Cited by 249Drug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationPoisoning and overdose treatments

The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Acute Liver Failure Including Acetaminophen Overdose

Open access

Fontana, Robert J.·2008·Medical Clinics of North America

DOI 10.1016/j.mcna.2008.03.005PMC PMC2504411

Open this paper in CoChat — free account

Abstract

Acute liver failure (ALF) is a dramatic, highly unpredictable clinical syndrome defined by the sudden onset of coagulopathy and encephalopathy. Acetaminophen overdose, the leading cause of ALF in the United States, has a 66% chance of recovery with early N-acetylcysteine treatment and supportive care. Cerebral edema and infectious complications are difficult to detect and treat in these patients and may cause irreversible brain damage and multiorgan failure. One-year survival after emergency liver transplantation is 70%, but 20% of listed patients die, highlighting the importance of early referral of patients who have ALF with a poor prognosis to a transplant center.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.mcna.2008.03.005

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R. H., Edwards, E. B., Freeman, R. B., Harper, A., Kim, W. R., Kamath, P. S., Kremers, W. K., Lake, J. R., Howard, T. K., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,524
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
Ostapowicz, G., Fontana, R. J., Schiødt, F. V., Larson, A., Davern, T. J., Han, S. H. B., McCashland, T. M., Shakil, A. O., Hay, J. E., Hynan, L., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-12-200212170-00007 · Cited by 2,227
Self-citation
Early indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
Acetaminophen‐induced acute liver failure
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., REISCH, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., et al. (2005) · Hepatology · doi:10.1002/hep.20948 · Cited by 1,913
Self-citation
Drug-induced hepatotoxicity
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries
Danan, G., & Benichou, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90101-6 · Cited by 1,481
Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy
Weinstein, L. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32330-4 · Cited by 1,252
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
ACETAMINOPHEN-INDUCED HEPATOTOXICITY
James, L. P., Mayeux, P. R., & Hinson, J. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.12.1499 · Cited by 1,033
AASLD position paper
Polson, J., & Lee, W. M. (2005) · Hepatology · doi:10.1002/hep.20703 · Cited by 983

Flagged first, then by citations

Show all 134 references

Research works printed but not linked: 7

Polson, 2004, Elevated bilirubin may cause false positive acetaminophen levels in hepatitis patients, Hepatology, 40, 496A
Food and Drug Administration, 21 CRF Parts 201 and 343, 2006, Internal analgesic, antipyretic, and antirheumatic drug products for over the counter human use: proposed amendment of the tentative final monograph, required warnings and other labeling, Federal Register, 71, 77314
Seremba, 2007, Use of nucleoside analogues in HBV related acute liver failure, Hepatology, 46, 79
Levitsky, 2008, Measurement of herpes simplex DNA-emia before and after liver transplantation, Liver Transpl
Dechene, 2005, Effectiveness of a steroid and ursodeoxycholic acid combination therapy with drug induced subacute liver failure, Hepatology, 42, 358A
Taylor, 2005, Acute liver failure due to ischemic hepatitis: natural history and predictors of outcome in a prospective, multi-center U.S. study, Gastroenterology, 128, A-706
Lee, 2007, Intravenous N-acetylcysteine improves spontaneous survival in early stage non-acetaminophen acute liver failure, Hepatology, 46, 79

