Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival

The Gene Ontology Resource: 20 years and still GOing strong

The Gene Ontology Consortium (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1055 · Cited by 4,747

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174

Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision

Bongomin, F., Gago, S., Oladele, R., & Denning, D. (2017) · Journal of Fungi · doi:10.3390/jof3040057 · Cited by 2,953

Candida albicans pathogenicity mechanisms

Mayer, F. L., Wilson, D., & Hube, B. (2013) · Virulence · doi:10.4161/viru.22913 · Cited by 1,848

INVITED REVIEW: What is a population? An empirical evaluation of some genetic methods for identifying the number of gene pools and their degree of connectivity

Waples, R. S., & Gaggiotti, O. E. (2006) · Molecular Ecology · doi:10.1111/j.1365-294x.2006.02890.x · Cited by 1,507

The Evolutionary Consequences of Polyploidy

Otto, S. P. (2007) · Cell · doi:10.1016/j.cell.2007.10.022 · Cited by 1,225

Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options

Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184

Characterization of the oral fungal microbiome (mycobiome) in healthy individuals

Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., et al. (2009) · Nature · doi:10.1038/nature08064 · Cited by 1,065

The gut mycobiome of the Human Microbiome Project healthy cohort

Nash, A. K., Auchtung, T. A., Wong, M. C., Smith, D. P., Gesell, J. R., Ross, M. C., Stewart, C. J., Metcalf, G., Muzny, D. M., Gibbs, R. A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0373-4 · Cited by 1,039

The diploid genome sequence of Candida albicans

Jones, T., Federspiel, N. A., Chibana, H., Dungan, J. M., Kalman, S., Magee, B. B., Newport, G., Thorstenson, Y. R., Agabian, N. M., Magee, P. T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401648101 · Cited by 784

Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicans

Selmecki, A., Forche, A., & Berman, J. (2006) · Science · doi:10.1126/science.1128242 · Cited by 733

Global trends in the distribution of Candida species causing candidemia

Guinea, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12539 · Cited by 680

Ploidy Regulation of Gene Expression

Galitski, T., Saldanha, A. J., Styles, C. A., Lander, E. S., & Fink, G. R. (1999) · Science · doi:10.1126/science.285.5425.251 · Cited by 633

The Population Genetics of Clonal and Partially Clonal Diploids

Balloux, F., Lehmann, L., & Meeûs, T. D. (2003) · Genetics · doi:10.1093/genetics/164.4.1635 · Cited by 586

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

Pavelka, N., Rancati, G., Zhu, J., Bradford, W. D., Saraf, A., Florens, L., Sanderson, B. W., Hattem, G. L., & Li, R. (2010) · Nature · doi:10.1038/nature09529 · Cited by 577

White-Opaque Switching in Candida albicans Is Controlled by Mating-Type Locus Homeodomain Proteins and Allows Efficient Mating

Miller, M. G., & Johnson, A. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00837-1 · Cited by 569

Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae

Dunham, M. J., Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., & Botstein, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242624799 · Cited by 564

The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast

Gresham, D., Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., & Dunham, M. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000303 · Cited by 482

Mechanism and Regulation of Meiotic Recombination InitiationPreprint

Lam, I., & Keeney, S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016634 · Cited by 477

Evidence for Mating of the "Asexual" Yeast Candida albicans in a Mammalian Host

Hull, C. M., Raisner, R. M., & Johnson, A. D. (2000) · Science · doi:10.1126/science.289.5477.307 · Cited by 465

Induction of Mating in Candida albicans by Construction of MTL a and MTL α Strains

Magee, B. B., & Magee, P. T. (2000) · Science · doi:10.1126/science.289.5477.310 · Cited by 443

Sex speeds adaptation by altering the dynamics of molecular evolution

McDonald, M. J., Rice, D. P., & Desai, M. M. (2016) · Nature · doi:10.1038/nature17143 · Cited by 436

Precise estimates of mutation rate and spectrum in yeast

Zhu, Y. O., Siegal, M. L., Hall, D. W., & Petrov, D. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323011111 · Cited by 429

Aneuploidy: Cells Losing Their Balance

Torres, E. M., Williams, B. R., & Amon, A. (2008) · Genetics · doi:10.1534/genetics.108.090878 · Cited by 410

A Mutation in Tac1p, a Transcription Factor Regulating CDR1 and CDR2 , Is Coupled With Loss of Heterozygosity at Chromosome 5 to Mediate Antifungal Resistance in Candida albicans

Coste, A., Turner, V., Ischer, F., Morschhäuser, J., Forche, A., Selmecki, A., Berman, J., Bille, J., & Sanglard, D. (2006) · Genetics · doi:10.1534/genetics.105.054767 · Cited by 385

Role of the Hog1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans

Enjalbert, B., Smith, D. A., Cornell, M. J., Alam, I., Nicholls, S., Brown, A. J. P., & Quinn, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0501 · Cited by 381

Identification of a Mating Type-Like Locus in the Asexual Pathogenic Yeast Candida albicans

Hull, C. M., & Johnson, A. D. (1999) · Science · doi:10.1126/science.285.5431.1271 · Cited by 370

Genome-wide genetic analysis of polyploidy in yeast

Štorchová, Z., Breneman, A., Cande, J., Dunn, J. G., Burbank, K. S., O'Toole, E. T., & Pellman, D. S. (2006) · Nature · doi:10.1038/nature05178 · Cited by 364

Contrasting evolutionary genome dynamics between domesticated and wild yeasts

Yue, J., Li, J., Aigrain, L., Hallin, J., Persson, K. O., Oliver, K. L., Bergström, A., Coupland, P. G., Warringer, J., Lagomarsino, M. C., et al. (2017) · Nature Genetics · doi:10.1038/ng.3847 · Cited by 350

The evolution of drug resistance in clinical isolates of Candida albicans.

