Brain abnormalities in human obesity: A voxel-based morphometric study
Abstract
Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m2) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m2) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P < 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post-central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity.
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Brain imaging studies comparing obese and lean individuals reported lower grey matter density in frontal regions (frontal operculum and middle frontal gyrus) and in post-central gyrus and putamen.
“Brain imaging studies comparing obese and lean individuals have also reported lower grey matter density in frontal regions (frontal operculum and middle frontal gyrus) and in post-central gyrus and putamen (128).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [128]
Brain imaging studies comparing obese and lean individuals have reported lower gray matter density in frontal regions, including frontal operculum and middle frontal gyrus, and in postcentral gyrus and putamen.
“Brain imaging studies comparing obese and lean individuals have also reported lower gray matter density in frontal regions (frontal operculum and middle frontal gyrus) and in postcentral gyrus and putamen (Pannacciulli et al 2006).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Pannacciulli et al 2006
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258 · see citing works
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0857 · Cited by 1,204 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · see citing works
Insulin and neurodegenerative disease: shared and specific mechanisms
Craft, S., & Stennis Watson, G. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00681-7 · Cited by 830 · see citing works
An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811 · see citing works
Unger, R. H. (2003) · Endocrinology · doi:10.1210/en.2003-0870 · Cited by 672 · see citing works
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
Tataranni, P. A., Gautier, J., Chen, K., Uecker, A., Bandy, D. J., Salbe, A. D., Pratley, R. E., Lawson, M. A., Reiman, E. M., & Ravussin, É. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4569 · Cited by 592 · see citing works
Self-citationCortical and limbic activation during viewing of high- versus low-calorie foods
Killgore, W. D. S., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun-Todd, D. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00191-5 · Cited by 581 · see citing works
Lee, J., Seroogy, K. B., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00747.x · Cited by 455 · see citing works
Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426 · see citing works
A 24-year follow-up of body mass index and cerebral atrophy
Gustafson, D., Lissner, L., Bengtsson, C., Björkelund, C., & Skoog, I. G. (2004) · Neurology · doi:10.1212/01.wnl.0000141850.47773.5f · Cited by 339 · see citing works
Differential brain responses to satiation in obese and lean men.
Gautier, J., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Heiman, M. L., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2000) · Diabetes · doi:10.2337/diabetes.49.5.838 · Cited by 283 · see citing works
Self-citationFlavor processing: more than the sum of its parts
Small, D. M., Jones-Gotman, M., Zatorre, R. J., Petrides, M., & Evans, A. C. (1997) · Neuroreport · doi:10.1097/00001756-199712220-00014 · Cited by 265 · see citing works
Leptin receptor action and mechanisms of leptin resistance
Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 261 · see citing works
Altered brain tissue composition in heavy marijuana users
Matochik, J. A., Eldreth, D. A., Cadet, J.-L., & Bolla, K. I. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.06.011 · Cited by 260 · see citing works
Brain abnormalities underlying altered activation in dyslexia: a voxel based morphometry study
Silani, G., Uta Frith, A., Démonet, J., Fazio, F., Perani, D., Price, C. J., Frith, C., & Paulesu, E. (2005) · Brain · doi:10.1093/brain/awh579 · Cited by 256 · see citing works
Adiposity signals and food reward: expanding the CNS roles of insulin and leptin
Figlewicz, D. P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00602.2002 · Cited by 221 · see citing works
Regional Gray Matter Abnormalities in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study
Valente, A. A., Miguel, E. C., de Castro, C. C., Amaro, E., Duran, F., Buchpiguel, C. A., Chitnis, X. A., McGuire, P. K., & Busatto, G. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.021 · Cited by 217 · see citing works
Effect of Satiation on Brain Activity in Obese and Lean Women
Gautier, J., Parigi, A. D., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2001) · Obesity Research · doi:10.1038/oby.2001.92 · Cited by 207 · see citing works
Self-citationParigi, A. D., Gautier, J., Chen, K., Salbe, A. D., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · PubMed · Cited by 206 · see citing works