Sorted by citations

Drug-induced liver injury
Katarey, D. R., & Verma, S. (2016) · Clinical Medicine · doi:10.7861/clinmedicine.16-6-s104 · Cited by 346
Acetaminophen-related Hepatotoxicity
Bunchorntavakul, C., & Reddy, K. R. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.07.005 · Cited by 322
Acute Liver Failure Guidelines
Shingina, A., Mukhtar, N. A., Wakim-Fleming, J., Alqahtani, S. A., Wong, R. J., Limketkai, B. N., Larson, A. M., & Grant, L. M. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002340 · Cited by 240
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure
Tuñón, M. J., Alvarez, M., Culebras, J. M., & González‐Gallego, J. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3086 · Cited by 211
Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives
Ramachandran, A., & Jaeschke, H. (2017) · Gene Expression · doi:10.3727/105221617x15084371374138 · Cited by 215
Drug-induced liver injury: a comprehensive review
Hosack, T., Damry, D., & Biswas, S. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231163410 · Cited by 214
Drug‐induced liver injury: Advances in mechanistic understanding that will inform risk management
Mosedale, M., & Watkins, P. B. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.564 · Cited by 211
Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction
LeFort, K. R., Rungratanawanich, W., & Song, B.-J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05061-7 · Cited by 202
Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure
Bunchorntavakul, C., & Reddy, K. R. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.01.007 · Cited by 184
Liver injury induced by paracetamol and challenges associated with intentional and unintentional use
Rotundo, L., & Pyrsopoulos, N. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i4.125 · Cited by 190
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand
Chiew, A. L., Reith, D., Pomerleau, A., Wong, A., Isoardi, K. Z., Soderstrom, J., & Buckley, N. A. (2020) · Medical Journal of Australia · doi:10.5694/mja2.50428 · Cited by 145
The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials
Izzo, C., Annunziata, M., Melara, G., Sciorio, R., Dallio, M., Masarone, M., Federico, A., & Persico, M. (2021) · Nutrients · doi:10.3390/nu13030933 · Cited by 138
Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity
Schyschka, L., Sánchez, J. M., Wang, Z., Burkhardt, B., Müller‐Vieira, U., Zeilinger, K., Bachmann, A., Nadalin, S., Damm, G., & Nussler, A. K. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1080-y · Cited by 128
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury
Jadeja, R. N., Upadhyay, K. K., Devkar, R., & Khurana, S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3453926 · Cited by 127
Outcomes in liver transplantation: Does sex matter?
Sarkar, M. A., Watt, K. D. S., Terrault, N. A., & Berenguer, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.023 · Cited by 116
Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease
Rabinowich, L., & Shibolet, O. (2015) · BioMed Research International · doi:10.1155/2015/168905 · Cited by 118
Acetaminophen: Old drug, new warnings
Schilling, A. N., Corey, R. L., Leonard, M. C., & Eghtesad, B. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77a.09084 · Cited by 114
Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes
Kon, K., Kim, J., Uchiyama, A., Jaeschke, H., & Lemasters, J. J. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq175 · Cited by 108
Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity
Chowdhury, A., Jahan, N., Adelusi, T. I., & Wang, S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105102 · Cited by 107
Resveratrol and liver disease: from bench to bedside and community
Bishayee, A., Darvesh, A. S., Politis, T., & McGory, R. W. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02295.x · Cited by 104
Review article: the current management of acute liver failure
CRAIG, D. G. N., Lee, A., Hayes, P. C., & Simpson, K. J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04175.x · Cited by 103
Acetaminophen Induces Apoptosis in Rat Cortical Neurons
Posadas, I., Santos, P. R., Blanco, A., Muñoz‐Fernández, M. Á., & Ceña, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015360 · Cited by 106
Liver transplant associated with paracetamol overdose: results from the seven‐country SALT study
Gulmez, S. E., Larrey, D., Pageaux, G., Bernuau, J., Bissoli, F., Horsmans, Y., Thorburn, D., McCormick, P. A., Stricker, B., Toussi, M., et al. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12635 · Cited by 99
Orthopaedic management of the Ehlers–Danlos syndromes
