Cited by 130Medical Image Segmentation TechniquesAdvanced Neural Network ApplicationsMedical Imaging and Analysis

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MIDeepSeg: Minimally interactive segmentation of unseen objects from medical images using deep learning

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Luo, Xiangde, Wang, Guotai, Song, Tao, Zhang, Jingyang, Aertsen, Michael, Deprest, Jan, Ourselin, Sebastien, Vercauteren, Tom, Zhang, Shaoting·2021·Medical Image Analysis

DOI 10.1016/j.media.2021.102102PMC PMC7613452

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Abstract

Segmentation of organs or lesions from medical images plays an essential role in many clinical applications such as diagnosis and treatment planning. Though Convolutional Neural Networks (CNN) have achieved the state-of-the-art performance for automatic segmentation, they are often limited by the lack of clinically acceptable accuracy and robustness in complex cases. Therefore, interactive segmentation is a practical alternative to these methods. However, traditional interactive segmentation methods require a large number of user interactions, and recently proposed CNN-based interactive segmentation methods are limited by poor performance on previously unseen objects. To solve these problems, we propose a novel deep learning-based interactive segmentation method that not only has high efficiency due to only requiring clicks as user inputs but also generalizes well to a range of previously unseen objects. Specifically, we first encode user-provided interior margin points via our proposed exponentialized geodesic distance that enables a CNN to achieve a good initial segmentation result of both previously seen and unseen objects, then we use a novel information fusion method that combines the initial segmentation with only a few additional user clicks to efficiently obtain a refined segmentation. We validated our proposed framework through extensive experiments on 2D and 3D medical image segmentation tasks with a wide range of previously unseen objects that were not present in the training set. Experimental results showed that our proposed framework 1) achieves accurate results with fewer user interactions and less time compared with state-of-the-art interactive frameworks and 2) generalizes well to previously unseen objects.

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Authors: Luo, X., Wang, G., Song, T., Zhang, J., Aertsen, M., Deprest, J., Ourselin, S., Vercauteren, T., & Zhang, S.
Affiliations: University of Electronic Science and Technology of China (CN)
Sensetime (China) (CN)
Shanghai Jiao Tong University (CN)
Universitair Ziekenhuis Leuven (BE)
King's College London (GB)
Corresponding author: Wang, Guotai
ORCID: Luo, Xiangde
Wang, Guotai
Song, Tao
Zhang, Jingyang
Deprest, Jan
Vercauteren, Tom
Zhang, Shaoting
Venue: Medical Image Analysis
Publisher: Elsevier BV
Published: 2021-08
Volume: 72
Pages: 102102
ISSN: 1361-8415 (ISSN-L)
DOI: 10.1016/j.media.2021.102102
PMC: PMC7613452
OpenAlex: W3159178846
Cited by: 126
References: 61
Citations by year: 2026: 10 · 2025: 36 · 2024: 29 · 2023: 31 · 2022: 18 · 2021: 2
FWCI: 7.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Medical Image Analysis (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
arXiv (Cornell University) (submittedVersion)
Lirias (submittedVersion, other-oa)
arXiv (Cornell University) (cc-by)
Funders: EPSRC
Wellcome Trust
National Natural Science Foundation of China
Topics: Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
Keywords: interactive segmentation, medical image segmentation, unseen objects, generalization, data fusion, organ segmentation, lesion segmentation, 3D medical images
MeSH terms: Deep Learning, Humans, Image Processing, Computer-Assisted, Neural Networks, Computer, Imaging, Three-Dimensional

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MIDeepSeg: Minimally interactive segmentation of unseen objects from medical images using deep learning

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