroid hormones. Indeed, mitochondrial activities have been shown to be regulated both directly and indirectly by T2-specific pathways. Herein, we describe the effects of T2 on energy metabolism.
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3,5-T2, in addition to its thyromimetic action at the classical T3 receptors at high concentrations, exerts rapid direct effects on mitochondria.
“Various groups have demonstrated that 3,5-T2, in addition to its thyromimetic action at the classical T3 receptors at high concentrations, exerts rapid direct effects on mitochondria (6, 16–19)”
From 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action (2020) · cites this paper as [19]
Cites
Knudsen, N., Laurberg, P., Rasmussen, L. B., Bülow, I., Perrild, H., Ovesen, L., & Jørgensen, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2225 · Cited by 753 · see citing works
Johnstone, A. M., Murison, S. D., Duncan, J. S., Rance, K. A., & Speakman, J. R. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.941 · Cited by 514 · see citing works
Fox, C. S. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.6.587 · Cited by 303 · see citing works
Metabolic Effects of Thyroid Hormone Derivatives
Moreno, M., de Lange, P., Lombardi, A., Silvestri, E., Lanni, A., & Goglia, F. (2008) · Thyroid · doi:10.1089/thy.2007.0248 · Cited by 226 · see citing works
Self-citationAl-Adsani, H. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1118 · Cited by 193 · see citing works
The thermogenic effect of thyroid hormone and its clinical implications
Silva, J. E. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00010 · Cited by 173 · see citing works
Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
Johannsen, D. L., Galgani, J. E., Johannsen, N. M., Zhang, Z., Covington, J. D., & Ravussin, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040837 · Cited by 57 · see citing works
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Köhrle, J., Lehmphul, I., Pietzner, M., Renko, K., Rijntjes, E., Richards, K., Anselmo, J., Danielsen, M., & Jonklaas, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00787 · Cited by 23 · see citing works
- Authors
- Moreno, M., Giacco, A., Di Munno, C., & Goglia, F.
- Affiliations
- University of Sannio (IT)
- Corresponding author
- Goglia, Fernando
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 458
- Pages
- 121-126
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2586134824
- Cited by
- 25
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- 3,5-diiodothyronine, thyroid hormone metabolites, energy metabolism, mitochondrial regulation, thermogenesis
- MeSH terms
- Animals, Diiodothyronines, Energy Metabolism, Humans, Mitochondria, Thermogenesis, Metabolic Networks and Pathways
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