Cited by 149Advanced Glycation End Products researchChronic Kidney Disease and DiabetesAdipokines, Inflammation, and Metabolic Diseases

Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects

Yamagishi, Sho-ichi, Adachi, Hisashi, Nakamura, Kazuo, Matsui, Takanori, Jinnouchi, Yuko, Takenaka, Katsuhiko, Takeuchi, Masayoshi, Enomoto, Mika +4 more·2006·Metabolism

Abstract

The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis is implicated in diabetic vascular complications. Administration of soluble form of RAGE (sRAGE) to mice has been shown to block the AGE-elicited tissue damage by acting as a decoy. These observations suggest that endogenous sRAGE may capture and eliminate circulating AGEs and decrease its serum levels. However, because AGEs up-regulate tissue RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, sRAGE may be positively, rather than inversely, associated with circulating AGEs by reflecting tissue RAGE expression. In this study, we investigated the association of sRAGE with serum levels of AGEs in humans. Data for fasting serum sRAGE and AGE levels of 184 nondiabetic subjects were obtained from a general population in Japan. We also measured body mass index (BMI), waist circumference, blood pressure, and blood biochemistries in this population. Uni- and multivariate analyses were applied for the determinants of serum sRAGE levels. The average sRAGE levels were 0.40 +/- 0.17 ng/mL in males and 0.43 +/- 0.14 ng/mL in females, respectively. In the univariate analysis, BMI (P < .05, inversely), waist circumference (P < .05, inversely), AGEs (P < .05), and alcohol intake (P < .05, inversely) were significantly associated with sRAGE levels. After performing multivariate analyses, BMI (P < .05, inversely) and AGEs (P < .05) still remained significant independently. The present study is the first demonstration that serum sRAGE levels were positively associated with circulating AGEs in the nondiabetic general population. Endogenous sRAGE levels are elevated in parallel with serum AGE levels.

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Crossref · 10.1016/j.metabol.2006.05.007

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  • Soluble forms of RAGE competitively bind AGEs, preventing their interaction with mRAGE and activation of downstream pathways including pro-inflammatory responses.

    “Furthermore, the soluble forms of the RAGE competitively bind AGEs preventing their interaction with mRAGE and the activation of downstream pathways, including pro-inflammatory responses.[42,43]”

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Authors
Yamagishi, S.-I., Adachi, H., Nakamura, K., Matsui, T., Jinnouchi, Y., Takenaka, K., Takeuchi, M., Enomoto, M., Furuki, K., Hino, A., Shigeto, Y., & Imaizumi, T.
Affiliations
  • Kurume University (JP)
  • Hokuriku University (JP)
Corresponding author
Yamagishi, Sho-ichi
Venue
Metabolism
Publisher
Elsevier BV
Published
2006-09
Volume
55
Issue
9
Pages
1227-1231
ISSN
0026-0495 (ISSN-L)
OpenAlex
W2042667331
Cited by
148
References
33
Citations by year
2026: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 1 · 2017: 5 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
FWCI
9.80
Type
journal article
Language
en
Open access
closed
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Kimura Memorial Heart Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
advanced glycation end products, soluble receptor for advanced glycation end products, non-diabetic patients, body mass index, waist circumference, alcohol consumption, diabetic vascular complications, AGE-RAGE axis
MeSH terms
Receptor for Advanced Glycation End Products, Aged, Alcohol Drinking, Analysis of Variance, Blood Chemical Analysis, Blood Pressure, Female, Humans, Japan, Male, Middle Aged, Receptors, Immunologic, Solubility, Body Mass Index, Glycation End Products, Advanced, Body Size

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