Self-citationParigi, A. D., Gautier, J., CHEN, K., Salbe, A. D., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04294.x · Cited by 192 · see citing works
Self-citationEffect of Leptin Replacement on Brain Structure in Genetically Leptin-Deficient Adults
Matochik, J. A., London, E. D., Yıldız, B. O., Özata, M., Çağlayan, S., DePaoli, A. M., Wong, M., & Licinio, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1979 · Cited by 181 · see citing works
Antonova, E., Kumari, V., Morris, R. G., Halari, R., Anilkumar, A. P., Mehrotra, R., & Sharma, T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.036 · Cited by 178 · see citing works
Ventrolateral striatal dopamine depletions impair feeding and food handling in rats
Salamone, J. D., Mahan, K., & Rogers, S. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90174-r · Cited by 173 · see citing works
Changes in Gray Matter Volume in Patients with Bipolar Disorder
Adler, C. M., Levine, A. D., DelBello, M. P., & Strakowski, S. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.022 · Cited by 173 · see citing works
A voxel-based morphometric study of nondemented adults with Down Syndrome
White, N. S., Alkire, M. T., & Haier, R. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00273-8 · Cited by 146 · see citing works
Bereiter, D. A., & Jeanrenaud, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90557-2 · Cited by 145 · see citing works
Sex differences in the human brain’s response to hunger and satiation
Parigi, A. D., Chen, K., Gautier, J., Salbe, A. D., Pratley, R. E., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.1017 · Cited by 141 · see citing works
Self-citationEnhanced resting activity of the oral somatosensory cortex in obese subjects
Wang, G.-J., Volkow, N. D., Felder, C., Fowler, J. S., Levy, A. V., Pappas, N. R., Wong, C. T., Zhu, W., & Netusil, N. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00016 · Cited by 121 · see citing works
Regional cerebral blood flow during food exposure in obese and normal- weight women
Karhunen, L. J. (1997) · Brain · doi:10.1093/brain/120.9.1675 · Cited by 107 · see citing works
Mattson, M. P., Duan, W., Chan, S. L., Cheng, A., Haughey, N. J., Gary, D. S., GUO, Z., Lee, J., & Furukawa, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00025-8 · Cited by 107 · see citing works
Chan, S., Tang, K.-W., Lam, K. C. A., Chan, L.-K., Mendola, J. D., & Kwong, K. K. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.02.021 · Cited by 89 · see citing works
Obesity exacerbates chemically induced neurodegeneration
Sriram, K., Benkovic, S. A., Miller, D. B., & O’Callaghan, J. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00306-8 · Cited by 78 · see citing works
Reward, memory and substance abuse: functional neuronal circuits in the nucleus accumbens
Deadwyler, S. A., Hayashizaki, S., Cheer, J. F., & Hampson, R. E. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.011 · Cited by 64 · see citing works
Parigi, A. D., Chen, K., Salbe, A. D., Reiman, E. M., & Tataranni, P. A. (2003) · Obesity Research · doi:10.1038/oby.2003.68 · Cited by 61 · see citing works
Self-citationParigi, A. D., Chen, K., Salbe, A. D., Gautier, J.-F. O., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00014 · Cited by 45 · see citing works
Self-citationZhu, J., Zhang, Y., Song, Y.-N., & Wang, J.-J. (2004) · Neuroscience Research · doi:10.1016/j.neures.2003.12.009 · Cited by 38 · see citing works
Beninger, R. J., D'Amico, C. M., & Ranaldi, R. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90249-s · Cited by 23 · see citing works
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Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400 · see citing works
Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry
Robbins, T. W., Gillan, C. M., Smith, D. G., de Wit, S., & Ersche, K. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.009 · Cited by 1,003 · see citing works
Obesity and addiction: Neurobiological overlaps
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Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 788 · see citing works
Smith, E., Hay, P., Campbell, L. V., & Trollor, J. N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00920.x · Cited by 706 · see citing works
Raji, C. A., Ho, A. J., Parikshak, N., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Leow, A., Toga, A. W., & Thompson, P. M. (2009) · Human Brain Mapping · doi:10.1002/hbm.20870 · Cited by 685 · see citing works
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 594 · see citing works
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Thanos, P. K., Logan, J., Alexoff, D., Ding, Y.-S., Wong, C., Ma, Y., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.002 · Cited by 573 · see citing works
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Weller, R. E., Cook, E. W., Avsar, K. B., & Cox, J. E. (2008) · Appetite · doi:10.1016/j.appet.2008.04.010 · Cited by 544 · see citing works
