The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia
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Citations
Cites
Reversible middle cerebral artery occlusion without craniectomy in rats.
Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 3×
“Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 and ERK1/2 signaling pathways [18], inhibits hepatic gluconeogenesis via the PI3K/Akt pathway [19], and inhibits hepatic cholesterol synthesis by activating AMP-activated protein kinase (AMPK)-SREBP2 signaling [20].”
FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 2×
“[21] Roca-Rivada A, Castelao C, Senin LL, Landrove MO, Baltar J, Belen Crujeiras A, et al.”
Resistance exercise induces a greater irisin response than endurance exercise
Tsuchiya, Y., Ando, D., Takamatsu, K., & Goto, K. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.010 · Cited by 207
Li, D.-J., Fu, H., Zhao, T., Ni, M., & Shen, F.-M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.009 · Cited by 92
Self-citation
Cited by
Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018) · Endocrine · doi:10.1007/s12020-017-1476-1 · Cited by 262
FNDC5/Irisin: Physiology and Pathophysiology
Waseem, R., Shamsi, A., Mohammad, T., Hassan, M. I., Kazim, S. N., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M., Ahmad, F., & Islam, A. (2022) · Molecules · doi:10.3390/molecules27031118 · Cited by 180
Myokines mediate the cross talk between skeletal muscle and other organs
Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162
Viel, T., Toricelli, M., Pereira, A. R., Souza Abrao, G., Malerba, H., Maia, J., & Buck, H. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.286952 · Cited by 102
The role of myokines and adipokines in hypertension and hypertension-related complications
Chen, K., Zhou, M., Wang, X., Li, S., & Yang, D. (2019) · Hypertension Research · doi:10.1038/s41440-019-0266-y · Cited by 54
Metadata
- Authors
- Li, D.-J., Li, Y.-H., Yuan, H.-B., Qu, L.-F., & Wang, P.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 68
- Pages
- 31-42
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2560155445
- Cited by
- 307
- References
- 7
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia. https://app.cochat.ai/papers/10.1016/j.metabol.2016.12.003
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- Li, D.-J., Li, Y.-H., Yuan, H.-B., Qu, L.-F., & Wang, P. (2017). The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia. Metabolism. https://doi.org/10.1016/j.metabol.2016.12.003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
