EHD1 is a synaptic protein that modulates exocytosis through binding to snapin
Abstract
EHD1 is an EH (Eps15 homology) domain-containing protein involved in endosomal recycling. Our yeast two hybrid screening experiments showed that EHD1 interacts with a synaptic protein, snapin, and the present study was carried out to further elucidate the functional significance of this interaction. Immunoreactivity to EHD1 is observed in the cerebral cortex, hippocampus and striatum, in the rat brain. The protein is colocalized with the axon terminal marker synaptophysin in cultured neurons. EHD1 binds to the C terminus of snapin via its C terminus EH domain. It negatively affects the binding of a SNARE complex protein, SNAP-25, to snapin, probably due to the competition for overlapping binding sites on the C terminus of snapin. EHD1 affects the coupling of synaptotagmin-1 to the SNARE complex, and could be a negative regulator of exocytosis. This is supported by electrophysiological findings that PC-12 cells which overexpress EHD1 show reduced depolarization-induced exocytosis compared to controls, but the reduced exocytosis is not observed in cells which overexpress the N terminus of EHD1 that is unable to bind snapin. Together, the above results indicate that EHD1 is a synaptic protein that negatively affects exocytosis through binding to snapin.
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Synaptic protein snapin, an EHD1-binding protein, was identified as a regulator of endosome-to-lysosome retrograde transport of BACE1.
“Recently, the synaptic protein snapin, which is an EHD1-binding protein, was identified as a regulator of the endosome-to-lysosome retrograde transport of BACE1 (27,45).”
From BIN1 regulates BACE1 intracellular trafficking and amyloid-β production (2016) · cites this paper as [45]
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- Authors
- Wei, S., Xu, Y., Shi, H., Wong, S.-H., Han, W., Talbot, K., Hong, W., & Ong, W.-Y.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Scripps Research Institute (US)
- National University of Singapore (SG)
- University of Pennsylvania (US)
- Institute of Molecular and Cell Biology (SG)
- Corresponding author
- Hong, Wanjin
- Ong, Wei-Yi
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 45
- Issue
- 4
- Pages
- 418-429
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W1983102888
- Cited by
- 22
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- A*Star
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- EHD1, EH domain, Snapin, exocytosis, synaptic proteins, SNARE complex, SNAP-25, synaptotagmin-1, endosomal recycling, synaptophysin, axon terminals, PC12 cells
- MeSH terms
- Animals, Brain, Exocytosis, Neurons, Synapses, Transfection, Microscopy, Immunoelectron, PC12 Cells, Two-Hybrid System Techniques, Vesicular Transport Proteins, Immunoprecipitation, SNARE Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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