Ford, C. B., Funt, J. M., Abbey, D., Issi, L., Guiducci, C., Martinez, D. A., Delorey, T., Li, B. Y., White, T. C., Cuomo, C., et al. (2015) · eLife · doi:10.7554/elife.00662 · Cited by 348

Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains

Bennett, R. J., & Johnson, A. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg235 · Cited by 343

A Human-Curated Annotation of the Candida albicans Genome

Braun, B. R., van het Hoog, M., d'Enfert, C., Martchenko, M., Dungan, J., Kuo, A., Inglis, D. O., Uhl, M. A., Hogues, H., Berriman, M., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010001 · Cited by 342

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

Rancati, G. I., Pavelka, N., Fleharty, B., Noll, A. C., Trimble, R., Walton, K., Perera, A. G., Staehling‐Hampton, K., Seidel, C. W., & Li, R. (2008) · Cell · doi:10.1016/j.cell.2008.09.039 · Cited by 341

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

Forche, A., Alby, K., Schaefer, D., Johnson, A. D., Berman, J., & Bennett, R. J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060110 · Cited by 338

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

Selmecki, A., Gerami‐Nejad, M., Paulson, C., Forche, A., & Berman, J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06176.x · Cited by 325

Genetic and phenotypic intra-species variation in Candida albicans

Hirakawa, M. P., Martinez, D. A., Sakthikumar, S., Anderson, M. Z., Berlin, A., Gujja, S., Zeng, Q., Zisson, E., Wang, J. M., Greenberg, J. M., et al. (2015) · Genome Research · doi:10.1101/gr.174623.114 · Cited by 320

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

Selmecki, A. M., Dulmage, K., Cowen, L. E., Anderson, J. B., & Berman, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000705 · Cited by 319

The many costs of sex

Lehtonen, J., Jennions, M. D., & Kokko, H. (2011) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2011.09.016 · Cited by 312

Molecular Phylogenetics of Candida albicans

Odds, F. C., Bougnoux, M., Shaw, D. J., Bain, J. M., Davidson, A. D., Diogo, D., Jacobsen, M. D., Lecomte, M., Li, S.-Y., Tavanti, A., et al. (2007) · Eukaryotic Cell · doi:10.1128/ec.00041-07 · Cited by 306

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

Pande, K., Chen, C., & Noble, S. M. (2013) · Nature Genetics · doi:10.1038/ng.2710 · Cited by 306

Bistable expression of WOR1 , a master regulator of white–opaque switching in Candida albicans

Huang, G., Wang, H., Chou, S., Nie, X., Chen, J., & Liu, H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605270103 · Cited by 293

The ‘obligate diploid’ Candida albicans forms mating-competent haploids

Hickman, M. A., Zeng, G., Forche, A., Hirakawa, M. P., Abbey, D., Harrison, B. D., Wang, Y.-M., Su, C.-H., Bennett, R. J., Wang, Y., et al. (2013) · Nature · doi:10.1038/nature11865 · Cited by 284

Mutations in the multi‐drug resistance regulator MRR1 , followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole‐resistant Candida albicans strains

Dunkel, N., Blaß, J., Rogers, P. D., & Morschhäuser, J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06309.x · Cited by 278

Stress-induced Gene Expression inCandida albicans: Absence of a General Stress Response

Enjalbert, B., Nantel, A., & Whiteway, M. S. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0546 · Cited by 277

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

Chen, G., Bradford, W. D., Seidel, C. W., & Li, R. (2012) · Nature · doi:10.1038/nature10795 · Cited by 274

Characterization of the Vaginal Micro- and Mycobiome in Asymptomatic Reproductive-Age Estonian Women

Drell, T., Lillsaar, T., Tummeleht, L., Simm, J., Aaspõllu, A., Väin, E., Saarma, I., Salumets, A., Donders, G. G. G., & METSIS, M. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054379 · Cited by 270

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

Selmecki, A., Forche, A., & Berman, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00060-10 · Cited by 247

Experimental evolution of a fungal pathogen into a gut symbiont

Tso, G. H. W., Reales‐Calderón, J. A., Tan, A. S. M., Sem, X., Le, G. T. T., Tan, T. G., Lai, G. C., Srinivasan, K. G., Yurieva, M., Liao, W. W. P., et al. (2018) · Science · doi:10.1126/science.aat0537 · Cited by 245

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection

Witchley, J. N., Penumetcha, P., Abon, N. V., Woolford, C. A., Mitchell, A. P., & Noble, S. M. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.008 · Cited by 245

In Candida albicans, White-Opaque Switchers Are Homozygous for Mating Type

Lockhart, S. R., Pujol, C., Daniels, K. J., Miller, M. G., Johnson, A. D., Pfaller, M. A., & Soll, D. R. (2002) · Genetics · doi:10.1093/genetics/162.2.737 · Cited by 235

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans

Forche, A., Abbey, D., Pisithkul, T., Weinzierl, M. A., Ringstrom, T., Bruck, D., Petersen, K., & Berman, J. (2011) · mBio · doi:10.1128/mbio.00129-11 · Cited by 234

Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans

Alby, K., Schaefer, D., & Bennett, R. J. (2009) · Nature · doi:10.1038/nature08252 · Cited by 226

Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination.

