Alzheimer's disease: cerebral glaucoma?
Abstract
In a 1994 Medical Hypotheses paper, it was speculated that high intracranial pressure (ICP) might increase the probability of developing Alzheimer's disease (AD). A study of cerebrospinal fluid pressure (CSFP) in normal volunteers showed interindividual variations in CSFP. Some normals had what would normally be considered elevated CSFP. The hypothesis postulated that this subgroup with a high characteristic individual ICP level might be more susceptible to developing AD. The Medical Hypotheses paper further speculated that in more advanced stages of AD, such pressure factor could already be missing due to the disease process. The present article discusses recent research findings regarding CSFP distribution in AD patients that could be interpreted as support for this hypothesis. Exposure of central nervous system tissue to high pressure stress is not unique to the ICP space. Indeed, a similar situation occurs in the intraocular pressure (IOP) space in eyes with glaucoma. Interestingly, recent research has revealed similarities in the process leading to retinal ganglion cell death in glaucoma and neuronal cell death in AD. In the present paper, we raise the question of whether AD could be a cerebral form of glaucoma. Indeed, the linking of glaucoma to mechanisms of AD could reflect the anatomical and functional similarities between the IOP space and the ICP space. Further studies are warranted, however, especially to determine the possible role of high ICP in at least some cases of AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AD has a multifactorial origin and seems to result from a complex interaction of multiple environmental and genetic factors.
“However, it is now known to have a multifactorial origin and it seems to result from a complex interaction of multiple environmental and genetic factors (Wostyn et al., 2010).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Wostyn et al., 2010
AD, PD, and glaucoma have similar mechanisms of cell injury and deposition of protein aggregates in specific anatomical areas.
“they have similar mechanisms of cell injury and deposition of protein aggregates in specific anatomical areas (Wostyn et al., 2010; Kaarniranta et al., 2011; Ghiso et al., 2013)”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Wostyn et al., 2010
Cites
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
The impact of ocular blood flow in glaucoma
Flammer, J., Orgül, S., Costa, V. P., Orzalesi, N., Krieglstein, G. K., Serra, L. M., Renard, J. P., & Stefánsson, E. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00008-3 · Cited by 1,714 · see citing works
The prevalence of dementia: A quantitative integration of the literature
Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02906.x · Cited by 1,301 · see citing works
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression
Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works
Sloane, P. D., Zimmerman, S. I., Suchindran, C., Reed, P. S., Wang, L., Boustani, M. A., & Sudha, S. (2002) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.23.100901.140525 · Cited by 461 · see citing works
Silverberg, G., Mayo, M., Saul, T., Rubenstein, E., & Mcguire, D. (2003) · Lancet Neurology · doi:10.1016/s1474-4422(03)00487-3 · Cited by 429 · see citing works
Cerebrospinal Fluid Pressure Is Decreased in Primary Open-angle Glaucoma
Berdahl, J. P., Allingham, R. R., & Johnson, D. H. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.01.013 · Cited by 428 · see citing works
Idiopathic intracranial hypertension: 12 cases treated by venous sinus stenting
Higgins, N. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.12.1662 · Cited by 359 · see citing works
