CoChat
Sign Up
Cited by 32Muscle metabolism and nutritionCardiovascular and exercise physiologyExercise and Physiological Responses

Free fatty acid kinetics in the late phase of postexercise recovery: Importance of resting fatty acid metabolism and exercise-induced energy deficit

Open access
Magkos, Faidon, Mohammed, B. Selma, Patterson, Bruce W., Mittendorfer, Bettina·2009·Metabolism
DOI 10.1016/j.metabol.2009.03.023PMC PMC2728784
Open this paper in CoChat — free account

Abstract

Free fatty acid (FFA) availability increases several-fold during exercise and remains significantly elevated for at least 3 to 6 hours after exercise cessation. Little, however, is known regarding the duration of the postexercise rise in FFA flux. In the present study, we used stable isotope-labeled palmitate infusion to examine fatty acid metabolism in 27 healthy untrained men and women (age, 29 +/- 7 years; body mass index, 25 +/- 4 kg/m2) between 13 to 16 hours and 21 to 24 hours after a single bout of moderate-intensity endurance exercise (1-2 hours at 60% of peak oxygen consumption), performed in the evening, and after a time-matched resting trial. Postabsorptive FFA rate of appearance (Ra) and FFA concentration in plasma were significantly greater after exercise than rest throughout the recovery period (P < .015), but the exercise-induced increases declined from approximately 40% at 13 to 16 hours to approximately 10% at 21 to 24 hours postexercise (P = .001). The magnitude of the exercise-induced increase in plasma FFA concentration was proportional to the increase in FFA Ra. Correlation analysis demonstrated that exercise-induced changes in plasma FFA Ra at 13 to 16 hours are (1) negatively associated with resting plasma FFA Ra and (2) positively associated with the net energy expenditure of exercise and the exercise-induced changes in whole-body fat oxidation rate (all P values < .05). In multivariate stepwise linear regression analysis, baseline plasma FFA Ra (P < or = .008) and net energy expenditure of exercise (P < or = .005) independently predicted the exercise-induced change in plasma FFA Ra at 13 to 16 hours. We conclude that the exercise-induced increase in FFA mobilization is (1) long-lived, persisting for 12 to 24 hours after exercise, with a progressive decline with time; (2) greater in subjects with low than high resting plasma FFA availability; and (3) greater after exercise with high than low energy demand.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2009.03.023

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • After the immediate increase, lipolysis in WAT stabilizes but remains higher than the baseline rate for up to 24 h post-exercise.

    “For instance, after the immediate increase, lipolysis in WAT stabilizes but remains higher than the baseline rate for up to 24 h post-exercise [18,240], while the increased BMR may persist for up to 48 h [33].”

    From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [240]

    The Abstract (page unavailable) reports that plasma FFA appearance remained above the resting rate at 21–24 hours after exercise. But the increase declined from about 40% at 13–16 hours to about 10% at 21–24 hours; the Discussion says the lipolytic surge diminished with time, not that it stabilized. The study measured whole-body FFA kinetics rather than isolating lipolysis in white adipose tissue (WAT). (LLM, conf=0.90)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Magkos, F., Mohammed, B. S., Patterson, B. W., & Mittendorfer, B.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Mittendorfer, Bettina
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2009-09
Volume
58
Issue
9
Pages
1248-1255
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2009.03.023
PMC
PMC2728784
OpenAlex
W2089547073
Cited by
32
References
63
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • National Institutes of Health (5p41rr000954-34, UL1TR000448)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK56341, P30DK056341)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049869, AR49869)
  • National Center for Research Resources (P41-RR000954, RR 00954, UL1RR024992, M01RR000036)
  • National Center for Advancing Translational Sciences
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD057796, P50HD057796)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
free fatty acids, post-exercise recovery, endurance exercise, negative energy balance, fat oxidation, energy expenditure, plasma fatty acid concentrations
MeSH terms
Adipose Tissue, Adult, Basal Metabolism, Energy Metabolism, Fatty Acids, Nonesterified, Female, Heart Rate, Humans, Insulin, Kinetics, Male, Oxidation-Reduction, Rest, Exercise, Palmitic Acid, Recovery of Function, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review