Gräser, Y., Volovsek, M., Arrington, J., Schönian, G., Presber, W., Mitchell, T. G., & Vilgalys, R. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12473 · Cited by 222

The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans

Cao, F., Lane, S., Raniga, P. P., Lü, Y., Zhou, Z., Ramon, K., Chen, J., & Liu, H. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0502 · Cited by 215

Monosomy of a specific chromosome determines l -sorbose utilization: A novel regulatory mechanism in Candida albicans

Janbon, G., Sherman, F., & Rustchenko, E. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5150 · Cited by 203

Gene flow contributes to diversification of the major fungal pathogen Candida albicans

Ropars, J., Maufrais, C., Diogo, D., Marcet-Houben, M., Perin, A., Sertour, N., Mosca, K., Permal, E., Laval, G., Bouchier, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04787-4 · Cited by 197

CO2 Regulates White-to-Opaque Switching in Candida albicans

Huang, G., Srikantha, T., Sahni, N., Song, Y., & Soll, D. R. (2009) · Current Biology · doi:10.1016/j.cub.2009.01.018 · Cited by 180

Parent–progeny sequencing indicates higher mutation rates in heterozygotes

Yang, S., Wang, L., Huang, J. W., Zhang, X., Yuan, Y., Chen, J., Hurst, L. D., & Tian, D. (2015) · Nature · doi:10.1038/nature14649 · Cited by 179

Cell biology of Candida albicans–host interactions

Dantas, A. D. S., Lee, K. K., Raziunaite, I., Schaefer, K., Wagener, J., Yadav, B., & Gow, N. A. R. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.08.006 · Cited by 179

Population Structure and Properties of Candida albicans , as Determined by Multilocus Sequence Typing

Tavanti, A., Davidson, A. D., Fordyce, M. J., Gow, N. A. R., Maiden, M. C. J., & Odds, F. C. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5601-5613.2005 · Cited by 176

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

Harrison, B. D., Hashemi, J., Bibi, M., Pulver, R., Bavli, D., Nahmias, Y., Wellington, M., Sapiro, G., & Berman, J. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001815 · Cited by 174

The Evolution of Sex Is Favoured During Adaptation to New Environments

Becks, L., & Agrawal, A. F. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001317 · Cited by 174

Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

Li, T., Du, H., Guan, G., Dai, Y., Nobile, C. J., Liang, W., Cao, C., Zhang, Q., Zhong, J., & Huang, G. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001830 · Cited by 168

Multilocus Sequence Typing Reveals Intrafamilial Transmission and Microevolutions of Candida albicans Isolates from the Human Digestive Tract

Bougnoux, M., Diogo, D., François, N., Sendid, B., Veirmeire, S., Colombel, J., Bouchier, C., Kruiningen, H. J. V., d’Enfert, C., & Poulain, D. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.5.1810-1820.2006 · Cited by 163

Evolution of Eukaryotic Microbial Pathogens via Covert Sexual Reproduction

Heitman, J. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.06.011 · Cited by 158

Environmental Induction of White–Opaque Switching in Candida albicans

Ramı́rez-Zavala, B., Reuß, O., Park, Y.-N., Ohlsen, K., & Morschhäuser, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000089 · Cited by 158

Property Differences among the Four Major Candida albicans Strain Clades

MacCallum, D. M., Castillo, L., Nather, K., Munro, C. A., Brown, A. J. P., Gow, N. A. R., & Odds, F. C. (2009) · Eukaryotic Cell · doi:10.1128/ec.00387-08 · Cited by 156

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen

Ene, I. V., Farrer, R. A., Hirakawa, M. P., Agwamba, K., Cuomo, C. A., & Bennett, R. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806002115 · Cited by 155

Unisexual and Heterosexual Meiotic Reproduction Generate Aneuploidy and Phenotypic Diversity De Novo in the Yeast Cryptococcus neoformans

Ni, M., Feretzaki, M., Li, W., Averette, A. F., Mieczkowski, P. A., Dietrich, F. S., & Heitman, J. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001653 · Cited by 155

DNA Content, Kinetic Complexity, and the Ploidy Question in Candida albicans

Riggsby, W. S., Torres-Bauzá, L. J., Wills, J. W., & Townes, T. M. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.7.853 · Cited by 151

The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast

Sharp, N. P., Sandell, L., James, C. G., & Otto, S. P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801040115 · Cited by 149

Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

Liu, G., Yong, M. Y. J., Yurieva, M., Srinivasan, K. G., Liu, J., Lim, J. S. Y., Poidinger, M., Wright, G. D., Zolezzi, F., Choi, H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.069 · Cited by 148

Evolution in Candida albicans Populations During a Single Passage Through a Mouse Host

Forche, A., Magee, P. T., Selmecki, A., Berman, J., & May, G. (2009) · Genetics · doi:10.1534/genetics.109.103325 · Cited by 147

YMAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens

Abbey, D. A., Funt, J., Lurie-Weinberger, M. N., Thompson, D. A., Regev, A., Myers, C. L., & Berman, J. (2014) · Genome Medicine · doi:10.1186/s13073-014-0100-8 · Cited by 147

Development of Fluconazole Resistance in Candida albicans Causing Disseminated Infection in a Patient Undergoing Marrow Transplantation

Marr, K. A., White, T. C., van Burik, J. H., & Bowden, R. A. (1997) · Clinical Infectious Diseases · doi:10.1086/515553 · Cited by 145

Mechanism of Candida pathogenesis: Revisiting the vital drivers

Mba, I. E., & Nweze, E. I. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03912-w · Cited by 143

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

Tye, B., Commins, N., Ryazanova, L. V., Wühr, M., Springer, M., Pincus, D., & Churchman, L. S. (2019) · eLife · doi:10.7554/elife.43002 · Cited by 141

Msn2- and Msn4-Like Transcription Factors Play No Obvious Roles in the Stress Responses of the Fungal Pathogen Candida albicans

Nicholls, S., Straffon, M. J., Enjalbert, B., Nantel, A., Macaskill, S., Whiteway, M. S., & Brown, A. J. P. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.5.1111-1123.2004 · Cited by 140

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

Todd, R. T., & Selmecki, A. (2020) · eLife · doi:10.7554/elife.58349 · Cited by 138

