Role of metabolism in neurodegenerative disorders
Abstract
Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases.
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Dysregulation of axonal energy metabolism appears to be a major risk factor for axonal degeneration in AMN, like in other neurodegenerative disorders.
“The dysregulation of axonal energy metabolism appears to be a major risk factor for axonal degeneration in AMN, like in other neurodegenerative disorders [304,305].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [305]
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- Authors
- Procaccini, C., Santopaolo, M., Faicchia, D., Colamatteo, A., Formisano, L., de Candia, P., Galgani, M., De Rosa, V., & Matarese, G.
- Affiliations
- Institute for Experimental Endocrinology and Oncology (IT)
- University of Naples Federico II (IT)
- University of Salerno (IT)
- University of Sannio (IT)
- Corresponding author
- Matarese, Giuseppe
- ORCID
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 65
- Issue
- 9
- Pages
- 1376-1390
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2417724549
- Cited by
- 258
- References
- 18
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 24 · 2023: 15 · 2022: 35 · 2021: 24 · 2020: 29 · 2019: 23 · 2018: 27 · 2017: 14 · 2016: 3
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R56NS042861)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- neurodegenerative diseases, energy metabolism, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, obesity, metabolic dysfunction, leptin, ghrelin, insulin, insulin-like growth factor I, neuronal injury
- MeSH terms
- Energy Metabolism, Hormones, Humans, Neurodegenerative Diseases, Receptor Cross-Talk
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