Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects
Abstract
The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis is implicated in diabetic vascular complications. Administration of soluble form of RAGE (sRAGE) to mice has been shown to block the AGE-elicited tissue damage by acting as a decoy. These observations suggest that endogenous sRAGE may capture and eliminate circulating AGEs and decrease its serum levels. However, because AGEs up-regulate tissue RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, sRAGE may be positively, rather than inversely, associated with circulating AGEs by reflecting tissue RAGE expression. In this study, we investigated the association of sRAGE with serum levels of AGEs in humans. Data for fasting serum sRAGE and AGE levels of 184 nondiabetic subjects were obtained from a general population in Japan. We also measured body mass index (BMI), waist circumference, blood pressure, and blood biochemistries in this population. Uni- and multivariate analyses were applied for the determinants of serum sRAGE levels. The average sRAGE levels were 0.40 +/- 0.17 ng/mL in males and 0.43 +/- 0.14 ng/mL in females, respectively. In the univariate analysis, BMI (P < .05, inversely), waist circumference (P < .05, inversely), AGEs (P < .05), and alcohol intake (P < .05, inversely) were significantly associated with sRAGE levels. After performing multivariate analyses, BMI (P < .05, inversely) and AGEs (P < .05) still remained significant independently. The present study is the first demonstration that serum sRAGE levels were positively associated with circulating AGEs in the nondiabetic general population. Endogenous sRAGE levels are elevated in parallel with serum AGE levels.
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Soluble forms of RAGE competitively bind AGEs, preventing their interaction with mRAGE and activation of downstream pathways including pro-inflammatory responses.
“Furthermore, the soluble forms of the RAGE competitively bind AGEs preventing their interaction with mRAGE and the activation of downstream pathways, including pro-inflammatory responses.[42,43]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [43]
Cites
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000380842.14048.7e · Cited by 1,600 · see citing works
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312 · see citing works
Park, L., Raman, K. G., Lee, K. J., Lu, Y., Ferran, L. J., Chow, W. S., Stern, D. M., & Schmidt, A. M. (1998) · Nature Medicine · doi:10.1038/2012 · Cited by 1,103 · see citing works
Vlassara, H., Bucala, R., & Striker, L. J. (1994) · PubMed · Cited by 851 · see citing works
Lander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17810 · Cited by 813 · see citing works
Activation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 792 · see citing works
YONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716 · see citing works
Self-citationRenal Insufficiency and Heart Failure
McAlister, F. A., Ezekowitz, J. A., Tonelli, M. A., & Armstrong, P. W. (2004) · Circulation · doi:10.1161/01.cir.0000116764.53225.a9 · Cited by 702 · see citing works
RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice
Bucciarelli, L. G., Wendt, T., Qu, W., Lu, Y., Lalla, E., Rong, L., Goova, M. T., Moser, B., Kislinger, T., Lee, D. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000039325.03698.36 · Cited by 562 · see citing works
Dyer, D. G., Blackledge, J. A., Thorpe, S. R., & Baynes, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99007-1 · Cited by 535 · see citing works
Grandhee, S. K., & Monnier, V. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99006-x · Cited by 459 · see citing works
Yamagishi, S., & Imaizumi, T. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054367300 · Cited by 455 · see citing works
Self-citationTanaka, N., Yonekura, H., Yamagishi, S., Fujimori, H., Yamamoto, Y., & Yamamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001235200 · Cited by 425 · see citing works
Self-citationFalcone, C., Emanuele, E., D’Angelo, A., Buzzi, M. P., Belvito, C., Cuccia, M., & Geroldi, D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160342.20342.00 · Cited by 378 · see citing works
Koyama, H., Shoji, T., Yokoyama, H., Motoyama, K., Mori, K., Fukumoto, S., Emoto, M., Shoji, T., Tamei, H., Matsuki, H., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000190660.32863.cd · Cited by 311 · see citing works
