EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1
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Here we report the characterization of an eps15 homology (EH) domain containing protein designated EHD3. EHD3 was mapped to human chromosome 2p22-23, while the murine Ehd3 homolog was mapped to chromosome 17p21. Both the human and the mouse genes contain a polymorphic (CA) repeat in their 3'UTR. One 3.6-kb Ehd3 transcript was mainly detected in adult mouse brain and kidney and at day 7 of mouse development. On the other hand, human tissues exhibited two, 4.2- and 3.6-kb, EHD3 RNA species. They were predominantly expressed in heart, brain, placenta, liver, kidney and ovary. EHD3, expressed as a green fluorescent fusion protein was localized to endocytic vesicles and to microtubule-dependent, membrane tubules. There was a clear colocalization of EHD3-positive structures and transferrin-containing recycling vesicles, implying that EHD3 resides within the endocytic recycling compartment. Shuffling the N-terminal domain of EHD1 (previously shown to reside in the transferrin-containing, endocytic recycling compartment) with that of EHD3 resulted in a chimeric EHD protein that was localized mainly to tubules instead of the endocytic vesicles, implicating the N-terminal domain as responsible for the tubular localization of EHD3. Mutant EHD3 forms, missing the N-terminal or the C-terminal domains, lost their tubular localization. Results of two-hybrid analyses indicated that EHD1 and EHD3 interact with each other. In addition, EHD1 and EHD3 could be coimmunoprecipitated from cellular extracts, confirming the interaction implied by two-hybrid analysis. Moreover, coexpression of EHD1 and EHD3 resulted in their colocalization in microtubule-dependent tubules as well as in punctate forms. Based on its specific intracellular localization and its interaction with EHD1, we postulate that EHD3 localizes on endocytic tubular and vesicular structures and regulates their microtubule-dependent movement.
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EHD3 plays a role in endocytic transport.
“EHD3 encodes a class of cardiac trafficking proteins and plays a role in endocytic transport (Galperin et al., 2002).”
From Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears (2014) · cites this paper as Galperin et al., 2002
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The Guanine Nucleotide-Binding Switch in Three Dimensions
Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875 · see citing works
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,521 · see citing works
Mukherjee, S., Ghosh, R. K., & Maxfield, F. R. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.759 · Cited by 1,299 · see citing works
Mechamisms of cell polarity: sorting and transport in epithelial cells
Matter, K., & Mellman, I. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90075-2 · Cited by 424 · see citing works
Endocytic Traffic in Polarized Epithelial Cells: Role of the Actin and Microtubule Cytoskeleton
Apodaca, G. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.020301.x · Cited by 408 · see citing works
Linking cargo to vesicle formation: receptor tail interactions with coat proteins
Kirchhausen, T. L., Bonifacino, J. S., & Riezman, H. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80024-5 · Cited by 401 · see citing works
Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module
Salcini, A. E., Confalonieri, S., Doria, M., Santolini, E., Tassi, E., Minenkova, O., Cesareni, G., Pelicci, P. G., & Di Fiore, P. P. (1997) · Genes & Development · doi:10.1101/gad.11.17.2239 · Cited by 315 · see citing works
Sorkin, A. D., Florez‐McClure, M. L., Huang, F., & Carter, R. E. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00785-5 · Cited by 300 · see citing works
Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains
Yamabhai, M., Hoffman, N. G., Hardison, N. L., McPherson, P. S., Castagnoli, L., Cesareni, G., & Kay, B. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31401 · Cited by 285 · see citing works
eps15, A Novel Tyrosine Kinase Substrate, Exhibits Transforming Activity
Fazioli, F., Minichiello, L., Matoskova, B., Wong, W. T., & Fiore, P. P. D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5814 · Cited by 270 · see citing works
