Cited by 315Pancreatic function and diabetesDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells

Lee, Young-Sun, Jun, Hee-Sook·2014·Metabolism

Abstract

Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin secretion from pancreatic beta-cells in a glucose-dependent manner. In addition, GLP-1 slows gastric emptying, suppresses appetite, reduces plasma glucagon, and stimulates glucose disposal, which are beneficial for glucose homeostasis. Therefore, incretin-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase IV, an enzyme which inactivates GLP-1, have been developed for treatment of diabetes. This review outlines our knowledge of the actions of GLP-1 on insulin secretion and biosynthesis, beta-cell proliferation and regeneration, and protection against beta-cell damage, as well as the involvement of recently discovered signaling pathways of GLP-1 action, mainly focusing on pancreatic beta-cells.

Overview

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Crossref · 10.1016/j.metabol.2013.09.010

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102 of 102 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Lee, Y.-S., & Jun, H.-S.
Affiliations
Gachon University (KR)
Corresponding author
Jun, Hee-Sook
Venue
Metabolism
Publisher
Elsevier BV
Published
2014-01
Volume
63
Issue
1
Pages
9-19
ISSN
0026-0495 (ISSN-L)
OpenAlex
W2063865446
Cited by
315
References
101
Citations by year
2026: 15 · 2025: 34 · 2024: 34 · 2023: 26 · 2022: 28 · 2021: 35 · 2020: 26 · 2019: 21 · 2018: 27 · 2017: 16 · 2016: 17 · 2015: 19 · 2014: 16
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
glucagon-like peptide-1, incretins, pancreatic beta cells, insulin secretion, insulin biosynthesis, beta-cell proliferation, beta cell regeneration, beta cell destruction, glucose homeostasis, diabetes treatment, GLP-1 receptor agonists, DPP-4 inhibitors
MeSH terms
Insulin Secretion, Animals, Cell Differentiation, Cell Survival, Humans, Hypoglycemic Agents, Insulin, Signal Transduction, Cell Proliferation, Insulin-Secreting Cells, Glucagon-Like Peptide 1, Incretins

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