Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse
Open accessAbstract
The reelin gene encodes an extracellular protein that is crucial for neuronal migration in laminated brain regions. To gain insights into the functions of Reelin, we performed high-resolution in situ hybridization analyses to determine the pattern of reelin expression in the developing forebrain of the mouse. We also performed double-labeling studies with several markers, including calcium-binding proteins, GAD65/67, and neuropeptides, to characterize the neuronal subsets that express reelin transcripts.reelin expression was detected at embryonic day 10 and later in the forebrain, with a distribution that is consistent with the prosomeric model of forebrain regionalization. In the diencephalon, expression was restricted to transverse and longitudinal domains that delineated boundaries between neuromeres. During embryogenesis,reelin was detected in the cerebral cortex in Cajal-Retzius cells but not in the GABAergic neurons of layer I. At prenatal stages,reelin was also expressed in the olfactory bulb, and striatum and in restricted nuclei in the ventral telencephalon, hypothalamus, thalamus, and pretectum. At postnatal stages,reelin transcripts gradually disappeared from Cajal-Retzius cells, at the same time as they appeared in subsets of GABAergic neurons distributed throughout neocortical and hippocampal layers. In other telencephalic and diencephalic regions,reelin expression decreased steadily during the postnatal period. In the adult, there was prominent expression in the olfactory bulb and cerebral cortex, where it was restricted to subsets of GABAergic interneurons that co-expressed calbindin, calretinin, neuropeptide Y, and somatostatin. This complex pattern of cellular and regional expression is consistent with Reelin having multiple roles in brain development and adult brain function.
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- Authors
- Alcántara, S., Ruiz, M., D’Arcangelo, G., Ezan, F., de Lecea, L., Curran, T., Sotelo, C., & Soriano, E.
- Affiliations
- Inserm (FR)
- Universitat de Barcelona (ES)
- St. Jude Children's Research Hospital (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-10-01
- Volume
- 18
- Issue
- 19
- Pages
- 7779-7799
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6792998
- OpenAlex
- W2151137318
- Cited by
- 568
- References
- 4
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 17 · 2020: 20 · 2019: 13 · 2018: 18 · 2017: 13 · 2016: 39 · 2015: 15 · 2014: 24 · 2013: 25 · 2012: 21
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion)
- PubMed
- Funders
- American Lebanese Syrian Associated Charities
- National Institutes of Health (RO1 NS36558)
- National Cancer Institute (P 30CA 21765, P30CA021765)
- National Institute of Neurological Disorders and Stroke (R01 NS36558, R01NS036558)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- reelin, forebrain development, neuronal migration, Cajal-Retzius cells, GABAergic interneurons, GAD65/67, neuropeptide Y, somatostatin, calbindin, calretinin, olfactory bulb, cerebral cortex, diencephalon, prosomeric model, telencephalon, postnatal development
- MeSH terms
- Reelin Protein, Age Factors, Animals, Diencephalon, Female, gamma-Aminobutyric Acid, Hippocampus, Interneurons, Mice, Neurologic Mutants, Nerve Tissue Proteins, Neuropeptide Y, Olfactory Bulb, Pregnancy, RNA, Messenger, Serine Endopeptidases, Somatostatin, Biomarkers, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Prosencephalon, In Situ Hybridization, Gene Expression Regulation, Developmental, Entorhinal Cortex, Neocortex, Mice, Calbindins, S100 Calcium Binding Protein G, Calbindin 2
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