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling
Grant, B. D., Zhang, Y., Paupard, M., Lin, S. X. H., Hall, D. H., & Hirsh, D. (2001) · Nature Cell Biology · doi:10.1038/35078549 · Cited by 269 · see citing works
Lin, S. X. H., Grant, B. D., Hirsh, D., & Maxfield, F. R. (2001) · Nature Cell Biology · doi:10.1038/35078543 · Cited by 260 · see citing works
Molecular aspects of the endocytic pathway
Clague, M. J. (1998) · Biochemical Journal · doi:10.1042/bj3360271 · Cited by 189 · see citing works
Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
Wendland, B., Emr, S. D., & Riezman, H. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80067-7 · Cited by 164 · see citing works
Hyman, J., Chen, H., Di Fiore, P. P., De Camilli, P., & Brunger, A. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.537 · Cited by 158 · see citing works
Association of Insulin-like Growth Factor 1 Receptor with EHD1 and SNAP29
Rotem‐Yehudar, R., Galperin, E., & Horowitz, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009913200 · Cited by 138 · see citing works
Self-citationConfalonieri, S., Salcini, A. E., Puri, C., Tacchetti, C., & Fiore, P. P. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.905 · Cited by 131 · see citing works
Structure and Asn-Pro-Phe Binding Pocket of the Eps15 Homology Domain
de Beer, T., Carter, R. E., Lobel-Rice, K. E., Sorkin, A. D., & Overduin, M. (1998) · Science · doi:10.1126/science.281.5381.1357 · Cited by 122 · see citing works
Santolini, E., Salcini, A. E., Kay, B. K., Yamabhai, M., & Fiore, P. P. D. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4694 · Cited by 121 · see citing works
Hamm‐Alvarez, S. F., & Sheetz, M. P. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1109 · Cited by 117 · see citing works
Guipponi, M., Scott, H. S., Chen, H., Schebesta, A., Rossier, C., & Antonarakis, S. E. (1998) · Genomics · doi:10.1006/geno.1998.5521 · Cited by 102 · see citing works
Nucleocytoplasmic Shuttling of Endocytic Proteins
Vecchi, M., Polo, S., Poupon, V., van de Loo, J.-W., Benmerah, A., & Fiore, P. P. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.7.1511 · Cited by 96 · see citing works
Pohl, U., Smith, J. S., Tachibana, I., Ueki, K., Lee, H. K., Ramaswamy, S., Wu, Q., Mohrenweiser, H. W., Jenkins, R. B., & Louis, D. N. (2000) · Genomics · doi:10.1006/geno.1999.6087 · Cited by 91 · see citing works
EHD1—An EH-Domain-Containing Protein with a Specific Expression Pattern
Mintz, L., Galperin, E., Pasmanik‐Chor, M., Tulzinsky, S., Bromberg, Y., Kozak, C. A., Joyner, A. L., Fein, A., & Horowitz, M. (1999) · Genomics · doi:10.1006/geno.1999.5800 · Cited by 89 · see citing works
Self-citationEH: a novel protein-protein interaction domain potentially involved in intracellular sorting
Fiore, P. P. D., Pelicci, P. G., & Sorkin, A. D. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01127-4 · Cited by 83 · see citing works
Coda, L., Salcini, A. E., Confalonieri, S., Pelicci, G., Sorkina, T., Sorkin, A. D., Pelicci, P. G., & Fiore, P. P. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.3003 · Cited by 76 · see citing works
Multiple Distinct Coiled-coils Are Involved in Dynamin Self-assembly
Okamoto, P. M., Tripet, B., Litowski, J. R., Hodges, R. S., & Vallée, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10277 · Cited by 73 · see citing works
Eps15 Is Constitutively Oligomerized Due to Homophilic Interaction of Its Coiled-coil Region
Tebar, F., Confalonieri, S., Carter, R. E., Fiore, P. P. D., & Sorkin, A. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15413 · Cited by 62 · see citing works
Lewin, D. A., & Mellman, I. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00130-4 · Cited by 52 · see citing works
Combinatorial libraries, epitope structures and the prediction of protein conformations
Gershoni, J. M., Stern, B., & Denisova, G. F. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01024-4 · Cited by 20 · see citing works
Haider, N. B., Searby, C. C., Galperin, E., Mintz, L., Horowitz, M., Stone, E. M., & Sheffield, V. C. (1999) · Gene · doi:10.1016/s0378-1119(99)00395-9 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
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- Mukherjee S, Ghosh RN, Maxfield FR, Endocytosis. Physiol Rev 1997;77:759-803.
