Irisin in metabolic diseases

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Correlation of mRNA and protein in complex biological samples

Maier, T., Güell, M., & Serrano, L. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.036 · Cited by 1,802 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · see citing works

Physiology and role of irisin in glucose homeostasis

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.221 · Cited by 621 · see citing works

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works

Circulating irisin in relation to insulin resistance and the metabolic syndrome.

Park, K., Zaichenko, L., Brinkoetter, M. T., Thakkar, B., Sahin-Efe, A., Joung, K., Tsoukas, M. A., Geladari, E., Huh, J., Dinçer, F., et al. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2373 · Cited by 527 · see citing works

Correlations between RNA and protein expression profiles in 23 human cell lines

Gry, M., Rimini, R., Strömberg, S., Asplund, A., Pontén, F., Uhlén, M., & Nilsson, P. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-365 · Cited by 520 · see citing works

The myokine irisin increases cortical bone mass

Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lü, P., Sartini, L., Comite, M. D., Mori, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516622112 · Cited by 513 · see citing works

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Kraus, D., Yang, Q., Kong, D., Banks, A. S., Zhang, L., Rodgers, J. T., Pirinen, E., Pulinilkunnil, T., Gong, F., Wang, Y.-C., et al. (2014) · Nature · doi:10.1038/nature13198 · Cited by 487 · see citing works

Lower circulating irisin is associated with type 2 diabetes mellitus

Liu, J., Wong, M. D. S., Toy, W. C., Tan, C., Liu, S., Ng, X. W., Subramaniam, T., Sum, C. F., & Lim, S. C. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.03.002 · Cited by 446 · see citing works

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index.

Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. (2013) · Peptides · doi:10.1016/j.peptides.2012.11.014 · Cited by 439 · see citing works

Serum irisin levels in new-onset type 2 diabetes

Choi, Y., Kim, M. K., Bae, K.-H., Seo, H.-A., Jeong, J.-Y., Lee, W.-K., Kim, J., Lee, I., & Park, K. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.007 · Cited by 422 · see citing works

Effects of obesity, diabetes and exercise on <i>Fndc5</i> gene expression and irisin release in human skeletal muscle and adipose tissue: <i>in vivo</i> and <i>in vitro</i> studies

Kurdiova, T., Balaz, M., Vician, M., Maderova, D., Vlcek, M., Valkovic, L., Srbecky, M., Imrich, R., Kyselovicova, O., Belan, V., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264655 · Cited by 401 · see citing works

Adipokines in nonalcoholic fatty liver disease

Pοlyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.11.006 · Cited by 359 · see citing works

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.

Liu, T.-Y., Shi, C.-X., Gao, R., Sun, H.-J., Xiong, X.-Q., Ding, L., Chen, Q., Li, Y.-H., Wang, J.-J., Kang, Y.-M., et al. (2015) · Clinical science · doi:10.1042/cs20150009 · Cited by 352 · see citing works

Irisin – a myth rather than an exercise-inducible myokine

Albrecht, E., Norheim, F., Thiede, B., Holen, T., Ohashi, T., Schering, L., Lee-Ødegård, S., Brenmoehl, J., Thomas, S., Drevon, C. A., et al. (2015) · Scientific Reports · doi:10.1038/srep08889 · Cited by 346 · see citing works

Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin Resistance and Adipocytokines

Pοlyzos, S. A., Kountouras, J., & Zavos, C. (2009) · Current Molecular Medicine · doi:10.2174/156652409787847191 · Cited by 336 · see citing works

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

Reza, M. M., Subramaniyam, N., Sim, C. M., Ge, X., Sathiakumar, D., McFarlane, C., Sharma, M., & Kambadur, R. (2017) · Nature Communications · doi:10.1038/s41467-017-01131-0 · Cited by 335 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 318 · see citing works

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.42 · Cited by 309 · see citing works

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

Li, D., Li, Y., Yuan, H., Qu, L., & Wang, P. (2016) · Metabolism · doi:10.1016/j.metabol.2016.12.003 · Cited by 308 · see citing works

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Colaianni, G., Mongelli, T., Cuscito, C., Pignataro, P., Lippo, L., Spiro, G., Notarnicola, A., Severi, I., Passeri, G., Mori, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02557-8 · Cited by 305 · see citing works

Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

Qiao, X., Nie, Y., Ma, Y., Chen, Y., Cheng, R., Yin, W., Hu, Y., Xu, W., & Xu, L. (2016) · Scientific Reports · doi:10.1038/srep18732 · Cited by 291 · see citing works

Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway

Xin, C., Liu, J., Zhang, J., Zhu, D., Wang, H., Xiong, L., Lee, Y., Ye, J., Lian, K., Xu, C., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.199 · Cited by 248 · see citing works

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

Xiong, X.-Q., Chen, D., Sun, H.-J., Ding, L., Wang, J.-J., Chen, Q., Li, Y.-H., Zhou, Y.-B., Han, Y., Zhang, F., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.017 · Cited by 242 · see citing works

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

Schumacher, M. A., Chinnam, N. B., Ohashi, T., Shah, R., & Erickson, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516641 · Cited by 240 · see citing works

Reduction in proximal femoral strength due to long-duration spaceflight

Keyak, J. H., Koyama, A. K., LeBlanc, A., Lu, Y., & Lang, T. F. (2009) · Bone · doi:10.1016/j.bone.2008.11.014 · Cited by 236 · see citing works

Leptin in nonalcoholic fatty liver disease: A narrative review

Polyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2014.10.012 · Cited by 235 · see citing works

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.030 · Cited by 234 · see citing works

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

Aydin, S., Kuloglu, T., Aydin, S., Kalayci, M., Yilmaz, M., Cakmak, T., Albayrak, S., Gungor, S., Colakoglu, N., & Ozercan, İ. H. (2014) · Peptides · doi:10.1016/j.peptides.2014.09.014 · Cited by 233 · see citing works

Irisin Enhances Osteoblast DifferentiationIn Vitro

Colaianni, G., Cuscito, C., Mongelli, T., Oranger, A., Mori, G., Brunetti, G., Colucci, S. C., Cinti, S., & Grano, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/902186 · Cited by 225 · see citing works

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

Pardo, M., Crujeiras, A. B., Amil, M., Agüera, Z., Jiménez‐Múrcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/857270 · Cited by 216 · see citing works

Irisin in patients with nonalcoholic fatty liver disease

Polyzos, S. A., Kountouras, J., Anastasilakis, A. D., Geladari, E. V., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2013.09.013 · Cited by 215 · see citing works

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

Löffler, D., Müller, U., Scheuermann, K., Friebe, D., Gesing, J. K., Bielitz, J., Erbs, S., Landgraf, K., Wagner, I. V., Kieß, W., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2932 · Cited by 213 · see citing works

A longitudinal study of the relationship of physical activity to bone mineral accrual from adolescence to young adulthood.

Baxter-Jones, A., Kontulainen, S., Faulkner, R., & Bailey, D. (2008) · Bone · doi:10.1016/j.bone.2008.07.245 · Cited by 213 · see citing works

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses

Zhu, D., Wang, H., Zhang, J., Zhang, X., Xin, C., Zhang, F., Lee, Y., Zhang, L., Lian, K., Yan, W., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.07.015 · Cited by 212 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

Lu, J., Xiang, G., Liu, M., Mei, W., Xiang, L., & Dong, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.020 · Cited by 190 · see citing works

Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

Anastasilakis, A. D., Pοlyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou‐Lampoudi, Τ., Siopi, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1367 · Cited by 186 · see citing works

Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

Zhang, J., Valverde, P., Zhu, X., Murray, D., Wu, Y., Yu, L., Jiang, H., Dard, M. M., Huang, J., Zhi-wei, X., et al. (2017) · Bone Research · doi:10.1038/boneres.2016.56 · Cited by 175 · see citing works

New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro

Park, M.-J., Kim, D.-I., Choi, J.-H., Heo, Y.-R., & Park, S.-H. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.04.010 · Cited by 168 · see citing works

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S. G., Sabico, S., Al‐Daghri, N. M., Saravanan, P., Barber, T. M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2013 · Cited by 167 · see citing works

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Aydın, S., Kuloğlu, T., Aydin, S., Eren, M. N., Çelik, A., Yılmaz, M., Kalaycı, M. Z., Şahin, İ., Gungor, O., Gürel, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.024 · Cited by 165 · see citing works

Effects of myokines on bone

Kaji, H. (2016) · BoneKEy Reports · doi:10.1038/bonekey.2016.48 · Cited by 162 · see citing works

Irisin and musculoskeletal health

Colaianni, G., Cinti, S., Colucci, S., & Grano, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13345 · Cited by 158 · see citing works

From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity

Castillo-Quan, J. I. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009894 · Cited by 157 · see citing works

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras, A. B., Pardo, M., Roca-Rivada, A., Navas‐Carretero, S., Zulet, M. Á., Martínez, J. A., & Casanueva, F. F. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22493 · Cited by 153 · see citing works

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

Tang, H. W., Yu, R., Liu, S., Huwatibieke, B., Li, Z., & Zhang, W. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.041 · Cited by 151 · see citing works

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.

