Defective neuronogenesis in the absence of Dlx5

Perera, Marzia; Merlo, Giorgio R; Verardo, Sara; Paleari, Laura; Corte, Giorgio; Levi, Giovanni

doi:10.1016/j.mcn.2003.10.004

Cited by 56Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Defective neuronogenesis in the absence of Dlx5

Perera, Marzia, Merlo, Giorgio R, Verardo, Sara, Paleari, Laura, Corte, Giorgio, Levi, Giovanni·2004·Molecular and Cellular Neuroscience

DOI 10.1016/j.mcn.2003.10.004

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Abstract

Dlx genes play an important role in the control of the development of the central nervous system (CNS). Single or compound inactivation of Dlx1, Dlx2, or Dlx5 in the mouse causes defects of neuronal migration and differentiation. Dlx5, in particular, is essential for the correct development of the olfactory system. Targeted inactivation of Dlx1 and Dlx2 in the mouse results in abnormal neuronal differentiation in the embryonic subcortical forebrain and is associated to the loss of Dlx5 and Dlx6 expression. So far, however, it has been impossible to investigate the role of Dlx genes on late neurogenesis, as their inactivation leads to perinatal death. We have now generated cultures of neural stem cells (NSCs) derived from embryonic and newborn Dlx5-null mice, and we have compared their capacity to differentiate in vitro to that of equivalent cells derived from normal littermates. We show here that in the absence of Dlx5, NSCs derived from newborn animals have a severely reduced capacity to generate neurons. This is not the case for cells derived from E12.5 embryos. Forced expression of Dlx5 in cultures of newborn mutant NSCs fully restores their neuronogenic potential. Our data suggest that Dlx5 is essential for secondary (postnatal) neuronogenesis.

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Defective neurogenesis in the absence of Dlx5.
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The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse
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Self-citation

Authors: Perera, M., Merlo, G. R., Verardo, S., Paleari, L., Corte, G., & Levi, G.
Affiliations: Dulbecco Telethon Institute (IT)
University of Genoa (IT)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Levi, Giovanni
ORCID: Merlo, Giorgio R
Paleari, Laura
Levi, Giovanni
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2004-01
Volume: 25
Issue: 1
Pages: 153-161
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1016/j.mcn.2003.10.004
OpenAlex: W2028569029
Cited by: 56
References: 63
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2022: 3 · 2021: 3 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 1.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Science Council
Fondazione Cariplo
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: Dlx5, Dlx genes, neural stem cells, postnatal neurogenesis, neuronal differentiation, DLX1, Dlx2, Dlx6, olfactory development, central nervous system development, neural stem cell differentiation
MeSH terms: Animals, Animals, Newborn, beta-Galactosidase, Brain, Cell Differentiation, Cell Division, Cells, Cultured, Fetus, Mutation, Nervous System Malformations, Neurons, Olfactory Pathways, Stem Cells, Genes, Reporter, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Mice

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Defective neuronogenesis in the absence of Dlx5

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