Cited by 249Drug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationPoisoning and overdose treatments

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Acute Liver Failure Including Acetaminophen Overdose

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Fontana, Robert J.·2008·Medical Clinics of North America

DOI 10.1016/j.mcna.2008.03.005PMC PMC2504411

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Abstract

Acute liver failure (ALF) is a dramatic, highly unpredictable clinical syndrome defined by the sudden onset of coagulopathy and encephalopathy. Acetaminophen overdose, the leading cause of ALF in the United States, has a 66% chance of recovery with early N-acetylcysteine treatment and supportive care. Cerebral edema and infectious complications are difficult to detect and treat in these patients and may cause irreversible brain damage and multiorgan failure. One-year survival after emergency liver transplantation is 70%, but 20% of listed patients die, highlighting the importance of early referral of patients who have ALF with a poor prognosis to a transplant center.

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Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R. H., Edwards, E. B., Freeman, R. B., Harper, A., Kim, W. R., Kamath, P. S., Kremers, W. K., Lake, J. R., Howard, T. K., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,524
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
Ostapowicz, G., Fontana, R. J., Schiødt, F. V., Larson, A., Davern, T. J., Han, S. H. B., McCashland, T. M., Shakil, A. O., Hay, J. E., Hynan, L., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-12-200212170-00007 · Cited by 2,227
Self-citation
Early indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
Acetaminophen‐induced acute liver failure
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., REISCH, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., et al. (2005) · Hepatology · doi:10.1002/hep.20948 · Cited by 1,913
Self-citation
Drug-induced hepatotoxicity
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries
Danan, G., & Benichou, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90101-6 · Cited by 1,481
Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy
Weinstein, L. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32330-4 · Cited by 1,252
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
ACETAMINOPHEN-INDUCED HEPATOTOXICITY
James, L. P., Mayeux, P. R., & Hinson, J. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.12.1499 · Cited by 1,033
AASLD position paper
Polson, J., & Lee, W. M. (2005) · Hepatology · doi:10.1002/hep.20703 · Cited by 983
Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group
Squires, R. H., Shneider, B. L., Bucuvalas, J. C., Alonso, E. M., Sokol, R. J., Narkewicz, M. R., Dhawan, A. K., Rosenthal, P. J., Rodriguez‐Baez, N., Murray, K. F., et al. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.12.051 · Cited by 866
Progress in Liver Disease
Greenberg, H. B. (1970) · JAMA · doi:10.1001/jama.1970.03170210085033 · Cited by 858
Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
ANDRADE, R., LUCENA, M., FERNANDEZ, M., PELAEZ, G., PACHKORIA, K., GARCIARUIZ, E., GARCIAMUNOZ, B., GONZALEZGRANDE, R., PIZARRO, A., & DURAN, J. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.006 · Cited by 856
A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
Cook, D., Guyatt, G. H., Marshall, J., Leasa, D. J., Fuller, H. D., Hall, R., Peters, S., Rutledge, F. S., Griffith, L. E., McLellan, A., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803193381203 · Cited by 726
Incidence of drug-induced hepatic injuries: A French population-based study
Sgro, C., Clinard, F., Ouazir, K., Chanay, H., Allard, C., Guilleminet, C., Lenoir, C., Lemoine, A., & Hillon, P. (2002) · Hepatology · doi:10.1053/jhep.2002.34857 · Cited by 716
PubMed Central: creating an Aladdin's cave of ideas
Delamothe, T. (2001) · BMJ · doi:10.1136/bmj.322.7277.1 · Cited by 671
Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure
Demetriou, A. A., Brown, R. S., Busuttil, R. W., Fair, J. H., McGuire, B. M., Rosenthal, P. J., Esch, J. S. A., Lerut, J. P., Nyberg, S. L., Salizzoni, M., et al. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000124298.74199.e5 · Cited by 670