Kilhovd, B. K., Berg, T. J., Birkeland, K. I., Thorsby, P. M., & Hanssen, K. F. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1543 · Cited by 269 · see citing works
Hanford, L. E., Enghild, J. J., Valnickova, Z., Petersen, S. V., Schaefer, L. M., Schaefer, T. M., Reinhart, T. A., & Oury, T. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409782200 · Cited by 217 · see citing works
Takeuchi, M., Makita, Z., Bucala, R., Suzuki, T., Koike, T., & Kameda, Y. (2000) · Molecular Medicine · doi:10.1007/bf03401779 · Cited by 192 · see citing works
Self-citationGeroldi, D., Falcone, C., Emanuele, E., D’Angelo, A., Calcagnino, M. M., Buzzi, M. P., Scioli, G. A., & Fogari, R. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000177535.45785.64 · Cited by 190 · see citing works
Atherosclerosis and diabetes: The rage connection
Schmidt, A. M., & Stern, D. M. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0082-4 · Cited by 166 · see citing works
Schlueter, C., Hauke, S., Flohr, A. M., Rogalla, P., & Bullerdiek, J. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2003.08.008 · Cited by 157 · see citing works
Regulation of Human Melanoma Growth and Metastasis by AGE–AGE Receptor Interactions
Abe, R., Shimizu, T., Sugawara, H., Watanabe, H., Nakamura, H., Choei, H., Sasaki, N., Yamagishi, S., Shimizu, H., & Takeuchi, M. (2004) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2004.22218.x · Cited by 145 · see citing works
Self-citationPark, I. H. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.027 · Cited by 140 · see citing works
Ferri, C., Desideri, G., Baldoncini, R., Bellini, C., Angelis, C. D., Mazzocchi, C., & Santucci, A. (1998) · Diabetes · doi:10.2337/diabetes.47.4.660 · Cited by 127 · see citing works
Involvement of Advanced Glycation End-products (AGEs) in Alzheimers Disease
Takeuchi, M., Kikuchi, S., Sasaki, N., Suzuki, T., 渡井孝幸, Iwaki, M., Bucala, R., & Yamagishi, S. (2004) · Current Alzheimer Research · doi:10.2174/1567205043480582 · Cited by 127 · see citing works
Self-citationSoluble Levels of Receptor for Advanced Glycation Endproducts (sRAGE) and Coronary Artery Disease
Hudson, B. I., Harja, E., Moser, B., & Schmidt, A. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000164804.05324.8b · Cited by 112 · see citing works
Advanced Glycation End Products in Nondiabetic Patients With Coronary Artery Disease
Kanauchi, M., Tsujimoto, N., & Hashimoto, T. (2001) · Diabetes Care · doi:10.2337/diacare.24.9.1620 · Cited by 112 · see citing works
Nakamura, K., Yamagishi, S., Nakamura, Y., Takenaka, K., Matsui, T., Jinnouchi, Y., & Imaizumi, T. (2005) · Microvascular Research · doi:10.1016/j.mvr.2005.10.002 · Cited by 101 · see citing works
Self-citationUpregulation of RAGE and its ligands in proliferative retinal disease
Pachydaki, S. I., Tari, S. R., Lee, S. E., Ma, W., Tseng, J., Sosunov, A. A., Cataldergirmen, G., Scarmeas, N., Caspersen, C. S., Chang, S., et al. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.09.022 · Cited by 101 · see citing works
Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors
Moens, K., Flamez, D., Schravendijk, C. V., Ling, Z., PIPELEERS, D. G., & Schuit, F. C. (1998) · Diabetes · doi:10.2337/diab.47.1.66 · Cited by 97 · see citing works
Yamagishi, S., Amano, S., Inagaki, Y., Okamoto, T., Takeuchi, M., & Makita, Z. (2002) · Molecular Medicine · doi:10.1007/bf03402164 · Cited by 45 · see citing works
Self-citationSelvaraj, N., Bobby, Z., Das, A. K., Ramesh, R., & Koner, B. C. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00211-5 · Cited by 43 · see citing works
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Sparvero, L. J., Asafu-Adjei, D. A., Kang, R., Tang, D., Amin, N., Im, J., Rutledge, R., Lin, B., Amoscato, A. A., Zeh, H. J., et al. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-17 · Cited by 625 · see citing works
Moldogazieva, N. T., Mokhosoev, I. M., Melnikova, T. I., Porozov, Y. B., & Terentiev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3085756 · Cited by 504 · see citing works
Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective
Bongarzone, S., Savickas, V., Luzi, F., & Gee, A. D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00058 · Cited by 313 · see citing works