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O’Brien, P. D., Hinder, L. M., Callaghan, B. C., & Feldman, E. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30084-4 · Cited by 535 · see citing works
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Mitchell, N. S., Catenacci, V. A., Wyatt, H. R., & Hill, J. O. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.08.005 · Cited by 526 · see citing works
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Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525 · see citing works
Batterink, L. J., Yokum, S., & Stice, E. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.059 · Cited by 527 · see citing works
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Yang, Y., Shields, G. S., Guo, C., & Liu, Y. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.020 · Cited by 498 · see citing works
Val‐Laillet, D., Aarts, E., Weber, B., Ferrari, M., Quaresima, V., Stoeckel, L. E., Alonso‐Alonso, M., Audette, M. A., Malbert, C., & Stice, E. M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.016 · Cited by 443 · see citing works
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Carnell, S., Gibson, C., Benson, L., Ochner, C. N., & Geliebter, A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00927.x · Cited by 441 · see citing works
Daulatzai, M. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23777 · Cited by 433 · see citing works
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Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 429 · see citing works
Brain Development Cooperative Group (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr018 · Cited by 372 · see citing works
Relationship Between Body Mass Index and Gray Matter Volume in 1,428 Healthy Individuals
Taki, Y., Kinomura, S., Sato, K., Inoue, K., Goto, R., Okada, K., Uchida, S., Kawashima, R., & Fukuda, H. (2008) · Obesity · doi:10.1038/oby.2007.4 · Cited by 366 · see citing works
Maayan, L., Hoogendoorn, C., Sweat, V., & Convit, A. (2011) · Obesity · doi:10.1038/oby.2011.15 · Cited by 345 · see citing works
Reinert, K. R. S., Po'e, E. K., & Barkin, S. L. (2013) · Journal of Obesity · doi:10.1155/2013/820956 · Cited by 344 · see citing works
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Volkow, N. D., Wang, G., Telang, F., Fowler, J. S., Goldstein, R. Z., Alia‐Klein, N., Logan, J., Wong, C., Thanos, P. K., Ma, Y., et al. (2009) · Obesity · doi:10.1038/oby.2008.469 · Cited by 344 · see citing works
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Gupta, S., Knight, A. G., Gupta, S., Keller, J. N., & Bruce‐Keller, A. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07660.x · Cited by 339 · see citing works
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Forny‐Germano, L., Felice, F. G. D., & Vieira, M. N. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01027 · Cited by 298 · see citing works
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Emmerzaal, T. L., Kiliaan, A. J., & Gustafson, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141086 · Cited by 295 · see citing works
Structural brain differences and cognitive functioning related to body mass index in older females
Walther, K., Birdsill, A. C., Glisky, E. L., & Ryan, L. (2010) · Human Brain Mapping · doi:10.1002/hbm.20916 · Cited by 290 · see citing works
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Hänggi, J., Koeneke, S., Bezzola, L., & Jäncke, L. (2009) · Human Brain Mapping · doi:10.1002/hbm.20928 · Cited by 283 · see citing works
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Martin, L. E., Holsen, L. M., Chambers, R. J., Bruce, A. S., Brooks, W. M., Zarcone, J. R., Butler, M. G., & Savage, C. R. (2009) · Obesity · doi:10.1038/oby.2009.220 · Cited by 278 · see citing works
Lew, L.-C., Hor, Y.-Y., Yusoff, N. A. A., Choi, S.-B., Yusoff, M. S. B., Roslan, N. S., Ahmad, A., Mohammad, J. A. M., Abdullah, M. F. I. L., Zakaria, N., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.010 · Cited by 272 · see citing works
Brooks, S. J., Cedernaes, J., & Schiöth, H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060393 · Cited by 269 · see citing works
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Winkler, A. M., Webster, M., Vidaurre, D., Nichols, T. E., & Smith, S. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.05.092 · Cited by 247 · see citing works
Ho, A. J., Stein, J. L., Hua, X., Lee, S., Hibar, D. P., Leow, A., Dinov, I. D., Toga, A. W., Saykin, A. J., Shen, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910878107 · Cited by 242 · see citing works
Self-citationObesity Is Associated With Reduced White Matter Integrity in Otherwise Healthy Adults*
Stanek, K. M., Grieve, S. M., Brickman, A. M., Korgaonkar, M. S., Paul, R. H., Cohen, R. A., & Gunstad, J. (2010) · Obesity · doi:10.1038/oby.2010.312 · Cited by 231 · see citing works
Bruehl, H., Wolf, O. T., Sweat, V., Tirsi, A., Richardson, S. B., & Convit, A. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.032 · Cited by 230 · see citing works