Cerebral Herniation in Patients With Acute E Liver Failure Is Correlated With Arterial Ammonia Concentration
Clemmesen, J. O., Larsen, F. S., Kondrup, J., Hansen, B. A., & Ott, P. (1999) · Hepatology · doi:10.1002/hep.510290309 · Cited by 666
The management of fulminant hepatic failure.
Trey, C., & Davidson, C. S. (1970) · PubMed · Cited by 642
Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily
Watkins, P. B., Kaplowitz, N., Slattery, J. T., Colonese, C. R., Colucci, S. V., Stewart, P. W., & Harris, S. (2006) · JAMA · doi:10.1001/jama.296.1.87 · Cited by 631
Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure
Harrison, P. M., Wendon, J. A., Gimson, A. E. S., Alexander, G. J. M., & Williams, R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106273242604 · Cited by 585
Fulminant hepatic failure: Summary of a workshop
Hoofnagle, J. H., Carithers, R. L., Shapiro, C. A., & Ascher, N. L. (1995) · Hepatology · doi:10.1002/hep.1840210137 · Cited by 578
Safety and Efficacy of a Recombinant Hepatitis E Vaccine
Shrestha, M. P., Scott, R. M., Joshi, D. M., Mammen, M. P., Thapa, G. B., Thapa, N., Myint, K. S. A., Fourneau, M., Kuschner, R. A., Shrestha, S. K., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061847 · Cited by 544
Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure
O’Grady, J. G., Gimson, A. E., O’Brien, C., Pucknell, A., Hughes, R. D., & Williams, R. L. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90011-x · Cited by 534
Outcome and prognostic markers in severe drug‐induced liver disease†
Björnsson, E., & Olsson, R. (2005) · Hepatology · doi:10.1002/hep.20800 · Cited by 524
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Bernal, W. E., Donaldson, N., Wyncoll, D. L. A., & Wendon, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07743-7 · Cited by 500
A Fetal Fatty-Acid Oxidation Disorder as a Cause of Liver Disease in Pregnant Women
Ibdah, J. A., Bennett, M. J., Rinaldo, P., Zhao, Y., Gibson, B., Sims, H. F., & Strauss, A. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906033402204 · Cited by 489
Association of Acetaminophen Hepatotoxicity With Fasting and Ethanol Use
Whitcomb, D. C. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520230055038 · Cited by 470
Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure
Zimmerman, H. J., & Maddrey, W. C. (1995) · Hepatology · doi:10.1002/hep.1840220312 · Cited by 458
A Practice Guideline on Wilson Disease
Roberts, E. A., & Schilsky, M. L. (2003) · Hepatology · doi:10.1053/jhep.2003.50252 · Cited by 450
Acetaminophen Toxicity in an Urban County Hospital
Schiødt, F. V., Rochling, F. A., Casey, D. L., & Lee, W. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371602 · Cited by 422
Liver transplantation for acute liver failure from drug induced liver injury in the United States
Russo, M. W., Galanko, J. A., Shrestha, R., Fried, M. W., & Watkins, P. (2004) · Liver Transplantation · doi:10.1002/lt.20204 · Cited by 393
Etiology and outcome for 295 patients with acute liver failure in the united states
Schiødt, F. V., Atillasoy, E. O., Shakil, A., Schiff, E. R., Caldwell, C. A., Kowdley, K. V., Stribling, R., Crippin, J. S., Flamm, S. L., Somberg, K. A., et al. (1999) · Liver Transplantation and Surgery · doi:10.1002/lt.500050102 · Cited by 391
Infection and the progression of hepatic encephalopathy in acute liver failure
Vaquero, J., Polson, J., Chung, C., Helenowski, I., Schiødt, F. V., REISCH, J. S., Lee, W. M., & Blei, A. T. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01051-5 · Cited by 384
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study
Hawton, K., Townsend, E., Deeks, J., Appleby, L., Gunnell, D., Bennewith, O., & Cooper, J. (2001) · BMJ · doi:10.1136/bmj.322.7296.1203 · Cited by 383
The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure
Murphy, N., Auzinger, G. M., Bernel, W., & Wendon, J. A. (2004) · Hepatology · doi:10.1002/hep.20056 · Cited by 375
A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
COOK, D., Guyatt, G. H., Marshall, J. K., Leasa, D. J., Fuller, H. D., Hall, R., Peters, S., Rutledge, F. S., Griffith, L. E., McLellan, A., et al. (1999) · Survey of Anesthesiology · doi:10.1097/00132586-199902000-00011 · Cited by 374