Hsieh, H.-M., Wu, W., & Hu, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.12.026 · Cited by 199 · see citing works
AGEs, RAGEs and s-RAGE; friend or foe for cancer
Ahmad, S., Khan, H., Siddiqui, Z., Khan, M. Y., Rehman, S., Shahab, U., Godovikova, T. S., Silnikov, V. N., & Moinuddin, M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.07.001 · Cited by 196 · see citing works
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works
Dattilo, B. M., Fritz, G., Leclerc, E., Kooi, C. W. V., Heizmann, C. W., & Chazin, W. (2007) · Biochemistry · doi:10.1021/bi7003735 · Cited by 193 · see citing works
Maillard-Lefebvre, H., Boulanger, E., Daroux, M., Gaxatte, C., Hudson, B. I., & Lambert, M. (2009) · Rheumatology · doi:10.1093/rheumatology/kep199 · Cited by 190 · see citing works
Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes
Yamagishi, S., Nakamura, N., Suematsu, M., Kaseda, K., & Matsui, T. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00067 · Cited by 176 · see citing works
Self-citationIshibashi, Y., Matsui, T., Maeda, S., Higashimoto, Y., & Yamagishi, S. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-125 · Cited by 164 · see citing works
Self-citationRAGE and Soluble RAGE: Potential Therapeutic Targets for Cardiovascular Diseases
Koyama, H., Yamamoto, H., & Nishizawà, Y. (2007) · Molecular Medicine · doi:10.2119/2007-00087.koyama · Cited by 156 · see citing works
Yamagishi, S., Nakamura, K., Matsui, T., Ueda, S., Fukami, K., & Okuda, S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.7.983 · Cited by 138 · see citing works
Self-citationNakamura, K., Yamagishi, S., Adachi, H., Kurita‐Nakamura, Y., Matsui, T., Yoshida, T., & Imaizumi, T. (2007) · Molecular Medicine · doi:10.2119/2006-00090.nakamura · Cited by 134 · see citing works
Self-citationsRAGE is Elevated in Septic Patients and Associated With Patients Outcome
Bopp, C., Hofer, S., Weitz, J., Bierhaus, A., Nawroth, P. P., Martin, E., Büchler, M. W., & Weigand, M. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.07.014 · Cited by 131 · see citing works
Soluble form of a receptor for advanced glycation end products sRAGE as a biomarker
Yamagishi, S. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e178 · Cited by 130 · see citing works
Self-citationTargeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis
Kwak, T., Drews‐Elger, K., Ergonul, A. B., Miller, P. C., Braley, A. E., Hwang, G. H., Zhao, D., Besser, A., Yamamoto, Y., Yamamoto, H., et al. (2016) · Oncogene · doi:10.1038/onc.2016.324 · Cited by 130 · see citing works
Takeuchi, M., & Yamagishi, S. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0974 · Cited by 122 · see citing works
Self-citationPrasad, K. (2014) · International Journal of Angiology · doi:10.1055/s-0033-1363423 · Cited by 118 · see citing works
Tchaikovski, V., Olieslagers, S., Böhmer, F. D., & Waltenberger, J. L. (2009) · Circulation · doi:10.1161/circulationaha.108.817528 · Cited by 115 · see citing works
Yoshizaki, A., Komura, K., Iwata, Y., Ogawa, F., Hara, T., Muroi, E., Takenaka, M., Shimizu, K., Hasegawa, M., Fujimoto, M., et al. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9252-x · Cited by 111 · see citing works
Gaens, K. H. J., Ferreira, I., Kallen, C., van Greevenbroek, M. M. J., Blaak, E. E., Feskens, E. J. M., Dekker, J. M., Nijpels, G., Heine, R. J., Hart, L. M. ‘., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1067 · Cited by 100 · see citing works
RAGE: a new frontier in chronic airways disease
Sukkar, M. B., Ullah, M. A., Gan, W. J., Wark, P. A. B., Chung, K. F., Hughes, J. M., Armour, C. L., & Phipps, S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01984.x · Cited by 98 · see citing works
Role of advanced glycation end products and insulin resistance in diabetic nephropathy
Parwani, K., & Mandal, P. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1797106 · Cited by 97 · see citing works
Nakamura, K., Yamagishi, S., Adachi, H., Matsui, T., Kurita‐Nakamura, Y., Takeuchi, M., Inoue, H., & Imaizumi, T. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.09.004 · Cited by 96 · see citing works
Self-citationTakeuchi, M., Takino, J.-I., & Yamagishi, S. (2010) · Current Drug Targets · doi:10.2174/1389450111009011468 · Cited by 95 · see citing works
Self-citationAdvanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?