Banizs, B., Pike, M. M., Millican, C. L., Ferguson, W. B., Komlosi, P., Sheetz, J., Bell, P. D., Schwiebert, E. M., & Yoder, B. K. (2005) · Development · doi:10.1242/dev.02153 · Cited by 349 · see citing works
Targeting amyloid-β in glaucoma treatment
Guo, L., Salt, T. E., Luong, V., Wood, N. W., Cheung, W., Maaß, A., Ferrari, G., Russo‐Marie, F., Sillito, A. M., Cheetham, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703707104 · Cited by 342 · see citing works
Causative and susceptibility genes for Alzheimer’s disease: a review
Rocchi, A., Pellegrini, S., Siciliano, G., & Murri, L. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00067-4 · Cited by 319 · see citing works
Cerebrospinal fluid production is reduced in healthy aging
May, C., Kaye, J. A., Atack, J. R., Schapiro, M. B., Friedland, R. P., & Рапопорт, С. И. (1990) · Neurology · doi:10.1212/wnl.40.3_part_1.500 · Cited by 317 · see citing works
Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
McKinnon, S. J., Lehman, D. M., Kerrigan, L. A., Merges, C. A., Pease, M. E., Kerrigan, D., Ransom, N. L., Tahzib, N. G., Reitsamer, H. A., Levkovitch-Verbin, H., et al. (2002) · PubMed · Cited by 296 · see citing works
The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer’s type
Silverberg, G. D., Heit, G., Huhn, S. L., Jaffe, R., Chang, S. D., Bronte-Stewart, H. M., Rubenstein, E., Possin, K. L., & Saul, T. (2001) · Neurology · doi:10.1212/wnl.57.10.1763 · Cited by 271 · see citing works
Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia
Engelborghs, S., de Vreese, K., de Casteele, T. V., Vanderstichele, H., Everbroeck, B. V., Cras, P. P., Martin, J., Vanmechelen, E., & Deyn, P. P. D. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.016 · Cited by 256 · see citing works
High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease
Tamura, H., Kawakami, H., Kanamoto, T., Kato, T., Yokoyama, T., Sasaki, K., Izumi, Y., Matsumoto, M., & Mishima, H. K. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.02.009 · Cited by 233 · see citing works
Glaucoma ocular Alzheimer s disease
McKinnon, S. J. (2003) · Frontiers in bioscience · doi:10.2741/1172 · Cited by 229 · see citing works
Brayne, C., & Calloway, P. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92081-8 · Cited by 209 · see citing works
Choroid plexus ageing of the brain and Alzheimer s disease
Faure, G. C. (2003) · Frontiers in bioscience · doi:10.2741/1085 · Cited by 203 · see citing works
Morphological alterations of the choroid plexus in late-onset Alzheimer’s disease
Sérot, J., Béné, M. C., Foliguet, B., & Faure, G. C. (2000) · Acta Neuropathologica · doi:10.1007/pl00007412 · Cited by 181 · see citing works
Vitreous fluid levels of β-amyloid(1–42) and tau in patients with retinal diseases
Yoneda, S., Hara, H., Hirata, A., Fukushima, M., Inomata, Y., & Tanihara, H. (2005) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-004-0156-x · Cited by 168 · see citing works
Aqueous Humor Outflow: What Do We Know? Where Will It Lead Us?
Fautsch, M. P., & Johnson, D. H. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0830 · Cited by 153 · see citing works
Retinal tau pathology in human glaucomas
Gupta, N., Fong, J., Ang, L. C., & Yücel, Y. H. (2008) · Canadian Journal of Ophthalmology · doi:10.3129/i07-185 · Cited by 134 · see citing works
Bateman, G. A. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00330-x · Cited by 119 · see citing works
Glucocorticoid-related genetic susceptibility for Alzheimer's disease
de Quervain, D. J. ‐. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg361 · Cited by 115 · see citing works
Alzheimer's disease and glaucoma: Is there a causal relationship?
