The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Understanding the potency of stressful early life experiences on brain and body function
Open accessAbstract
Early life experiences have powerful effects on the brain and body lasting throughout the entire lifespan and influencing brain function, behavior and the risk for a number of systemic and mental disorders. Animal models of early life adversity are providing mechanistic insights, including glimpses into the fascinating world that is now called “epigenetics” as well as the role of naturally occurring alleles of a number of genes. These studies also provide insights into the adaptive value, as well as the negative consequences, of early life stress, exposure to novelty, and poor vs good quality maternal care. Animal models begin to provide a mechanistic basis for understanding how brain development and physiological functioning is affected in children exposed to early life abuse and neglect, where there is a burgeoning literature on the consequences for physical health and emotional and cognitive development. An important goal is to identify interventions that are likely to be most effective in early life and some guidelines are provided.
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Self-citationRole of genotype in the cycle of violence in maltreated children
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Cited by
Oxidative Stress and the Central Nervous System
Salim, S. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,247
Epigenetic transmission of the impact of early stress across generations
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Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
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Social determinants of health and survival in humans and other animals
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Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607
Metadata
- Authors
- McEwen, B. S.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 57
- Pages
- S11-S15
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2103252476
- Cited by
- 261
- References
- 60
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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