Davis, K. E., Prasad, C., Vijayagopal, P., Juma, S., & Imrhan, V. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.744738 · Cited by 94 · see citing works
Tam, X., Shiu, S. W. M., Leng, L., Bucala, R., Betteridge, D. J., & Tan, K. C. B. (2010) · Clinical Science · doi:10.1042/cs20100256 · Cited by 89 · see citing works
RAGE and cardiovascular disease
Shim, C. Y. (2010) · Frontiers in bioscience · doi:10.2741/3700 · Cited by 86 · see citing works
Nakamura, K., Yamagishi, S., Adachi, H., Matsui, T., Kurita‐Nakamura, Y., Takeuchi, M., Inoue, H., & Imaizumi, T. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.766 · Cited by 86 · see citing works
Self-citationKalousová, M., Jáchymová, M., Mestek, O., Hodkova, M., Kazderová, M., Tesař, V., & Zima, T. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm050 · Cited by 79 · see citing works
Lu, L., Pu, L. J., Zhang, Q., Wang, L. J., Kang, S., Zhang, R., Chen, Q., Wang, J. G., Caterina, R. D., & Shen, W. F. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.045 · Cited by 77 · see citing works
Creagh-Brown, B. C., Quinlan, G. J., Evans, T. W., & Burke-Gaffney, A. C. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1952-z · Cited by 76 · see citing works
Diabetes Mellitus and Atrial Remodeling: Mechanisms and Potential Upstream Therapies
Zhang, Q., Liu, T., Ng, C. Y., & Li, G. (2014) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12089 · Cited by 74 · see citing works
Younessi, P., & Yoonessi, A. (2011) · Europe PMC (PubMed Central) · Cited by 72 · see citing works
Jiao, L., Taylor, P. R., Weinstein, S. J., Graubard, B. I., Virtamo, J. R. K., Albanes, D., & Stolzenberg‐Solomon, R. Z. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0066 · Cited by 71 · see citing works
Liu, W., Li, Z., Feng, C., Hu, S., Yang, X., Xiao, K., Nong, Q.-N., Xiao, Q., Wu, K., Li, X., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.119001 · Cited by 69 · see citing works
Nin, J. W. M., Ferreira, I., Schalkwijk, C., Prins, M. H., Chaturvedi, N., Fuller, J., Stehouwer, C. D. A., & EURODIAB Prospective Complications Study Group (2009) · Diabetologia · doi:10.1007/s00125-009-1263-5 · Cited by 69 · see citing works
Jiao, L., Weinstein, S. J., Albanes, D., Taylor, P. R., Graubard, B. I., Virtamo, J. R. K., & Stolzenberg‐Solomon, R. Z. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2573 · Cited by 70 · see citing works
Kocsis, Á. K., Szabolcs, A., Hofner, P., Takács, T., Farkas, G., Boda, K., & Mándi, Y. (2009) · Pancreatology · doi:10.1159/000181172 · Cited by 68 · see citing works
Soluble Receptor for Advanced Glycation End Products (RAGE) is a Prognostic Factor for Heart Failure
Koyama, Y., Takeishi, Y., Niizeki, T., Suzuki, S., Kitahara, T., Sasaki, T., & Kubota, I. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.10.019 · Cited by 67 · see citing works
Mulder, D. J., van Haelst, P. L., Groß, S., de Leeuw, K., Bijzet, J., Graaff, R., Gans, R. O. B., Zijlstra, F., & Smit, A. J. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.03.027 · Cited by 63 · see citing works
Yamagishi, S. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0618 · Cited by 62 · see citing works
Self-citationSoluble RAGE as a severity marker in community acquired pneumonia associated sepsis
Narvaez-Rivera, R. M., Rendón, A., Salinas-Carmona, M. C., & Rosas-Taraco, A. G. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-15 · Cited by 61 · see citing works
Evidence for a role of advanced glycation end products in atrial fibrillation
Raposeiras‐Roubín, S., Rodiño‐Janeiro, B. K., Grigorian-Shamagian, L., Seoane‐Blanco, A., Moure‐González, M., Roman, A. V., Álvarez, E., & González‐Juanatey, J. R. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.05.072 · Cited by 59 · see citing works
Cystic fibrosis-related diabetes and lung disease: an update
Prentice, B. J., Jaffé, A., Hameed, S., Verge, C. F., Waters, S. A., & Widger, J. (2021) · European Respiratory Review · doi:10.1183/16000617.0293-2020 · Cited by 59 · see citing works