Improved cardiovascular stability during continuous modes of renal replacement therapy in critically ill patients with acute hepatic and renal failure
Davenport, A., Will, E. J., & Davidson, A. M. (1993) · Critical Care Medicine · doi:10.1097/00003246-199303000-00007 · Cited by 356
Acetaminophen Hepatotoxicity: The First 35 Years
Rumack, B. H. (2002) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-120002882 · Cited by 333
Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy
Vaquero, J., Fontana, R. J., Larson, A. M., Bass, N. M., Davern, T. J., Shakil, A. O., Han, S., Harrison, M. E., Stravitz, R. T., Muñoz, S. J., et al. (2005) · Liver Transplantation · doi:10.1002/lt.20625 · Cited by 301
Self-citation
Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failure.
Canalese, J., Gimson, A. E., Davis, C., Mellon, P. J., Davis, M., & Williams, R. L. (1982) · Gut · doi:10.1136/gut.23.7.625 · Cited by 301
Estimates of acetaminophen (paracetomal)‐associated overdoses in the United States
Nourjah, P. A., Ahmad, S. R., Karwoski, C. B., & Willy, M. E. (2005) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1191 · Cited by 292
Measurement of Serum Acetaminophen–Protein Adducts in Patients With Acute Liver Failure
Davern, T. J., James, L. P., Hinson, J. A., Polson, J., Larson, A. M., Fontana, R. J., Lalani, E., Munoz, S., Shakil, A. O., & Lee, W. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.033 · Cited by 284
Self-citation
Drug-induced liver injury: Summary of a single topic clinical research conference
Watkins, P. B., & Seeff, L. B. (2006) · Hepatology · doi:10.1002/hep.21095 · Cited by 278
Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension
Jalan, R., Damink, S. W. M. O., Deutz, N. E. P., Hayes, P. C., & Lee, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.005 · Cited by 265
UK legislation on analgesic packs: before and after study of long term effect on poisonings
Hawton, K. E., Simkin, S., Deeks, J. J., Cooper, J., Johnston, A., Waters, K., Arundel, M., Bernal, W. E., Gunson, B. K., Hudson, M., et al. (2004) · BMJ · doi:10.1136/bmj.38253.572581.7c · Cited by 264
Haemostatic abnormalities in patients with liver disease
Lisman, T., Leebeek, F. W. G., & de Groot, P. G. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00199-x · Cited by 260
Early indicators of prognosis in fulmitant hepatic failure: an assessment of the King's criteria
Anand, A. C., Nightingale, P., & Neuberger, J. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80010-4 · Cited by 258
Wilson's disease: clinical presentation and use of prognostic index.
Nazer, H. M., Ede, R. J., Mowat, A. P., & Williams, R. L. (1986) · Gut · doi:10.1136/gut.27.11.1377 · Cited by 253
Recombinant activated factor VII for coagulopathy in fulminant hepatic failure compared with conventional therapy
Shami, V. M., Caldwell, S. H., Hespenheide, E. E., Arseneau, K. O., Bickston, S. J., & Macik, G. B. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.50017 · Cited by 235
Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity
Schmidt, L. E., & Dalhoff, K. (2002) · Hepatology · doi:10.1053/jhep.2002.35069 · Cited by 235
MELD score as a predictor of pretransplant and posttransplant survival in OPTN/UNOS status 1 patients
Kremers, W. K., van IJperen, M., Kim, W. R., Freeman, R. B., Harper, A., Kamath, P. S., & Wiesner, R. H. (2004) · Hepatology · doi:10.1002/hep.20083 · Cited by 218
Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis
Kessler, W. R., Cummings, O. W., Eckert, G. J., Chalasani, N., Lumeng, L., & Kwo, P. Y. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00246-0 · Cited by 213
Comparison of Two Clinical Scales for Causality Assessment in Hepatotoxicity
Lucena, M. I., Camargo, R., Andrade, R. J., Perez-Sanchez, C. J., & De La Cuesta, F. S. (2001) · Hepatology · doi:10.1053/jhep.2001.20645 · Cited by 212
Viral and Clinical Factors Associated With the Fulminant Course of Hepatitis A Infection
Rezende, G., Roque‐Afonso, A., Samuel, D., Gigou, M., Nicand, É., Ferré, V., Dussaix, É., Bismuth, H., & Féray, C. (2003) · Hepatology · doi:10.1053/jhep.2003.50366 · Cited by 211
Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes
Taylor, R. M., Davern, T. J., Muñoz, S. J., Han, S.-H., McGuire, B. M., Larson, A. M., Hynan, L. S., Lee, W. M., & Fontana, R. J. (2006) · Hepatology · doi:10.1002/hep.21439 · Cited by 211
Self-citation
Acute Fatty Liver of Pregnancy: A Clinicopathologic Study of 35 Cases
Rolfes, D. B., & Ishak, K. G. (1985) · Hepatology · doi:10.1002/hep.1840050615 · Cited by 204
A randomized controlled trial of lamivudine to treat acute hepatitis B
Kumar, M., Satapathy, S. K., Monga, R., Das, K., Hissar, S. S., Pande, C., Sharma, B. C., & Sarin, S. K. (2006) · Hepatology · doi:10.1002/hep.21486 · Cited by 204
Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury
Schmidt, L. E., & Dalhoff, K. (2004) · Hepatology · doi:10.1002/hep.20511 · Cited by 200
Emergency liver transplantation for acute liver failure
Pauwels, A., Mostefa-Kara, N., Florent, C., & Vg, L. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80532-x · Cited by 199
The natural history of histologically proved drug induced liver disease
Aithal, G. P., & Day, C. P. (1999) · Gut · doi:10.1136/gut.44.5.731 · Cited by 199
Mushroom poisoning-from diarrhea to liver transplantation
Broussard, C. N., Aggarwal, A., Lacey, S. R., Post, A. B., Gramlich, T., Henderson, J. M., & Younossi, Z. M. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05283.x · Cited by 190
Recognizing Drug-Induced Liver Injury: Current Problems, Possible Solutions
Lee, W. M., & Senior, J. R. (2005) · Toxicologic Pathology · doi:10.1080/01926230590522356 · Cited by 187
Severe Hepatotoxicity Associated with the Dietary Supplement LipoKinetix
Favreau, J. T., Ryu, M. L., Braunstein, G., Orshansky, G., Park, S. S., Coody, G. L., Love, L. A., & Fong, T.-L. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-8-200204160-00008 · Cited by 186
Aetiology and prognostic factors in acute liver failure in India
Khuroo, M. S., & Kamili, S. (2003) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.2003.00415.x · Cited by 175
High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure
Estes, J. D. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.8.852 · Cited by 174
Acute liver failure induced by green tea extracts: Case report and review of the literature
Molinari, M., Watt, K. D. S., Kruszyna, T., Nelson, R., Walsh, M. J., Huang, W.-Y., Nashan, B., & Peltekian, K. M. (2006) · Liver Transplantation · doi:10.1002/lt.21021 · Cited by 170
Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure
Forbes, A., Alexander, G., O'Grady, J. G., Keays, R. T., GULLAN, R. W., Dawling, S., & Williams, R. L. (1989) · Hepatology · doi:10.1002/hep.1840100309 · Cited by 166
Subclinical Seizure Activity and Prophylactic Phenytoin Infusion in Acute Liver Failure: A Controlled Clinical Trial
Ellis, A. J., Wendon, J. A., & Williams, R. L. (2000) · Hepatology · doi:10.1053/jhep.2000.9775 · Cited by 163
Maternal and perinatal outcome in severe pregnancy-related liver disease
Pereira, S. P., O’Donohue, J., Wendon, J. A., & Williams, R. L. (1997) · Hepatology · doi:10.1002/hep.510260525 · Cited by 162
Moderate hypothermia prevents cerebral hyperemia and increase in intracranial pressure in patients undergoing liver transplantation for acute liver failure
Jalan, R., Damink, S. W. M. O., Deutz, N. E. P., Davies, N. A., Garden, O. J., Madhavan, K. K., Hayes, P. C., & Lee, A. (2003) · Transplantation · doi:10.1097/01.tp.0000066240.42113.ff · Cited by 157
Amanita poisoning: Treatment and the role of liver transplantation
Klein, A. S., Hart, J., Brems, J. J., Goldstein, L., Lewin, K. J., & Busuttil, R. W. (1989) · The American Journal of Medicine · doi:10.1016/0002-9343(89)90267-2 · Cited by 150
Renal failure in fulminant hepatic failure and terminal cirrhosis: a comparison between incidence, types, and prognosis.
Ring‐Larsen, H., & Palazzo, U. (1981) · Gut · doi:10.1136/gut.22.7.585 · Cited by 148
CONTROLLED TRIAL OF EXCHANGE-TRANSFUSION THERAPY IN FULMINANT HEPATITIS
Redeker, A., & Yamahiro, H. S. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91220-8 · Cited by 147
Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension
Durward, Q. J., Amacher, A. L., Maestro, R. F. D., & Sibbald, W. J. (1983) · Journal of neurosurgery · doi:10.3171/jns.1983.59.6.0938 · Cited by 146
ACUTE HEPATIC NECROSIS WITH STUPOR OR COMA An Analysis of Thiety-One Patients
