Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
Open accessAbstract
The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum). Within the telencephalon, the anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in Nkx2.1 function does not form pallidal structures, lacks basal forebrain TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex. We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062 · see citing works
The Atlas of Mouse Development
Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,749 · see citing works
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471 · see citing works
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Self-citationThe atlas of mouse development
Beddington, R. S. P. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90071-o · Cited by 1,431 · see citing works
Kimura, S., Hara, Y., Pineau, T., Fernández‐Salguero, P. M., Fox, C. H., Ward, J. M., & Gonzalez, F. J. (1996) · Genes & Development · doi:10.1101/gad.10.1.60 · Cited by 1,221 · see citing works
Self-citationPax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Ericson, J., Rashbass, P., Schedl, A., Brenner‐Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M., & Briscoe, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80323-2 · Cited by 1,044 · see citing works
Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870 · see citing works
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807 · see citing works
Self-citationPuelles, L., & Rubenstein, J. L. R. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90080-6 · Cited by 784 · see citing works
Self-citationLavdas, A. A., Grigoriou, M., Pachnis, V., & Parnavelas, J. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07881.1999 · Cited by 765 · see citing works
Inductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659 · see citing works
Self-citationLongitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan-O’Connor, D. J., Martı́nez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 657 · see citing works
Self-citationBulfone, A., Puelles, L., Porteus, M. H., FROHMAN, M., Martin, G. R., & Rubenstein, J. L. R. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03155.1993 · Cited by 574 · see citing works
Self-citationMice Deficient in Golf Are Anosmic
Belluscio, L., Gold, G. H., Nemes, A., & Axel, R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80435-3 · Cited by 563 · see citing works
Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessel, T. M., & Edlund, T. (1995) · Cell · doi:10.1016/0092-8674(95)90536-7 · Cited by 553 · see citing works
REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE
Rubenstein, J. L. R., Shimamura, K., Martı́nez, S., & Puelles, L. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.445 · Cited by 546 · see citing works
Self-citationAnderson, S. A., Qiu, M. S., Bulfone, A., Eisenstat, D. D., Meneses, J. J., Pedersen, R. A., & Rubenstein, J. L. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80345-1 · Cited by 541 · see citing works
Self-citationGuazzi, S., Price, M., Felice, M. D., Damante, G., Mattéi, M., & Lauro, R. D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07574.x · Cited by 536 · see citing works
The Embryonic Vertebrate Forebrain: the Prosomeric Model
Rubenstein, J. L. R., Martinez, S., Shimamura, K., & Puelles, L. (1994) · Science · doi:10.1126/science.7939711 · Cited by 535 · see citing works
Self-citationMatise, M. P., Epstein, D. J., Park, H. L., Platt, K. A., & Joyner, A. L. (1998) · Development · doi:10.1242/dev.125.15.2759 · Cited by 489 · see citing works
Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat
Carlos, J., López‐Mascaraque, L., & Valverde, F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06146.1996 · Cited by 403 · see citing works
Origin and Route of Tangentially Migrating Neurons in the Developing Neocortical Intermediate Zone
Tamamaki, N., Fujimori, K. E., & Takauji, R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08313.1997 · Cited by 394 · see citing works
Forebrain patterning defects in Small eye mutant mice
Stoykova, A., Fritsch, R., Walther, C., & Gruß, P. (1996) · Development · doi:10.1242/dev.122.11.3453 · Cited by 378 · see citing works