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

Xie, J., Li, T., Nobile, C. J., Tong, Y., Guan, G., Sun, Y., Cao, C., Hernday, A. D., Johnson, A. D., Zhang, L., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001525 · Cited by 135

The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity

Schönherr, F. A., Sparber, F., Kirchner, F. R., Guiducci, E., Trautwein-Weidner, K., Gladiator, A., Sertour, N., Hetzel, U., Le, G. T. T., Pavelka, N., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.2 · Cited by 133

Variations of Candida albicans electrophoretic karyotypes

Rustchenko-Bulgac, E. P. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.20.6586-6596.1991 · Cited by 132

Dosage compensation can buffer copy-number variation in wild yeast

Hose, J., Yong, C. M., Sardi, M. I., Wang, Z., Newton, M. A., & Gasch, A. P. (2015) · eLife · doi:10.7554/elife.05462 · Cited by 132

Ploidy and the Causes of Genomic Evolution

Gerstein, A. C., & Otto, S. P. (2009) · Journal of Heredity · doi:10.1093/jhered/esp057 · Cited by 131

Environmental change drives accelerated adaptation through stimulated copy number variation

Hull, R. M., Cruz, C., Jack, C. V., & Houseley, J. M. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001333 · Cited by 125

Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations

Pierce, J. V., & Kumamoto, C. A. (2012) · mBio · doi:10.1128/mbio.00117-12 · Cited by 123

Assembly of a phased diploid Candida albicansgenome facilitates allele-specific measurements and provides a simple model for repeat and indel structure

Muzzey, D., Schwartz, K., Weissman, J. S., & Sherlock, G. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-r97 · Cited by 123

Single-cell copy number variant detection reveals the dynamics and diversity of adaptation

Lauer, S. L., Avecilla, G., Spealman, P., Sethia, G., Brandt, N., Levy, S. F., & Gresham, D. (2018) · PLoS Biology · doi:10.1371/journal.pbio.3000069 · Cited by 123

Sex and Virulence of Human Pathogenic Fungi

Nielsen, K., & Heitman, J. (2007) · Advances in genetics · doi:10.1016/s0065-2660(06)57004-x · Cited by 122

Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution

Todd, R. T., Forche, A., & Selmecki, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0051-2016 · Cited by 121

Chromosome instability in Candida albicans

Rustchenko, E. P. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00150.x · Cited by 120

Stress-Induced Phenotypic Switching in Candida albicans

Alby, K., & Bennett, R. J. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0040 · Cited by 120

Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity

Bennett, R. J., Forche, A., & Berman, J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019604 · Cited by 118

The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen

Morschhäuser, J. (2016) · Journal of Microbiology · doi:10.1007/s12275-016-5628-4 · Cited by 118

Genome plasticity in Candida albicans is driven by long repeat sequences

Todd, R. T., Wikoff, T. D., Forche, A., & Selmecki, A. (2019) · eLife · doi:10.7554/elife.45954 · Cited by 118

Control of Transcription by Cell Size

Wu, C., Rolfe, A., Gifford, D. K., & Fink, G. R. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000523 · Cited by 117

Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata

Wong, S., Fares, M. A., Zimmermann, W., Butler, G., & Wolfe, K. H. (2003) · Genome biology · doi:10.1186/gb-2003-4-2-r10 · Cited by 113

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

Hickman, M. A., Paulson, C., Dudley, A., & Berman, J. (2015) · Genetics · doi:10.1534/genetics.115.178020 · Cited by 113

Chromosomal alterations of Candida albicans are associated with the gain and loss of assimilating functions

Rustchenko, E. P., Howard, D. H., & Sherman, F. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.11.3231-3241.1994 · Cited by 111

Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation†

Legrand, M., Lephart, P., Forche, A., Mueller, F. C., Walsh, T., Magee, P. T., & Magee, B. B. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04068.x · Cited by 110

The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi

Li, C., Li, Y., & Ding, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010175 · Cited by 107

Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence

Wu, W., Lockhart, S. R., Pujol, C., Srikantha, T., & Soll, D. R. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05759.x · Cited by 104

Aneuploidy in yeast: Segregation error or adaptation mechanism?

Gilchrist, C., & Stelkens, R. (2019) · Yeast · doi:10.1002/yea.3427 · Cited by 104

Aneuploidy Enables Cross-Adaptation to Unrelated Drugs

Yang, F., Teoh, F., Tan, A. S. M., Cao, Y., Pavelka, N., & Berman, J. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz104 · Cited by 101

Ploidy determination of Canadida albicans

Olaiya, A. F., & Sogin, S. J. (1979) · Journal of Bacteriology · doi:10.1128/jb.140.3.1043-1049.1979 · Cited by 98

Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

Kim, S. H., Clark, S. T., Surendra, A., Copeland, J. K., Wang, P. W., Ammar, R., Collins, C., Tullis, D. E., Nislow, C., Hwang, D. M., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005308 · Cited by 96

The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice

Böhm, L., Torsin, S., Tint, S. H., Eckstein, M., Ludwig, T., & Pérez, J. C. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006699 · Cited by 96

The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

Sunshine, A. B., Payen, C., Ong, G. T., Liachko, I., Tan, K. M., & Dunham, M. J. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002155 · Cited by 96

Candida africana sp. nov., a new human pathogen or a variant of Candida albicans?

