The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Relevance of collagen piezoelectricity to “Wolff's Law”: A critical review
Open accessAbstract
According to "Wolff's Law", bone is deposited and reinforced at areas of greatest stress. From a clinical perspective, this "law" is supported by the strong association between bone density and physical activity. From a mechanistic standpoint, however, the law presents a challenge to scientists seeking to understand how osteocytes and osteoblasts sense the mechanical load. In the 1960s, collagen piezoelectricity was invoked as a potential mechanism by which osteocytes could detect areas of greater stress but piezoelectricity diminished in importance as more compelling mechanisms, such as streaming potential, were identified. In addition, accumulating evidence for the role of fluid-related shear stress in osteocyte's mechanosensory function has made piezoelectricity seemingly more obsolete in bone physiology. This review critically evaluates the role of collagen piezoelectricity (if any) in Wolff's Law--specifically, the evidence regarding its involvement in strain-generated potentials, existing alternate mechanisms, the present understanding of bone mechanosensation, and whether piezoelectricity serves an influential role within the context of this newly proposed mechanism. In addition to reviewing the literature, this review generates several hypotheses and proposes future research to fully address the relevance of piezoelectricity in bone physiology.
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Citations
Cites
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Collagen for bone tissue regeneration
Ferreira, A. M., Gentile, P., Chiono, V., & Ciardelli, G. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.014 · Cited by 938
Piezoelectric polymers as biomaterials for tissue engineering applications
Ribeiro, C., Sencadas, V., Correia, D. M., & Lanceros-Méndez, S. (2015) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2015.08.043 · Cited by 521
Liu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 478
Piezoelectric smart biomaterials for bone and cartilage tissue engineering
Jacob, J., More, N., Kalia, K., & Kapusetti, G. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0059-8 · Cited by 454
The use of composite materials in modern orthopaedic medicine and prosthetic devices: A review
Scholz, M.-S., Blanchfield, J. P., Bloom, L. D., Coburn, B. H., Elkington, M., Fuller, J. D., Gilbert, M. E., Muflahi, S. A., Pernice, M. F., Rae, S. I., et al. (2011) · Composites Science and Technology · doi:10.1016/j.compscitech.2011.08.017 · Cited by 311
Metadata
- Authors
- Ahn, A. C., & Grodzinsky, A. J.
- Venue
- Medical Engineering & Physics
- Publisher
- IOP Publishing
- Published
- 2009-03-14
- Volume
- 31
- Issue
- 7
- Pages
- 733-741
- ISSN
- 1350-4533 (ISSN-L)
- 1873-4030
- OpenAlex
- W1524646771
- Cited by
- 257
- References
- 29
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ahn, A. C., & Grodzinsky, A. J. (2009). Relevance of collagen piezoelectricity to “Wolff's Law”: A critical review. Medical Engineering & Physics. https://doi.org/10.1016/j.medengphy.2009.02.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