Wostyn, P., Audenaert, K., & Deyn, P. P. D. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.148064 · Cited by 109 · see citing works
Dickerman, R. D., Smith, G. H., Langham-Roof, L., McConathy, W. J., East, J. W., & Smith, A. B. (1999) · Neurological Research · doi:10.1080/01616412.1999.11740925 · Cited by 106 · see citing works
Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
Silverberg, G. D., Huhn, S. L., Jaffe, R., Chang, S. D., Saul, T., Heit, G., Essen, A. V., & Rubenstein, E. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.97.6.1271 · Cited by 105 · see citing works
Assessment of low-flow CSF drainage as a treatment for AD
Silverberg, G. D., Levinthal, E. C., Sullivan, E. V., Bloch, D. A., Chang, S. D., Leverenz, J. B., Flitman, S. S., Winn, R., Marciano, F. F., Saul, T., et al. (2002) · Neurology · doi:10.1212/01.wnl.0000031794.42077.a1 · Cited by 95 · see citing works
Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease
Johanson, C. E., McMillan, P. N., Tavares, R., Spangenberger, A. G., Duncan, J., Silverberg, G. D., & Stopa, E. G. (2004) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-1-3 · Cited by 94 · see citing works
Silverberg, G. D., Mayo, M. R., Saul, T., FELLMANN, J. D., Carvalho, J., & McGuire, D. (2008) · Neurology · doi:10.1212/01.wnl.0000316197.04157.6f · Cited by 88 · see citing works
Normal cerebrospinal fluid pressure
Gilland, O., Tourtellotte, W. W., O'Tauma, L., & Henderson, W. G. (1974) · Journal of neurosurgery · doi:10.3171/jns.1974.40.5.0587 · Cited by 79 · see citing works
Normal pressure hydrocephalus (NPH): ischaemia, CSF stagnation or both
Silverberg, G. D. (2004) · Brain · doi:10.1093/brain/awh178 · Cited by 79 · see citing works
Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease
Silverberg, G. D., Mayo, M. R., Saul, T., FELLMANN, J. D., & McGuire, D. (2006) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-3-7 · Cited by 76 · see citing works
Klinge, P. M., Samii, A., Mühlendyck, A., Visnyei, K., Meyer, G.-J., Walter, G. F., Silverberg, G. D., & Brinker, T. (2003) · Stroke · doi:10.1161/01.str.0000048820.17198.15 · Cited by 63 · see citing works
Realistic Expectations: The Management of Severe Alzheimer Disease
Bullock, R. A., & Hammond, G. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200307003-00004 · Cited by 61 · see citing works
Hoar, R. M. (1982) · Environmental Health Perspectives · doi:10.1289/ehp.824431 · Cited by 59 · see citing works
Wostyn, P., Audenaert, K., & de Deyn, P. (2008) · Clinical neurology and neurosurgery (Dutch-Flemish ed. Print) · doi:10.1016/j.clineuro.2007.10.011 · Cited by 58 · see citing works
Vitamin B12, Folic Acid, and the Prevention of Dementia
Clarke, R. (2006) · New England Journal of Medicine · doi:10.1056/nejme068086 · Cited by 49 · see citing works
Pseudotumor cerebri: Clinical and neuroradiological findings
Wessell, K., Thron, A. K., Linden, D., Petersen, D., & DICHGANS, J. (1987) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00385667 · Cited by 37 · see citing works
Wostyn, P. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.013 · Cited by 32 · see citing works
Hydrocephalus decreases chloride efflux from the choroid plexus epithelium
Knuckey, N., Preston, J. E., Palm, D. E., Epstein, M. H., & Johanson, C. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)91282-w · Cited by 28 · see citing works
More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure
Wostyn, P., Audenaert, K., & Deyn, P. P. D. (2009) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-6-14 · Cited by 24 · see citing works
Jiang, G., Akar, F., Cobbs, S. L., Lomashvilli, K., Lakkis, R., Gordon, F. J., Sutliff, R. L., & O'Neill, W. C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00695.2003 · Cited by 22 · see citing works
Intracranial pressure and Alzheimer's disease: A hypothesis
Wostyn, P. (1994) · Medical Hypotheses · doi:10.1016/0306-9877(94)90069-8 · Cited by 19 · see citing works
Iencean, Ş. M. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00209-3 · Cited by 19 · see citing works
Cerebrospinal Fluid Production
Czosnyka, M., Czosnyka, Z. H., Schmidt, E. A., & Momjian, S. (2003) · Journal of neurosurgery · doi:10.3171/jns.2003.99.1.0206 · Cited by 14 · see citing works
Increased ALZ-50 immunoreactivity in CSF of pseudotumor cerebri patients.
Peng, J. H. F., Kung, F.-T., Peng, W., & Parker, J. C. (2006) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The retina as a window to the brain—from eye research to CNS disorders
London, A., Benhar, I., & Schwartz, M. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.227 · Cited by 1,417 · see citing works
The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works
“However, it is now known to have a multifactorial origin and it seems to result from a complex interaction of multiple environmental and genetic factors (Wostyn et al., 2010).”