Crujeiras, A., Zulet, M. D. L. Á., Lopez-Legarrea, P., de la Iglesia, R., Pardo, M., Carreira, M., Martinez, J., & Casanueva, F. (2014) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2013.12.007 · Cited by 143 · see citing works

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

Sesti, G., Andreozzi, F., Fiorentino, T. V., Mannino, G. C., Sciacqua, A., Marini, M. A., & Perticone, F. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0576-0 · Cited by 142 · see citing works

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells

Liu, S.-W., Du, F., Li, X., Wang, M.-M., Duan, R., Zhang, J.-X., Wu, Y., & Zhang, Q. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175498 · Cited by 138 · see citing works

Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury

Wang, H., Zhao, Y., Zhang, S.-Y., Dubielecka, P., Du, J., Yano, N., Chin, Y., Zhuang, S., Qin, G., & Zhao, T. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25857 · Cited by 136 · see citing works

Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months

Anastasilakis, A. D., Pοlyzos, S. A., Makras, P., Gkiomisi, A. I., Bisbinas, I., Katsarou, A., Filippaios, A., & Mantzoros, C. S. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2673-x · Cited by 132 · see citing works

Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

Gouni‐Berthold, I., Berthold, H. K., Huh, J. Y., Berman, R., Spenrath, N., Krone, W., & Mantzoros, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072858 · Cited by 132 · see citing works

Irisin: A renaissance in metabolism?

Polyzos, S. A., Kountouras, J., Shields, K., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.008 · Cited by 131 · see citing works

Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway

Han, F., Zhang, S., Hou, N., Wang, D., & Sun, X. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00443.2015 · Cited by 123 · see citing works

Irisin: A potentially candidate marker for myocardial infarction

Kuloğlu, T., Aydın, S., Eren, M. N., Yılmaz, M., Sahin, İ., Kalayci, M., Sarman, E., Kaya, N., Yılmaz, O., Türk, A., et al. (2014) · Peptides · doi:10.1016/j.peptides.2014.02.008 · Cited by 121 · see citing works

Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction

Zhang, Y.-Z., Mu, Q., Zhou, Z., Song, H.-B., Zhang, Y., Wu, F., Jiang, M., Wang, F., Zhang, W., Li, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158038 · Cited by 121 · see citing works

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion

Natalicchio, A., Marrano, N., Biondi, G., Spagnuolo, R., Labarbuta, R., Porreca, I., Cignarelli, A., Bugliani, M., Marchetti, P., Perrini, S., et al. (2017) · Diabetes · doi:10.2337/db17-0002 · Cited by 121 · see citing works

Circulating serum irisin levels in obesity and type 2 diabetes mellitus

Shoukry, A., Shalaby, S. M., Bdeer, S. E., Mahmoud, A. A., Mousa, M. M., & Khalifa, A. (2016) · IUBMB Life · doi:10.1002/iub.1511 · Cited by 120 · see citing works

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

Palermo, A., Strollo, R., Maddaloni, E., Tuccinardi, D., D’Onofrio, L., Briganti, S., Defeudis, G., Pascalis, M. D., Lazzaro, M. C., Colleluori, G., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12672 · Cited by 118 · see citing works

Elevated Circulating Levels of Irisin and the Effect of Metformin Treatment in Women With Polycystic Ovary Syndrome

Li, M., Yang, M., Zhou, X., Fang, X., Hu, W., Zhu, W., Wang, C., Liu, D., Li, S., Liu, H., et al. (2015) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2014-2544 · Cited by 115 · see citing works

Relationship between circulating irisin, renal function and body composition in type 2 diabetes

Liu, J., Liu, S., Wong, M. D. S., Tan, C. S. H., Subramaniam, T., Sum, C. F., & Lim, S. C. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.09.011 · Cited by 114 · see citing works

Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk

Panagiotou, G., Mu, L., Na, B., Mukamal, K. J., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.06.001 · Cited by 111 · see citing works

Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects

Al‐Daghri, N. M., Alkharfy, K. M., Rahman, S., Amer, O. E., Vinodson, B., Sabico, S., Piya, M. K., Harte, A. L., McTernan, P. G., Alokail, M. S., et al. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12196 · Cited by 111 · see citing works

Disorders Associated With Acute Rapid and Severe Bone Loss

Epstein, S., Inzerillo, A. M., Caminis, J. N., & Zaidi, M. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2083 · Cited by 110 · see citing works

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway

Peng, J., Deng, X., Huang, W. G., Yu, J., Wang, J., Wang, J., Yang, S., Liu, X., Wang, L., Zhang, Y., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.09.014 · Cited by 110 · see citing works

Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology

Aydın, S., Aydın, S., Kobat, M. A., Kalaycı, M. Z., Eren, M. N., Yılmaz, M., Kuloğlu, T., Gül, E., Seçen, Ö., Alataş, Ö. D., et al. (2014) · Peptides · doi:10.1016/j.peptides.2014.04.002 · Cited by 104 · see citing works

Irisin, Turning Up the Heat

Villarroya, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.010 · Cited by 104 · see citing works

Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates

Singhal, V., Lawson, E. A., Ackerman, K. E., Fazeli, P. K., Clarke, H., Lee, H., Eddy, K. T., Marengi, D. A., Derrico, N. P., Bouxsein, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100218 · Cited by 102 · see citing works

Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis

Du, X.-L., Jiang, W.-X., & Lv, Z.-T. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-108730 · Cited by 101 · see citing works

Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis.

Qiu, S., Cai, X., Yin, H., Zügel, M., Sun, Z.-L., Steinacker, J., & Schumann, U. (2016) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2016.02.006 · Cited by 99 · see citing works

Lower irisin level in patients with type 2 diabetes mellitus: A case‐control study and meta‐analysis

Zhang, C., Ding, Z., Lv, G., Li, J., Zhou, P., & Zhang, J. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12256 · Cited by 97 · see citing works

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

Xie, C., Zhang, Y., Tran, T. D. N., Wang, H., Li, S., George, E. V., Zhuang, H., Zhang, P., Kandel, A., Lai, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136816 · Cited by 95 · see citing works

Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy

Xiang, L., Xiang, G., Yue, L., Zhang, J., & Zhao, L. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.04.036 · Cited by 95 · see citing works

Irisin levels before and after physical activity among school‐age children with different BMI : A direct relation with leptin

Palacios‐González, B., Vadillo‐Ortega, F., Polo‐Oteyza, E., Sánchez, T. S., Ancira‐Moreno, M., Romero‐Hidalgo, S., Meraz‐Cruz, N., & Antuna-Puente, B. P. (2015) · Obesity · doi:10.1002/oby.21029 · Cited by 93 · see citing works

Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects

Moreno, M., Moreno‐Navarrete, J. M., Serrano, M., Ortega, F. J., Delgado, E., Sánchez-Ragnarsson, C., Valdés, S., Botas, P., Ricart, W., & Fernández‐Real, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124100 · Cited by 88 · see citing works

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.

Mo, L., Shen, J., Liu, Q.-H., Zhang, Y., Kuang, J.-Y., Pu, S.-Y., Cheng, S., Zou, M., Jiang, W., Jiang, C.-T., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1292 · Cited by 87 · see citing works

Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.

Yang, Z., Xu, C., Chen, Y., & Zhao, Q. (2015) · Europe PMC (PubMed Central) · Cited by 86 · see citing works

Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma

Shi, G., Tang, N., Qiu, J., Zhang, D., Huang, F., Cheng, Y., Ding, K., Li, W., Zhang, P., & Tan, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.148 · Cited by 86 · see citing works

Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery

Ebert, T., Stepan, H., Schrey-Petersen, S., Kralisch, S., Hindricks, J., Hopf, L., Platz, M., Lössner, U., Jeßnitzer, B., Drewlo, S., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.11.009 · Cited by 85 · see citing works

The relationship between circulating irisin levels and endothelial function in lean and obese subjects