Tietz, H., Hopp, M., Schmalreck, A., Sterry, W., & Czaika, V. A. (2001) · Mycoses · doi:10.1046/j.1439-0507.2001.00707.x · Cited by 96

Infrequent Genetic Exchange and Recombination in the Mitochondrial Genome of Candida albicans

Anderson, J. B., Wickens, C., Khan, M., Cowen, L. E., Federspiel, N. A., Jones, T., & Kohn, L. M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.3.865-872.2001 · Cited by 95

The Early days of yeast genetics

Hall, M., & Linder, P. (1993) · Choice Reviews Online · doi:10.5860/choice.31-6029 · Cited by 95

Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche in Candida albicans

Forche, A., Cromie, G., Gerstein, A. C., Solis, N. V., Pisithkul, T., Srifa, W., Jeffery, E., Abbey, D., Filler, S. G., Dudley, A. M., et al. (2018) · Genetics · doi:10.1534/genetics.118.301019 · Cited by 94

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans

Sasse, C., Dunkel, N., Schäfer, T., Schneider, S., Dierolf, F., Ohlsen, K., & Morschhäuser, J. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08210.x · Cited by 93

Ca3 Fingerprinting of Candida albicans Isolates from Human Immunodeficiency Virus-Positive and Healthy Individuals Reveals a New Clade in South Africa

Blignaut, E., Pujol, C., Lockhart, S. R., Joly, S., & Soll, D. R. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.3.826-836.2002 · Cited by 92

Ancient Evolutionary Trade-Offs between Yeast Ploidy States

Zörgö, E., Chwiałkowska, K., Gjuvsland, A. B., Garré, E., Sunnerhagen, P., Liti, G., Blomberg, A., Omholt, S. W., & Warringer, J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003388 · Cited by 91

Normal Adaptation of Candida albicans to the Murine Gastrointestinal Tract Requires Efg1p-Dependent Regulation of Metabolic and Host Defense Genes

Pierce, J. V., Dignard, D., Whiteway, M. S., & Kumamoto, C. A. (2012) · Eukaryotic Cell · doi:10.1128/ec.00236-12 · Cited by 89

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

Liang, S.-H., Anderson, M. Z., Hirakawa, M. P., Wang, J. M., Frazer, C., Alaalm, L., Thomson, G. J., Ene, I. V., & Bennett, R. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.005 · Cited by 88

Chromosome 1 trisomy compromises the virulence of Candida albicans

Chen, X., Magee, B. B., Dawson, D., Magee, P. T., & Kumamoto, C. A. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03852.x · Cited by 86

Ploidy plasticity: a rapid and reversible strategy for adaptation to stress

Berman, J. G. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow020 · Cited by 86

The parasexual lifestyle of Candida albicans

Bennett, R. J. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.06.017 · Cited by 86

Aneuploidy underlies a multicellular phenotypic switch

Tan, Z., Hays, M., Cromie, G. A., Jeffery, E. W., Scott, A. C., Ahyong, V., Sirr, A., Skupin, A., & Dudley, A. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301047110 · Cited by 85

Spontaneous Changes in Ploidy Are Common in Yeast

Harari, Y., Ram, Y., Rappoport, N., Hadany, L., & Kupiec, M. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.062 · Cited by 82

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling

Yang, F., Zhang, L., Wakabayashi, H., Myers, J., Jiang, Y., Cao, Y., Jimenez-Ortigosa, C., Perlin, D. S., & Rustchenko, E. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00071-17 · Cited by 81

Candida albicansclades

Soll, D. R., & Pujol, C. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00242-6 · Cited by 80

Genetic Structure of Typical and Atypical Populations of Candida albicans from Africa

Forche, A., Schönian, G., Gräser, Y., Vilgalys, R. J., & Mitchell, T. G. (1999) · Fungal Genetics and Biology · doi:10.1006/fgbi.1999.1164 · Cited by 78

Mitotic recombination in Candida albicans: Recessive lethal alleles linked to a gene required for methionine biosynthesis

Whelan, W. L., & Soll, D. R. (1982) · Molecular and General Genetics MGG · doi:10.1007/bf00332632 · Cited by 77

Does stress induce (para)sex? Implications for Candida albicans evolution

Berman, J. G., & Hadany, L. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.01.004 · Cited by 76

Phenotypic Switching and Mating Type Switching of Candida glabrata at Sites ofColonization

Brockert, P. J., Lachke, S. A., Srikantha, T., Pujol, C., Galask, R., & Soll, D. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.12.7109-7118.2003 · Cited by 75

Variance of ploidy in Candida albicans

Suzuki, T., Nishibayashi, S., Kuroiwa, T., Kanbe, T., & Tanaka, K. (1982) · Journal of Bacteriology · doi:10.1128/jb.152.2.893-896.1982 · Cited by 74

Ploidy variation as an adaptive mechanism in human pathogenic fungi

Morrow, C. A., & Fraser, J. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.01.008 · Cited by 74

A combinational theory for maintenance of sex

Hörandl, E. (2009) · Heredity · doi:10.1038/hdy.2009.85 · Cited by 74

DNA translocations contribute to chromosome length polymorphisms in Candida albicans

Thrash-Bingham, C., & Gorman, J. A. (1992) · Current Genetics · doi:10.1007/bf00351467 · Cited by 69

Ploidy dynamics and evolvability in fungi

Wertheimer, N. B., Stone, N. R. H., & Berman, J. G. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0461 · Cited by 68

Genetic Diversity among Korean Candida albicans Bloodstream Isolates: Assessment by Multilocus Sequence Typing and Restriction Endonuclease Analysis of Genomic DNA by Use of BssHII

Shin, J. H., Bougnoux, M., d’Enfert, C., Kim, S. H., Moon, C.-J., Joo, M. Y., Lee, K., Kim, M., Lee, H. S., Shin, M., et al. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02153-10 · Cited by 68

Genomic evidence for a hybrid origin of the yeast opportunistic pathogen Candida albicans

Mixão, V., & Gabaldón, T. (2020) · BMC Biology · doi:10.1186/s12915-020-00776-6 · Cited by 67

Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples

O’Brien, C. E., Oliveira-Pacheco, J., Cinnéide, E. Ó., Haase, M. A. B., Hittinger, C. T., Rogers, T. R., Zaragoza, Ó., Bond, U., & Butler, G. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009138 · Cited by 67

Mating is rare within as well as between clades of the human pathogen Candida albicans

Bougnoux, M., Pujol, C., Diogo, D., Bouchier, C., Soll, D. R., & d’Enfert, C. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2007.10.008 · Cited by 66

High-Resolution SNP/CGH Microarrays Reveal the Accumulation of Loss of Heterozygosity in Commonly UsedCandida albicansStrains

Abbey, D., Hickman, M. A., Gresham, D., & Berman, J. G. (2011) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.000885 · Cited by 66

Metabolism‐induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells

Thomson, G. J., Hernon, C., Austriaco, N. P. G., Shapiro, R. S., Belenky, P. A., & Bennett, R. J. (2019) · The EMBO Journal · doi:10.15252/embj.2019101597 · Cited by 65

Appearance and Properties of l-Sorbose-Utilizing Mutants of Candida albicans Obtained on a Selective Plate

Janbon, G., Sherman, F., & Rustchenko, E. P. (1999) · Genetics · doi:10.1093/genetics/153.2.653 · Cited by 64

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination

Wang, J. M., Bennett, R. J., & Anderson, M. Z. (2018) · mBio · doi:10.1128/mbio.01205-18 · Cited by 64

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Losada, L. C., Sugui, J. A., Eckhaus, M., Chang, Y. C., Mounaud, S. H., Abigail, F., Joardar, V., Pakala, S., Pakala, S. M., Venepally, P., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004834 · Cited by 61

Chromosome 5 Monosomy of Candida albicans Controls Susceptibility to Various Toxic Agents, Including Major Antifungals

Yang, F., Kravets, A., Bethlendy, G., Welle, S., & Rustchenko, E. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00516-13 · Cited by 60

Parasexuality and Ploidy Change in Candida tropicalis

Seervai, R. N. H., Jones, S. K., Hirakawa, M. P., Porman, A. M., & Bennett, R. J. (2013) · Eukaryotic Cell · doi:10.1128/ec.00128-13 · Cited by 59

Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene

Staib, P., Kretschmar, M., Nichterlein, T., Hof, H., & Morschhäuser, J. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02967.x · Cited by 58

Interspecies pheromone signaling promotes biofilm formation and same-sex mating in Candida albicans

Alby, K., & Bennett, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017234108 · Cited by 57

Fitness benefits of loss of heterozygosity in Saccharomyces hybridsPreprint

Lancaster, S. M., Payen, C., Heil, C. S., & Dunham, M. J. (2019) · Genome Research · doi:10.1101/gr.245605.118 · Cited by 57

A ‘parameiosis’ drives depolyploidization and homologous recombination in Candida albicans

Anderson, M. Z., Thomson, G. J., Hirakawa, M. P., & Bennett, R. J. (2019) · Nature Communications · doi:10.1038/s41467-019-12376-2 · Cited by 57

Homologous recombination in Candida albicans : role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length

Ciudad, T., Andaluz, E., Steinberg‐Neifach, O., Lue, N. F., Gow, N. A. R., Calderone, R., & Larriba, G. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04197.x · Cited by 56

Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection

Pais, P., Galocha, M., Viana, R., Cavalheiro, M., Pereira, D., & Teixeira, M. C. (2019) · Microbial Cell · doi:10.15698/mic2019.03.670 · Cited by 54

A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans

Anderson, M. Z., Saha, A., Haseeb, A., & Bennett, R. J. (2017) · Microbiology · doi:10.1099/mic.0.000478 · Cited by 53

Comparison of classical multi-locus sequence typing software for next-generation sequencing data

Page, A. J., Alikhan, N.-F., Carleton, H. A., Seemann, T., Keane, J. A., & Katz, L. S. (2017) · Microbial Genomics · doi:10.1099/mgen.0.000124 · Cited by 53

Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype

Forche, A., Solis, N. V., Swidergall, M., Thomas, R., Guyer, A., Beach, A., Cromie, G. A., Le, G. T., Lowell, E., Pavelka, N., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008137 · Cited by 52

Within-Host Genomic Diversity of Candida albicans in Healthy Carriers

Sitterlé, E., Maufrais, C., Sertour, N., Palayret, M., d’Enfert, C., & Bougnoux, M.-E. (2019) · Scientific Reports · doi:10.1038/s41598-019-38768-4 · Cited by 51

Effects of Ploidy and Mating Type on Virulence of Candida albicans

Ibrahim, A. S., Magee, B. B., Sheppard, D. C., Yang, M., Kauffman, S., Becker, J., Edwards, J. E., & Magee, P. T. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7366-7374.2005 · Cited by 48

Candida albicans repetitive elements display epigenetic diversity and plasticity

Freire-Benéitez, V., Price, R. J., Tarrant, D., Berman, J. G., & Buscaino, A. (2016) · Scientific Reports · doi:10.1038/srep22989 · Cited by 47

Mechanisms of genome evolution in Candida albicans

Ene, I. V., Bennett, R. J., & Anderson, M. Z. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.05.001 · Cited by 47

Parasex Generates Phenotypic Diversity de Novo and Impacts Drug Resistance and Virulence in Candida albicans

Hirakawa, M. P., Chyou, D. E., Huang, D., Slan, A. R., & Bennett, R. J. (2017) · Genetics · doi:10.1534/genetics.117.300295 · Cited by 47

Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans

Thewes, S., Moran, G. P., Magee, B. B., Schaller, M., Sullivan, D. J., & Hube, B. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-187 · Cited by 46

