Cited by 225Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationGenetics and Neurodevelopmental Disorders

Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences

Yau, H.-J.·2003·Cerebral Cortex

Abstract

The receptor tyrosine kinases represent an important class of signal transduction molecules that have been shown to play critical roles in neural development. We report in the present study that the neuregulin receptor ErbB4 is preferentially expressed by interneurons that are migrating tangentially from the ventral to the dorsal rat telencephalon. ErbB4 immunoreactivity was detected in the medial ganglionic eminence as early as embryonic day (E) 13 at the inception of tangential migration. Prominent ErbB4-positive migratory streams consisting of cells double-labeled with ErbB4 and Dlx, a marker of tangentially migrating cells, were found to advance along the lower intermediate zone and the marginal zone from the ventrolateral to the dorsomedial cortex at E16-E18. After E20, the ErbB4-positive stream in the lower intermediate zone shifted towards the germinal zone and further extended via the cortex into the hippocampal primordium. ErbB4 was not expressed by Tbr1-positive glutamatergic projection neurons during development. ErbB4 was preferentially expressed by the majority of parvalbumin-positive interneurons and subsets of other GABAergic interneurons in the cerebral cortex and the hippocampus in adulthood. The early onset and preferential expression of ErbB4 in tangentially migrating interneurons suggests that neuregulin/ErbB4 signaling may regulate the development and function of telencephalic interneurons.

Integrity signals

Registry

Crossref · 10.1093/cercor/13.3.252

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Nrg1 acts through ErbB4, the main neuregulin receptor expressed by interneurons.

    “The function of Nrg1 is mediated by the tyrosine kinase receptor ErbB4, the main neuregulin receptor expressed by interneurons (Flames et al., 2004; Yau et al., 2003).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Yau et al., 2003

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yau, H.-J.
Affiliations
National Yang Ming University (TW)
Corresponding author
Yau, H.-J.
Venue
Cerebral Cortex
Published
2003-03-01
Volume
13
Issue
3
Pages
252-264
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2064313800
Cited by
225
References
78
Citations by year
2026: 3 · 2025: 2 · 2024: 14 · 2023: 5 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 13 · 2013: 17 · 2012: 9
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns032367-09)
  • National Institute of Neurological Disorders and Stroke (R01NS039411, R01 NS32367, R01 NS 39411)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
ErbB4, neuregulin signaling, interneuron migration, tangential migration, cortical development, hippocampus development, medial ganglionic eminence, parvalbumin interneurons, GABAergic interneurons, DLX, Tbr1, telencephalon, receptor tyrosine kinase, intermediate zone
MeSH terms
Animals, Cell Movement, Cerebral Cortex, Female, Hippocampus, Interneurons, Pregnancy, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Neuregulins, Rats, ErbB Receptors, Receptor, ErbB-4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review