Barth, K. A., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.6.1755 · Cited by 332 · see citing works
Formation of Rathke’s pouch requires dual induction from the diencephalon
Takuma, N., SHENG, H. Z., Furuta, Y., Ward, J. M., Sharma, K., Hogan, B. L. M., Pfaff, S. L., Westphal, H., Kimura, S., & Mahon, K. A. (1998) · Development · doi:10.1242/dev.125.23.4835 · Cited by 328 · see citing works
Self-citationSobreviela, T., Clary, D. O., Reichardt, L. F., Brandabur, M. M., Kordower, J. H., & Mufson, E. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500407 · Cited by 326 · see citing works
Bulfone, A., Wang, F., Hevner, R. F., Anderson, S. A., Cutforth, T., Chen, S., Meneses, J. J., Pedersen, R. A., Axel, R., & Rubenstein, J. L. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80647-9 · Cited by 325 · see citing works
Self-citationGrigoriou, M. E., Tucker, A. S., Sharpe, P. T., & Pachnis, V. (1998) · Development · doi:10.1242/dev.125.11.2063 · Cited by 307 · see citing works
Kim, Y., & Nirenberg, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7716 · Cited by 303 · see citing works
Dale, J. K., Vesque, C., Lints, T., Sampath, T. K., Furley, A. J., Dodd, J., & Placzek, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80334-7 · Cited by 295 · see citing works
Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain
Price, M., Lazzaro, D., Pohl, T., Mattéi, M., Rüther, U., Olivo‐Marín, J., Duboule, D., & Lauro, R. D. (1992) · Neuron · doi:10.1016/0896-6273(92)90291-k · Cited by 289 · see citing works
Weiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998) · Genes & Development · doi:10.1101/gad.12.22.3591 · Cited by 250 · see citing works
Meyer, G., Soria, J. M., Martinez-Galan, J. R., Mart�n-Clemente, B., & Fair�n, A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980810)397:4 · Cited by 228 · see citing works
Hynes, M., Poulsen, K., Tessier‐Lavigne, M., & Rosenthal, A. (1995) · Cell · doi:10.1016/0092-8674(95)90454-9 · Cited by 226 · see citing works
Patterning of the embryonic forebrain
Rubenstein, J. L. R., & Beachy, P. A. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80004-4 · Cited by 220 · see citing works
Self-citationLiu, J. K., Ghattas, I. R., Liu, S., Chen, S., & Rubenstein, J. L. R. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199712)210:4 · Cited by 217 · see citing works
Self-citationPorteus, M. H., Bulfone, A., Liu, J., Puelles, L., Lo, L., & Rubenstein, J. L. R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06370.1994 · Cited by 215 · see citing works
Self-citationPatterning of the chick forebrain anlage by the prechordal plate
Pera, E. M., & Kessel, M. (1997) · Development · doi:10.1242/dev.124.20.4153 · Cited by 210 · see citing works
Genetic control of brain morphogenesis through Otx gene dosage requirement
Acampora, D., Avantaggiato, V., Tuorto, F., & Simeone, A. (1997) · Development · doi:10.1242/dev.124.18.3639 · Cited by 208 · see citing works
Álvarez-Bolado, G., Rosenfeld, M. G., & Swanson, L. W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903550207 · Cited by 205 · see citing works
Kohtz, J. D., Baker, D. P., Corte, G., & Fishell, G. (1998) · Development · doi:10.1242/dev.125.24.5079 · Cited by 181 · see citing works
Generation and migration of cells in the developing striatum
Halliday, A. L., & Cepko, C. L. (1992) · Neuron · doi:10.1016/0896-6273(92)90216-z · Cited by 179 · see citing works
McDonald, J. A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C. Q., & Mellerick, D. M. (1998) · Genes & Development · doi:10.1101/gad.12.22.3603 · Cited by 162 · see citing works
Qiu, M. S., Shimamura, K., Sussel, L., Chen, S., & Rubenstein, J. L. R. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00018-5 · Cited by 151 · see citing works
Self-citationMizuno, K., Gonzalez, F. J., & Kimura, S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.4927 · Cited by 136 · see citing works
Self-citationStrategies utilized by migrating neurons of the postnatal vertebrate forebrain
Goldman, S. A., & Luskin, M. B. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01191-0 · Cited by 134 · see citing works
vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein.