Hou, N., Han, F., & Sun, X. (2014) · Clinical Endocrinology · doi:10.1111/cen.12658 · Cited by 84 · see citing works

Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population

Oelmann, S., Nauck, M., Völzke, H., Bahls, M., & Friedrich, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154319 · Cited by 83 · see citing works

Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling

So, W. Y., & Leung, P. S. (2016) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2016.07.022 · Cited by 83 · see citing works

Association of circulating irisin levels with metabolic and metabolite profiles of Korean adolescents

Jang, H. B., Kim, H.-J., Kang, J., Park, S. I., Park, K., & Lee, H. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.007 · Cited by 76 · see citing works

Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy

Anastasilakis, A. D., Koulaxis, D., Kefala, N., Pοlyzos, S. A., Upadhyay, J., Pagkalidou, E., Economou, F. I., Anastasilakis, C. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.002 · Cited by 75 · see citing works

Irisin inhibits high glucose‐induced endothelial‐to‐mesenchymal transition and exerts a dose‐dependent bidirectional effect on diabetic cardiomyopathy

Liu, X., Mujahid, H., Rong, B., Lu, Q., Zhang, W., Li, P., Li, N., Liang, E., Wang, Q., Tang, D., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13360 · Cited by 72 · see citing works

Irisin Inhibits Atherosclerosis by Promoting Endothelial Proliferation Through microRNA126‐5p

Zhang, Y.-Z., Song, H.-B., Zhang, Y., Wu, F., Mu, Q., Jiang, M., Wang, F., Zhang, W., Li, L., Shao, L., et al. (2016) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.116.004031 · Cited by 71 · see citing works

Maternal serum and fetal cord blood irisin levels in gestational diabetes mellitus

Yüksel, M. A., Öncül, M., Tüten, A., İmamoğlu, M., Açıkgöz, A. S., Kücür, M., & Madazlı, R. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.12.025 · Cited by 70 · see citing works

Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid

Huerta, A. E., Prieto-Hontoria, P. L., Fernández‐Galilea, M., Sáinź, N., Cuervo, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0400-5 · Cited by 69 · see citing works

Metformin promotes irisin release from murine skeletal muscle independently of AMP ‐activated protein kinase activation

Li, D., Huang, F., Lu, W., Jiang, G. ‐., Deng, Y., & Shen, F. (2014) · Acta Physiologica · doi:10.1111/apha.12421 · Cited by 65 · see citing works

Increased levels of irisin in people with long‐standing Type 1 diabetes

Espes, D., Lau, J., & Carlsson, P. (2015) · Diabetic Medicine · doi:10.1111/dme.12731 · Cited by 65 · see citing works

The association of new inflammatory markers with type 2 diabetes mellitus and macrovascular complications: a preliminary study.

Zhang, M., Chen, P., Chen, S., Sun, Q., Qc, Z., Jy, C., Yx, L., Xh, C., Ren, M., & Wang, J.-K. (2014) · PubMed · Cited by 65 · see citing works

Circulating Irisin and Glucose-Dependent Insulinotropic Peptide Are Associated With the Development of Polycystic Ovary Syndrome

Chang, C. L., Huang, S. Y., Soong, Y. K., Cheng, P. J., Wang, C., & Liang, I. T. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1180 · Cited by 65 · see citing works

Serum irisin concentration in women with gestational diabetes

Kuźmicki, M., Telejko, B., Lipińska, D., Pliszka, J., Szamatowicz, M., Wilk, J., Zbucka-Krętowska, M., Laudański, P., Kretowski, A. J., Górska, M., et al. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.920006 · Cited by 64 · see citing works

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

Gao, S., Li, F., Li, H., Yi, H., Liu, Y., & Chen, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147480 · Cited by 63 · see citing works

Irisin: A true, circulating hormone

Pοlyzos, S. A., Mathew, H., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.09.001 · Cited by 62 · see citing works

Free androgen index and Irisin in polycystic ovary syndrome

Li, H., Xu, X., Wang, X., Liao, X., Li, L., Yang, G., & Gao, L. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0403-7 · Cited by 62 · see citing works

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

Duan, H., Ma, B., Ma, X., Wang, H., Ni, Z., Wang, B., Li, X., Jiang, P., Umar, M., & Li, M. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.12.049 · Cited by 62 · see citing works

Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease

Deng, W. (2016) · Medical Science Monitor · doi:10.12659/msm.897376 · Cited by 62 · see citing works

Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy

Hu, W., Wang, R., Li, J., Zhang, J., & Wang, W. (2015) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563215582072 · Cited by 59 · see citing works

Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees

Choi, E. S., Kim, M. K., Song, M. K., Kim, J., Kim, E. S., Chung, W. J., Park, K. S., Cho, K. B., Hwang, J. S., & Jang, B. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110680 · Cited by 58 · see citing works

Role of Irisin on the bone–muscle functional unit

Colaianni, G., & Grano, M. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.134 · Cited by 57 · see citing works

Lower circulating irisin is associated with nonalcoholic fatty liver disease and type 2 diabetes

Shanaki, M., Moradi, N., Emamgholipour, S., Fadaei, R., & Poustchi, H. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.03.037 · Cited by 57 · see citing works

An update on the validity of irisin assays and the link between irisin and hepatic metabolism

Pοlyzos, S. A., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.06.005 · Cited by 56 · see citing works

Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes

Klangjareonchai, T., Nimitphong, H., Saetung, S., Bhirommuang, N., Samittarucksa, R., Chanprasertyothin, S., Sudatip, R., & Ongphiphadhanakul, B. (2014) · International Journal of Endocrinology · doi:10.1155/2014/261545 · Cited by 55 · see citing works

Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state?

García-Fontana, B., Reyes‐García, R., Morales, S., Ávila-Rubio, V., Muñoz‐Garach, A., Rozas-Moreno, P., & Muñoz‐Torres, M. (2015) · Endocrine · doi:10.1007/s12020-015-0758-8 · Cited by 54 · see citing works

Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance

Nigro, E., Scudiero, O., Monaco, M. L., Polito, R., Schettino, P., Grandone, A., Perrone, L., del Giudice, E. M., & Daniele, A. (2017) · Cytokine · doi:10.1016/j.cyto.2016.12.018 · Cited by 54 · see citing works

Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women

Yan, J., Liu, H.-J., Guo, W., & Yang, J. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.03.011 · Cited by 52 · see citing works

High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus

Huh, J. H., Ahn, S. V., Choi, J. H., Koh, S. B., & Chung, C. H. (2016) · Medicine · doi:10.1097/md.0000000000003742 · Cited by 51 · see citing works

Emerging and future therapies for nonalcoholic steatohepatitis in adults

Mintziori, G., & Pοlyzos, S. A. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1225727 · Cited by 50 · see citing works

The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients

Zhu, L., Wang, G., Zhu, Y., Li, C.-G., Tang, Y., Jiang, Z., Yang, M. H., Ni, C., Chen, L., & Niu, W.-Y. (2017) · Bioscience Reports · doi:10.1042/bsr20170213 · Cited by 50 · see citing works

Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Petta, S., Valenti, L. V. C., Svegliati‐Baroni, G., Ruscica, M., Pipitone, R. M., Dongiovanni, P., Rychlicki, C., Ferri, N., Cammà, C., Fracanzani, A. L., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00056 · Cited by 50 · see citing works

N-Glycosylation is required for FDNC5 stabilization and irisin secretion

Nie, Y., & Liu, D. (2017) · Biochemical Journal · doi:10.1042/bcj20170241 · Cited by 50 · see citing works

FNDC 5 could be regulated by leptin in adipose tissue

Gutiérrez‐Repiso, C., García‐Serrano, S., Rodríguez‐Pacheco, F., García‐Escobar, E., Haro‐Mora, J. J., García-Arnés, J. A., Valdés, S., Gonzalo, M., Soriguer, F., Moreno‐Ruiz, F. J., et al. (2014) · European Journal of Clinical Investigation · doi:10.1111/eci.12324 · Cited by 48 · see citing works

The relationships of irisin with bone mineral density and body composition in PCOS patients

Gao, S., Cheng, Y., Zhao, L., Chen, Y., & Liu, Y. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2767 · Cited by 48 · see citing works

Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

Yang, M., Chen, P., Jin, H., Xie, X., Gao, T., Yang, L., & Yu, X. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-133 · Cited by 46 · see citing works

Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy

Shelbaya, S., Abushady, M. M., Nasr, M. S., Bekhet, M. M., Mageed, Y. A.-A., & Abbas, M. (2018) · Current Diabetes Reviews · doi:10.2174/1573399813666170829163442 · Cited by 46 · see citing works

Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation

Aydın, S., Ögetürk, M., Kuloğlu, T., Kavaklı, A., & Aydın, S. (2014) · Peptides · doi:10.1016/j.peptides.2014.11.008 · Cited by 44 · see citing works

Irisin in goldfish ( Carassius auratus ): Effects of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 expression

Butt, Z. D., Hackett, J. D., & Volkoff, H. (2017) · Peptides · doi:10.1016/j.peptides.2017.02.003 · Cited by 44 · see citing works

Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

Abalı, R., Yüksel, İ. T., Yüksel, M. A., Bulut, B., İmamoğlu, M., Emirdar, V., Ünal, F., Güzel, S., & Celik, C. (2016) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2016.1174200 · Cited by 43 · see citing works

SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Al‐Daghri, N. M., Mohammed, A. K., Al-Attas, O. S., Amer, O. E., Clerici, M., Alenad, A. M. H., & Alokail, M. S. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0224-5 · Cited by 42 · see citing works

Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients

Akour, A. A., Kasabri, V. N., Bulatova, N., Bustanji, Y. K., Naffa, R. G., Hyassat, D., Khawaja, N. M., Bustanji, H., Zayed, A. A., & Momani, M. S. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0926-1 · Cited by 42 · see citing works

Irisin levels in the progression of diabetes in sedentary women

Duran, İ. D., Gülçelik, N. E., Ünal, M., Topçuoğlu, C., Sezer, S., Tuna, M. M., Berker, D. S., & Güler, S. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.07.098 · Cited by 41 · see citing works

Low Bone Mineral Density and Fragility Fractures in Permanent Vegetative State Patients

Oppl, B., Michitsch, G., Misof, B. M., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2122 · Cited by 41 · see citing works

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis

Pοlyzos, S. A., Goulis, D. G., Kountouras, J., Mintziori, G., Chatzis, P., Papadakis, E. P., Katsikis, I., & Panidis, D. (2014) · HORMONES · doi:10.14310/horm.2002.1493 · Cited by 41 · see citing works

Irisin relaxes mouse mesenteric arteries through endothelium-dependent and endothelium-independent mechanisms.

Jiang, M., Wan, F., Wang, F., & Wu, Q. (2015) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2015.11.040 · Cited by 41 · see citing works

Irisin as an early marker for predicting gestational diabetes mellitus: a prospective study

Erol, O. Ö., Erkal, N., Elli̇dağ, H. Y., İsenlik, B. S., Aydın, Ö., Derbent, A. U., & Yılmaz, N. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2016.1142967 · Cited by 41 · see citing works

Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile

Mehrabian, S., Taheri, E., Karkhaneh, M., Qorbani, M., & Hosseini, S. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-016-0239-5 · Cited by 41 · see citing works

Circulating irisin is lower in gestational diabetes mellitus

Zhao, L., Li, J., Li, Z., Yang, J., Li, M., & Wang, G.-L. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej15-0230 · Cited by 40 · see citing works

Increased Maternal and Cord Blood Betatrophin in Gestational Diabetes

Wawrusiewicz‐Kurylonek, N., Telejko, B., Kuźmicki, M., Sobota, A., Lipińska, D., Pliszka, J., Raczkowska, B. A., Kuć, P., Urban, R., Szamatowicz, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131171 · Cited by 39 · see citing works

Relationship between serum irisin levels and urinary albumin excretion in patients with type 2 diabetes

Wang, H.-H., Zhang, X., Chen, W.-K., Huang, Q., & Chen, Q.-Q. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.01.001 · Cited by 38 · see citing works

Cord blood irisin levels are positively correlated with birth weight in newborn infants

Joung, K. E., Park, K., Filippaios, A., Dincer, F., Christou, H. A., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.07.019 · Cited by 38 · see citing works

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska, A., Karczewska‐Kupczewska, M., Łebkowska, A., Milewski, R. J., Górska, M., Otziomek, E., Nikołajuk, A., Wołczyński, S., & Kowalska, I. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0249 · Cited by 38 · see citing works

Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study

Huang, J., Wang, S., Xu, F., Wang, D., Yin, H., Lai, Q., Liao, J., Hou, X., & Hu, M. (2017) · PeerJ · doi:10.7717/peerj.3669 · Cited by 38 · see citing works

