Menopause
Abstract
Women generally spend the last third of their lifetime in menopause, after their reproductive years have ended. During menopause, women experience a variety of predictable symptoms and conditions related to changes in sex hormone levels and aging. The menopausal transition precedes menopause by several years and is usually characterized by irregularity of the menstrual cycle and by hot flashes and night sweats. After menopause, genitourinary symptoms predominate, including vulvovaginal atrophy and dryness and lower urinary tract symptoms, including urinary frequency, urgency, and nocturia. Hormonal treatment is effective for vasomotor and genitourinary symptoms, but the understanding of its impact on cardiovascular disease, cognitive dysfunction, and depression continues to evolve.
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Age-dependent hormonal alterations, manifested primarily as lower estrogen levels in women after menopause, could plausibly explain the age-related differences in liraglutide response.
“It is plausible that these differences could be attributed to age-dependent hormonal alterations, manifested primarily as lower estrogen levels in women after menopause [55].”
From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [55]
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- Authors
- Takahashi, T. A., & Johnson, K. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Takahashi, Traci A.
- Venue
- Medical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 99
- Issue
- 3
- Pages
- 521-534
- ISSN
- 0025-7125 (ISSN-L)
- OpenAlex
- W4254396244
- Cited by
- 355
- References
- 52
- Citations by year
- 2026: 26 · 2025: 47 · 2024: 45 · 2023: 42 · 2022: 48 · 2021: 45 · 2020: 41 · 2019: 23 · 2018: 17 · 2017: 8 · 2016: 6 · 2015: 6
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- menopause, perimenopause, hot flashes, night sweats, vaginal atrophy, genitourinary symptoms, lower urinary tract symptoms, hormone replacement therapy, vasomotor symptoms, cardiovascular disease, cognitive impairment, depression
- MeSH terms
- Female, Humans, Menopause, Estrogen Replacement Therapy, Hot Flashes, Female Urogenital Diseases
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