Jiménez, F., Martin‐Morris, L. E., Velasco, L., Chu, H., Sierra, J., Rosen, D. R., & White, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07355.x · Cited by 133 · see citing works
Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesisPreprint
Chu, H., Parras, C. M., White, K., & Jiménez, F. (1998) · Genes & Development · doi:10.1101/gad.12.22.3613 · Cited by 113 · see citing works
Shimamura, K., Martı́nez, S., Puelles, L., & Rubenstein, J. L. R. (1997) · Developmental Neuroscience · doi:10.1159/000111190 · Cited by 104 · see citing works
Self-citationGaykema, R. P. A., & Záborszky, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961028)374:4 · Cited by 103 · see citing works
Pabst, O., Herbrand, H., & Arnold, H.-H. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00035-5 · Cited by 81 · see citing works
Demarcation of ventral territories by the homeobox gene NKX2.1 during early chick development
Pera, E. M., & Kessel, M. (1998) · Development Genes and Evolution · doi:10.1007/s004270050170 · Cited by 65 · see citing works
Neural Patterning: A forward role for Hedgehog
Lumsden, A., & Graham, A. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00266-1 · Cited by 28 · see citing works
LIM-Homeodomain Gene Family in Neural Development
Wanaka, A., Matsumoto, K., Kashihara, Y., Furuyama, T., Tanaka, T., Mori, T., Tanno, Y., Yokoya, S., Kitanaka, J., Takemura, M., et al. (1997) · Developmental Neuroscience · doi:10.1159/000111191 · Cited by 16 · see citing works
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gorski, J. A., Talley, T., Qiu, M. S., Puelles, L., Rubenstein, J. L. R., & Jones, K. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06309.2002 · Cited by 1,367 · see citing works
Self-citationInterneuron cell types are fit to function
Kepecs, A., & Fishell, G. (2014) · Nature · doi:10.1038/nature12983 · Cited by 1,110 · see citing works
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,050 · see citing works
Self-citationThe origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
Wilson, M. T., & Snow, D. M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000828)424:3 · Cited by 72 · see citing works
Self-citationC ELL M IGRATION IN THE F OREBRAIN
Marín, Ó., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 917 · see citing works
Self-citation1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 913 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Fused cerebral organoids model interactions between brain regions
Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods · doi:10.1038/nmeth.4304 · Cited by 790 · see citing works
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738 · see citing works
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline
Ballinger, E. C., Ananth, M. R., Talmage, D. A., & Role, L. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.006 · Cited by 735 · see citing works
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Kitamura, K., Yanazawa, M., Sugiyama, N., Miura, H., Iizuka‐Kogo, A., Kusaka, M., Omichi, K., Suzuki, R., Fukui, Y., Kamiirisa, K., et al. (2002) · Nature Genetics · doi:10.1038/ng1009 · Cited by 708 · see citing works
Modes of neuronal migration in the developing cerebral cortex
Nadarajah, B., & Parnavelas, J. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn845 · Cited by 683 · see citing works
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
Felice, M. D., & Lauro, R. D. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 655 · see citing works
Distinct cortical migrations from the medial and lateral ganglionic eminences
Anderson, S. A., Marín, Ó., Horn, C., Jennings, K., & Rubenstein, J. L. R. (2001) · Development · doi:10.1242/dev.128.3.353 · Cited by 651 · see citing works
Self-citationOrigins of Cortical Interneuron Subtypes
Xu, Q., Cobos, I., De La Cruz, E., Rubenstein, J. L., & Anderson, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5667-03.2004 · Cited by 639 · see citing works
Self-citationOrigin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