BackgroundSpectral-Domain OCT Measurements in Alzheimer’s Disease
Chan, V. T. T., Sun, Z., Tang, S., Chen, L. J., Wong, A., Tham, C. C. Y., Wong, T. Y., Chen, C., Ikram, M. K., Whitson, H. E., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.08.009 · Cited by 362 · see citing works
Krieg, M., Stühmer, J., Cueva, J. G., Fetter, R. D., Spilker, K. A., Cremers, D., Shen, K., Dunn, A. R., & Goodman, M. B. (2017) · eLife · doi:10.7554/elife.20172 · Cited by 128 · see citing works
“Intriguingly, mechanical stress has also been implicated in neurodegenerative disease (Levy Nogueira et al., 2016; Wostyn et al., 2010).”
BackgroundThe interactions of genes, age, and environment in glaucoma pathogenesis
Doucette, L. P., Rasnitsyn, A., Seifi, M., & Walter, M. A. (2015) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2015.01.004 · Cited by 114 · see citing works
Changes of Visual Pathway and Brain Connectivity in Glaucoma: A Systematic Review
Nuzzi, R., Dallorto, L., & Rolle, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00363 · Cited by 91 · see citing works
Moon, J. Y., Kim, H. J., Park, Y. H., Park, T. K., Park, E., Kim, C. Y., & Lee, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-29557-6 · Cited by 84 · see citing works
Autophagy in axonal degeneration in glaucomatous optic neuropathy
Munemasa, Y., & Kitaoka, Y. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.03.002 · Cited by 81 · see citing works
Nucci, C., Martucci, A., Cesareo, M., Mancino, R., Russo, R., Bagetta, G., Cerulli, L., & Garaci, F. G. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.08.004 · Cited by 75 · see citing works
Chen, Z., Lin, F., Wang, J., Li, Z., Dai, H., Mu, K., Ge, J., & Zhang, H. (2012) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2012.02832.x · Cited by 74 · see citing works
“However, recent studies have shown that it may be a neurodegenerative disease like Alzheimer’s or Parkinson’s disease.(4,5) Neuronal damage caused by glaucoma is present not only in the retina but also in the central visual system.”
BackgroundYu, L., Xie, B., Yin, X., Liang, M., Evans, A. C., Wang, J., & Dai, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073208 · Cited by 70 · see citing works
“Recent studies have shown that glaucoma may be a neurodegenerative disease similar to Alzheimer’s or Parkinson’s disease [3,4].”
BackgroundThe current research status of normal tension glaucoma
Mi, X.-S., Yuan, T., & So, K. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s67263 · Cited by 57 · see citing works
“disease similar to neurodegenerative disease in the central nervous system.(108,109) Up to now, because the definite mechanism of POAG is still unclear, it is not the appropriate time to separate completely NTG from POAG.”
Sabel, B. A., Flammer, J., & Merabet, L. B. (2018) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-180880 · Cited by 56 · see citing works
Ngoo, Q. Z., Hitam, W. H. W., & Razak, A. A. (2019) · Journal of Ophthalmology · doi:10.1155/2019/6248185 · Cited by 50 · see citing works
“Alzheimer’s disease is a chronic and progressive neurodegenerative disease which involves both genetic and environmental factors [13].”