Ritt, D. J., Whelan, G., WERNER, D. J., Eigenbrodt, E. H., Schenker, S., & Combes, B. (1969) · Medicine · doi:10.1097/00005792-196903000-00003 · Cited by 145
Alpha-fetoprotein and prognosis in acute liver failure
Schiødt, F. V., Ostapowicz, G., Murray, N., Satyanarana, R., Zaman, A., Muñoz, S. J., Lee, W. M., & Acute Liver Failure Study Group (2006) · Liver Transplantation · doi:10.1002/lt.20886 · Cited by 140
Clinical outcome and virological characteristics of hepatitis B‐related acute liver failure in the United States
Wai, C. T., Fontana, R. J., Polson, J., Hussain, M., Shakil, A. O., Han, S. H., Davern, T. J., Lee, W. M., Lok, A. S.-F., & The US Acute Liver Failure Study Group (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00581.x · Cited by 139
Self-citation
Acetaminophen hepatoxicity: What do we know, what don’t we know, and what do we do next?†
Kaplowitz, N. (2004) · Hepatology · doi:10.1002/hep.20312 · Cited by 138
Earlier identification of patients at risk from acetaminophen-induced acute liver failure
Mitchell, I., Bihari, D. J., Chang, R., Wendon, J. A., & Williams, R. L. (1998) · Critical Care Medicine · doi:10.1097/00003246-199802000-00026 · Cited by 132
Immunological alterations in pregnant women with acute hepatitis E
Pal, R., Aggarwal, R., Naik, S. R., Das, V., DAS, S., & Naik, S. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03875.x · Cited by 130
Effect of Maximal Daily Doses of Acetaminophen on the Liver of Alcoholic Patients
Kuffner, E. K., Dart, R. C., Bogdan, G. M., Hill, R. E., Casper, E., & Darton, L. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.18.2247 · Cited by 129
Drug-induced liver injury network (DILIN)
Hoofnagle, J. H. (2004) · Hepatology · doi:10.1002/hep.1840400403 · Cited by 125
Restoration of Cerebral Blood Flow Autoregulation and Reactivity to Carbon Dioxide in Acute Liver Failure by Moderate Hypothermia
Jalan, R., Damink, S. W. M. O., Deutz, N. E. P., Hayes, P. C., & Lee, A. (2001) · Hepatology · doi:10.1053/jhep.2001.25386 · Cited by 124
Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy
Shawcross, D. L., Davies, N. A., Mookerjee, R. P., Hayes, P. C., Williams, R. L., Lee, A., & Jalan, R. (2004) · Hepatology · doi:10.1002/hep.20044 · Cited by 124
Causality Assessment of Drug-Induced Hepatotoxicity: Promises and Pitfalls
Shapiro, M. A., & Lewis, J. H. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.003 · Cited by 122
A double-blinded, randomized trial of hydrocortisone in acute hepatic failure
Rakela, J. L., Mosley, J. W., Edwards, V. M., Govindarajan, S., Alpert, E., & The Acute Hepatic Failure Study Group (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01307513 · Cited by 120
Herpes simplex virus-associated acute liver failure: A difficult diagnosis with a poor prognosis
Ichaı̈, P., Roque‐Afonso, A., Sebagh, M., González, M. E., Codés, L., Azoulay, D., Saliba, F., Karam, V. H., Dussaix, É., Guettier, C., et al. (2005) · Liver Transplantation · doi:10.1002/lt.20545 · Cited by 116
Propofol to control intracranial pressure in fulminant hepatic failure
Wijdicks, E. F. M., & Nyberg, S. L. (2002) · Transplantation Proceedings · doi:10.1016/s0041-1345(02)02804-x · Cited by 116
Thrombocytopenic Disorders in Critically Ill Patients
Drews, R. E., & Weinberger, S. E. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.ncc3-00 · Cited by 114
Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure
Strauss, G., Hansen, B. A., Knudsen, G. M., & Larsen, F. S. (1998) · Journal of Hepatology · doi:10.1016/0168-8278(88)80006-0 · Cited by 112
Functional loss of cerebral blood flow autoregulation in patients with fulminant hepatic failure
Larsen, F. S., Ejlersen, E., Hansen, B. A., Knudsen, G. M., Tygstrup, N., & Secher, N. H. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80338-6 · Cited by 103
Paracetamol-induced acute renal failure in the absence of fulminant liver damage.
Cobden, I., Record, C. O., Ward, M. K., & Kerr, D. N. (1982) · BMJ · doi:10.1136/bmj.284.6308.21 · Cited by 103
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Kao, L. W., Kirk, M. A., Furbee, R. B., Mehta, N. H., Skinner, J. R., & Brizendine, E. J. (2003) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(03)00508-0 · Cited by 102