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Sorted by citations
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Liu, S., Lorenzen, E. D., Fumagalli, M., Li, B., Harris, K., Xiong, Z., Zhou, L., Korneliussen, T. S., Somel, M., Babbitt, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.054 · Cited by 411 · see citing works
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
Lü, Q., Insinna, C., Ott, C. M., Stauffer, J. K., Pintado, P. A., Rahajeng, J., Baxa, U., Walia, V., Cuenca, A. A., Hwang, Y.-S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3109 · Cited by 299 · see citing works
EHD proteins: key conductors of endocytic transport
Naslavsky, N., & Caplan, S. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.10.003 · Cited by 237 · see citing works
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization
Morén, B., Shah, C., Howes, M. T., Schieber, N. L., McMahon, H. T., Parton, R. G., Daumke, O., & Lundmark, R. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0787 · Cited by 207 · see citing works
Endocytosis Promotes Rapid Dopaminergic Signaling
Kotowski, S. J., Hopf, F. W., Seif, T., Bonci, A., & von Zastrow, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.036 · Cited by 198 · see citing works
Interactions between EHD Proteins and Rab11-FIP2: A Role for EHD3 in Early Endosomal Transport
Naslavsky, N., Rahajeng, J., Sharma, M., Jović, M., & Caplan, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-05-0466 · Cited by 184 · see citing works
Myosin Vb Interacts with Rab8a on a Tubular Network Containing EHD1 and EHD3
Roland, J. T., Kenworthy, A. K., Peränen, J., Caplan, S., & Goldenring, J. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-02-0169 · Cited by 169 · see citing works
Braun, A., Pinyol, R., Dahlhaus, R., Koch, D. C., Fonarev, P., Grant, B. D., Kessels, M. M., & Qualmann, B. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0076 · Cited by 159 · see citing works
Mechanisms of EHD/RME‐1 Protein Function in Endocytic Transport
Grant, B. D., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00834.x · Cited by 147 · see citing works
Rabenosyn-5 and EHD1 Interact and Sequentially Regulate Protein Recycling to the Plasma Membrane
Naslavsky, N., Boehm, M., Backlund, P. S., & Caplan, S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0733 · Cited by 144 · see citing works
EHD1 Interacts with Retromer to Stabilize SNX1 Tubules and Facilitate Endosome‐to‐Golgi Retrieval
Gokool, S., Tattersall, D., & Seaman, M. N. J. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00652.x · Cited by 131 · see citing works
Genome-wide functional analysis of human cell-cycle regulators
Mukherji, M., Bell, R. N., Supeková, Ľ., Wang, Y., Orth, A. P., Batalov, S., Miraglia, L. J., Huesken, D., Lange, J., Martin, C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604320103 · Cited by 130 · see citing works
Jović, M., Naslavsky, N., Rapaport, D., Horowitz, M., & Caplan, S. (2007) · Journal of Cell Science · doi:10.1242/jcs.03383 · Cited by 125 · see citing works
Self-citationGuilherme, A., Soriano, N. A., Furcinitti, P. S., & Czech, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401918200 · Cited by 123 · see citing works
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Doherty, K. R., Demonbreun, A. R., Wallace, G. Q., Cave, A., Posey, A. D., Heretis, K., Pytel, P., & McNally, E. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802306200 · Cited by 119 · see citing works
George, M., Ying, G., Rainey, M. A., Solomon, A., Parikh, P. T., Gao, Q., Band, V., & Band, H. (2007) · BMC Cell Biology · doi:10.1186/1471-2121-8-3 · Cited by 115 · see citing works
A Role for EHD4 in the Regulation of Early Endosomal Transport
Sharma, M., Naslavsky, N., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00732.x · Cited by 113 · see citing works
C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?
Naslavsky, N., & Caplan, S. (2005) · Journal of Cell Science · doi:10.1242/jcs.02595 · Cited by 105 · see citing works
EH and UIM: Endocytosis and More
Polo, S., Confalonieri, S., Salcini, A. E., & Fiore, P. P. D. (2003) · Science s STKE · doi:10.1126/stke.2132003re17 · Cited by 104 · see citing works
Smith, C. A., Dho, S. E., Donaldson, J. G., Tepaß, U., & McGlade, C. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-01-0026 · Cited by 104 · see citing works
Bar, M., & Avni, A. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03897.x · Cited by 102 · see citing works
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Lee, D., Zhao, X., Scarselletta, S., Schweinsberg, P. J., Eisenberg, E., Grant, B. D., & Greene, L. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412751200 · Cited by 80 · see citing works
Patrakka, J., Xiao, Z., Nukui, M., Takemoto, M., He, L., Oddsson, Á., Matic, L. P., Kaukinen, A., Szigyarto, C. A., Uhlén, M., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006060675 · Cited by 80 · see citing works