Hudson, B. I., Moon, Y. P., Kalea, A. Z., Khatri, M., Marquez, C., Schmidt, A. M., Paik, M. C., Yoshita, M., Sacco, R. L., DeCarli, C. S., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.01.024 · Cited by 59 · see citing works
Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function
Jules, J., Maiguel, D. A., & Hudson, B. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078267 · Cited by 57 · see citing works
Brix, J., Höllerl, F., Kopp, H., Schernthaner, G.-H., & Schernthaner, G.-H. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.107 · Cited by 56 · see citing works
V domain of RAGE interacts with AGEs on prostate carcinoma cells
Allmen, E. U., Koch, M., Fritz, G., & Legler, D. F. (2008) · The Prostate · doi:10.1002/pros.20736 · Cited by 55 · see citing works
Takeuchi, M. (2016) · Diagnostics · doi:10.3390/diagnostics6020023 · Cited by 52 · see citing works
Self-citationMcNair, E., Wells, C., Qureshi, A., Basran, R., Pearce, C., Orvold, J., Devilliers, J., & Prasad, K. (2009) · International Journal of Angiology · doi:10.1055/s-0031-1278352 · Cited by 51 · see citing works
Ueda, S., Yamagishi, S., Matsui, T., Noda, Y., Ueda, S., Jinnouchi, Y., Sasaki, K., Takeuchi, M., & Imaizumi, T. (2011) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2011.00264.x · Cited by 50 · see citing works
Self-citationKerkeni, M., Saïdi, A., Bouzidi, H., Yahya, S. B., & Hammami, M. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.07.006 · Cited by 50 · see citing works
Advanced glycation end products in senile diabetic and nondiabetic patients with cataract
Gul, A., Rahman, M. A., Salim, A., & Sımjee, S. U. (2008) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2008.04.001 · Cited by 49 · see citing works
Dozio, E., Briganti, S., Delnevo, A., Vianello, E., Ermetici, F., Secchi, F., Sardanelli, F., Morricone, L. F., Malavazos, A. E., & Romanelli, M. M. C. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1291-0 · Cited by 48 · see citing works
Takeuchi, M. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00614-3 · Cited by 50 · see citing works
Self-citationMulrennan, S. A., Baltic, S., Aggarwal, S. R., Wood, J., Miranda, A., Frost, F. A., Kaye, J. M., & Thompson, P. J. (2015) · Scientific Reports · doi:10.1038/srep08931 · Cited by 47 · see citing works
Nakamura, T., Sato, E., Fujiwara, N., Kawagoe, Y., Suzuki, T., Ueda, Y., Yamada, S., Shoji, H., Takeuchi, M., Ueda, S., et al. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.05.002 · Cited by 46 · see citing works
Self-citationIłżecka, J. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01133.x · Cited by 47 · see citing works
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases
Lee, T., Kao, Y., Chen, Y., Chao, T., & Lee, T.-I. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03204-3 · Cited by 46 · see citing works
Sterenczak, K. A., Willenbrock, S., Barann, M., Klemke, M., Soller, J. T., Eberle, N., Nolte, I. J. A., Bullerdiek, J., & Escobar, H. M. (2008) · Gene · doi:10.1016/j.gene.2008.10.027 · Cited by 47 · see citing works
Nakamura, I., Oyama, J., Komoda, H., Shiraki, A., Sakamoto, Y., Taguchi, I., Atsushi, H., Komatsu, A., Takeuchi, M., Yamagishi, S., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-15 · Cited by 44 · see citing works
Self-citationAGEs/sRAGE, a novel risk factor in the pathogenesis of end-stage renal disease
Prasad, K., Dhar, I., Zhou, Q., Elmoselhi, H., Shoker, M., & SHOKER, A. S. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2829-4 · Cited by 44 · see citing works
Reichert, S., Triebert, U., Santos, A. N., Hofmann, B., Schaller, H., Schlitt, A., & Schulz, S. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.015 · Cited by 44 · see citing works
McNair, E. D., Wells, C. R., Qureshi, A. M., Basran, R., Pearce, C., Orvold, J., Devilliers, J., & Prasad, K. (2010) · Clinical Cardiology · doi:10.1002/clc.20815 · Cited by 44 · see citing works