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Willeumier, K. C., Taylor, D. V., & Amen, D. G. (2011) · Obesity · doi:10.1038/oby.2011.16 · Cited by 223 · see citing works
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Brain size, sex, and the aging brain
Jäncke, L., Mérillat, S., Liem, F., & Hänggi, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22619 · Cited by 204 · see citing works
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Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 203 · see citing works
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Obesity and vulnerability of the CNS
Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.004 · Cited by 200 · see citing works
Yokum, S., Ng, J., & Stice, E. M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.175 · Cited by 197 · see citing works
Siervo, M., Arnold, R. J., Wells, J. C. K., Tagliabue, A., Colantuoni, A., Albanese, E., Brayne, C., & Stephan, B. C. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00903.x · Cited by 198 · see citing works
Selective Alterations Within Executive Functions in Adolescents With Excess Weight
Verdejo‐García, A., Pérez‐Expósito, M., Schmidt‐RioValle, J., Fernández-Serrano, M. J., Cruz‐Quintana, F., Pérez-Garcı́a, M., López‐Belmonte, G., Martín‐Matillas, M., Martín‐Lagos, J. A., Marcos, A., et al. (2010) · Obesity · doi:10.1038/oby.2009.475 · Cited by 198 · see citing works
fMRI reactivity on a delay discounting task predicts weight gain in obese women
Kishinevsky, F. I., Cox, J. E., Murdaugh, D. L., Stoeckel, L. E., Cook, E. W., & Weller, R. E. (2012) · Appetite · doi:10.1016/j.appet.2011.11.029 · Cited by 191 · see citing works
Body mass index and magnetic resonance markers of brain integrity in adults
Gazdzinski, S., Kornak, J., Weiner, M. W., & Meyerhoff, D. J. (2008) · Annals of Neurology · doi:10.1002/ana.21377 · Cited by 191 · see citing works
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
Dalamaga, Μ., Chou, S. H.-H., Shields, K. S., Papageorgiou, P., Pοlyzos, S. A., & Mantzoros, C. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.010 · Cited by 191 · see citing works
Obesity: Pathophysiology and Intervention
Zhang, Y., Liu, J., Yao, J., Ji, G., Qian, L., Wang, J., Zhang, G., Tian, J., Nie, Y., Zhang, Y., et al. (2014) · Nutrients · doi:10.3390/nu6115153 · Cited by 191 · see citing works
Association of body mass index and waist-to-hip ratio with brain structure
Hamer, M., & Batty, G. D. (2019) · Neurology · doi:10.1212/wnl.0000000000006879 · Cited by 190 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Astrup, A., & Bügel, S. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0143-9 · Cited by 179 · see citing works
Neural vulnerability factors that increase risk for future weight gain
Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179 · see citing works
Le, D. S. N. T., Pannacciulli, N., Chen, K., Parigi, A. D., Salbe, A. D., Reiman, E. M., & Krakoff, J. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.725 · Cited by 178 · see citing works
Self-citationCognitive Function and Decline in Obesity
Stanek, K. M., & Gunstad, J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111073 · Cited by 178 · see citing works
The Neurobiology of “Food Addiction” and Its Implications for Obesity Treatment and Policy
Carter, A., Hendrikse, J. J., Lee, N., Yücel, M., Verdejo‐García, A., Andrews, Z. B., & Hall, W. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050909 · Cited by 176 · see citing works
Higher normal fasting plasma glucose is associated with hippocampal atrophy
Cherbuin, N., Sachdev, P. S., & Anstey, K. J. (2012) · Neurology · doi:10.1212/wnl.0b013e31826846de · Cited by 170 · see citing works
Morys, F., Dadar, M., & Dagher, A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab135 · Cited by 169 · see citing works
Guillemot‐Legris, O., Masquelier, J., Everard, A., Cani, P. D., Alhouayek, M., & Muccioli, G. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0666-8 · Cited by 168 · see citing works
García‐García, I., Michaud, A., Dadar, M., Zeighami, Y., Neseliler, S., Collins, D. L., Evans, A. C., & Dagher, A. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0164-4 · Cited by 167 · see citing works
The Complex Interactions Between Obesity, Metabolism and the Brain
Uranga, R. M., & Keller, J. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00513 · Cited by 166 · see citing works
Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus
Soczynska, J. K., Kennedy, S. H., Woldeyohannes, H. O., Liauw, S. S. L., Alsuwaidan, M. T., Yim, C. Y., & McIntyre, R. S. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8140-8 · Cited by 162 · see citing works
Correlations among Brain Gray Matter Volumes, Age, Gender, and Hemisphere in Healthy Individuals
Taki, Y., Thyreau, B., Kinomura, S., Sato, K., Goto, R., Kawashima, R., & Fukuda, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022734 · Cited by 164 · see citing works
Does the brain shrink as the waist expands?