BackgroundChen, Y.-Y., Hu, H.-Y., Chu, D., Chen, H., Chang, C., & Chou, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163210 · Cited by 45 · see citing works
Nakashima, T., Sone, M., Teranishi, M., Yoshida, T., Terasaki, H., Kondo, M., Yasuma, T. R., Wakabayashi, T., Nagatani, T., & Naganawa, S. (2011) · Auris Nasus Larynx · doi:10.1016/j.anl.2011.05.005 · Cited by 45 · see citing works
Bakalash, S., Pham, M. D., Koronyo, Y., Salumbides, B. C., Kramerov, A. A., Seidenberg, H., Berel, D., Black, K. L., & Koronyo‐Hamaoui, M. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7498 · Cited by 44 · see citing works
Li, K., Lu, C.-X., Huang, Y., Li, Y., Zeng, D., & Wu, K. X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097445 · Cited by 36 · see citing works
Mechanical stress models of Alzheimer's disease pathology
Levy-Nogueira, M., Epelbaum, S., Steyaert, J.-M., Dubois, B., & Schwartz, L. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.10.005 · Cited by 33 · see citing works
Levy-Nogueira, M., Moreira, J. D. V., Baronzio, G., Dubois, B., Steyaert, J.-M., & Schwartz, L. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00197 · Cited by 35 · see citing works
Bermejo‐Pareja, F., & del Ser, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020536 · Cited by 35 · see citing works
Mechanical stress related to brain atrophy in Alzheimer's disease
Lévy, M., Lafitte, O. D., Steyaert, J., Bakardjian, H., Dubois, B., Hampel, H. J., & Schwartz, L. H. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.03.005 · Cited by 33 · see citing works
Hou, R., Zhang, Z., Yang, D., Wang, H., Chen, W., Li, Z., Sang, J., Liu, S., Cao, Y., Xie, X., et al. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5022-9 · Cited by 32 · see citing works
Glaucoma – Diabetes of the brain: A radical hypothesis about its nature and pathogenesis
Faiq, M. A., Dada, R., Saluja, D., & Dada, T. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.02.005 · Cited by 26 · see citing works
Lazaldin, M. A. M., Iezhitsa, I. N., Agarwal, R., Bakar, N. S., Agarwal, P., & Ismail, N. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14662 · Cited by 24 · see citing works
Ocular manifestations of central insulin resistance
Dada, T., Chan, K. C., Faiq, M. A., Sengupta, T., Nath, M., Velpandian, T., Saluja, D., & Dada, R. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355765 · Cited by 20 · see citing works
“…(Rad et al., 2018), tauopathy (Mullins et al., 2017), glutamate excitotoxicity (Datusalia et al., 2018), inflammation, and neuronal apoptosis in Alzheimer’s disease, glaucoma, and maculopathy (Wostyn et al., 2010; Faiq et al., 2014; Ermilov and Nesterova, 2016; Regland and McCaddon, 2019).”
BackgroundAge-related macular degeneration and Alzheimer disease
Çerman, E., Eraslan, M., & Çekıç, O. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1406-146 · Cited by 19 · see citing works
Wu, Y., Wang, X., Wang, N., Han, Y., Ma, D., & Lu, Y. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1438428 · Cited by 16 · see citing works
“Previous reports have shown that patients with AD may have a significantly increased rate of glaucoma occurrence [31,32].”
BackgroundRolle, T., Dallorto, L., Rossatto, S., Curto, D., & Nuzzi, R. (2020) · Journal of Ophthalmology · doi:10.1155/2020/7879436 · Cited by 15 · see citing works
Glaucoma and Alzheimer’s Disease in the Elderly
Bizrah, M., Guo, L., & Cordeiro, M. F. (2011) · Aging Health · doi:10.2217/ahe.11.51 · Cited by 14 · see citing works
Zhong, Y.-L., Liu, H., & Huang, X. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.013 · Cited by 13 · see citing works
Prins, D., Jansonius, N. M., & Cornelissen, F. W. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20404 · Cited by 12 · see citing works
Brain Functional Network Analysis of Patients with Primary Angle-Closure Glaucoma
Liu, D., Gao, J., You, T., Li, S., Cai, F., Pei, C.-G., & Zeng, X. (2022) · Disease Markers · doi:10.1155/2022/2731007 · Cited by 11 · see citing works
“Moreover, recent pathological data have demonstrated that neurodegenerative processes in the central nervous system of patients with glaucoma, such as apoptosis and reactive oxygen species production, were similar to the processes identified in Alzheimer’s disease (AD) [4, 5], which suggests that glaucoma is a neurode…”
ResultKojima, K., Kitaoka, Y., Munemasa, Y., & Ueno, S. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10271 · Cited by 10 · see citing works
Guo, H., Li, M., Wang, Z., Liu, Q., & Wu, X. (2015) · PubMed Central · Cited by 9 · see citing works
Zanoni, D. S., da Silva, G. A., Ezra-Elia, R., de Carvalho, M., Quitzan, J. G., Ofri, R., Laus, J. L., & Amorim, R. L. (2017) · International Journal of Experimental Pathology · doi:10.1111/iep.12233 · Cited by 8 · see citing works
“In addition, there is growing evidence that local ischaemia, vascular factors and reduced perfusion of the optic nerve may play a role in glaucomatous neuropathy pathogenesis (Yanagi et al. 2001; Quigley & Broman 2006; Flammer & Mozaffarieh 2007; Quigley 2007; Wostyn et al. 2010; Lin et al. 2014).”