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş, İ., Arikan, M. F., Erdogan, K., Kaplan, M., Yuksel, M., Topçuoğlu, C., Yilmaz, N., & Guler, S. (2017) · Endocrine Regulations · doi:10.1515/enr-2017-0001 · Cited by 38 · see citing works

Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population

Tang, S., Zhang, R., Jiang, F., Wang, J., Chen, M., Peng, D., Yan, J. Y., Wang, S., Bao, Y., Hu, C., et al. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12439 · Cited by 37 · see citing works

Study on the Distribution and Elimination of the New Hormone Irisin In Vivo: New Discoveries Regarding Irisin

Lv, J., Pan, Y., Li, X., Cheng, D., Ju, H., Tian, J., Shi, H., & Zhang, Y. (2015) · Hormone and Metabolic Research · doi:10.1055/s-0035-1547261 · Cited by 36 · see citing works

The effect of Irisin on antioxidant system in liver

Batirel, S., Bozaykut, P., Mutlu Altundag, E., Kartal Ozer, N., & Mantzoros, C. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.592 · Cited by 35 · see citing works

Serum irisin levels in patients with polycystic ovary syndrome.

Bostancı, M. S., Akdemir, N., Cinemre, B., et al. (2015) · PubMed · Cited by 35 · see citing works

Association of irisin and FNDC5 rs16835198 G > T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study

Khidr, E. G., Ali, S. S., Elshafey, M. M., & Fawzy, O. (2017) · Gene · doi:10.1016/j.gene.2017.05.010 · Cited by 35 · see citing works

Irisin regulates cardiac physiology in zebrafish

Sundarrajan, L., Yeung, C., Hahn, L., Weber, L. P., & Unniappan, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181461 · Cited by 35 · see citing works

&bgr;‐arrestin‐2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling

Pang, Y.-L., Zhu, H., Xu, J., Yang, L., Liu, L., & Li, J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.006 · Cited by 35 · see citing works

Role of serum levels of irisin and oxidative stress markers in pregnant women with and without gestational diabetes

Usluoğullari, B., Usluoğulları, C. A., Balkan, F., & Örkmez, M. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1284789 · Cited by 34 · see citing works

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Pukajło, K., Łaczmański, Ł., Kolačkov, K., Kuliczkowska-Płaksej, J., Bolanowski, M., Milewicz, A., & Daroszewski, J. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1065482 · Cited by 32 · see citing works

Irisin in the Glucose Continuum

Assyov, Y. S., Gateva, A., Tsakova, A. D., et al. (2015) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0035-1564130 · Cited by 32 · see citing works

Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes

Wang, C., Wang, L., Liu, J., et al. (2016) · Endocrine · doi:10.1007/s12020-016-0905-x · Cited by 31 · see citing works

Alteration of maternal serum irisin levels in gestational diabetes mellitus

Ural, Ü. M., Şahin, S. B., Tekın, Y. B., Cüre, M. C., & Sezgin, H. (2016) · Ginekologia Polska · doi:10.5603/gp.2016.0013 · Cited by 28 · see citing works

Exercise, muscle, and the applied load-bone strength balance

Giangregorio, L., & El-Kotob, R. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3780-7 · Cited by 28 · see citing works

Higher circulating irisin levels in patients with polycystic ovary syndrome:a meta-analysis

Wang, C., Zhang, X., Sun, Y. S., Hou, X., & Chen, L. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1393065 · Cited by 25 · see citing works

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

Hernández‐Trejo, M., García‐Rivas, G., Torres‐Quintanilla, A., & Laresgoiti‐Servitje, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165229 · Cited by 24 · see citing works

Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway

Song, H., Xu, J., Lv, N., Zhang, Y., Wu, F., Li, H., Shao, L., Mu, Q., Wang, F., Tang, D., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.052 · Cited by 23 · see citing works

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Viitasalo, A., Atalay, M., Pihlajamäki, J., Jääskeläinen, J., Korkmaz, A., Kamińska, D., Lindi, V., & Lakka, T. A. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.010 · Cited by 18 · see citing works

Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans

Schlögl, M., Piaggi, P., Votruba, S. B., Walter, M. F., Krakoff, J. A., & Thearle, M. S. (2015) · Appetite · doi:10.1016/j.appet.2015.03.003 · Cited by 17 · see citing works

Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

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