Willette, A. A., & Kapogiannis, D. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.007 · Cited by 162 · see citing works
Neural vulnerability factors for obesity
Stice, E. M., & Burger, K. S. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.12.002 · Cited by 155 · see citing works
Obesity-Related Differences between Women and Men in Brain Structure and Goal-Directed Behavior
Horstmann, A., Busse, F. P., Mathar, D., Müller, K., Lepsien, J., Schlögl, H., Kabisch, S., Kratzsch, J., Neumann, J., Stümvoll, M., et al. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00058 · Cited by 155 · see citing works
Individual differences in the neurophysiology of reward and the obesity epidemic
Small, D. M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.71 · Cited by 144 · see citing works
The effects of physical activity, education, and body mass index on the aging brain
Ho, A. J., Raji, C. A., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Dinov, I. D., Stein, J. L., Rosano, C., Toga, A. W., et al. (2010) · Human Brain Mapping · doi:10.1002/hbm.21113 · Cited by 145 · see citing works
S100B protein in neurodegenerative disorders
Steiner, J. H., Bogerts, B., Schroeter, M. L., & Bernstein, H. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.083 · Cited by 143 · see citing works
Food Addiction: Implications for the Diagnosis and Treatment of Overeating
Adams, R. C., Sedgmond, J., Maizey, L., Chambers, C., & Lawrence, N. (2019) · Nutrients · doi:10.3390/nu11092086 · Cited by 143 · see citing works
Brain White Matter Expansion in Human Obesity and the Recovering Effect of Dieting
Haltia, L. T., Viljanen, A., Parkkola, R., Kemppainen, N., Rinne, J. O., Nuutila, P., & Kaasinen, V. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2495 · Cited by 139 · see citing works
Xu, J., Yang, L., Lin, H., Sinha, R., & Potenza, M. N. (2011) · Human Brain Mapping · doi:10.1002/hbm.21491 · Cited by 138 · see citing works
Increased body mass index is associated with specific regional alterations in brain structure
Medic, N., Ziauddeen, H., Ersche, K. D., Farooqi, I. S., Bullmore, E. T., Nathan, P. J., Ronan, L., & Fletcher, P. C. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.42 · Cited by 135 · see citing works
Preliminary evidence of cognitive and brain abnormalities in uncomplicated adolescent obesity
Yau, P. L., Kang, E. H., Javier, D., & Convit, A. J. (2014) · Obesity · doi:10.1002/oby.20801 · Cited by 135 · see citing works
Le, D. S. N. T., Pannacciulli, N., Chen, K., Salbe, A. D., Hill, J. O., Wing, R. R., Reiman, E. M., & Krakoff, J. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.573 · Cited by 132 · see citing works
Self-citationObesity-mediated inflammation may damage the brain circuit that regulates food intake
Cazettes, F., Cohen, J. I., Yau, P. L., Talbot, H., & Convit, A. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.12.008 · Cited by 131 · see citing works
Mueller, K., Anwander, A., Möller, H. E., Horstmann, A., Lepsien, J., Busse, F. P., Mohammadi, S., Schroeter, M. L., Stümvoll, M., Villringer, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018544 · Cited by 132 · see citing works
Brooks, S. J., Benedict, C., Burgos, J., Kempton, M. J., Kullberg, J., Nordenskjöld, R., Kilander, L., Nylander, R., Larsson, E.-M., Johansson, L., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.13 · Cited by 130 · see citing works
Orbitofrontal cortex volume and brain reward response in obesity
Shott, M. E., Cornier, M.-A., Mittal, V. A., Pryor, T. L., Orr, J. M., Brown, M. S., & Frank, G. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.121 · Cited by 129 · see citing works
Cheke, L. G., Bonnici, H. M., Clayton, N. S., & Simons, J. S. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.01.013 · Cited by 130 · see citing works
Cross-sectional and longitudinal association of body mass index and brain volume
