The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Acute Liver Failure Including Acetaminophen Overdose
Open accessAbstract
Acute liver failure (ALF) is a dramatic, highly unpredictable clinical syndrome defined by the sudden onset of coagulopathy and encephalopathy. Acetaminophen overdose, the leading cause of ALF in the United States, has a 66% chance of recovery with early N-acetylcysteine treatment and supportive care. Cerebral edema and infectious complications are difficult to detect and treat in these patients and may cause irreversible brain damage and multiorgan failure. One-year survival after emergency liver transplantation is 70%, but 20% of listed patients die, highlighting the importance of early referral of patients who have ALF with a poor prognosis to a transplant center.
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“Intentional and unintentional overdose emerged as a leading cause of acute liver failure in many countries and remains one of the most common causes of drug-induced liver injury worldwide ( 12 – 14 ].”
From Paracetamol: A History of Assumptions, Errors, and Evidence Reversals in Pain Management (2026) · cites this paper as [12]
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“Severe toxicity has long been recognized, but it was historically dismissed as a distinct complication of acute overdose [ 12 , 13 ].”
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Cites
Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R. H., Edwards, E. B., Freeman, R. B., Harper, A., Kim, W. R., Kamath, P. S., Kremers, W. K., Lake, J. R., Howard, T. K., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,524
Ostapowicz, G., Fontana, R. J., Schiødt, F. V., Larson, A., Davern, T. J., Han, S. H. B., McCashland, T. M., Shakil, A. O., Hay, J. E., Hynan, L., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-12-200212170-00007 · Cited by 2,227
Self-citationEarly indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
Acetaminophen‐induced acute liver failure
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., REISCH, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., et al. (2005) · Hepatology · doi:10.1002/hep.20948 · Cited by 1,913
Self-citationLee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Danan, G., & Benichou, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90101-6 · Cited by 1,481
Weinstein, L. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32330-4 · Cited by 1,252
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
ACETAMINOPHEN-INDUCED HEPATOTOXICITY
James, L. P., Mayeux, P. R., & Hinson, J. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.12.1499 · Cited by 1,033
Polson, J., & Lee, W. M. (2005) · Hepatology · doi:10.1002/hep.20703 · Cited by 983
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Research works printed but not linked: 7
- Polson, 2004, Elevated bilirubin may cause false positive acetaminophen levels in hepatitis patients, Hepatology, 40, 496A
- Food and Drug Administration, 21 CRF Parts 201 and 343, 2006, Internal analgesic, antipyretic, and antirheumatic drug products for over the counter human use: proposed amendment of the tentative final monograph, required warnings and other labeling, Federal Register, 71, 77314
- Seremba, 2007, Use of nucleoside analogues in HBV related acute liver failure, Hepatology, 46, 79
- Levitsky, 2008, Measurement of herpes simplex DNA-emia before and after liver transplantation, Liver Transpl
- Dechene, 2005, Effectiveness of a steroid and ursodeoxycholic acid combination therapy with drug induced subacute liver failure, Hepatology, 42, 358A
- Taylor, 2005, Acute liver failure due to ischemic hepatitis: natural history and predictors of outcome in a prospective, multi-center U.S. study, Gastroenterology, 128, A-706
- Lee, 2007, Intravenous N-acetylcysteine improves spontaneous survival in early stage non-acetaminophen acute liver failure, Hepatology, 46, 79
Cited by
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Leonard, M. C., Lehmann, M. K., White, D., Wyman, M. J., Sekel, A. T., Kvancz, D. A., & Goldman, M. (2008)
Acetaminophen: drug, new warnings
Schilling, A. N. (2010)
Sotelo, N., Durazo, Z. M. D. L. Á., & Villeda, D. G. R. (2010) · Archivos de Neurociencias
Intensivtherapie bei akutem und chronischem Leberversagen
Sarrazin, C., Schneider, M., Bechstein, W. O., & Zeuzem, S. (2015) · Springer eBooks · doi:10.1007/978-3-642-54675-4_74-1
Diagnosis and treatment of acute liver failure in children
Cruz, N. S. (2010)
van Hoek, B. (2009)
Cowley, N. J., Cullis, K., Dennis, A., Ebrahim, H., Francis, R., Garside, M., Gibb, S., Johnson, E., Leifer, S., Mullhi, R., et al. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316227633.010
Pharmacovigilance of the Analgesic Therapy
Ussai, S. (2017) · InTech eBooks · doi:10.5772/67243
Ghorbel, A., Aref, H. L., Essafi, F., Abid, S., Jemaa, O. B., Akrout, F. M., & Chaker, C. H. (2016)
Poudel, S. (2016) · KU ScholarWorks (University of Kansas)
Foudah, A. I., Soliman, G. A., Abdel-Rahman, R. F., Alankuş‐Çalışkan, Ö., & Yusufoglu, H. S. (2017) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v14i5.5
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Bari, M. A. M. A. (2018) · International Journal of Pharma and Bio Sciences · doi:10.22376/ijpbs.2018.9.2.p240-245
Hay, J. E. (2010) · doi:10.1002/9781444325249.ch13