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Rapaport, D., Auerbach, W., Naslavsky, N., Pasmanik‐Chor, M., Galperin, E., Fein, A., Caplan, S., Joyner, A. L., & Horowitz, M. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00359.x · Cited by 76 · see citing works
Self-citationBlume, J. J., Halbach, A., Behrendt, D., Paulsson, M., & Plomann, M. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.10.006 · Cited by 74 · see citing works
EHD1 and Eps15 Interact with Phosphatidylinositols via Their Eps15 Homology Domains
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Rainey, M. A., George, M., Ying, G., Akakura, R., Burgess, D. J., Siefker, E., Bargar, T. W., Doglio, L. T., Crawford, S. E., Todd, G. L., et al. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-37 · Cited by 67 · see citing works
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Rapaport, D., Lugassy, Y., Sprecher, E., & Horowitz, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009759 · Cited by 65 · see citing works
Self-citationDiscovery of epigenetically silenced genes in acute myeloid leukemias
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AtEHDs, novel Arabidopsis EH‐domain‐containing proteins involved in endocytosis
Bar, M., Aharon, M., Benjamin, S., Rotblat, B., Horowitz, M., & Avni, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03571.x · Cited by 56 · see citing works
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Bar, M., Sharfman, M., Schuster, S., & Avni, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007973 · Cited by 46 · see citing works
Larsen, J. E., Massol, R., Nieland, T. J. F., & Kirchhausen, T. L. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0578 · Cited by 43 · see citing works
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Yap, C. C., Lasiecka, Z. M., Caplan, S., & Winckler, B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5428-09.2010 · Cited by 40 · see citing works
Imamura, M., Takahashi, A., Matsunami, M., Horikoshi, M., Iwata, M., Araki, S.-I., Toyoda, M., Susarla, G., Ahn, J., Park, K. H., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab044 · Cited by 39 · see citing works
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Xu, Y., Shi, H., Wei, S., Wong, S. H., & Hong, W. (2004) · Molecular Membrane Biology · doi:10.1080/09687680410001716871 · Cited by 40 · see citing works
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Verma, P., Ostermeyer-Fay, A. G., & Brown, D. A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-05-0417 · Cited by 36 · see citing works
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Finch, N., Fawaz, S., Neal, C. R., Butler, M. J., Lee, V. K., Salmon, A. J., Lay, A. C., Stevens, M., Dayalan, L., Band, H., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021030294 · Cited by 37 · see citing works
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Simone, L., Caplan, S., & Naslavsky, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074519 · Cited by 35 · see citing works
EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity.
Benjamin, S., Weidberg, H., Rapaport, D., Pekar, O., Nudelman, M., Segal, D., Hirschberg, K., Katzav, S., Ehrlich, M., & Horowitz, M. (2011) · Biochemical Journal · doi:10.1042/bj20111010 · Cited by 36 · see citing works
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Chukkapalli, S., Amessou, M., Dekhil, H., Dilly, A. K., Liu, Q., Bandyopadhyay, S., Thomas, R., Bejna, A., Batist, G., & Kandouz, M. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt399 · Cited by 21 · see citing works
de Melo, A. A., Sprink, T., Noel, J. K., Vázquez-Sarandeses, E., van Hoorn, C., Mohd, S., Loerke, J., Spahn, C. M. T., & Daumke, O. (2022) · Nature Communications · doi:10.1038/s41467-022-35164-x · Cited by 16 · see citing works
Curran, J. W., Musa, H., Kline, C. F., Makara, M. A., Little, S. C., Higgins, J. D. D., Hund, T. J., Band, H., & Mohler, P. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646893 · Cited by 16 · see citing works
Nonaka, H., Sugano, S., & Miyajima, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.014 · Cited by 15 · see citing works
Bozzato, A., Barlati, S., & Borsani, G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.01.002 · Cited by 12 · see citing works
Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact
Santos, H. J., Hanadate, Y., Imai, K., Watanabe, H., & Nozaki, T. (2022) · mBio · doi:10.1128/mbio.03849-21 · Cited by 11 · see citing works
Xie, K., Sun, Y., Li, X., Yang, S., Wang, M., Zhang, Y., Wang, Q., Wu, K., Kong, D., Guo, T., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01922-9 · Cited by 9 · see citing works
Increased EHD 1 in non‐small cell lung cancer predicts poor survival