Braley, A. E., Kwak, T., Jules, J., Harja, E., Landgraf, R., & Hudson, B. I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.702399 · Cited by 43 · see citing works
Davis, K. E., Prasad, C., Vijayagopal, P., Juma, S., ADAMS-HUET, B. A., & Imrhan, V. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003487 · Cited by 41 · see citing works
Šebeková, K., Krivošíková, Z., & Gajdoš, M. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0879 · Cited by 41 · see citing works
Steenbeke, M., Bruyne, S. D., Buyzere, M. D., Lapauw, B., Speeckaert, R., Petrović, M., Delanghe, J., & Speeckaert, M. M. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1791045 · Cited by 41 · see citing works
Effects of Toxic AGEs (TAGE) on Human Health
Takeuchi, M., Sakai, A., Takata, T., Takino, J.-I., & Koriyama, Y. (2022) · Cells · doi:10.3390/cells11142178 · Cited by 40 · see citing works
Self-citationKoerich, S., Parreira, G. M., de Almeida, D. L., Vieira, R. P., & de Oliveira, A. C. P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220922153903 · Cited by 40 · see citing works
Davis, K. E., Prasad, C., Vijayagopal, P., Juma, S., & Imrhan, V. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.04.012 · Cited by 38 · see citing works
Advanced glycation end products and diabetes and other metabolic indicators
Jiang, T., Zhang, Y., Dai, F., Liu, C., Hu, H., & Zhang, Q. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00873-2 · Cited by 38 · see citing works
Yamagishi, S., & Imaizumi, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.139923 · Cited by 35 · see citing works
Self-citationPertyńska−Marczewska, M., Głowacka, E., Sobczak, M., Cypryk, K., & Wilczyński, J. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00679.x · Cited by 34 · see citing works
Decreased plasma sRAGE levels in COPD: influence of oxygen therapy
Gopal, P., Rutten, E. P. A., Dentener, M. A., Wouters, E. F. �., & Reynaert, N. L. (2012) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2012.02646.x · Cited by 33 · see citing works
Raposeiras‐Roubín, S., Rodiño‐Janeiro, B. K., Grigorian-Shamagian, L., Moure‐González, M., Seoane‐Blanco, A., Roman, A. V., Bonet, L. A., Álvarez, E., & González‐Juanatey, J. R. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.011 · Cited by 34 · see citing works
Hagen, I., Schulte, D. M., Müller, N., Martinsen, J., Türk, K., Hedderich, J., Schreiber, S., & Laudes, M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.022 · Cited by 33 · see citing works
Xanthis, A., Hatzitolios, A. I., Koliakos, G., & Tatola, V. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00508.x · Cited by 33 · see citing works
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies
Takeuchi, M. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i12.880 · Cited by 32 · see citing works
Self-citationTakino, J.-I. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i23.2459 · Cited by 32 · see citing works
Nakamura, T., Sato, E., Fujiwara, N., Kawagoe, Y., Koide, H., Ueda, Y., Takeuchi, M., & Yamagishi, S. (2011) · Clinical Cardiology · doi:10.1002/clc.20885 · Cited by 31 · see citing works
Self-citationHuang, J., Chuang, L., Guh, J., & Huang, Y.-J. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp134 · Cited by 31 · see citing works
Nishizawà, Y., & Koyama, H. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2007.10.016 · Cited by 27 · see citing works
Tavares, J. F., Ribeiro, P. V. D. M., Coelho, O. G. L., da Silva, L. E., & Alfenas, R. D. C. G. (2020) · Obesity Reviews · doi:10.1111/obr.13000 · Cited by 27 · see citing works
Pathological Role of Receptor for Advanced Glycation End Products in Calcified Aortic Valve Stenosis
Saku, K., Tahara, N., Takaseya, T., Otsuka, H., Takagi, K., Shojima, T., Shintani, Y., Zaima, Y., Kikusaki, S., Fukuda, T., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015261 · Cited by 26 · see citing works
Self-citationCould Oxidative Stress Associate with Age Products in Cataractogenesis?