Bobb, J. F., Schwartz, B. S., Davatzikos, C. A., & Caffo, B. C. (2012) · Human Brain Mapping · doi:10.1002/hbm.22159 · Cited by 130 · see citing works
Knight, A., Bryan, J., & Murphy, K. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.005 · Cited by 128 · see citing works
Grey matter alterations in obesity: A meta‐analysis of whole‐brain studies
Herrmann, M. J., Tesar, A., Beier, J. S., Berg, M., & Warrings, B. (2018) · Obesity Reviews · doi:10.1111/obr.12799 · Cited by 129 · see citing works
Age prediction on the basis of brain anatomical measures
Valizadeh, S. A., Hänggi, J., Mérillat, S., & Jäncke, L. (2016) · Human Brain Mapping · doi:10.1002/hbm.23434 · Cited by 124 · see citing works
Walker, J., & Harrison, F. E. (2015) · Nutrients · doi:10.3390/nu7095341 · Cited by 127 · see citing works
Burwell, R. G., Aujla, R. K., Grevitt, M. P., Dangerfield, P., Moulton, A., Randell, T. L., & Anderson, S. (2009) · Scoliosis · doi:10.1186/1748-7161-4-24 · Cited by 125 · see citing works
Vascular Risk Factors: Imaging and Neuropathologic Correlates
Knopman, D. S., & Roberts, R. O. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091555 · Cited by 122 · see citing works
Shefer, G., Marcus, Y., & Stern, N. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.015 · Cited by 124 · see citing works
Verstynen, T., Weinstein, A. M., Schneider, W. W., Jakicic, J. M., Rofey, D. L., & Erickson, K. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318261909c · Cited by 124 · see citing works
Frontal cortical thinning and subcortical volume reductions in early adulthood obesity
Marqués‐Iturria, I., Pueyo, R., Garolera, M., Segura, B., Junqué, C., García‐García, I., Palacios, M. J. S., Vernet‐Vernet, M., Narberhaus, A., Ariza, M., et al. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.06.004 · Cited by 123 · see citing works
Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder
Schäfer, A., Vaitl, D., & Schienle, A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.063 · Cited by 122 · see citing works
Alfaro, F. J., Gavrieli, A., Saade-Lemus, P., Lioutas, V., Upadhyay, J., & Novak, V. (2017) · Metabolism · doi:10.1016/j.metabol.2017.08.009 · Cited by 122 · see citing works
Naomi, R., Teoh, S. H., Embong, H., Balan, S. S., Othman, F., Bahari, H., & Yazid, M. D. (2023) · Antioxidants · doi:10.3390/antiox12051071 · Cited by 121 · see citing works
Karlsson, H. K., Tuulari, J. J., Hirvonen, J., Saunavaara, V., Parkkola, R. K., Hiltunen, J., Hannukainen, J. C., Soinio, M., Pham, T. T., Salminen, P. T. P., et al. (2013) · Obesity · doi:10.1002/oby.20386 · Cited by 120 · see citing works
A life course of adiposity and dementia
Gustafson, D. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.052 · Cited by 117 · see citing works
- Authors
- Pannacciulli, N., Del Parigi, A., Chen, K., Le, D. S. N. T., Reiman, E. M., & Tataranni, P. A.
- Affiliations
- National Institutes of Health (US)
- Banner - University Medical Center Phoenix (US)
- Corresponding author
- Pannacciulli, Nicola
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 31
- Issue
- 4
- Pages
- 1419-1425
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2077965626
- Cited by
- 523
- References
- 45
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 22 · 2022: 22 · 2021: 28 · 2020: 23 · 2019: 34 · 2018: 34 · 2017: 36 · 2016: 41 · 2015: 37 · 2014: 41 · 2013: 31 · 2012: 27
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- obesity, brain structure, gray matter density, body mass index, postcentral gyrus, frontal operculum, putamen, middle frontal gyrus, adiposity
- MeSH terms
- Adult, Anthropometry, Blood Glucose, Brain, Brain Chemistry, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Insulin, Magnetic Resonance Imaging, Male, Obesity, Body Mass Index
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