Self-citationFode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624 · see citing works
Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works
The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Flames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560 · see citing works
Self-citationFate mapping Nkx2.1‐lineage cells in the mouse telencephalon
Xu, Q., Tam, M., & Anderson, S. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21529 · Cited by 560 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
Nery, S., Fishell, G., & Corbin, J. G. (2002) · Nature Neuroscience · doi:10.1038/nn971 · Cited by 558 · see citing works
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
Lowe, C. J., Wu, M., Salic, A., Evans, L., Lander, E., Stange-Thomann, N., Gruber, C. E., Gerhart, J., & Kirschner, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00469-0 · Cited by 531 · see citing works
Stenman, J. M., Toresson, H., & Campbell, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00167.2003 · Cited by 508 · see citing works
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
Cobos, I., Calcagnotto, M. E., Vilaythong, A. J., Thwin, M. T., Noebels, J. L., Baraban, S. C., & Rubenstein, J. L. R. (2005) · Nature Neuroscience · doi:10.1038/nn1499 · Cited by 502 · see citing works
Self-citationTeleostean and mammalian forebrains contrasted: Evidence from genes to behavior
Wullimann, M. F., & Mueller, T. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20183 · Cited by 491 · see citing works
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon
Yun, K., Potter, S., & Rubenstein, J. L. R. (2001) · Development · doi:10.1242/dev.128.2.193 · Cited by 449 · see citing works
Self-citationShort- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
Flames, N., Long, J. E., Garratt, A. N., Fischer, T. M., Gassmann, M., Birchmeier, C., Lai, C., Rubenstein, J. L. R., & Marı́n, O. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.028 · Cited by 431 · see citing works
Self-citationRegulation of oligodendrocyte development in the vertebrate CNS.
Miller, R. (2002) · Progress in neurobiology · doi:10.1016/s0301-0082(02)00058-8 · Cited by 426 · see citing works
Fogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Miyoshi, G., Butt, S. J. B., Takebayashi, H., & Fishell, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1807-07.2007 · Cited by 400 · see citing works
The origin and migration of cortical neurones: new vistas
Parnavelas, J. G. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01553-8 · Cited by 393 · see citing works
Bortone, D., & Polleux, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.034 · Cited by 387 · see citing works
Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2
Toresson, H., Potter, S. S., & Campbell, K. (2000) · Development · doi:10.1242/dev.127.20.4361 · Cited by 387 · see citing works
Liodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., & Pachnis, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3055-06.2007 · Cited by 377 · see citing works
The genetics of early telencephalon patterning: some assembly required
Hébert, J. M., & Fishell, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2463 · Cited by 377 · see citing works
López‐Bendito, G., Cautinat, A., Sánchez‐Alcañiz, J. A., Bielle, F., Flames, N., Garratt, A. N., Talmage, D. A., Role, L. W., Charnay, P., Marín, Ó., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.042 · Cited by 367 · see citing works
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Storm, E. E., Garel, S., Borello, U., Hébert, J. M., Martı́nez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R. (2006) · Development · doi:10.1242/dev.02324 · Cited by 361 · see citing works
Self-citationPleasure, S. J., Anderson, S. A., Hevner, R. F., Bagri, A., Marín, Ó., Lowenstein, D. H., & Rubenstein, J. L. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00149-5 · Cited by 356 · see citing works
Self-citationDeep homology of arthropod central complex and vertebrate basal ganglia.