Ericson, W. B., & Wolman, R. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31551 · Cited by 94
Generation of Carbon Monoxide Releasing Molecules (CO-RMs) as Drug Candidates for the Treatment of Acute Liver Injury: Targeting of CO-RMs to the Liver
Marques, A. R., Kromer, L., Gallo, D. J., Penacho, N., Rodrigues, S. S., Seixas, J. D., Bernardes, G. J. L., Reis, P. M., Otterbein, S. L., Ruggieri, R. A., et al. (2012) · Organometallics · doi:10.1021/om300360c · Cited by 83
Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline
Hu, J., Kholmukhamedov, A., Lindsey, C. C., Beeson, C. C., Jaeschke, H., & Lemasters, J. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.024 · Cited by 81
Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose
Bhushan, B., Borude, P., Edwards, G., Walesky, C., Cleveland, J., Li, F., Ma, X., & Apte, U. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.07.012 · Cited by 79
Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
Yang, X., Salminen, W. F., Shi, Q., Greenhaw, J. J., Gill, P. S., Bhattacharyya, S., Beger, R. D., Mendrick, D. L., Mattes, W. B., & James, L. P. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.02.013 · Cited by 78
Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157
Sikirić, P., Seiwerth, S., Ručman, R., Turković, B., Rokotov, D. S., Brčić, L., Sever, M., Kliček, R., Radić, B., Drmić, D., et al. (2012) · Current Pharmaceutical Design · doi:10.2174/1381612811306010076 · Cited by 77
Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice
Miyakawa, K., Joshi, N., Sullivan, B. P., Albee, R., Brandenberger, C., Jaeschke, H., McGill, M. R., Scott, M. A., Ganey, P. E., Luyendyk, J. P., et al. (2015) · Blood · doi:10.1182/blood-2014-09-598656 · Cited by 75
Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women
Rubin, J. B., Hameed, B., Gottfried, M., Lee, W. M., & Sarkar, M. A. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.11.042 · Cited by 77
Dose Predictions for Drug Design
Maurer, T. S., Smith, D. A., Beaumont, K. C., & Di, L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01365 · Cited by 73
High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).
Ilić, S., Drmić, D., Žarković, K., Kolenc, D., Coric, M., Brcic, L., Kliček, R., Radić, B., Sever, M., Djuzel, V., et al. (2010) · PubMed · Cited by 68
Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity in mice
Cha, H., Lee, S., Lee, J. H., & Park, J. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.060 · Cited by 69
Acute liver failure: A review for emergency physicians
Montrief, T., Koyfman, A., & Long, B. (2018) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2018.10.032 · Cited by 65
Variability in opioid prescribing for children undergoing ambulatory surgery in the United States
Cleve, W. V., & Grigg, E. B. (2017) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2017.05.014 · Cited by 59
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats
Ilić, S., Drmić, D., Žarković, K., Kolenc, D., Brčić, L., Radić, B., Djuzel, V., Blagaić, A. B., Romić, Ž., Džidić, S., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.038 · Cited by 57
Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice
Cho, Y., Seo, W., Kim, D., Moon, P., Kim, S., Lee, B.-H., Song, B., & Baek, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-34309-7 · Cited by 55
Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs
González-Ponce, H. A., Rincón‐Sánchez, A. R., Jaramillo‐Juárez, F., & Moshage, H. J. (2018) · Nutrients · doi:10.3390/nu10020117 · Cited by 57
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5)
Chiew, A. L., James, L. P., Isbister, G. K., Pickering, J. W., McArdle, K., Chan, B. S. H., & Buckley, N. A. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.030 · Cited by 53
Acute liver failure in Scotland between 1992 and 2009; incidence, aetiology and outcome
Bretherick, A. D., CRAIG, D. G. N., Masterton, G., Bates, C. M., Davidson, J., Martin, K. G., Iredale, J. P., & Simpson, K. J. (2011) · QJM · doi:10.1093/qjmed/hcr098 · Cited by 55
Diagnosis and Management of Drug-Induced Liver Injury (DILI) in Patients with Pre-Existing Liver Disease
Teschke, R., & Danan, G. (2016) · Drug Safety · doi:10.1007/s40264-016-0423-z · Cited by 52
Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy
Zhang, J., Zhao, L., Hu, C., Wang, T., Lu, J., Wu, C., Chen, L., Jin, M., Hu, H., Ji, G., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00162 · Cited by 52
Human drug hepatotoxicity: a contemporary clinical perspective
Assis, D. N., & Navarro, V. J. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250902927386 · Cited by 50
Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver
Bao, Y., Wang, P., Shao, X., Zhu, J., Xiao, J., Shi, J., Zhang, L., Zhu, H., Ma, X., Manautou, J. E., et al. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.089557 · Cited by 49
Drug-Induced Hepatotoxicity or Drug-Induced Liver Injury
Pugh, A. J., Barve, A. J., Falkner, K. C., Patel, M., & McClain, C. J. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.02.008 · Cited by 51
Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
Zhao, L., Zhang, J., Hu, C., Wang, T., Lu, J., Wu, C., Chen, L., Jin, M., Ji, G., Cao, Q., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00514 · Cited by 51
N-acetylcysteine treatment blunts liver failure-associated impairment of locomotor activity
Ommati, M. M., Jamshidzadeh, A., Niknahad, H., Mohammadi, H., Sabouri, S., Heidari, R., & Abdoli, N. (2017) · PharmaNutrition · doi:10.1016/j.phanu.2017.10.003 · Cited by 48
Outcomes of liver transplantation for paracetamol (acetaminophen)-induced hepatic failure
Cooper, S. C., Aldridge, R. C., Shah, T., Webb, K., Nightingale, P., Paris, S., Gunson, B. K., Mutimer, D., & Neuberger, J. (2009) · Liver Transplantation · doi:10.1002/lt.21799 · Cited by 46
A Population Study of the Frequency of High-Dose Acetaminophen Prescribing and Dispensing
Albertson, T. E., Walker, V. M., Stebbins, M. R., Ashton, E. W., Owen, K. P., & Sutter, M. E. (2010) · Annals of Pharmacotherapy · doi:10.1345/aph.1p012 · Cited by 45
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs
Szkolnicka, D., Lucendo‐Villarin, B., Moore, J. K., Simpson, K. J., Forbes, S. J., & Hay, D. C. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0117 · Cited by 45
The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice
Karthivashan, G., Arulselvan, P., Tan, S. W., & Fakurazi, S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.007 · Cited by 45
A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury
Li, G., Liu, H., Feng, R., Kang, T., Wang, W., Ko, C.-N., Wong, C., Ye, M., Ma, D., Wan, J., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102129 · Cited by 44
Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury
Win, S., Min, R. W. M., Chen, C. Q., Zhang, J., Chen, Y., Li, M., Suzuki, A., Abdelmalek, M. F., Wang, Y., Aghajan, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128289 · Cited by 42
Clinical implications of prescribing nonsteroidal anti-inflammatory drugs in oral health care—a review
Nagi, R., Devi, B., Rakesh, N., Reddy, S. S., & Patil, D. J. (2014) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2014.12.002 · Cited by 43
Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis
Hussain, S., Ashafaq, M., Alshahrani, S., Siddiqui, R., Ahmed, R. A., Khuwaja, G., & Islam, F. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.09.008 · Cited by 43
Cell-delivery therapeutics for liver regeneration☆
Zhang, W., Tucker‐Kellogg, L., Narmada, B. C., Venkatraman, L., Chang, S., Yin, L., Tan, N., White, J., Jia, R., & Bhowmick, S. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.02.005 · Cited by 41
Acute Liver Failure
Pathikonda, M., & Muñoz, S. J. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31673-4 · Cited by 38
Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity
Elshazly, S. M., El‐Moselhy, M. A., & Barakat, W. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.042 · Cited by 36
Social, economic, and policy implications of organ preservation advances
Ward, A., Klassen, D. K., Franz, K. M., Giwa, S. E., & Lewis, J. K. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000532 · Cited by 36
Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure
González-Ponce, H. A., Martínez-Saldaña, M. C., Tepper, P. G., Quax, W. J., Buist‐Homan, M., Faber, K. N., & Moshage, H. J. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109461 · Cited by 36
Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice
Morsy, M. A., Ibrahim, S. A., Abdelwahab, S. A., Zedan, M. Z., & El-Bitar, H. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.10.004 · Cited by 35
An assessment of parents’ knowledge and awareness regarding paracetamol use in children: a cross-sectional study from Palestine
Daifallah, A., Jabr, R., Al-Tawil, F., Elkourdi, M., Salman, Z., Koni, A. A., Samara, A., Al‐Jabi, S. W., & Zyoud, S. H. (2021) · BMC Public Health · doi:10.1186/s12889-021-10432-5 · Cited by 35
Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America
Offor, S. J., Amadi, C. N., Chijioke-Nwauche, I. N., Manautou, J. E., & Orisakwe, O. E. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.04.025 · Cited by 37
Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells
Parikh, H., Pandita, N. S., & Khanna, A. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.950675 · Cited by 35
Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice
Zhang, J., Song, S., Pang, Q., Zhang, R., Zhou, L., Liu, S., Meng, F., Wu, Q., & Liu, C. (2015) · Scientific Reports · doi:10.1038/srep08098 · Cited by 34
Liver Failure in Pregnancy
Bacak, S. J., & Thornburg, L. L. (2015) · Critical Care Clinics · doi:10.1016/j.ccc.2015.08.005 · Cited by 36
Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A
Sotelo, N., Durazo, M. D. L. Á., González, A., & Dhanakotti, N. (2009) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31749-1 · Cited by 35
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline
Hu, J., & Lemasters, J. J. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114930 · Cited by 34
A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure
Öztürk, N. B., Herdan, E., Saner, F. H., & Gurakar, A. O. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12237451 · Cited by 33
Neurological Management of Fulminant Hepatic Failure
Frontera, J. A., & Kalb, T. H. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9470-y · Cited by 32
Acute hepatitis and acute liver failure: Pathologic diagnosis and differential diagnosis
Kwong, S., Meyerson, C., Zheng, W., Kassardjian, A., Stanzione, N., Zhang, K., & Wang, H. L. (2019) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2019.07.005 · Cited by 31
Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure
Orandi, B. J., McLeod, M. C., MacLennan, P. A., Lee, W. M., Fontana, R. J., Karvellas, C. J., McGuire, B. M., Lewis, C. E., Terrault, N. M., Locke, J. E., et al. (2023) · JAMA · doi:10.1001/jama.2023.1080 · Cited by 30
Self-citation
Mechanisms of Hepatic Cholestatic Drug Injury
Kolarić, T. O., Ninčević, V., Smolić, R., Smolić, M., & Wu, G. Y. (2019) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2018.00042 · Cited by 31
In vitro Antioxidant and in vivo Hepatoprotective Activities of Root Bark Extract and Solvent Fractions of Croton macrostachyus Hochst. Ex Del. (Euphorbiaceae) on Paracetamol-Induced Liver Damage in Mice
Tafere, G. G., Tuem, K. B., Kahsu, A., & Balasubramanian, R. (2020) · Journal of Experimental Pharmacology · doi:10.2147/jep.s259081 · Cited by 29
Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes
Pingili, R. B., Pawar, A. K., & Challa, S. R. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.014 · Cited by 28
A Cytochrome P450–Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes
Miyakawa, K., Albee, R., Letzig, L. G., Lehner, A. F., Scott, M. A., Buchweitz, J. P., James, L. P., Ganey, P. E., & Roth, R. A. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.223537 · Cited by 27
Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
Park, D. W., Jeon, H., Kwon, J. E., Lee, Y. G., So, R., Choe, T. H., Jeong, Y. J., & Kang, S. C. (2021) · Toxicological Research · doi:10.1007/s43188-020-00063-0 · Cited by 31
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice
Kim, T. H., Choi, D., Kim, J. Y., Lee, J. H., & Koo, S. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0680-z · Cited by 27
Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure
Henderson, M. W., Sparkenbaugh, E., Wang, S., Ilich, A., Noubouossie, D. F., Mailer, R. K., Renné, T., Flick, M. J., Luyendyk, J. P., Chen, Z., et al. (2021) · Blood · doi:10.1182/blood.2020006198 · Cited by 26
A survey of adult awareness and use of medicine containing acetaminophen
Boudreau, D. M., Wirtz, H. S., Korff, M. V., Catz, S. L., John, J. S., & Stang, P. (2012) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3335 · Cited by 26
Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer
Patten, D. A., Wilkinson, A. L., O'Keeffe, A., & Shetty, S. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1733876 · Cited by 26
Effects of hydrocodone rescheduling on opioid use outcomes: A systematic review
Usmani, S. A., Hollmann, J., Goodin, A. J., Hincapie‐Castillo, J. M., Adkins, L., Ourhaan, N., Oueini, R., Bhagwandass, H., Easey, T., & Vouri, S. M. (2020) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2020.09.013 · Cited by 25
The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity
Lőrincz, T., Deák, V., Makk‐Merczel, K., Varga, D., Hajdinák, P., & Szarka, A. (2021) · Life · doi:10.3390/life11080856 · Cited by 24
Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity
Aguayo‐Orozco, A., Bois, F. Y., Brunak, S., & Taboureau, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00396 · Cited by 24
Leukocyte cell derived chemotaxin-2 (Lect2) as a predictor of survival in adult acute liver failure