BackgroundLiu, Y., Bu, Q., Hu, D., Chen, C., Zhu, J., Zhou, Q., Li, Z., & Pan, X. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114137 · Cited by 7 · see citing works
Hanafiah, M., Johari, B., Mumin, N. A., Musa, A. A., & Hanafiah, H. (2022) · British Journal of Radiology · doi:10.1259/bjr.20210857 · Cited by 5 · see citing works
Yang, X., Gan, J., & Ji, Y. (2024) · BMC Neurology · doi:10.1186/s12883-023-03502-1 · Cited by 3 · see citing works
Зуева, М. В., Zhuravleva, A. N., & Bogolepova, A. N. (2021) · Ophthalmology in Russia · doi:10.18008/1816-5095-2021-2-198-207 · Cited by 2 · see citing works
Rolle, T., Rossi, G. C. M., & Brusini, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.919775 · Cited by 2 · see citing works
颅内压与眼内压的相关性及对视神经的影响:北京颅眼压力研究(iCOP)
章, 征., 陈, 伟., 张, 亚., 桑, 景., 任, 若., 王, 宁., 谢, 晓., 李, 臻., 侯, 若., 曹, 怡., et al. (2016) · Scientia Sinica Vitae · doi:10.1360/n052016-00279 · Cited by 1 · see citing works
Зуева, М. В., Zhuravleva, A. N., & Bogolepova, A. N. (2022) · Ophthalmology in Russia · doi:10.18008/1816-5095-2022-3-532-540 · Cited by 1 · see citing works
Alzheimer Disease: Intracranial Pressure and Glaucoma
Lu, Y., & Wang, N. (2019) · Advances in visual science and eye diseases · doi:10.1007/978-981-13-2137-5_45 · Cited by 1 · see citing works
Ocular and systemic vascular dysfunction in neurodegenerative disease
Mroczkowska, S. (2012) · Aston Publications Explorer (Aston University) · doi:10.48780/publications.aston.ac.uk.00016525
Review Article Mechanical stress models of Alzheimer's disease pathology
Lévy, M., Steyaert, J., Dubois, B., & Schwartz, L. H. (2016)
Lewis, T. J., & Trempe, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812112-2.00006-9
Ghergal, D. (2017) · Optician · doi:10.12968/opti.2017.4.4917
Effect of COVID-19 on Alzheimer's and dementia measured through ocular indications
Marsh, H. D., Rossettie, S. S., & John, A. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00017-9
Matwiejczuk, S., Niedziałek, A., Toborek, K., Midura, M., Wróbel‐Dudzińska, D., Żarnowski, T., Pietura, R., & Kosior‐Jarecka, E. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341306
“These findings support the classification of POAG as a neurodegenerative disease [8], with some considering glaucoma an “ocular AD” [49] or referring to AD as “cerebral glaucoma” [50].”
Vascular and respiratory impact in neurodegenerative diseases
Zmudka, J. (2017) · theses.fr (ABES) · doi:10.70675/9adb83e1z9fdfz4b08z9f4dz0c2b0dfee38f
- Authors
- Wostyn, P., Audenaert, K., & De Deyn, P. P.
- Affiliations
- Ghent University Hospital (BE)
- Corresponding author
- Wostyn, Peter
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 74
- Issue
- 6
- Pages
- 973-977
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2048424771
- Cited by
- 51
- References
- 50
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 1 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- School of Medicine, Stanford University
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, intracranial pressure, cerebrospinal fluid pressure, intraocular pressure, glaucoma, retinal ganglion cell death, neuronal cell death, pressure stress, disease susceptibility
- MeSH terms
- Alzheimer Disease, Glaucoma, Humans, Models, Neurological, Ocular Hypertension, Retinal Ganglion Cells, Cerebrospinal Fluid Pressure, Cell Death, Intracranial Hypertension
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
