Prior exercise and postprandial substrate extraction across the human leg
Abstract
Prior exercise decreases postprandial plasma triacylglycerol (TG) concentrations, possibly through changes to skeletal muscle TG extraction. We measured postprandial substrate extraction across the leg in eight normolipidemic men aged 21-46 yr. On the afternoon preceding one trial, subjects ran for 2 h at 64 +/- 1% of maximal oxygen uptake (exercise); before the control trial, subjects had refrained from exercise. Samples of femoral arterial and venous blood were obtained, and leg blood flow was measured in the fasting state and for 6 h after a meal (1.2 g fat, 1.2 g carbohydrate/kg body mass). Prior exercise increased time averaged postprandial TG clearance across the leg (total TG: control, 0.079 +/- 0.014 ml.100 ml tissue(-1).min(-1) ; exercise, 0.158 +/- 0.023 ml.100 ml tissue(-1).min(-1), P <0.01), particularly in the chylomicron fraction, so that absolute TG uptake was maintained despite lower plasma TG concentrations (control, 1.53 +/- 0.13 mmol/l; exercise, 1.01 +/- 0.16 mmol/l, P < 0.001). Prior exercise increased postprandial leg blood flow and glucose uptake (both P < 0.05). Mechanisms other than increased leg TG uptake must account for the effect of prior exercise on postprandial lipemia.
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Acute physical exercise can increase muscle glucose uptake on the following day and improve insulin sensitivity for 48 hours.
“Acute physical exercise can increase muscle glucose uptake on the following day (Malkova et al. 2000), and improve insulin sensitivity for 48 h (Mikines et al. 1988).”
From Glycaemic index methodology (2005) · cites this paper as Malkova et al. 2000
Exercise usually lowers plasma insulin concentrations in response to nutrient ingestion, although it generally has no effect on systemic fasting plasma glucose concentrations.
“This usually results in lower plasma insulin concentrations in response to nutrient ingestion (Tsetsonis & Hardman, 1996;Tsetsonis et al. 1997), although generally there is no effect on systemic fasting plasma glucose concentrations (Tsetsonis & Hardman, 1996;Tsetsonis et al. 1997;Malkova et al. 2000).”
From Glycaemic index methodology (2005) · cites this paper as Malkova et al. 2000
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“However, there seems to be a gender-specific regulation, since plasma GH was not found to be significantly increased by 1 h of exercise at 65% VO2peak or 30–180 min into recovery from this exercise bout in female in contrast to male subjects [16].”
BackgroundMethodInfluentialAerobic Exercise and Postprandial Lipemia in Men with the Metabolic Syndrome
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- Authors
- Malkova, D., Evans, R. D., Frayn, K. N., Humphreys, S. M., Jones, P. R. M., & Hardman, A. E.
- Affiliations
- Human Muscle Metabolism Research Group, Department of Physical Education, Sports Science and Recreation Management,
- University of Oxford (GB)
- Loughborough University (GB)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2000-11-01
- Volume
- 279
- Issue
- 5
- Pages
- E1020-E1028
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W1880038169
- Cited by
- 117
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- prior exercise, postprandial lipemia, leg blood flow, glucose uptake
- MeSH terms
- Adult, Blood Flow Velocity, Blood Glucose, Energy Metabolism, Fatty Acids, Nonesterified, Femoral Artery, Femoral Vein, Food, Humans, Insulin, Leg, Male, Metabolic Clearance Rate, Middle Aged, Oxygen Consumption, Running, Triglycerides, Vascular Resistance, Exercise, Muscle, Skeletal, Lactic Acid, 3-Hydroxybutyric Acid
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