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Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival
Open accessAbstract
Candida albicans is the most implicated fungal species that grows as a commensal or opportunistic pathogen in the human host. It is associated with many life-threatening infections, especially in immunocompromised persons. The genome of Candida albicans is very flexible and can withstand a wide assortment of variations in a continuously changing environment. Thus, genome plasticity is central to its adaptation and has long been of considerable interest. C. albicans has a diploid heterozygous genome that is highly dynamic and can display variation from small to large scale chromosomal rearrangement and aneuploidy, which have implications in drug resistance, virulence, and pathogenicity. This review presents an up-to-date overview of recent genomic studies involving C. albicans. It discusses the accumulating evidence that shows how mitotic recombination events, ploidy dynamics, aneuploidy, and loss of heterozygosity (LOH) influence evolution, adaptation, and survival in C. albicans. Understanding the factors that affect the genome is crucial for a proper understanding of species and rapid development and adjustment of therapeutic strategies to mitigate their spread.
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“Furthermore, mutations in the ERG11 gene, which encodes the essential enzyme 14α‐demethylase (Erg11p) for ergosterol biosynthesis, along with overexpression of ergosterol in the plasma membrane, further contribute to antifungal resistance [2, 46].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [46]
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The rapid emergence of antifungal-resistant human-pathogenic fungi
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Metadata
- Authors
- Mba, I. E., Nweze, E. I., Eze, E. A., & Anyaegbunam, Z. K. G.
- Affiliations
- University of Nigeria (NG)
- Corresponding author
- Nweze, Emeka Innocent
- Venue
- Infection, Genetics and Evolution
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 99
- Pages
- 105256
- ISSN
- 1567-1348 (ISSN-L)
- OpenAlex
- W4214710995
- Cited by
- 46
- References
- 224
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Infection Genetics and Evolution (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- Candida albicans, genome plasticity, chromosomal rearrangements, aneuploidy, mitotic recombination, loss of heterozygosity, drug resistance, virulence, fungal evolution, opportunistic fungal pathogens, diploid genome
- MeSH terms
- Aneuploidy, Candida albicans, Humans, Virulence, Genome, Genome, Fungal, Loss of Heterozygosity
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