STAT5A/B activity is required in the developing forebrain and spinal cord
Abstract
Formation of the CNS requires the coordination and integration of processes such as cell proliferation, neuronal differentiation, neuronal migration, axon tract formation and synaptogenesis, all of which must occur at precise times and places during development. Although growth factors are known to play a role in regulating many of these processes, very little is known of the signaling events immediately downstream of ligand-receptor interactions in the developing CNS. Here we present evidence that STAT5, an important mediator of cytokine signaling, is required for some aspects of CNS development. We show that phosphorylated and hence activated forms of STAT5 (pSTAT5) are expressed in a temporally restricted manner in a subset of early-born telencephalic neurons and axons. Accordingly, Stat5 mutants have reduced numbers of interneurons in the cortical marginal zone, suggestive of migration defects. Moreover, corticofugal axons develop aberrantly in Stat5 mutants, indicative of a role for pSTAT5 in axon guidance. Notably, pSTAT5 is also expressed in commissural axons in the embryonic spinal cord, where it is also required for their guidance. Taken together, we provide the first evidence that STAT5 is a key effector molecule in the developing mammalian CNS.
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STAT5a is involved in cell fate decisions such as differentiation, proliferation, and apoptosis, as well as neuronal migration and axon guidance.
“In particular, STAT5a is involved in cell fate decisions such as differentiation, proliferation, and apoptosis, as well as neuronal migration and axon guidance (Markham et al. 2007).”
From The Human Accelerated Region HAR202 Controls <i>NPAS3</i> Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences (2024) · cites this paper as Markham et al. 2007
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“In particular, STAT5a is involved in cell fate decisions such as differentiation, proliferation, and apoptosis, as well as neuronal migration and axon guidance (Markham et al. 2007).”
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- Authors
- Markham, K., Schuurmans, C., & Weiss, S.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Markham, Kathryn
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 35
- Issue
- 2
- Pages
- 272-282
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W1985991090
- Cited by
- 27
- References
- 46
- Citations by year
- 2025: 1 · 2024: 3 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- STAT5, Stat5a/b, forebrain development, spinal cord development, cortical interneurons, neuronal migration, corticofugal axons, axon guidance, commissural axons, telencephalic neurons, cytokine signaling
- MeSH terms
- Doublecortin Domain Proteins, Age Factors, Analysis of Variance, Animals, Cell Count, Cells, Cultured, Embryo, Mammalian, Female, Mice, Transgenic, Microtubule-Associated Proteins, Neurons, Neuropeptides, Pregnancy, Spinal Cord, Tubulin, Cell Adhesion Molecules, Neuronal, Prosencephalon, Neurofilament Proteins, In Situ Hybridization, Gene Expression Regulation, Developmental, Mutant Proteins, STAT5 Transcription Factor, Mice, Contactin 2
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