Cited by 873Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

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Sussel, Lori, Marin, Oscar, Kimura, Shioko, Rubenstein, John L. R.·1999·Development

Abstract

The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum). Within the telencephalon, the anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in Nkx2.1 function does not form pallidal structures, lacks basal forebrain TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex. We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage.

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Crossref · 10.1242/dev.126.15.3359

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Authors
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R.
Affiliations
  • University of California, San Francisco (US)
  • 1 Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology and Biomedical Sciences, 401 Parnassus Avenue, University of California at San Francisco, CA 94143-0984, USA
  • National Institutes of Health (US)
Corresponding author
Rubenstein, John L. R.
Venue
Development
Published
1999-08-01
Volume
126
Issue
15
Pages
3359-3370
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2165130538
Cited by
873
References
56
Citations by year
2026: 12 · 2025: 19 · 2024: 12 · 2023: 23 · 2022: 27 · 2021: 44 · 2020: 35 · 2019: 23 · 2018: 30 · 2017: 25 · 2016: 32 · 2015: 40 · 2014: 43 · 2013: 42 · 2012: 28
FWCI
7.52
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
Funders
  • National Institutes of Health (2k02mh001046-06)
  • National Institute of Mental Health (K02 MH01046-01)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
TTF-1, homeobox genes, globus pallidus, striatum, basal ganglia, basal telencephalon, cholinergic neurons, TrkA, GABAergic interneurons, Dlx2, calbindin, knockout mice, forebrain development
MeSH terms
Thyroid Nuclear Factor 1, Animals, Base Sequence, Cell Movement, Corpus Striatum, Female, Genes, Homeobox, Globus Pallidus, Interneurons, Male, Mice, Mutant Strains, Nuclear Proteins, Phenotype, Pregnancy, Proteins, Telencephalon, Transcription Factors, Trans-Activators, DNA Primers, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins

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