Recommended Adult Immunization Schedule: United States, October 2007–September 2008
Advisory Committee on Immunization Practices† (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-10-200711200-00187 · Cited by 98
Histopathological heterogeneity in fulminant hepatic failure
Hanau, C. A., Muñoz, S. J., & Rubin, R. (1995) · Hepatology · doi:10.1002/hep.1840210213 · Cited by 97
Herpes Simplex Hepatitis in Pregnancy
Kang, A. H., & Graves, C. R. (1999) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199907000-00026 · Cited by 95
Herpes Simplex-Induced Fulminant Hepatitis In Adults
Peters, D. J., Greene, W. H., Ruggiero, F. M., & McGarrity, T. J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005699210816 · Cited by 91
Outcomes Following Liver Transplantation for Seronegative Acute Liver Failure: Experience During a 12-Year Period With More Than 100 Patients
Wigg, A. J., Gunson, B. K., & Mutimer, D. (2004) · Liver Transplantation · doi:10.1002/lt.20289 · Cited by 88
Clinical and Radiologic Features of Cerebral Edema in Fulminant Hepatic Failure
Wijdicks, E. F. M., Plevak, D. J., Rakela, J. L., & Wiesner, R. H. (1995) · Mayo Clinic Proceedings · doi:10.4065/70.2.119 · Cited by 86
Hepatotoxicity Associated With Acetaminophen Usage in Patients Receiving Multiple Drug Therapy for Tuberculosis
Nolan, C. M., Sandblom, R. E., Thummel, K. E., Slattery, J. T., & Nelson, S. D. (1994) · CHEST Journal · doi:10.1378/chest.105.2.408 · Cited by 85
Lamivudine treatment for acute severe hepatitis B: a pilot study
Schmilovitz‐Weiss, H., Ben‐Ari, Z., Sikuler, E., Zuckerman, E., Sbeit, W., Ackerman, Z., Safadi, R., Lurie, Y., Rosner, G., Tur‐Kaspa, R., et al. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0983.x · Cited by 85
Association of acetaminophen hepatotoxicity with fasting and ethanol use
Whitcomb, D. C. (1994) · JAMA · doi:10.1001/jama.272.23.1845 · Cited by 76
The Prometheus® Device for Extracorporeal Support of Combined Liver and Renal Failure
Rifai, K., Ernst, T., Kretschmer, U., Hafer, C., Haller, H. G., Manns, M. P., & Fliser, D. (2005) · Blood Purification · doi:10.1159/000086552 · Cited by 74
Investigation of SEN Virus Infection in Patients with Cryptogenic Acute Liver Failure, Hepatitis‐Associated Aplastic Anemia, or Acute and Chronic Non–A–E Hepatitis
Umemura, T., Tanaka, E. I., Ostapowicz, G., Brown, K. E., Heringlake, S., Tassopoulos, N. C., Wang, R. Y. ‐., Yeo, A. E. T., Shih, J. W., Orii, K. O., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/379216 · Cited by 73
Drug-induced liver injury network (DILIN)
Hoofnagle, J. H. (2004) · Hepatology · doi:10.1002/hep.20445 · Cited by 72
Acetylcysteine Treatment for Non–Acetaminophen-Induced Acute Liver Failure
Sklar, G. E., & Subramaniam, M. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d209 · Cited by 66
Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure
Jalan, R. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.04.010 · Cited by 63
Recombinant activated factor VII (rFVIIa) as a hemostatic agent in liver disease: A break from convention in need of controlled trials
Caldwell, S. H., Chang, C., & Macik, B. G. (2004) · Hepatology · doi:10.1002/hep.20123 · Cited by 62
A controlled trial of steroid therapy in massive hepatic necrosis.
Ware, A. J., Jones, R. E., Shorey, J. W., & Combes, B. (1974) · PubMed · Cited by 61
New Liver Support Devices in Acute Liver Failure: A Critical Evaluation
Sen, S., & Williams, R. L. (2003) · Seminars in Liver Disease · doi:10.1055/s-2003-42646 · Cited by 60
Fulminant hepatic failure: observation with serial CT.
Itai, Y., Sekiyama, K., Ahmadi, T., Obuchi, M., & Yoshiba, M. (1997) · Radiology · doi:10.1148/radiology.202.2.9015061 · Cited by 60
Prognostic Value of Abdominal CT Scanning and Hepatic Histopathology in Patients with Acute Liver Failure
Shakil, A., Jones, B. C., Lee, R. G., Federle, M. P., Fung, J. J., & Rakela, J. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005416727424 · Cited by 59
Effect of Lidocaine on ICP Response to Endotracheal Suctioning
Yano, M., Nishiyama, H., Yokota, H., Kato, K., Yamamoto, Y., & Otsuka, T. (1986) · Anesthesiology · doi:10.1097/00000542-198605000-00019 · Cited by 59
Acute Budd-Chiari syndrome with fulminant hepatic failure in a pregnant woman with factor V Leiden mutation