Ploidy tug-of-war: Evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen

Gerstein, A. C., Lim, H., Berman, J. G., & Hickman, M. A. (2017) · Evolution · doi:10.1111/evo.13205 · Cited by 46

Candida albicans Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole

Gerstein, A. C., & Berman, J. G. (2020) · mSphere · doi:10.1128/msphere.00480-20 · Cited by 46

Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination

Popp, C., Ramı́rez-Zavala, B., Schwanfelder, S., Krüger, I., & Morschhäuser, J. (2019) · mBio · doi:10.1128/mbio.02740-18 · Cited by 45

Genotyping Candida albicans from Candida Leukoplakia and Non-Candida Leukoplakia Shows No Enrichment of Multilocus Sequence Typing Clades but Enrichment of ABC Genotype C in Candida Leukoplakia

Abdulrahim, M. H., McManus, B. A., Flint, S. R., & Coleman, D. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073738 · Cited by 44

Species Distribution, Antifungal Susceptibility, and Molecular Epidemiology of Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand

Boonsilp, S., Homkaew, A., Phumisantiphong, U., Nutalai, D., & Wongsuk, T. (2021) · Journal of Fungi · doi:10.3390/jof7070577 · Cited by 44

The Yeast Mating-Type Switching Mechanism: A Memoir

Klar, A. J. S. (2010) · Genetics · doi:10.1534/genetics.110.122531 · Cited by 42

A study of the DNA damage checkpoint in C andida albicans: uncoupling of the functions of Rad 53 in DNA repair, cell cycle regulation and genotoxic stress‐induced polarized growth

Loll‐Krippleber, R., d’Enfert, C., Feri, A., Diogo, D., Perin, A., Marcet‐Houben, M., Bougnoux, M., & Legrand, M. (2013) · Molecular Microbiology · doi:10.1111/mmi.12471 · Cited by 42

Real-Time Evolution of a Subtelomeric Gene Family in Candida albicans

Anderson, M. Z., Wigen, L., Burrack, L. S., & Berman, J. G. (2015) · Genetics · doi:10.1534/genetics.115.177451 · Cited by 41

Nonsex Genes in the Mating Type Locus of Candida albicans Play Roles in a/α Biofilm Formation, Including Impermeability and Fluconazole Resistance

Srikantha, T., Daniels, K. J., Pujol, C., Sahni, N., Song, Y., & Soll, D. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002476 · Cited by 40

Drug Resistance Is Not Directly Affected by Mating Type Locus Zygosity in Candida albicans

Pujol, C., Messer, S. A., Pfaller, M. A., & Soll, D. R. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.4.1207-1212.2003 · Cited by 40

The Three Clades of the Telomere-Associated TLO Gene Family of Candida albicans Have Different Splicing, Localization, and Expression Features

Anderson, M. Z., Baller, J. A., Dulmage, K., Wigen, L., & Berman, J. G. (2012) · Eukaryotic Cell · doi:10.1128/ec.00230-12 · Cited by 40

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans

Liang, S.-H., & Bennett, R. J. (2019) · Journal of Fungi · doi:10.3390/jof6010010 · Cited by 38

Disentangling the Benefits of Sex

Roze, D. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001321 · Cited by 38

Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi

Gusa, A., & Jinks-Robertson, S. (2019) · Genes · doi:10.3390/genes10110901 · Cited by 38

THE EFFECTS OF SEX AND MUTATION RATE ON ADAPTATION IN TEST TUBES AND TO MOUSE HOSTS BY SACCHAROMYCES CEREVISIAE

Grimberg, B. T., & Zeyl, C. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb01001.x · Cited by 37

Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome

Feri, A., Loll‐Krippleber, R., Commère, P., Maufrais, C., Sertour, N., Schwartz, K., Sherlock, G., Bougnoux, M., d’Enfert, C., & Legrand, M. (2016) · mBio · doi:10.1128/mbio.01109-16 · Cited by 37

Effect of the Major Repeat Sequence on Mitotic Recombination in Candida albicans

Lephart, P., & Magee, P. T. (2006) · Genetics · doi:10.1534/genetics.106.063271 · Cited by 36

Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans

Dunn, M. J., Kinney, G. M., Washington, P. M., Berman, J. G., & Anderson, M. Z. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007326 · Cited by 36

Candida africana vulvovaginitis: Prevalence and geographical distribution

Fakhim, H., Vaezi, A., Javidnia, J., Nasri, E., Mahdi, D., Diba, K., & Badali, H. (2020) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2020.100966 · Cited by 33

Rad52 function prevents chromosome loss and truncation in Candida albicans

Andaluz, E., Bellido, A., Gómez‐Raja, J., Selmecki, A. M., Bouchonville, K. J., Calderone, R., Berman, J. G., & Larriba, G. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07532.x · Cited by 32

Selective Advantages of a Parasexual Cycle for the YeastCandida albicans

Zhang, N., Magee, B. B., Magee, P. T., Holland, B. R., Rodrigues, E., Holmes, A. R., Cannon, R. D., & Schmid, J. (2015) · Genetics · doi:10.1534/genetics.115.177170 · Cited by 31

Genomic clustering within functionally related gene families in Ascomycota fungi

Hagee, D., Hardan, A. A., Botero, J., & Arnone, J. T. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.020 · Cited by 31

PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans

Manoharlal, R., Gorantala, J., Sharma, M., Sanglard, D., & Prasad, R. (2009) · Microbiology · doi:10.1099/mic.0.035154-0 · Cited by 30

Efficient mating-type switching in Candida glabrata induces cell death

Boisnard, S., Zhou Li, Y., Arnaise, S., Sequeira, G., Raffoux, X., Enache-Angoulvant, A., Bolotin-Fukuhara, M., & Fairhead, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140990 · Cited by 29

Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility

Suwunnakorn, S., Wakabayashi, H., & Rustchenko, E. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01888-16 · Cited by 28

Correction: N-Acetylglucosamine Induces White to Opaque Switching, a Mating Prerequisite in Candida albicans

Huang, G., Yi, S. S., Sahni, N., Daniels, K. J., Srikantha, T., & Soll, D. R. (2010) · PLoS Pathogens · doi:10.1371/annotation/ed4d1473-cf80-4e85-ad9d-7a390be260f6 · Cited by 27

Genomic and Phenotypic Variation in Morphogenetic Networks of Two Candida albicans Isolates Subtends Their Different Pathogenic Potential

Cavalieri, D., Paola, M. D., Rizzetto, L., Tocci, N., Filippo, C. D., Lionetti, P., Ardizzoni, A., Colombari, B., Paulone, S., Gut, I. G., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01997 · Cited by 27

Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans

Braunsdorf, C., & LeibundGut‐Landmann, S. (2018) · Pathogens · doi:10.3390/pathogens7010011 · Cited by 26

The Magnitude of Candida albicans Stress-Induced Genome Instability Results from an Interaction Between Ploidy and Antifungal Drugs

Avramovska, O., & Hickman, M. A. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400752 · Cited by 26

The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans

Sah, S. K., Hayes, J. J., & Rustchenko, E. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009564 · Cited by 26

Molecular mechanism of azoles resistant Candida albicans in a patient with chronic mucocutaneous candidiasis

Zhang, M.-R., Zhao, F., Wang, S., Lv, S., Mou, Y., Yao, C.-L., Zhou, Y., & Li, F.-Q. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-4856-8 · Cited by 26

Particular Candida albicans Strains in the Digestive Tract of Dyspeptic Patients, Identified by Multilocus Sequence Typing

Gong, Y.-B., Zheng, J.-G., Jin, B., Zhuo, D.-X., Huang, Z.-Q., Qi, H., Zhang, W., Duan, W., Fu, J.-T., Wang, C.-J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035311 · Cited by 24

Comparison of Candida albicans strain types among isolates from three countries

Takakura, S., Ichiyama, S., Bain, J. M., Davidson, A. D., Jacobsen, M. D., Shaw, D. J., Gow, N. A. R., & Odds, F. C. (2008) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.11.002 · Cited by 24

The Mechanisms of Mating in Pathogenic Fungi—A Plastic Trait

Usher, J. (2019) · Genes · doi:10.3390/genes10100831 · Cited by 24

Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1–Hsp90 pathway

Guan, G., Li, T., Yue, H., Liang, W., Gong, J., Bing, J., Zheng, Q., Veri, A. O., Fan, S., Robbins, N., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006966 · Cited by 24

Synchronization of stochastic expressions drives the clustering of functionally related genes

Xu, H., Liu, J., Liu, Z., Li, Y., Jin, Y., & Zhang, J. (2019) · Science Advances · doi:10.1126/sciadv.aax6525 · Cited by 24

Chromatin Profiling of the Repetitive and Nonrepetitive Genomes of the Human Fungal Pathogen Candida albicans

Price, R. J., Weindling, E., Berman, J. G., & Buscaino, A. (2019) · mBio · doi:10.1128/mbio.01376-19 · Cited by 22

Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States

Smith, A. C., & Hickman, M. A. (2020) · mSphere · doi:10.1128/msphere.00433-20 · Cited by 22

A Predominance of Clade 17 Candida albicans Isolated From Hemocultures in a Tertiary Care Hospital in Thailand

Pham, L. T. T., Pharkjaksu, S., Chongtrakool, P., Suwannakarn, K., & Ngamskulrungroj, P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01194 · Cited by 21

Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in Saccharomyces cerevisiae

Cera, A., Holganza, M. K., Hardan, A. A., Gamarra, I., Eldabagh, R. S., Deschaine, M., Elkamhawy, S., Sisso, E. M., Foley, J. J., & Arnone, J. T. (2019) · mSphere · doi:10.1128/msphere.00063-19 · Cited by 20

The rapid emergence of antifungal-resistant human-pathogenic fungi

Lockhart, S. R., Chowdhary, A., & Gold, J. A. W. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00960-9 · Cited by 323

Candida albicans and Candida glabrata : global priority pathogens

Katsipoulaki, M., Stappers, M. H. T., Malavia-Jones, D., Brunke, S., Hube, B., & Gow, N. A. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-23 · Cited by 180

Metal Nanoparticles to Combat Candida albicans Infections: An Update

do Carmo, P. H. F., Garcia, M. T., Figueiredo-Godoi, L. M. A., Lage, A. C. P., da Silva, N. S., & Junqueira, J. C. (2023) · Microorganisms · doi:10.3390/microorganisms11010138 · Cited by 88

The Candida Genome Database: annotation and visualization updates

Lew-Smith, J., Binkley, J., & Sherlock, G. (2025) · Genetics · doi:10.1093/genetics/iyaf001 · Cited by 37

Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations

Dutta, A., Dutreux, F., & Schacherer, J. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac214 · Cited by 27

P335 Genome plasticity in Candida albicans : acutting-edge strategy for evolution, adaptation, and survival

Mba, I. E., & Nweze, E. I. (2022) · Medical Mycology · doi:10.1093/mmy/myac072.p335

Mechanisms of genome evolution in Candida albicans

Ene, I. V., Bennett, R. J., & Anderson, M. Z. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.05.001 · Cited by 47

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

Selmecki, A., Forche, A., & Berman, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00060-10 · Cited by 247

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans

Liang, S.-H., & Bennett, R. J. (2019) · Journal of Fungi · doi:10.3390/jof6010010 · Cited by 38

Genomic variation in C. albicans.

Wickes, B. L., & Petter, R. (1996) · PubMed · Cited by 11