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Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival
Open accessAbstract
Candida albicans is the most implicated fungal species that grows as a commensal or opportunistic pathogen in the human host. It is associated with many life-threatening infections, especially in immunocompromised persons. The genome of Candida albicans is very flexible and can withstand a wide assortment of variations in a continuously changing environment. Thus, genome plasticity is central to its adaptation and has long been of considerable interest. C. albicans has a diploid heterozygous genome that is highly dynamic and can display variation from small to large scale chromosomal rearrangement and aneuploidy, which have implications in drug resistance, virulence, and pathogenicity. This review presents an up-to-date overview of recent genomic studies involving C. albicans. It discusses the accumulating evidence that shows how mitotic recombination events, ploidy dynamics, aneuploidy, and loss of heterozygosity (LOH) influence evolution, adaptation, and survival in C. albicans. Understanding the factors that affect the genome is crucial for a proper understanding of species and rapid development and adjustment of therapeutic strategies to mitigate their spread.
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“Furthermore, mutations in the ERG11 gene, which encodes the essential enzyme 14α‐demethylase (Erg11p) for ergosterol biosynthesis, along with overexpression of ergosterol in the plasma membrane, further contribute to antifungal resistance [2, 46].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [46]
Citations
Cites
The Gene Ontology Resource: 20 years and still GOing strong
The Gene Ontology Consortium (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1055 · Cited by 4,747
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174
Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision
Bongomin, F., Gago, S., Oladele, R., & Denning, D. (2017) · Journal of Fungi · doi:10.3390/jof3040057 · Cited by 2,953
Candida albicans pathogenicity mechanisms
Mayer, F. L., Wilson, D., & Hube, B. (2013) · Virulence · doi:10.4161/viru.22913 · Cited by 1,848
Waples, R. S., & Gaggiotti, O. E. (2006) · Molecular Ecology · doi:10.1111/j.1365-294x.2006.02890.x · Cited by 1,507
The Evolutionary Consequences of Polyploidy
Otto, S. P. (2007) · Cell · doi:10.1016/j.cell.2007.10.022 · Cited by 1,225
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184
Characterization of the oral fungal microbiome (mycobiome) in healthy individuals
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., et al. (2009) · Nature · doi:10.1038/nature08064 · Cited by 1,065
The gut mycobiome of the Human Microbiome Project healthy cohort
Nash, A. K., Auchtung, T. A., Wong, M. C., Smith, D. P., Gesell, J. R., Ross, M. C., Stewart, C. J., Metcalf, G., Muzny, D. M., Gibbs, R. A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0373-4 · Cited by 1,039
Research works printed but not linked: 13
- Bennett, 2009, Stress-induced phenotypic switching in Candida albicans, Mol. Biol. Cell, 20, 3178, 10.1091/mbc.e09-01-0040 · DOI
- Cludad, 2016, Phenotypic consequences of a spontaneous loss of heterozygosity in a common laboratory strain of Candida albicans, Genetics, 23, 1161
- Cludad, 2020, DLH1, the Candida albicans homologue of the meiosis-specific DMC1, is not involved in DNA repair but catalyzes spontaneous interhomologous recombination and might promote non-crossover events, Cell. Microbiol., 22
- d’ENfert, 2017, Genome diversity and dymanics in Candida albicans. R. Prasa (ed.), Candida albicans, Cell. Mol. Biol.
- d’Enfert, 2021, the impact of the fungus-host microbiota interplay upon Candida albicans infections: current knowledge and new perspectives, FEMS Microbiol. Rev., 45
- Forche, 2008, The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains, PLoS Biol., 6, 10.1371/journal.pbio.0060110 · DOI · Paper page
- Freire-Benéitez, 2016, Sir2 regulates stability of repetitive domains differentially in the human fungal pathogen Candida albicans, Nucleic Acids Res., 44
- Potocki, 2019, Activation of transposable elements and genetic instability during long-term culture of the human fungal pathogens Candida albicans, Biotechnology, 20, 457
- Russel, 1986, structure of the Saccharomycees cerevisiae HO gene and analysis of its upstream regulatory region, Mol. Cell. Biol., 6, 4281
- Sionov, 2010, Cryptococcal neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes, PLoS Pathoens, 6
- Soll, 2014, the role of phenotypic switching in the basic biology and pathogenesis of Candida albicans, J. Oral Microbiol., 6, 895
- Yang, 2021, The fitness costs and benefits of trisomy of each Candida albicans chromosomes, Genetics, 2
- Zhu, 2012, Karyotypic determinants of chromosome instability in aneuploidy budding yeast, Yeast Genet, 8
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Metadata
- Authors
- Mba, I. E., Nweze, E. I., Eze, E. A., & Anyaegbunam, Z. K. G.
- Affiliations
- University of Nigeria (NG)
- Corresponding author
- Nweze, Emeka Innocent
- Venue
- Infection, Genetics and Evolution
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 99
- Pages
- 105256
- ISSN
- 1567-1348 (ISSN-L)
- OpenAlex
- W4214710995
- Cited by
- 46
- References
- 224
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Infection Genetics and Evolution (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- Candida albicans, genome plasticity, chromosomal rearrangements, aneuploidy, mitotic recombination, loss of heterozygosity, drug resistance, virulence, fungal evolution, opportunistic fungal pathogens, diploid genome
- MeSH terms
- Aneuploidy, Candida albicans, Humans, Virulence, Genome, Genome, Fungal, Loss of Heterozygosity
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