the Acute Liver Failure Study Group, Slowik, V., Borude, P. C., Jaeschke, H., Woolbright, B. L., Lee, W. M., & Apte, U. M. (2019) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.03.03 · Cited by 23
Accidental Acetaminophen Overdose Results in Liver Transplant During Second Trimester of Pregnancy: A Case Report
Franko, K. R., Mekeel, K., Woelkers, D., Khanna, A., & Hemming, A. W. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2012.10.046 · Cited by 23
Supratherapeutic Dosing of Acetaminophen Among Hospitalized Patients
Zhou, L., Maviglia, S. M., Mahoney, L. M., CHANG, F. Y., Orav, E. J., Plasek, J. M., Boulware, L. J., Lou, H. X., Bates, D. W., & Rocha, R. A. (2012) · Archives of Internal Medicine · doi:10.1001/2013.jamainternmed.438 · Cited by 22
Effect of Ocimum basilicum leaves extract on acetaminophen-induced nephrotoxicity in BALB/c mice
Karaali, H., Fahmi, R. R., & Borjac, J. (2018) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2018-0111 · Cited by 22
Oxidative Stress and Inflammation in the Liver
Lemasters, J. J., & Jaeschke, H. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch55 · Cited by 23
Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury
Wu, K., Guo, C., Su, M., Wu, X., & Li, R. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000482003 · Cited by 21
Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice
Mohamad, N. E., Yeap, S. K., Beh, B., Kỳ, H., Lim, K. L., Ho, W. Y., Sharifuddin, S. A., Long, K., & Alitheen, N. B. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2199-4 · Cited by 21
Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte
Kim, M. W., Kang, J., Jung, H. J., Park, S. Y., Phan, T., Namgung, H., Seo, S., Yoon, Y. S., & Oh, S. H. (2020) · Nutrients · doi:10.3390/nu12113585 · Cited by 21
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
Heldring, M. M., Shaw, A. H., & Beltman, J. B. (2022) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00238-5 · Cited by 23
The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies
Zyoud, S. H., Waring, W. S., Al‐Jabi, S. W., Sweileh, W. M., & Awang, R. (2016) · SpringerPlus · doi:10.1186/s40064-016-3240-z · Cited by 21
Endoplasmic Reticulum-Targeted Carbon Monoxide Photoreleaser for Drug-Induced Hepatotoxicity Remediation
Li, Y., Zhang, J., Cheng, S., Wang, X., Zhang, J., Xie, X., Jiao, X., & Tang, B. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03540 · Cited by 20
Electrochemical Detection of Acetaminophen with Silicon Nanowires
Pandey, R. R., Alshahrani, H. S., Krylyuk, S. G., Williams, E. H., Davydov, A. V., & Chusuei, C. C. (2018) · Electroanalysis · doi:10.1002/elan.201700806 · Cited by 20
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
Yu, H., Barrass, N. C., Gales, S., Lenz, E. M., Parry, T., Powell, H., Thurman, D., Hutchison, M., Wilson, I. D., Bi, L., et al. (2014) · Xenobiotica · doi:10.3109/00498254.2014.973000 · Cited by 19
Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1α and β‐dependent decay and miRNA
Rashid, H., Kim, H., Junjappa, R., Kim, H., & Chae, H. (2016) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13619 · Cited by 19
Drug-Induced Liver Injury in the Setting of Analgesic Use
Darr, U., & Sussman, N. (2019) · Clinics in Liver Disease · doi:10.1016/j.cld.2019.09.008 · Cited by 18

Authors: Fontana, R. J.
Affiliations: University of Michigan (US)
Corresponding author: Fontana, Robert J.
ORCID: Fontana, Robert J.
Venue: Medical Clinics of North America
Publisher: Elsevier BV
Published: 2008-07
Volume: 92
Issue: 4
Pages: 761-794
ISSN: 0025-7125 (ISSN-L)
DOI: 10.1016/j.mcna.2008.03.005
PMC: PMC2504411
OpenAlex: W1979020366
Cited by: 249
References: 134
Citations by year: 2026: 7 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 9 · 2021: 26 · 2020: 19 · 2019: 18 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 9
FWCI: 1.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Medical Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01dk065184-22)
National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK-065184, UO1 DK058389-07, U01DK058369)
National Center for Research Resources (M01RR000042)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
Keywords: acute liver failure, acetaminophen overdose, N-acetylcysteine, coagulopathy, encephalopathy, cerebral edema, infectious complications, liver transplantation, survival after liver transplantation
MeSH terms: Acetaminophen, Humans, Prognosis, Liver Transplantation, Liver Failure, Acute, Analgesics, Non-Narcotic, Drug Overdose

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Acute Liver Failure Including Acetaminophen Overdose

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks