The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells
Abstract
Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin secretion from pancreatic beta-cells in a glucose-dependent manner. In addition, GLP-1 slows gastric emptying, suppresses appetite, reduces plasma glucagon, and stimulates glucose disposal, which are beneficial for glucose homeostasis. Therefore, incretin-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase IV, an enzyme which inactivates GLP-1, have been developed for treatment of diabetes. This review outlines our knowledge of the actions of GLP-1 on insulin secretion and biosynthesis, beta-cell proliferation and regeneration, and protection against beta-cell damage, as well as the involvement of recently discovered signaling pathways of GLP-1 action, mainly focusing on pancreatic beta-cells.
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In the citing paper
“DPP-4 inhibitors are employed either as an add-on drug therapy when metformin (a biguanide), or sulfonylurea is inadequate or as monotherapy in individuals who should not be taking those medications or who are intolerant to them (70).”
In the citing paper
“It stimulates insulin release and secretion in hyperglycemic states, inhibits glucagon release in hyperglycemic or euglycemic states, slows gastric emptying, and reduces food intake.(6, 7)”
From Semaglutide for the treatment of obesity (2023) · cites this paper as [6]
In the citing paper
“The hormone binds to GLP-1 receptors expressed in tissues such as the pancreatic beta cells, gastric mucosa, kidney, heart, and hypothalamus.(6, 7)”
From Semaglutide for the treatment of obesity (2023) · cites this paper as [6]
Citations
Cites
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The mechanism of pancreatic secretion
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Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 2×
“[12] Jang HJ, Kokrashvili Z, Theodorakis MJ, et al.”
BackgroundPancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
Elashoff, M., Matveyenko, A. V., Gier, B., Elashoff, R., & Butler, P. C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.018 · Cited by 944
Tissue and Plasma Concentrations of Amidated and Glycine-Extended Glucagon-Like Peptide I in Humans
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The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
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Hassanein, M. M., Alessa, T., Hafidh, K., Alzubaidi, L. M. Y., Jallo, M. K. I., Slail, F. Y. A., Elbadawi, H., & Malik, R. A. (2025) · Diabetes Therapy · doi:10.1007/s13300-025-01824-6
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Rajan, K., Jutley, A., Holliday, M. W., & Navaneethan, S. D. (2026) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s522424
Caimi, E., Ghetti, E. M., Giovagnoli, F., Vaccari, S., Ceglia, G., Cavallero, M. F., Comunian, R., Giuli, R. D., Veronesi, A., Klinger, F. M., et al. (2026) · Aesthetic Plastic Surgery · doi:10.1007/s00266-026-06155-w
Maher, O. W., El-Sayed, N. M., El‐Awady, E., El-Orabi, N. F., & Radwan, A. (2026) · Biomedicines · doi:10.3390/biomedicines14081714
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Trends in preoperative weight loss modalities among patients receiving body contouring surgery
Liang, J., Anderson, J. L., Cathey, J. M., Zhang, J., Yi, V. N., & Patel, A. (2026) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2026.08.008
Raptis, D., Nazarenko, N., Agarwal, R., Shah, M. K., Gao, Y., Theodoropoulos, P., Borkowski, P., Maliha, M., Policarpio, M. A., Yakkali, S., et al. (2026) · Diabetology · doi:10.3390/diabetology7080155
Yang, X., Wu, J., Gao, B., Zhu, Y., Sun, Y., Ouyang, L., Wu, B., Lan, W., Zhang, J., Zhang, Y., et al. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1880819 · Cited by 1
Signalling and Regulation of the Glucagon-like Peptide-1 receptor
Lu, J. N. (2014) · Figshare
Metadata
- Authors
- Lee, Y.-S., & Jun, H.-S.
- Affiliations
- Gachon University (KR)
- Corresponding author
- Jun, Hee-Sook
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 63
- Issue
- 1
- Pages
- 9-19
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2063865446
- Cited by
- 315
- References
- 101
- Citations by year
- 2026: 15 · 2025: 34 · 2024: 34 · 2023: 26 · 2022: 28 · 2021: 35 · 2020: 26 · 2019: 21 · 2018: 27 · 2017: 16 · 2016: 17 · 2015: 19 · 2014: 16
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucagon-like peptide-1, incretins, pancreatic beta cells, insulin secretion, insulin biosynthesis, beta-cell proliferation, beta cell regeneration, beta cell destruction, glucose homeostasis, diabetes treatment, GLP-1 receptor agonists, DPP-4 inhibitors
- MeSH terms
- Insulin Secretion, Animals, Cell Differentiation, Cell Survival, Humans, Hypoglycemic Agents, Insulin, Signal Transduction, Cell Proliferation, Insulin-Secreting Cells, Glucagon-Like Peptide 1, Incretins
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