Afsharzadeh, D. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.121499227
Oladele, O. A., NOTTIDGE, H. O., Esan, O. O., & Bakre, A. A. (2021) · Research Square · doi:10.21203/rs.3.rs-246140/v1
Management of Paracetamol (Acetaminophen) Intoxication
Elumar, F. (2022) · Eurasian Journal of Toxicology · doi:10.51262/ejtox.1098185
Plunkett, E., Johnson, E., & Pierson, A. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781316227633.024
Metselaar, H. J., & van Hoek, B. (2009) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7437-3_7
Silverman, M. E., & Shih, R. D. (2012) · Springer eBooks · doi:10.1007/978-3-642-00418-6_795
Yıldırım, M., & Akın, M. (2019) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2019.04.027
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Comparative analysis of delivery methods for stem cell therapy in liver diseases
Zhu, Z. (2021) · McGill Science Undergraduate Research Journal · doi:10.26443/msurj.v16i1.65
Clinical features analysis of 105 children with liver failurePreprint
Chen, L., Zheng, Y., Hu, G., leilei, C., Lu, Y., & Liu, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4158601/v1
Kravtsova, S. E., Попова, Т. Н., Крыльский, Е. Д., Agarkov, A. A., Shikhaliev, K. S., Medvedeva, S. M., Oleinik, S. A., & Lavruschev, A. I. (2024) · Сорбционные и хроматографические процессы · doi:10.17308/sorpchrom.2023.23/11872
Perioperative Use of Acetaminophen and Non-steroidal Anti-inflammatory Agents
VanderWielen, B. A., & Borden, S. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-67648-2_40
Approaches to the End of Life: Disease Trajectories
Shaw, P. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-70495-6_4
Ngetich, D. K., & Korir, S. C. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20250474
Medisah, M. E., Badiee, M. S., Mahdavinia, M., Motamed, H., & Rahmani, A. H. (2025) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2025.05.007 · Cited by 1
Drug intoxication: a silent obstacle to organ donation
García, A., & Rodríguez, S. F. (2025) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2025-004580
Toxicology in Emergency Medicine
Aki, E. S., Abdurabu, M., & Elgassim, M. A. M. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1010983
Investigation of self-care behaviours in a rat model of acute liver injury induced by paracetamol
Çalışkan, H. (2025) · Anatolian Current Medical Journal · doi:10.38053/acmj.1691817
Gandhi, N. N., & Rajagopalan, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.09.681454
Butt, M. S., & Shah, S. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0005358
Daifallah, A., Jabr, R., Al-Tawil, F., Elkourdi, M., Salman, Z., Koni, A. A., Samara, A., Al-Jabi, S. W., & Zyoud, S. H. (2021) · Figshare · doi:10.6084/m9.figshare.14059464
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284065
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284062
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284071
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284068
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284074
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284059
Bouhayene, S., & Djerrou, Z. (2026) · Revista Científica de la Facultad de Ciencias Veterinarias · doi:10.52973/rcfcv-e361816
Huang, Y.-Q., Li, S., Wu, G., Guo, J.-J., Yang, D., Bo, Y., Yang, X., Lv, Y.-N., Zhang, Q.-R., Zhao, D., et al. (2026) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2026.100774
Sulochana, N., Suma, B. P., Supritha, K. M., Neelagund, S., Gowtham, M. D., & Srinivas, M. (2026) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-026-17826-4
Evaluation of β-asarone's Hepatoprotective Potential in rats Induced Hepatotoxicity by Paracetamol
Tiwari, A., Singh, N., Athbhaiya, G., Rout, S., Sahu, C., Deep, P., & Samal, P. K. (2026) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2026.00434
Kathwate, D. R. U. K. S. G., Dev, D. M. H., & Lawate, V. V. M. B. A. (2026) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-37813
McCann, T. A., Lin, J., Crain, E. F., & Cunningham, S. J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511919268.010
TOXICIDADE IN VITRO E IN VIVO DO ORTOBENZAMOL, ANÁLOGO DO PARACETAMOL.
Melo, L. T. M., & de Queiroz, D. (2014)
Metadata
- Authors
- Fontana, R. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Fontana, Robert J.
- ORCID
- Fontana, Robert J.
- Venue
- Medical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 92
- Issue
- 4
- Pages
- 761-794
- ISSN
- 0025-7125 (ISSN-L)
- PMC
- PMC2504411
- OpenAlex
- W1979020366
- Cited by
- 249
- References
- 134
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 9 · 2021: 26 · 2020: 19 · 2019: 18 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 9
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medical Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01dk065184-22)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK-065184, UO1 DK058389-07, U01DK058369)
- National Center for Research Resources (M01RR000042)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Keywords
- acute liver failure, acetaminophen overdose, N-acetylcysteine, coagulopathy, encephalopathy, cerebral edema, infectious complications, liver transplantation, survival after liver transplantation
- MeSH terms
- Acetaminophen, Humans, Prognosis, Liver Transplantation, Liver Failure, Acute, Analgesics, Non-Narcotic, Drug Overdose
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