Lu, H., Meng, Q., Wen, Y., Hu, J., Zhao, Y., & Cai, L. (2013) · Thoracic Cancer · doi:10.1111/1759-7714.12043 · Cited by 9 · see citing works
Jiménez‐Guerrero, I., Sonawane, M., Eckshtain‐Levi, N., Tuang, Z. K., da Silva, G. M., Pérez‐Montaño, F., Leibman‐Markus, M., Gupta, R., Noda‐García, L., Bar, M., et al. (2023) · The Plant Journal · doi:10.1111/tpj.16507 · Cited by 7 · see citing works
Bar, M., Benjamin, S., Horowitz, M., & Avni, A. (2008) · Plant Signaling & Behavior · doi:10.4161/psb.6708 · Cited by 7 · see citing works
Self-citationWaxmonsky, N. C., & Conner, S. D. (2013) · Journal of Cell Science · doi:10.1242/jcs.122465 · Cited by 7 · see citing works
Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling
Henmi, Y., Oe, N., Kono, N., Taguchi, T., Takei, K., & Tanabe, K. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.02.011 · Cited by 7 · see citing works
Zhang, R., Li, X., Ma, Y., Liu, Y., Zhang, Y., Cheng, X., & Ning, Z. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102402 · Cited by 7 · see citing works
EHDS are serine phosphoproteins: EHD1 phosphorylation is enhanced by serum stimulation
Fichtman, B., Ravid, L., Rapaport, D., & Horowitz, M. (2008) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-008-0027-4 · Cited by 7 · see citing works
Self-citationSUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment
Cabasso, O., Pekar, O., & Horowitz, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134053 · Cited by 6 · see citing works
Self-citationTsushima, H., Malabarba, M. G., Confalonieri, S., Senic-Matuglia, F., Verhoef, L. G. G. C., Bartocci, C., D’Ario, G., Cocito, A., Fiore, P. P. D., & Salcini, A. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056383 · Cited by 5 · see citing works
de Melo, A. A., Sprink, T., Noel, J. K., Vázquez-Sarandeses, E., van Hoorn, C., Loerke, J., Spahn, C. M. T., & Daumke, O. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.20.461157 · Cited by 4 · see citing works
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Mohd, S., Oder, A., Specker, E., Neuenschwander, M., von Kries, J. P., & Daumke, O. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302704 · Cited by 2 · see citing works
Davisson, M. T., Cook, S. A., Akeson, E. C., Liu, D., Heffner, C. S., Gudis, P., Fairfield, H. E., & Murray, S. A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00410.2014 · Cited by 2 · see citing works
Endocytosis of LeEix and EHD Proteins During Plant Defense Signalling
Bar, M., & Avni, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-32463-5_15 · Cited by 1 · see citing works
Proteinbiochemische Charakterisierung von PACSIN1 und seines Bindungspartners PAST2
Halbach, A. (2003) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 1 · see citing works
Jiménez‐Guerrero, I., Sonawane, M., Eckshtain‐Levi, N., da Silva, G. M., Pérez‐Montaño, F., Leibman‐Markus, M., Noda‐García, L., Bar, M., & Burdman, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.24.445476 · Cited by 1 · see citing works
The Role of Early Endosomal Sorting in Integrin Function
Waxmonsky, N. C. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Funktionale Analyse der EHD-Proteine bei tubulären Transportprozessen
Blume, J. (2006) · Kölner Universitäts PublikationsServer (Universität zu Köln)
The Mechanism of Tubular Recycling Endosome Biogenesis
Xie, S. (2016) · DigitalCommons@UNMC
Hawley, B. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-6225
Xu, Z., Zhang, R., Tian, N., & Gan, N. (2025) · European journal of medical research · doi:10.1186/s40001-025-03458-7
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Frisby, D., Misri, G., Naslavsky, N., & Caplan, S. (2026) · Traffic · doi:10.1111/tra.70039
- Authors
- Galperin, E., Benjamin, S., Rapaport, D., Rotem‐Yehudar, R., Tolchinsky, S., & Horowitz, M.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Horowitz, Mia
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2002-07-16
- Volume
- 3
- Issue
- 8
- Pages
- 575-589
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1978232287
- Cited by
- 83
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Cancer Research Fund
- Ministry of Health, State of Israel
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- EHD3, EHD1, Eps15 homology domain, recycling endosomes, membrane tubules, protein-protein interaction, N-terminal domain, gene mapping, 3'UTR polymorphism, tissue expression, subcellular localization
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Chromosome Mapping, Chromosomes, Human, Pair 2, DNA, Endocytosis, Female, Humans, Intracellular Membranes, Male, Molecular Sequence Data, Pregnancy, Recombinant Fusion Proteins, RNA, Messenger, Species Specificity, Tissue Distribution, Gene Expression, Sequence Homology, Amino Acid, Dinucleotide Repeats, Vesicular Transport Proteins, Mice, In Vitro Techniques
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