Fickert, P., Ramschak, H., Kenner, L., Höefler, G., Hinterleitner, T., Petritsch, W., Klimpfinger, M., Krejs, G. J., & Stauber, R. E. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70031-8 · Cited by 57
Acute liver failure due to lymphoma
Woolf, G. M., Petrovic, L. M., Rojter, S. E., Villamil, F. G., Makowka, L., Podestá, L. G., Sher, L. S., Memsic, L., & Vierling, J. M. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02093804 · Cited by 57
MELD / PELD and the allocation of deceased donor livers for status 1 recipients with acute fulminant hepatic failure, primary nonfunction, hepatic artery thrombosis, and acute Wilson’s disease
Wiesner, R. H. (2004) · Liver Transplantation · doi:10.1002/lt.20273 · Cited by 55
Case Report: Acute Liver Failure Due to Hepatic Involvement by Hematologic Malignancy
Shehab, T. M., Kaminski, M. S., & Lok, A. S. F. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018889904839 · Cited by 52
Hepatitis B Infection in Patients With Acute Liver Failure in the United States
Teo, E. K., Ostapowicz, G., Hussain, M., Lee, W. M., Fontana, R. J., & Lok, A. S.-F. (2001) · Hepatology · doi:10.1053/jhep.2001.23065 · Cited by 52
Self-citation
Efficacy of N-acetylcysteine in the treatment of acetaminophen overdose
Federiuk, C. S. (1989) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(89)80551-7 · Cited by 52
Varicella‐Zoster Virus Infection Associated with Acute Liver Failure
Dits, H., Frans, E., Wilmer, A. P., Ranst, M. A. V., Fevery, J., & Bobbaers, H. (1998) · Clinical Infectious Diseases · doi:10.1086/514613 · Cited by 44
Histopathological heterogeneity in fulminant hepatic failure*1
Hanau, C. A. (1995) · Hepatology · doi:10.1016/0270-9139(95)90091-8 · Cited by 40
Timing and aetiology of bacterial infections in a liver intensive care unit
Wade, J. J., Rolando, N., Philpott‐Howard, J., & Wendon, J. A. (2003) · Journal of Hospital Infection · doi:10.1053/jhin.2002.1363 · Cited by 38
Brief Report: No Evidence for Parvovirus B19 or Hepatitis E Virus as a Cause of Acute Liver Failure
Lee, W. M., Brown, K. E., Young, N. S., Dawson, G. J., Schlauder, G. G., Gutierrez, R. A., Fontana, R. J., Rossaro, L., Davern, T. J., Lalani, E., et al. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9061-5 · Cited by 34
Self-citation
Liver transplantation for status 1: The consequences of good intentions
McDiarmid, S. V., Goodrich, N. P., Harper, A., & Merion, R. M. (2007) · Liver Transplantation · doi:10.1002/lt.21125 · Cited by 34
Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose
Sato, R. L., Wong, J. J., Sumida, S. M., Marn, R. Y., Enoki, N. R., & Yamamoto, L. G. (2003) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(02)42251-6 · Cited by 33
Clinical characteristics and prognostic indicators of drug-induced fulminant hepatic failure.
Ohmori, S., Shiraki, K., Inoue, H., Okano, H., Yamanaka, T., Deguchi, M., Sakai, T., Takase, K., Nakano, T., & Tameda, Y. (2003) · PubMed · Cited by 30
Prediction of survival for patients with fulminant hepatic failure
Neuberger, J. (2004) · Hepatology · doi:10.1002/hep.20562 · Cited by 30
Treatment of fulminant hepatic failure with intravenous prostaglandin E1
Sterling, R. K., Luketic, V. A., Sanyal, A. J., & Shiffman, M. L. (1998) · Liver Transplantation and Surgery · doi:10.1002/lt.500040501 · Cited by 29
Treating Budd-Chiari Syndrome
Olzinski, A. T., & Sanyal, A. J. (2000) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200003000-00007 · Cited by 26
“Unintentional” Acetaminophen Overdose on the Rise: Who is Responsible?
Fontana, R. J., & Adams, P. C. (2006) · Canadian Journal of Gastroenterology · doi:10.1155/2006/498157 · Cited by 17
Self-citation
Attempting to predict the unpredictable in acute liver injury
O’Grady, J. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.11.007 · Cited by 17
Liver transplantation in acute liver failure.
Higgins, P., & Fontana, R. J. (2003) · PubMed · Cited by 14
Self-citation
Hepatic assist devices.
Aa, D. (2005) · PubMed · Cited by 11
The need for a population‐based surveillance system for liver disease in the United States
Verma, A., & Lilienfeld, D. E. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1022 · Cited by 5