Strausfeld, N. J., & Hirth, F. (2013) · Science · doi:10.1126/science.1231828 · Cited by 354 · see citing works
Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
Kessaris, N., Woodruff, R. H., Hall, A. C., Gaffield, W., Kimura, S., Stiles, C. D., Rowitch, D. H., & Richardson, W. D. (2001) · Development · doi:10.1242/dev.128.13.2545 · Cited by 343 · see citing works
Self-citationStrategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
He, M., Tucciarone, J., Lee, S., Nigro, M. J., Kim, Y., Levine, J. M., Kelly, S. M., Krugikov, I., Wu, P., Chen, Y., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.021 · Cited by 339 · see citing works
Molecular mechanisms underlying cell fate specification in the developing telencephalon
Schuurmans, C. J., & Guillemot, F. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00286-6 · Cited by 339 · see citing works
Powell, E. M., Campbell, D. B., Stanwood, G. D., Davis, C., Noebels, J. L., & Levitt, P. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00622.2003 · Cited by 333 · see citing works
Levitt, P. R., Eagleson, K. L., & Powell, E. M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.008 · Cited by 331 · see citing works
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330 · see citing works
Self-citationChoreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
Krude, H., Schütz, B., Biebermann, H., von Moers, A., Schnabel, D., Neitzel, H., Tönnies, H., Weise, D., Lafferty, A. R. A., Schwarz, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14341 · Cited by 329 · see citing works
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Hansen, D. V., Lui, J. H., Flandin, P., Yoshikawa, K., Rubenstein, J. L., Alvarez-Buylla, A., & Kriegstein, A. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3541 · Cited by 328 · see citing works
Self-citationMicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors
Shibata, M., Nakao, H., Kiyonari, H., Abe, T., & Aizawa, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5085-10.2011 · Cited by 294 · see citing works
Subcortical origins of human and monkey neocortical interneurons
Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322 · see citing works
Self-citationPax6Modulates the Dorsoventral Patterning of the Mammalian Telencephalon
Stoykova, A., Treichel, D., Hallonet, M. E. R., & Gruß, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08042.2000 · Cited by 314 · see citing works
Induction and Dorsoventral Patterning of the Telencephalon
Wilson, S. W., & Rubenstein, J. L. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00171-9 · Cited by 314 · see citing works
Self-citationLi, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T. M., & Zhang, S. (2009) · Development · doi:10.1242/dev.036624 · Cited by 312 · see citing works
Okaty, B. W., Miller, M. N., Sugino, K., Hempel, C. M., & Nelson, S. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0105-09.2009 · Cited by 309 · see citing works
Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
Liu, Y., Liu, H., Sauvey, C., Yao, L., Żarnowska, E. D., & Zhang, S. (2013) · Nature Protocols · doi:10.1038/nprot.2013.106 · Cited by 300 · see citing works
Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain
Nery, S. V., Wichterle, H., & Fishell, G. (2001) · Development · doi:10.1242/dev.128.4.527 · Cited by 296 · see citing works
Niimi, T., Nagashima, K., Ward, J. M., Minoo, P., Zimonjic, D. B., Popescu, N. C., & Kimura, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7380-7390.2001 · Cited by 294 · see citing works
Self-citationTelencephalic cells take a tangent: non-radial migration in the mammalian forebrain
Corbin, J. G., Nery, S. V., & Fishell, G. (2001) · Nature Neuroscience · doi:10.1038/nn749 · Cited by 293 · see citing works
Ma, L., Hu, B., Liu, Y., Vermilyea, S., Liu, H., Gao, L., Sun, Y., Zhang, X., & Zhang, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.021 · Cited by 293 · see citing works
A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity
Tricoire, L., Pelkey, K. A., Erkkila, B. E., Jeffries, B. W., Yuan, X., & McBain, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-11.2011 · Cited by 292 · see citing works
CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration
Wang, Y., Li, G., Stanco, A., Long, J. E., Crawford, D., Potter, G. B., Pleasure, S. J., Behrens, T., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.005 · Cited by 290 · see citing works
Self-citationGenetic and activity-dependent mechanisms underlying interneuron diversity
Wamsley, B., & Fishell, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.30 · Cited by 290 · see citing works
Ohkubo, Y., Chiang, C. C., & Rubenstein, J. L. R. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00616-9 · Cited by 289 · see citing works
Self-citationPreferential Origin and Layer Destination of GAD65-GFP Cortical Interneurons
López‐Bendito, G. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh072 · Cited by 288 · see citing works
DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
Eisenstat, D. D., Liu, J. K., Mione, M., Zhong, W., Yu, G. K., Anderson, S. A., Ghattas, I. R., Puelles, L., & Rubenstein, J. L. R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991115)414:2 · Cited by 286 · see citing works
Self-citationFour-Dimensional Migratory Coordinates of GABAergic Interneurons in the Developing Mouse Cortex
Ang, E. S. B. C., Haydar, T. F., Gluncic, V., & Rakic, P. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05805.2003 · Cited by 282 · see citing works
The embryonic preoptic area is a novel source of cortical GABAergic interneurons
Gelman, D. M., Martini, F. J., Nóbrega-Pereira, S., Pierani, A., Kessaris, N., & Marín, O. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0604-09.2009 · Cited by 280 · see citing works
The spatial and temporal origin of chandelier cells in mouse neocortex
Taniguchi, H., Lu, J., & Huang, Z. J. (2013) · Science · doi:10.1126/science.1227622 · Cited by 278 · see citing works
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types
Merkle, F. T., Fuentealba, L. C., Sanders, T. A., Magno, L., Kessaris, N., & Álvarez-Buylla, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3610 · Cited by 277 · see citing works
Liu, Y., Weick, J. P., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G., Ayala, M., & Zhang, S. (2013) · Nature Biotechnology · doi:10.1038/nbt.2565 · Cited by 276 · see citing works
Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain
Andrews, W. D., Liapi, A., Plachez, C., Camurri, L., Zhang, J., Mori, S., Murakami, F., Parnavelas, J. G., Sundaresan, V., & Richards, L. J. (2006) · Development · doi:10.1242/dev.02379 · Cited by 271 · see citing works
Liem, K. F., Jessell, T. M., & Briscoe, J. (2000) · Development · doi:10.1242/dev.127.22.4855 · Cited by 271 · see citing works
Sander, M., Paydar, S., Ericson, J., Briscoe, J., Berber, E., German, M., Jessell, T. M., & Rubenstein, J. L. R. (2000) · Genes & Development · doi:10.1101/gad.820400 · Cited by 270 · see citing works
Self-citationChoreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
Krude, H., Schütz, B., Biebermann, H., von Moers, A., Schnabel, D., Neitzel, H., Tönnies, H., Weise, D., Lafferty, A., Schwarz, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214341 · Cited by 268 · see citing works
Comparative aspects of cerebral cortical development
Molnár, Z., Métin, C., Stoykova, A., Tarabykin, V. S., Price, D. J., Francis, F., Meyer, G., Dehay, C., & Kennedy, H. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04611.x · Cited by 266 · see citing works
Crossley, P. H., Martı́nez, S., Ohkubo, Y., & Rubenstein, J. L. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00411-0 · Cited by 265 · see citing works
Self-citationEarly emergence of cortical interneuron diversity in the mouse embryo
Mi, D., Li, Z., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T. X., Pratt, T., Price, D. J., et al. (2018) · Science · doi:10.1126/science.aar6821 · Cited by 259 · see citing works
Thyroid transcription factors in development, differentiation and disease
Fernández, L. P., López-Márquez, A., & Santisteban, P. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.186 · Cited by 258 · see citing works
Olig1 and Olig2 triplication causes developmental brain defects in down syndrome.
Chakrabarti, L., Best, T. K., Cramer, N. P., Carney, R. S. E., Isaac, J. T. R., Galdzicki, Z., & Haydar, T. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2600 · Cited by 258 · see citing works
Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
Stühmer, T., Anderson, S. A., Ekker, M., & Rubenstein, J. L. R. (2002) · Development · doi:10.1242/dev.129.1.245 · Cited by 257 · see citing works
Self-citationNóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256 · see citing works
Self-citationChauvet, S., Cohen, S., Yoshida, Y., Fekrane, L., Livet, J., Gayet, O., Ségu, L., Buhot, M.-C., Jessell, T. M., Henderson, C. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.019 · Cited by 251 · see citing works
Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus
Abdi, A., Mallet, N., Mohamed, F. Y., Sharott, A., Dodson, P. D., Nakamura, K. C., Suri, S., Avery, S. V., Larvin, J. T., Garas, F. N., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4662-14.2015 · Cited by 247 · see citing works
“You Shall Not Pass”—tight junctions of the blood brain barrier
Bauer, H., Krizbai, I. A., Bauer, H., & Traweger, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00392 · Cited by 240 · see citing works
Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly
Ming, J. E., Kaupas, M. E., Roessler, E., Brunner, H. G., Golabi, M., Tekin, M., Stratton, R. F., Sujansky, E., Bale, S. J., & Muenke, M. (2002) · Human Genetics · doi:10.1007/s00439-002-0695-5 · Cited by 239 · see citing works
Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
Shanmugalingam, S., Houart, C., Picker, A., Reifers, F., MacDonald, R. E., Barth, A., Griffin, K. J. P., Brand, M., & Wilson, S. W. (2000) · Development · doi:10.1242/dev.127.12.2549 · Cited by 233 · see citing works
Neuronal Migration in the Developing Cerebral Cortex: Observations Based on Real-time Imaging
Nadarajah, B. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.607 · Cited by 229 · see citing works
Zhao, Y., Marín, O., Hermesz, E., Powell, A., Flames, N., Palkovits, M., Rubenstein, J. L. R., & Westphal, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537759100 · Cited by 227 · see citing works
Self-citationJeong, Y., El-Jaick, K. B., Roessler, E., Muenke, M., & Epstein, D. J. (2006) · Development · doi:10.1242/dev.02239 · Cited by 227 · see citing works
The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
Corbin, J. G., Gaiano, N., Machold, R. P., Langston, A., & Fishell, G. (2000) · Development · doi:10.1242/dev.127.23.5007 · Cited by 227 · see citing works
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon.
Backman, M., Machoň, O., Mygland, L., van den Bout, C. J., Zhong, W., Taketo, M., & Krauss, S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.010 · Cited by 243 · see citing works
Genetic Control of Cortical Regionalization and Connectivity
Rubenstein, J. L. R. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.6.524 · Cited by 224 · see citing works
Self-citationChapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network
Batista‐Brito, R., & Fishell, G. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)01203-4 · Cited by 223 · see citing works
Sura‐Trueba, S., Augé, J., Mattei, G., Etchevers, H., Martinovic, J., Czernichow, P., Vekemans, M. J. J., Polak, M., & Attié‐Bitach, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1358 · Cited by 223 · see citing works
Mutations in TITF-1 are associated with benign hereditary chorea
Breedveld, G. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.8.971 · Cited by 223 · see citing works
Xu, R., Boreland, A. J., Li, X., Erickson, C., Jin, M., Atkins, C., Pang, Z. P., Daniels, B. P., & Jiang, P. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.06.011 · Cited by 222 · see citing works
- Authors
- Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R.
- Affiliations
- University of California, San Francisco (US)
- 1 Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology and Biomedical Sciences, 401 Parnassus Avenue, University of California at San Francisco, CA 94143-0984, USA
- National Institutes of Health (US)
- Corresponding author
- Rubenstein, John L. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-08-01
- Volume
- 126
- Issue
- 15
- Pages
- 3359-3370
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2165130538
- Cited by
- 873
- References
- 56
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 12 · 2023: 23 · 2022: 27 · 2021: 44 · 2020: 35 · 2019: 23 · 2018: 30 · 2017: 25 · 2016: 32 · 2015: 40 · 2014: 43 · 2013: 42 · 2012: 28
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (2k02mh001046-06)
- National Institute of Mental Health (K02 MH01046-01)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- TTF-1, homeobox genes, globus pallidus, striatum, basal ganglia, basal telencephalon, cholinergic neurons, TrkA, GABAergic interneurons, Dlx2, calbindin, knockout mice, forebrain development
- MeSH terms
- Thyroid Nuclear Factor 1, Animals, Base Sequence, Cell Movement, Corpus Striatum, Female, Genes, Homeobox, Globus Pallidus, Interneurons, Male, Mice, Mutant Strains, Nuclear Proteins, Phenotype, Pregnancy, Proteins, Telencephalon, Transcription Factors, Trans-Activators, DNA Primers, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Body Patterning, Mice, Hedgehog Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review