Gul, A., Rahman, M. A., Hasnain, S. N., Salim, A., & Sımjee, S. U. (2008) · Current Eye Research · doi:10.1080/02713680802250939 · Cited by 26 · see citing works
Advanced glycation end products (AGEs) and its receptors in the pathogenesis of hyperthyroidism
Caspar‐Bell, G., Dhar, I., & Prasad, K. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2669-2 · Cited by 26 · see citing works
Biomarkers Associated with Atrial Fibrosis and Remodeling
Dilaveris, P., Antoniou, C. K., Manolakou, P., Tsiamis, E. G., Gatzoulis, K. A., & Tousoulis, D. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867324666170918122502 · Cited by 26 · see citing works
Chuong, C. F., Katz, J., Pauley, K. M., Bulosan, M., & Cha, S. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21873 · Cited by 25 · see citing works
Gryszczyńska, B., Budzyń, M., Krasińska, B., Osińska, A., Boruczkowski, M., Kaczmarek, M., Bukowska, A., Iskra, M., & Kasprzak, M. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163942 · Cited by 25 · see citing works
Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy
Takeuchi, M., Takino, J.-I., & Yamagishi, S. (2010) · Journal of Ophthalmology · doi:10.1155/2010/170393 · Cited by 25 · see citing works
Self-citationEndogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases
Koyama, H., Yamamoto, H., & Nishizawà, Y. (2007) · Biomarker Insights · doi:10.1177/117727190700200021 · Cited by 24 · see citing works
Endogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases.
Koyama, H., Yamamoto, H., & Nishizawà, Y. (2007) · PubMed Central · Cited by 24 · see citing works
sRAGE in septic shock: a potential biomarker of mortality
Hamasaki, M. Y., Barbeiro, H. V., de Souza, H. P., Machado, M. C. C., & da Silva, F. P. (2014) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20140060 · Cited by 23 · see citing works
Momma, H., Niu, K., Kobayashi, Y., Huang, C. X., Chujo, M., Otomo, A., Tadaura, H., Miyata, T., & Nagatomi, R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2936 · Cited by 21 · see citing works
Sakai, A., Takeda, K., & Takeuchi, M. (2023) · Antioxidants · doi:10.3390/antiox12030748 · Cited by 20 · see citing works
Self-citationNakamura, K., Adachi, H., Matsui, T., Kurita, Y., Takeuchi, M., & Yamagishi, S. (2009) · Metabolism · doi:10.1016/j.metabol.2008.10.020 · Cited by 19 · see citing works
Self-citationBasta, G., Castagnini, M., Turco, S. D., Epistolato, M. C., Righini, P., Sangiorgi, G., Caterina, R. D., & Tanganelli, P. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02212.x · Cited by 19 · see citing works
Gurecká, R., Koborová, I., Csongová, M., Šebek, J., & Šebeková, K. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9696-9 · Cited by 18 · see citing works
- Authors
- Yamagishi, S.-I., Adachi, H., Nakamura, K., Matsui, T., Jinnouchi, Y., Takenaka, K., Takeuchi, M., Enomoto, M., Furuki, K., Hino, A., Shigeto, Y., & Imaizumi, T.
- Affiliations
- Kurume University (JP)
- Hokuriku University (JP)
- Corresponding author
- Yamagishi, Sho-ichi
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 55
- Issue
- 9
- Pages
- 1227-1231
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2042667331
- Cited by
- 148
- References
- 33
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 1 · 2017: 5 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Kimura Memorial Heart Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- advanced glycation end products, soluble receptor for advanced glycation end products, non-diabetic patients, body mass index, waist circumference, alcohol consumption, diabetic vascular complications, AGE-RAGE axis
- MeSH terms
- Receptor for Advanced Glycation End Products, Aged, Alcohol Drinking, Analysis of Variance, Blood Chemical Analysis, Blood Pressure, Female, Humans, Japan, Male, Middle Aged, Receptors, Immunologic, Solubility, Body Mass Index, Glycation End Products, Advanced, Body Size
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