Flagged first, then by citations

Research works printed but not linked: 7

Polson, 2004, Elevated bilirubin may cause false positive acetaminophen levels in hepatitis patients, Hepatology, 40, 496A
Food and Drug Administration, 21 CRF Parts 201 and 343, 2006, Internal analgesic, antipyretic, and antirheumatic drug products for over the counter human use: proposed amendment of the tentative final monograph, required warnings and other labeling, Federal Register, 71, 77314
Seremba, 2007, Use of nucleoside analogues in HBV related acute liver failure, Hepatology, 46, 79
Levitsky, 2008, Measurement of herpes simplex DNA-emia before and after liver transplantation, Liver Transpl
Dechene, 2005, Effectiveness of a steroid and ursodeoxycholic acid combination therapy with drug induced subacute liver failure, Hepatology, 42, 358A
Taylor, 2005, Acute liver failure due to ischemic hepatitis: natural history and predictors of outcome in a prospective, multi-center U.S. study, Gastroenterology, 128, A-706
Lee, 2007, Intravenous N-acetylcysteine improves spontaneous survival in early stage non-acetaminophen acute liver failure, Hepatology, 46, 79

Sorted by citations

Drug-induced liver injury
Katarey, D. R., & Verma, S. (2016) · Clinical Medicine · doi:10.7861/clinmedicine.16-6-s104 · Cited by 346
Acetaminophen-related Hepatotoxicity
Bunchorntavakul, C., & Reddy, K. R. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.07.005 · Cited by 322
Acute Liver Failure Guidelines
Shingina, A., Mukhtar, N. A., Wakim-Fleming, J., Alqahtani, S. A., Wong, R. J., Limketkai, B. N., Larson, A. M., & Grant, L. M. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002340 · Cited by 240
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure
Tuñón, M. J., Alvarez, M., Culebras, J. M., & González‐Gallego, J. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3086 · Cited by 211
Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives
Ramachandran, A., & Jaeschke, H. (2017) · Gene Expression · doi:10.3727/105221617x15084371374138 · Cited by 215

See all 249

Authors: Fontana, R. J.
Affiliations: University of Michigan (US)
Corresponding author: Fontana, Robert J.
ORCID: Fontana, Robert J.
Venue: Medical Clinics of North America
Publisher: Elsevier BV
Published: 2008-07
Volume: 92
Issue: 4
Pages: 761-794
ISSN: 0025-7125 (ISSN-L)
DOI: 10.1016/j.mcna.2008.03.005
PMC: PMC2504411
OpenAlex: W1979020366
Cited by: 249
References: 134
Citations by year: 2026: 7 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 9 · 2021: 26 · 2020: 19 · 2019: 18 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 9
FWCI: 1.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Medical Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01dk065184-22)
National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK-065184, UO1 DK058389-07, U01DK058369)
National Center for Research Resources (M01RR000042)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
Keywords: acute liver failure, acetaminophen overdose, N-acetylcysteine, coagulopathy, encephalopathy, cerebral edema, infectious complications, liver transplantation, survival after liver transplantation
MeSH terms: Acetaminophen, Humans, Prognosis, Liver Transplantation, Liver Failure, Acute, Analgesics, Non-Narcotic, Drug Overdose

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Acute Liver Failure Including Acetaminophen Overdose

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